This day in history Nov 2, 2009
In 1947, Howard Hughes piloted his huge wooden flying boat, the Hughes H-4 Hercules (derisively dubbed the Spruce Goose by detractors), on its only flight, which lasted about a minute over Long Beach Harbor in California. In 1948, President Truman surprised the experts by winning a narrow upset over Republican challenger Thomas E. Dewey. (Boston Globe)
Stress-induced Changes In Brain Circuitry Linked To Cocaine Relapse Nov 1, 2009
Palmiter is also a Howard Hughes Medical Institute investigator. The research was supported by U.S. Public Health Services grants from the National Institute on Drug Abuse of the National Institutes of Health, and the Hope for Depression Foundation. (Science Daily)
Sight gone, but not necessarily lost? Oct 31, 2009
D., a professor of molecular biology and genetics, neuroscience and ophthalmology at Johns Hopkins and a Howard Hughes Medical Institute investigator ... This study was funded by the National Eye Institute and the Howard Hughes Medical Institute. (EurekAlert!)
This is your brain on fatty acids Oct 31, 2009
D., a Howard Hughes Medical Institute postdoctoral fellow at Hopkins ... This study was supported by research grants from the National Institute of Mental Health and the Howard Hughes Medical Institute. (EurekAlert!)
Geneticists Hunt For Scleroderma Triggers Oct 31, 2009
For the current study, he received support from the Scleroderma Research Foundation, as well as a biomedical research award to Dartmouth from the Howard Hughes Medical Institute. "Several different pathways likely contribute to the gene expression subsets in scleroderma, and each subset may need to be treated differently," Whitfield says, before adding, "We're getting inquiries from rheumatologists and companies that are looking at drug trials.". (Science Daily)
Elizabeth Davies: Taking every precaution against the flu Oct 31, 2009
Just call me Mrs. Howard Hughes. This year s flu season has turned me into a germaphobe. (Belmont Citizen Herald, MA)
Key To How 'Triggering Event' In Cancer Occurs: Researchers Link Hormone To Creation Of Gene Fusion In Prostate Cancer Oct 31, 2009
Chinnaiyan is also a Howard Hughes Medical Institute investigator. Chinnaiyan and his team identified in 2005 a prostate-specific gene called TMPRSS2 that fuses with the gene ERG, which is known to play a role in prostate cancer. (Science Daily)
HIV Tamed By Designer 'Leash' Oct 30, 2009
"Tetherin is essentially a rod with anchors at either end that are critical for its function," says Paul Bieniasz of Howard Hughes Medical Institute and the Aaron Diamond AIDS Research Center at The Rockefeller University. Either one of those anchors gets incorporated into the envelope surrounding HIV or other viruses as they bud through the plasma membrane of an infected cell. (Science Daily)
Salk Institute Awarded Grant For ALS Project Oct 29, 2009
Sam Pfaff, a professor at the Salk's Gene Expression Laboratory and an investigator for the Howard Hughes Medical Institute, will lead the group of researchers working on the four-year project. Lou Gehrig's disease, also called Amyotrophic Lateral Sclerosis, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. (TheSanDiegoChannel.com, CA)
Promising New Path For Treating Traumas Discovered Oct 27, 2009
The current research was made possible by support from the Howard Hughes Medical Institute. Adapted from materials provided by. (Science Daily)
Gene therapy experiment restores sight in a few Oct 27, 2009
"All 12 patients given gene therapy in one eye showed improvement in retinal function," Dr Katherine High of The Children's Hospital of Philadelphia and the Howard Hughes Medical Institute and colleagues wrote in a report to be released at the same time by the Lancet medical journal. LCA causes the retina to degenerate and the researchers found that the younger the patient treated with the therapy, the better the effects. (MSNBC -- Health)
A solution to Darwin's 'mystery of the mysteries' emerges from the dark matter of the genome Oct 27, 2009
Earlier this year Malik, a Howard Hughes Medical Institute Early Career Scientist, was awarded the Presidential Early Career Award for his unique combination of evolutionary and genetic approaches to tackle important problems like speciation and infectious disease ... Grants from the National Institutes of Health, the Mathers Foundation and the Howard Hughes Medical Institute funded this research. (EurekAlert!)
David Denby: Tales of Amelia Earhart, Valery Gergiev, and the Paris Opera Ballet. Oct 26, 2009
But Martin Scorsese did a lot better in The Aviator, by aggressively styling Howard Hughes and the heroic-aviation period as a kind of Art Deco poster. Alas, the impression of fervent clich. (New Yorker)
1 shot of gene therapy and children with congenital blindness can now see Oct 25, 2009
High, an investigator of the Howard Hughes Medical Institute and a past president of the American Society of Gene Therapy, has been a pioneer in translational and clinical studies of gene therapy for genetic disease ... D., Howard Hughes Medical Institute Investigator and director of the Carver Center, a genetic testing laboratory at the University of Iowa, identified and verified several of the disease-causing mutations in the study subjects ... High and Stone are Investigators of the Howard... (EurekAlert!)
A Tishman default in LA Oct 24, 2009
A Tishman Speyer Properties LP office park in California where reclusive aviator Howard Hughes 0000079D once worked is the subject of a foreclosure lawsuit saying the owners failed to repay $154 million in debt due in July ... A Tishman Speyer Properties LP office park in California where reclusive aviator Howard Hughes once worked is the subject of a foreclosure lawsuit saying the owners failed to repay $154 million in debt due in July. (New York Post -- Business)
'Holy Grail' Of Cancer Therapy: Researchers Find Way To Protect Healthy Cells From Radiation Damage Oct 22, 2009
The research was funded by the Intramural Research Program of the National Cancer Institute, the Howard Hughes Medical Institute-NIH Research Scholars Program and the NIH. The inventions described in this paper are the subject of a patent application. Adapted from materials provided by , via , a service of AAAS. Email or share this story. (Science Daily)
Single-stranded DNA-binding protein is dynamic, critical to DNA repair Oct 22, 2009
Whenever the double helix of DNA unravels, exposing each strand to the harsh environment of the cell, SSB is usually first on the scene, said University of Illinois physics professor and Howard Hughes Medical Institute investigator Taekjip Ha, who led the study ... This research was supported by the National Science Foundation, the Howard Hughes Medical Institute and the National Institutes of Health. (EurekAlert!)
Process That Determines Fate Of White Blood Cells Uncovered Oct 20, 2009
(July 17, 2005) Howard Hughes Medical Institute researchers have discovered a novel way in which the brain size of developing mammals may be regulated. They have identified a signaling pathway that controls the. (Science Daily)
Cellular Mechanism That Causes Lupus-like Symptoms In Mice Identified Oct 20, 2009
Support was also provided by the Stanford Medical Scientist Training Program, the American Heart Association, Dean's Fellowship and the Howard Hughes Medical Institute Gilliam Fellows. Adapted from materials provided by , via , a service of AAAS. Email or share this story. (Science Daily)
Xenotropic Murine Leukemia Virus-related Virus May Not Be Associated With Human Prostate Cancer Oct 20, 2009
31, 2006) Howard Hughes Medical Institute researchers and their colleagues have discovered a new retrovirus in humans that is closely related to a cancer-causing virus found in mice. Their findings describe. (Science Daily)
Scan Of Turkish Infant's Genome Yields A Surprise Diagnosis Oct 20, 2009
"We believe this heralds the dawn of a new era in genetics and personalized medicine," said Lifton, an investigator for the Howard Hughes Medical Institute. The new approach is a marriage of advanced DNA sequencing technology and microarray protocols that can selectively sequence protein-coding regions of the genomes. (Science Daily)
Top Media Hoaxes Oct 20, 2009
Howard Hughes Hoaxster: Heene Ordeal Brought 'Pleasure' to Public ... "It was fun and games," said Clifford Irving, the man who managed to convince the world in 1972 that he had been granted exclusive access to the reclusive billionaire Howard Hughes to write his autobiography. (ABC News)
Stanford study identifies cellular mechanism that causes lupuslike symptoms in mice Oct 19, 2009
Support was also provided by the Stanford Medical Scientist Training Program, the American Heart Association, Dean's Fellowship and the Howard Hughes Medical Institute Gilliam Fellows. The Stanford University School of Medicine consistently ranks among the nation's top 10 medical schools, integrating research, medical education, patient care and community service. (EurekAlert!)
The mental illness that flies under the radar Oct 19, 2009
I knew Howard Hughes suffered from obsessive compulsive disorder, a form of anxiety along with generalised anxiety disorder, phobias, post traumatic stress disorder and panic disorder. My other image of the illness was standing behind a man at a chemist handing over his subscription to anxiety tablets with a shaking hand. (Sydney Morning Herald -- Opinion)
Better Stem Cells From Adult Tissue Oct 19, 2009
12, 2007) Using a nuclear transfer procedure, scientists at Rockefeller University and the Howard Hughes Medical Institute have, for the first time, shown reproducibly that mice can be cloned from adult stem. (Sep. (Science Daily)
Richard Whitcomb; solved jet design problem Oct 19, 2009
Previous recipients included aviation pioneers including Howard Hughes, Chuck Yeager, Glenn Curtiss, Glenn Martin, and Elmer Sperry. Besides the Collier Trophy, Mr. Whitcomb in 1973 received the National Medal of Science, the nation s highest honor for science and engineering. (Boston Globe)
NormanChadCouch Slouch America's Slogan Buster surveys the vast wasteland of TV ads. Oct 19, 2009
A. I believe Howard Hughes ordered room service at the Desert Inn every day between 1966 and 1971. Q. You are funny on the poker show and I really enjoy your column, but I was wondering if you ever had a real job. (SportsIllustrated.CNN)
Hollywood’s love affair with aviation has had its ups, downs Oct 18, 2009
Howard Hughes was far from alone in having such a strong attraction to both building planes and making movies ... You d think its director, Scorsese, had spent as much of his boyhood making model airplanes as he did watching old movies on TV. The real-life hero of The Aviator, Howard Hughes (Leonardo DiCaprio), was both movie mogul and aviation mogul. (Boston Globe)
Mechanism Of Gene Linked To Autism, Schizophrenia Pinpointed Oct 17, 2009
"One of the most perplexing things about autism is the heterogeneity of the disease," said Sudhof, who is also a Howard Hughes Medical Institute investigator. "Autism might be one disease, or it might be thousands of diseases.". (Science Daily)
Science study: Teacher participation in Columbia program improves student achievement in science Oct 17, 2009
Columbia's Summer Research Program has been supported by the Howard Hughes Medical Institute, Ambrose Monel, Braitmayer, Bristol Myers Squibb, Camille and Henry Dreyfus, Greenwald, Mellam Family, J.P. Morgan, and NY Times Company Foundations; the Charles Edison Fund, and Hebrew Technical Institute; the National Institute of Allergy and Infectious Diseases and the National Center for Research Resources Science Education Partnerships Awards of the National Institutes of Health, National Science... (EurekAlert!)
Select 'Friendly' Bacteria Shape Immune System Oct 16, 2009
"It's the first example of a commensal bacteria that can induce accumulation in the gut of a highly specific branch of the immune system," said Dan Littman of the Howard Hughes Medical Institute and the New York University School of Medicine, who led the study reported in Cell ... The researchers include Ivaylo I. Ivanov, New York University School of Medicine, New York, NY; Koji Atarashi, Osaka University, Osaka, Japan, Nicolas Manel, New York University School of Medicine, New York, NY; Eoin... (Science Daily)
The food-energy cellular connection revealed Oct 16, 2009
"Shift workers face a 100 percent increase in the risk for obesity and its consequences, such as high blood pressure, insulin resistance and an increased risk of heart attacks," says Howard Hughes Medical Investigator Ronald M. Evans, Ph. D., a professor in the Salk Institute's Gene Expression Laboratory. (EurekAlert!)
Protein Receptor For Carbonation Taste Found Oct 16, 2009
In this week's issue of the journal Science, researchers at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health, and their colleagues from the Howard Hughes Medical Institute at the University of California, San Diego (UCSD) report that they have discovered the answer in mice, whose sense of taste closely resembles that of humans. They found that the taste of carbonation is initiated by an enzyme tethered like a small flag from the... (Science Daily)
Silence Of The Genes: Researchers Get First Look At Gene-Silencing Human RISC-Loading Complex Oct 15, 2009
Doudna and Nogales both hold joint appointments with Berkeley Lab, the University of California (UC) Berkeley, and the Howard Hughes Medical Institute (HHMI). Co-authoring the paper with them were Hong-Wei Wang, Cameron Noland, Bunpote Siridechadilok, David Taylor, Enbo Ma and Karin Felderer. (Science Daily)
UM School of Medicine researchers find extreme genetic variability in malaria parasite Oct 15, 2009
The CVD researchers, including Christopher Plowe, M.D., M.P.H., Howard Hughes Medical Institute investigator, professor of medicine and chief of the Malaria Section at the University of Maryland School of Medicine, looked at the genetic diversity in a surface protein of the Plasmodium falciparum the AMA-1 protein that is the target of some candidate malaria vaccines. By tracking the changes in the AMA-1 protein each time a child became infected with malaria, researchers found a surprising... (EurekAlert!)
Celebrities and their obsessions. Oct 14, 2009
When portraying Howard Hughes in the movie The Aviator (who co-incidentally had the same obsession), Leo told a reporter that it took him a while to get to the set, having to step on tons of things. Leonardo DiCaprio. (The Star Online, Malaysia)
Ribosome Unraveled: A Q&A with Nobelist Thomas Steitz Oct 13, 2009
Thomas Steitz, Sterling Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry at Yale University and Howard Hughes Medical Institute Investigator, receives one-third of for elucidating the structure and function of the ribosome, the protein-making factory of the cell. Joining him are Venkatraman Ramakrishnan of the MRC Laboratory of in Cambridge, England, and Ada Yonath at the Weizmann Institute of Science in Rehovot, Israel, who also worked on the problem. (Scientific American)
Figuring Out The Heads Or Tails Decision In Regeneration Oct 10, 2009
"We really want to understand the mechanism for how the polarity decision is made during regeneration hos iw it specified that a the wound is facing the old head or facing the old tail?" asks Reddien, who is also an assistant professor of biology at Massachusetts Institute of Technology and a Howard Hughes Medical Institute (HHMI) early career scientist ... He is also a Howard Hughes Medical Institute early career scientist and an assistant professor of biology at Massachusetts Institute of... (Science Daily)
Unequal access: Hispanic children rarely get top-notch care for brain tumors Oct 9, 2009
The research was funded in part by the Howard Hughes Medical Institute, the Children's Cancer Foundation and Johns Hopkins Center for Innovative Medicine. Co-investigators in the study include Thomas Kosztowski, B.S.; Hasan Zaidi, B.S.; Benjamin Carson, M.D.; and David Chang, Ph. (EurekAlert!)
New Approach For Growing Bone To Fight Osteoporosis And Other Diseases Oct 9, 2009
The study was funded by the Arthritis Foundation, NIH, and Veterans Affairs Medical Administration and supported by the Howard Hughes Medical Institute. Other authors include Pat Flannery, Ling Yuan, Leonor Corsino, and Robert Spurney of the Duke Department of Medicine. (Science Daily)
Major Step Forward In Cell Reprogramming Oct 9, 2009
Howard Hughes Medical Institute. and the. (Science Daily)
Yale hails U.S. Nobel Prize in Chemistry laureates Oct 8, 2009
Steitz is also a Howard Hughes Medical Institute (HHMI) investigator. The HHMI got two Nobel Prizes this week. (Xinhuanet, China)
Nobel Prize In Chemistry: What Ribosomes Look Like And How They Functions At Atomic Level Oct 8, 2009
27, 2005) Howard Hughes Medical Institute researchers chiseling away at the problem of antibiotic resistance now have a detailed explanation of how the drugs' main cellular target in bacteria evolves to. (Oct. (Science Daily)
Nobel chemistry prize honors atomic study Oct 8, 2009
Steitz, a 69-year-old born in Milwaukee, is a professor of molecular biophysics and biochemistry at Yale University and is an investigator with the Howard Hughes Medical Institute. Steitz told the AP that the research cited by the academy was done in parallel, but independently and said he has known Ramakrishnan since the 1980s. (MSNBC -- International)
Nobel honors ribosome research Oct 8, 2009
Steitz is a professor at Yale University and an investigator at Howard Hughes Medical Institute at Yale, the site said. Yonath is a professor at the Weizmann Institute of Science in Rehovot, Israel, and director of the Helen & Milton A. Kimmelman Center for Biomolecular Structure & Assembly at the Weizmann Institute, the Nobel site said. (CNN)
U.S. Trio Wins Medicine Nobel for Telomerase Oct 7, 2009
Berg said Szostak, who works at Harvard Medical School in Boston, Massachusetts General Hospital and the Howard Hughes Medical Institute, had moved along since his work on telomerase. "He is trying to figure out how he can make proto-cells and get them to copy their genetic material. That's almost literally creating life in a test tube.". (MEDLINEplus)
Telomere Copy Protection: Nobel Goes To Scientists Who Solved How Chromosome Ends Work Oct 6, 2009
He is also affiliated with the Howard Hughes Medical Institute. Adapted from materials provided by. (Science Daily)
Nobel in Medicine Goes to 3 Americans Oct 6, 2009
He is also affiliated with the Howard Hughes Medical Institute, the citation said. The award includes a 10 million kronor ($1. (CBS News)
Tom Cruise's Runaway Mom 'Dead' to Friends Oct 5, 2009
Leo is looking more and more like a young Clark Gable, or is it Howard Hughes from "The Aviator". As many of us know, Cinemax equals naked women. (Yahoo News -- Celebrity Couples)
3 Americans share 2009 Nobel medicine prize Oct 5, 2009
He is also affiliated with the Howard Hughes Medical Institute, the citation said. The award, announced Monday, includes a 10 million kronor ($1. (San Francisco Chronicle -- Science)
Researchers Determine Composition Of Centromeric Chromatin Oct 5, 2009
25, 2004) A new technique developed by Howard Hughes Medical Institute researchers significantly reduces the time required to isolate genetic material from the so-called black holes of. (June 17, 2008) Recombination at centromeres is higher than anywhere else on the chromosome, even though methyltransferases do their best to prevent it, according to new research. (Science Daily)
'Promiscuous' Protein Interactions Found In The Nuclear Pore Complex Oct 4, 2009
nter Blobel, John D. Rockefeller Jr. Professor and an investigator at the Howard Hughes Medical Institute. In experiments to be published online in the Proceedings of the National Academy of Sciences, in September Nagy, Hoelz and colleagues provide the molecular specifics of the only piece of the Nup84 complex that remained unknown, furthering the structural characterization of this building module. (Science Daily)
Fung rejoins Vermillion as science chief Oct 3, 2009
Before that he was a Howard Hughes sponsored researcher at Stanford University. Most Read Stories. (San Jose Business Journal, CA)
Longer-lived, Healthier Mice Offer Promise Of Drug Treatments For Age-related Diseases Oct 3, 2009
(July 20, 2007) The traditional prescriptions for a healthy life-sensible diet, exercise and weight control -- extend life by reducing signaling through a specific pathway in the brain, according to Howard Hughes. (Apr. (Science Daily)
Why One Way Of Learning Is Better Than Another Oct 3, 2009
2, 2009) A new study from the Montreal Neurological Institute and Hospital (The Neuro) of McGill University reveals that different patterns of training and learning lead to different types of memory formation. The significance of the study, published in the Journal of Neuroscience, is that it identifies the molecular differences between spaced training (distributed over time) and massed training (at very short intervals), shedding light on brain function and guiding learning and training... (Science Daily)
A New Class of Antibiotics Could Offer Hope Against TB Oct 1, 2009
"I would say that most of the American public believe that bacterial infections were conquered with the discovery of penicillin and streptomycin and that the dawn of the antibiotic age meant the end of bacterial infection as an important threat," says Richard Ebright, a Howard Hughes Medical Institute investigator at Rutgers and a co-author on the study. What has happened instead, says Zhenkun Ma, head of research at the Global Alliance for TB Drug Development, who was not involved in the new... (Time.com)
First human gets new antibody aimed at rabies virus Oct 1, 2009
The work of UMMS researcher Craig Mello, PhD, an investigator of the prestigious Howard Hughes Medical Institute (HHMI), and his colleague Andrew Fire, PhD, then of the Carnegie Institution of Washington, toward the discovery of RNA interference was awarded the 2006 Nobel Prize in Physiology or Medicine and has spawned a new and promising field of research, the global impact of which may prove astounding. UMMS is the academic partner of UMass Memorial Health Care, the largest health care... (EurekAlert!)
Million-dollar homes regaining their luster Sep 30, 2009
Rancho Santa Fe is a luxury enclave in San Diego County that has over the years lured the likes of Howard Hughes and Bill Gates. Equestrian trails border golf courses, and the most expensive home on the market is listed for $29. (MSNBC -- Business)
How would Einstein use e-mail? Sep 26, 2009
"People are not that rational," added Amaral, who also is an Early Career Scientist with the Howard Hughes Medical Institute. "If a doctor, for example, better understands how we make decisions, he or she may be able to get better compliance with a treatment if it is tied to something a person does with regularity.". (EurekAlert!)
Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells Sep 25, 2009
But it's not as simple as that, explains Grant Jensen, associate professor of biology at Caltech and an investigator with the Howard Hughes Medical Institute (HHMI), who led the team ... Their work was funded by grants from the National Institutes of Health, the Howard Hughes Medical Institute, the Beckman Institute at Caltech, and gifts to Caltech from the Gordon and Betty Moore Foundation and the Agouron Institute. (EurekAlert!)
Blocking Signal Molecule Can Prevent Growth Of Large Intestine And Colon Cancer Sep 25, 2009
22, 2004) Cancer researchers at the Case Western Reserve University (Case) School of Medicine, University Hospitals of Cleveland (UHC) and the Howard Hughes Medical Institute have found a. (Oct. (Science Daily)
Thomson Reuters Predicts Nobel Laureates Sep 24, 2009
USA -and- Jack W. Szostak Professor of Genetics, Harvard Medical School and Alexander Rich Distinguished Investigator at Massachusetts General Hospital; also, Howard Hughes Medical Institute Investigator Boston, Mass ... USA -and- Randy Schekman Professor of Cell and Developmental Biology, University of California Berkeley; also, Howard Hughes Medical Institute Investigator Berkeley, Ca., USA -- For their research on cellular membrane trafficking. (PR Newswire)
Evolution cant be reversed, research suggests Sep 24, 2009
"Evolutionary biologists have long been fascinated by whether evolution can go backwards," said study researcher Joe Thornton of the University of Oregon's Center for Ecology and Evolutionary Biology and the Howard Hughes Medical Institute. "But the issue has remained unresolved, because we seldom know exactly what features our ancestors had, or the mechanisms by which they evolved into their modern forms.". (MSNBC -- Environment)
Explaining Why Pruning Encourages Plants To Thrive Sep 23, 2009
8, 2007) A secret long held by plants has been revealed by Howard Hughes Medical Institute researchers. The new discovery, which builds on more than a decade of painstaking surveillance of cellular. (Science Daily)
Forging history - one contract hit at a time Sep 20, 2009
Many real people have set up shop in these pages, among them are J. Edgar Hoover ( the old girl, senile and obsessed with race); Howard Hughes (called Drac, because of his penchant for blood transfusions, and nutsy in the highest degree); Richard Nixon and First Friend Bebe Rebozo; underworld bosses Sam Giancana and Carlos Marcello; and Sonny Liston, training on a regimen of booze, smack, and hatred of Muhammad Ali. The cast of fictional characters is huge, a number having played parts in the... (Boston Globe)
