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    News and Articles on Caenorhabditis elegans

    Latest News: Caenorhabditis elegans

    Study Provides New Insights Into Brain Organization  Aug 22, 2006
    The computer programme, run over several days, took information about the length of nerve fibres in the primate brain and neuronal connections called axons in the brain of a species of worm known as Caenorhabditis elegans. It then tested if the total length of fibres could be reduced, by testing billions of different position arrangements. (Science Daily)

    Long lifespan inhibits tumors  Aug 18, 2006
    The authors found that mutant Caenorhabditis elegans worms that live twice as long show increased cell death and decreased cell division in tumor cells ... H. Murakami et al., "Aging-dependent and -independent modulation of associative learning behavior by insulin/insulin-like growth factor-1 signal in Caenorhabditis elegans," Journal of Neuroscience, November 23, 2005 ... C.F. Glenn et al., "Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory... (The Scientist)

    Longevity genes fight back at cancer  Aug 18, 2006
    Cynthia Kenyon and colleagues from the University of California, San Francisco, studied the link in the tiny transparent worm Caenorhabditis elegans, a species that doesn't usually get cancer. Some genetic mutations in these worms are known to boost lifespan by affecting processes such as hormone signalling, food intake and respiration. (Nature News Service)

    Longevity genes fight cancer at its source  Aug 18, 2006
    Pinkston experimented with the roundworm Caenorhabditis elegans, and created a genetic variant that expressed the longevity producing daf-2 gene and also the life-shortening gld-1 gene. She found that the double mutants lived just as long as the long-lived worms with just daf-2. (New Scientist (subscription))

    Capturing humanity on film  Aug 12, 2006
    E. Lozano et al., "Regulation of growth by ploidy in Caenorhabditis elegans," Current Biology, March 2006. R.B. Azevedo et al., "The simplicity of metazoan cell lineages," Nature, January 2005. (The Scientist)

    'Friend' protein keeps nerve signals in check  Jul 25, 2006
    Richmond and her colleagues used the soil nematode worm Caenorhabditis elegans to study the function of tomosyn using a recording technique she developed to understand how synaptic proteins affect release of neurotransmitters at the nerve cell junctions. The lab's ability to study synaptic transmission was recently improved with the addition of high pressure freeze electron microscopy and immuno-gold staining, which together provide a clearer picture of where neurotransmitter-containing synaptic... (EurekAlert!)

    Expressing G protein coupled receptors in C. elegans  Jul 21, 2006
    Caenorhabditis elegans is a soil-dwelling, bacteria-feeding nematode that uses GPCRs expressed in chemosensory neurons to detect bacteria and environmental compounds, making this an ideal system for studying in vivo GPCR-ligand interactions. We sought to test this by functionally expressing two medically important mammalian GPCRs, somatostatin receptor 2 (Sstr2) and chemokine receptor 5 (CCR5) in the gustatory neurons of C. elegans. (BioMed Central)

    Geneticist investigated for misconduct  Jun 3, 2006
    S.R. Thompson, et al. "Rapid deadenylation and Poly(A)-dependent translational repression mediated by the Caenorhabditis elegans tra-2 3' untranslated region in Xenopus embryos," Molecular Cell Biology, March, 2000. 1986-2006 The Scientist. (The Scientist)

    AceTree: a tool for visual analysis of Caenorhabditis elegans embryogenesis  Jun 2, 2006
    The invariant lineage of the nematode Caenorhabditis elegans has potential as a powerful tool for the description of mutant phenotypes and gene expression patterns. We previously described procedures for the imaging and automatic extraction of the cell lineage from C. elegans embryos. (BioMed Central)

    Sex and the single worm  Apr 21, 2006
    As an evolutionary developmental biologist, Haag studies the tiny animal known as Caenorhabditis elegans, hoping that he can unravel some of the mysteries about the role that genes play in sexual development, how sex evolved and why we bother with it ... Haag's research is focused on comparing Caenorhabditis elegans with Caenorhabditis briggsae, two species of worm that developed a useful reproductive trick before they went their separate ways on the evolutionary tree millions of years ago. (SunSpot.net)

    Cell-Growth 'Switch' Holds Clues to Cancer  Apr 20, 2006
    Reporting in the April 18 issue of Current Biology, they studied a tiny roundworm called Caenorhabditis elegans, and found that a tumor suppressor gene called PTEN also functions to keep the animal in a waiting state by blocking cell growth when food is absent. If the worms hatch from their eggs and are unable to find any food, they can remain in a young state for a long period of time without growing. (Health-Finder)

    Worm Procreation: 50 Ways To Be Your Lover  Apr 5, 2006
    The nematodes Caenorhabditis elegans and briggsae are cousins in a common family of tiny bacteria-eating worm found in shallow soil and compost piles ... (February 3, 2005) -- The nematode Caenorhabditis elegans is a little less lonely than the rest of us--it is a self-fertile hermaphrodite, which as a larva makes and stores sperm before switching to egg production for the. (Science Daily)

    Understanding the life of C. elegans  Apr 5, 2006
    HOUSTON (April 4, 2006) When the nematode Caenorhabditis elegans has enough to eat, enjoys the right temperatures and is not crowded out by its fellows, it produces a hormone, which binds to a receptor called DAF12 that allows it to reach reproductive maturity and live a natural lifespan. When conditions are harsher, however, the worm a classic model organism frequently studied in the laboratory does not produce the hormone and enters a special stage called the dauer diapause in which it... (EurekAlert!)

    Three little pigs go healthy  Mar 28, 2006
    " Meat is generally low in omega-3 fatty acids and high in omega-6 fatty acids, which do not have the same healthy properties. Fish such as salmon and tuna are omega-3 rich, but some scientists are concerned about people eating a lot of such fish because they contain toxic heavy metals such as mercury, and because of the pressure on collapsing fish stocks. A group led by Yifan Dai, of the University of Pittsburgh, genetically modified pig cells to express a gene called fat-1, which is normally... (Australian)

    Why the the fat from this little piggy could be good for us  Mar 27, 2006
    In the study, a group led by Dr Dai, Dr Kang and Professor Randall Prather of the University of Minnesota, genetically modified pig cells to express a gene called fat-1, which is normally found in the nematode worm Caenorhabditis elegans, and which converts omega 6 fats into omega 3. They then cloned embryos from the transgenic pig cells, producing ten male piglets. (Times Online)

    Cloned pigs 'porky and best'  Mar 27, 2006
    A team led by Yifan Dai of the University of Pittsburgh's School of Medicine transferred into foetal pig cells a gene called fat-1 that had been identified in a well-studied lab animal, a tiny worm known as Caenorhabditis elegans. Fat-1 converts the abundant but less desirable omega-6 fatty acids into the coveted omega-3. (iAfrica.com)

    Manipulating Single Cell Receptor Alters Animal Behavior  Mar 25, 2006
    Posted: March 24, 2006. Researchers at the University at Buffalo and the University of Pennsylvania were the first to demonstrate that two intracellular events, both stimulated by the same cell receptor, can provoke different behaviors in mammals. (Science Daily)

    Worm Hormone Discovery May Aid Fight Against Parasitic Disease  Mar 15, 2006
    UT Southwestern researchers have discovered a molecule that activates genes involved in the development and reproduction of Caenorhabditis elegans, a common research worm about the size of a pinhead. In a study available online and appearing in the March 24 issue of the journal Cell, UT Southwestern scientists describe how the molecule, called a ligand, acts like a hormone, the first such hormonal ligand identified in C. elegans. (Science Daily)

    For The First Time: Longevity Modulated Without Disrupting Life-sustaining Function  Mar 13, 2006
    D., Dillin's team identified a protein in the worm Caenorhabditis elegans that allowed them to do just that. The protein is encoded by the Smk-1 gene. (Science Daily)

    Biologists develop genome-wide map of miRNA-mRNA interactions  Mar 9, 2006
    Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans). MicroRNAs bind to messenger RNA (mRNA) in a specific section, called 3'UTR, and are known to regulate them. (EurekAlert!)

    Anti-aging Drugs on Horizon  Feb 20, 2006
    The enzyme has the same effect in common laboratory animals such as the worm Caenorhabditis elegans, and the fly, Drosophila melanogaster. But we dont know if its quite the same in mammals, which have more complicated metabolism regulation, and different hormones, said Professor Imai. (Red Herring)

    Worm starvation response  Feb 7, 2006
    In Caenorhabditis elegans, the switch to increased stress resistance to promote survival through periods of starvation is regulated by the DAF-16/FOXO transcription factor. Reduction-of-function mutations in AGE-1, the C. elegans Class IA phosphoinositide 3-kinase (PI3K), increase lifespan and stress resistance in a daf-16 dependent manner. (BioMed Central)

    Algal Protein In Worm Neurons Allows Remote Control Of Behavior By Light  Jan 1, 2006
    Nagel et al.: "Light Activation of Channelrhodopsin-2 in Excitable Cells of Caenorhabditis elegans Triggers Rapid Behavioral Responses." Publishing in Current Biology, Vol. 15, 2279-2284, December 20, 2005, DOI 10. 1016/j. (Science Daily)


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