Are you running yourself to death? Nov 4, 2008
Your adrenal glands and brain produce the stress hormones cortisol and vasopressin; your damaged muscles churn out proteins called cytokines, which trigger your liver to start producing C-reactive protein. More stories from Men's Health. (MSNBC -- Health)
Vasopressors in Cardiopulmonary Resuscitation Oct 10, 2008
To the Editor: Gueugniaud et al. (July 3 issue)1 report that administering the combination of vasopressin and epinephrine, as compared with epinephrine alone, during advanced cardiac life support for out-of-hospital cardiac arrest does not improve outcome. The results of this study, however, are not surprising, considering that the average time from collapse to the arrival of advanced cardiac life support (downtime) was 16. (New England Journal of Medicine)
Urinary Frequency Sep 11, 2008
Vasopressin (also known as antidiuretic hormone) is a hormone that controls the amount of urine produced ... Desmopressin (DDAVP), a synthetic equivalent of vasopressin, can be used as a treatment. (Suite101.com)
PINs and needles Sep 7, 2008
The gene helps determine how the brain responds to vasopressin, a hormone that appears to make people monogamous. Men with one version of the gene recorded low scores on a questionnaire, designed to assess how well they bonded with their partners. (Sydney Morning Herald -- Opinion)
Is monogamy genetic? Sep 7, 2008
Scientists have long known that the gene that controls the hormone vasopressin is responsible for monogamy in prairie voles -- small rodents, common in the grasslands of North America, that remain faithful to their mates. Now, researchers from the Karolinska Institute in Stockholm, Sweden, have uncovered it in men -- and say it seems to play a role in whether they and their spouses are happily married. (Chicago Sun-Times)
Scientists Find Gene That Affects Pair-Bonding Behaviour In Men Sep 5, 2008
Studies on voles show that the hormone and neurotransmitter arginine vasopressin (AVP) plays an important role in this process, and that there is a strong link between a genetic sequence that codes for a subtype of the AVP receptor and the tendency for male voles to remain monogamous ... The researchers found that men with a particular variant of the AVPR1A gene (that codes for vasopressin in humans) scored lower on the bonding questions and were less likely to be married compared to men who did... (Medical News Today)
A Kissing Gene Sep 5, 2008
One of the human cell receptors that detect arginine vasopressin takes slightly different forms, with the variants controlled by genes we inherit from our parents ... For voles, genes also control the pair-bonding behavior of males, and the gene in question is also the DNA sequence that codes for an arginine vasopressin receptor. (Slate)
Gene Variant Holds The Key To A Long And Happy Marriage Sep 5, 2008
According to a recent research, the gene that controls the hormone vasopressin and is responsible for monogamy in prairie voles which are studied for their human-like social qualities also plays a role in human relationships ... Men with a certain variation of the AVPR1A gene, which affects neuropeptide arginine vasopressin, a brain chemical, causing blood pressure disturbances got low scores on the bonding test and were not as likely to be married as men who did not have that gene... (eFluxMedia)
Some men carry 'commitment-phobia' gene Sep 4, 2008
This gene can affect the production of a hormone called vasopressin, which has been shown to influence monogamy in animals. They found that men who had two copies of allele 334 were twice as likely to have had a marital or relationship crisis in the last year compared with those who lacked the gene variant. (Los Angeles Times)
Gene associated with pair-bonding in animals has similar effects in human males Sep 4, 2008
Variation in the gene for one of the receptors for the hormone vasopressin appears to be associated with how human males bond with their partners, according to an international team of researchers. The researchers found that the "334" allele of a common AVPR1A variation, the human version of avpr1a studied in voles, seemed to have negative effects on men's relationship with their spouses. (EurekAlert!)
Your Cheatin' Heart: It's Genetic Sep 4, 2008
The gene in question controls the production of a molecule receptor for vasopressin, a hormone that is found in most mammals ... The researchers said they hoped greater knowledge of the effect of vasopressin on human relations could also help understand the causes of diseases characterised by problems with social interaction, such as autism. (Newsmax)
Study: Fear of Commitment May Be in a Man's Genes Sep 3, 2008
Looking at a gene that controls a brain receptor of the hormone vasopressin, researchers found that some men who had a gene variation, called allele 334, bonded less with their mates and had more relationship conflict, according to the report. Vasopressin has been found to play a role in whether certain animals remain monogamous. (Fox News)
Commitment phobes can blame genes Sep 3, 2008
Animal studies have shown the same hormone - vasopressin - affects voles' abilities to remain monogamous ... It is thought that the gene, which was carried by 40% of the men, may affect the way the brain uses vasopressin. (BBC News -- Health)
Infidelity Gene? Genetic Link To Relationship Difficulties Found Sep 3, 2008
The gene under study codes for one of the receptors for vasopressin, a hormone found in the brains of most mammals ... The team hopes that greater knowledge of the effect of vasopressin on human relations will one day give science a better understanding of the causes of diseases characterised by problems with social interaction, such as autism ... Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans. (Science Daily)
Male Monogamy Gene? Not So Fast Sep 3, 2008
Or so women are encouraged to think by coverage of a new study on genes linked to arginine vasopressin -- a hormone that's found in mammals, helps bodies retain water, and has been linked to mate stability in prairie voles. Swedish men with variations in DNA next to the gene responsible for vasopressin sensitivity are generally more likely to have marital problems -- and less likely to be married in the first place -- than those without the variations. (Wired News)
Is fidelity in men's genes? Sep 2, 2008
The allele that Walum and a team of scientists studied in a sample of more than 1,000 heterosexual couples regulates the activity of a hormone in the brain known as vasopressin. It dictates how and where vasopressin receptors are situated in the brain ... Effectively, said Larry Young, a psychiatrist who studies the genetics of social behavior at Emory University, brain receptors act like locks, and vasopressin acts like a key. (Atlanta Journal-Constitution)
'Bonding gene' could help men stay married Sep 2, 2008
A study of Swedish twin brothers found that differences in a gene modulating the hormone vasopressin were strongly tied to how well each man fared in marriage. "Our main finding was an association between a variant of the vasopressin receptor 1a gene and how strong bonds men reported they had to their partners," said lead researcher Hasse Walum, of the department of medical epidemiology and biostatistics at the Karolinska Institute in Stockholm ... Walum's team first got interested in the role... (Yahoo News)
Be sure his genes fit if you want Mr Right Sep 2, 2008
Researchers say it plays a crucial role in determining how the brain responds to vasopressin, a chemical that is central to the bonding process between a man and a woman ... They looked at a protein in the body which responds to vasopressin ... Earlier research on the gene in prairie voles showed that boosting levels of vasopressin in the brain made the animals more monogamous. (Sydney Morning Herald -- World)
Immune System Protein Accurate Predictor Of Survival In Pediatric Septic Shock Aug 5, 2008
14, 2007) Vasopressin should be used with great caution for the treatment of hypotension in septic shock, according to new results. The experiments -- conducted in pigs -- show it can significantly reduce. (Science Daily)
Two-Drug Treatment Didn't Improve Cardiac Arrest Survival Rates Jul 4, 2008
WEDNESDAY, July 2 (HealthDay News) -- Injecting the artery-constricting hormone vasopressin in addition to adrenaline did not improve survival among people who had sudden cardiac arrest in an European trial, but American cardiologists said the finding does not rule out use of that treatment in some cases. The report comes from a group, primarily French, that several years ago described promising results of combining vasopressin and epinephrine -- the formal name of adrenaline -- as part of the... (MEDLINEplus)
Epinephrine with or without Vasopressin in Cardiopulmonary Resuscitation Jul 3, 2008
NEJM -- Vasopressin and Epinephrine vs. Epinephrine Alone in Cardiopulmonary Resuscitation ... Vasopressin and Epinephrine vs. Epinephrine Alone in Cardiopulmonary Resuscitation ... Background During the administration of advanced cardiac life support for resuscitation from cardiac arrest, a combination of vasopressin and epinephrine may be more effective than epinephrine or vasopressin alone, but evidence is insufficient to make clinical recommendations. (New England Journal of Medicine)
U.S. Food and Drug Administration Advisory Committee Recommends Approval of Tolvaptan, an Investigational Treatment for Hyponatremia Jun 26, 2008
"Otsuka is pleased that the FDA Advisory Committee supports the potential approval of tolvaptan, an investigational selective V2-vasopressin receptor antagonist," said Taro Iwamoto, Ph ... (iii) Tolvaptan is an investigational selective antagonist of the vasopressin V2 receptor, which is located predominantly in the kidney and plays a role in the regulation of fluid retention in the body ... Vasopressin V2 antagonists work by selectively blocking the V2 receptor. (PR Newswire)
Vasopressin in Septic Shock Jun 19, 2008
To the Editor: The results of the Vasopressin and Septic Shock Trial (VASST), reported by Russell et al. (Feb. 28 issue),1 do not fully support the conclusion that "low-dose vasopressin did not reduce mortality." The secondary hypothesis that "the beneficial effects of vasopressin would be more pronounced . . . in the subgroup of patients with more severe (as opposed to less severe) septic shock" was clearly refuted ... However, in the vasopressin-treated patients with less severe shock, the 25.... (New England Journal of Medicine)
New Class of Drugs Might Treat Many Conditions May 13, 2008
Vaptans, short for vasopressin-receptor antagonists, work by targeting the vasopressin hormone system, which plays an important role in controlling blood and water volume in the body. These drugs, which can be taken orally or intravenously, block the action of vasopressin, according to the report in the May 10 issue of The Lancet. (MEDLINEplus)
Upper Gastrointestinal Bleeding Apr 19, 2008
Management of Hemorrhage From the Esophagus, Stomach, and Duodenum. Upper GI bleeding requires several steps for management. (Suite101.com)
Ruthless behavior may be genetic... Apr 5, 2008
Ebstein and his colleagues decided to look at AVPR1a because it is known to produce receptors in the brain that detect vasopressin, a hormone involved in altruism and 'prosocial' behaviour ... It isn't clear how the length of AVPR1a affects vasopressin receptors: it is thought that rather than controlling the number of receptors, it may control where in the brain the receptors are distributed ... Ebstein suggests the vasopressin receptors in the brains of people with short AVPR1a may be... (The Drudge Report)
Two Drugs Found Equal in Treatment of Septic Shock Feb 29, 2008
But vasopressin might be slightly better than norepinephrine in less severe cases ... WEDNESDAY, Feb. 27 (HealthDay News) -- The artery-tightening medication vasopressin holds no overall advantage over an older drug, norepinephrine, in the treatment of severe septic shock, a new study finds ... But vasopressin did appear to be better for less severe cases in the study, said Dr. James. (MEDLINEplus)
Septic Shock — Vasopressin, Norepinephrine, and Urgency Feb 28, 2008
NEJM -- Septic Shock -- Vasopressin, Norepinephrine, and Urgency ... Septic Shock Vasopressin, Norepinephrine, and Urgency ... Septic Shock: Norepinephrine Alone -- Or with Vasopressin. (New England Journal of Medicine)
Pituitary Gland Tumors Feb 24, 2008
Antidiuretic hormone (ADH), also called vasopressin, to help maintain body water. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to regulate the reproductive glands. (Suite101.com)
Holly Springs man builds his own 'man cave' Feb 16, 2008
" Guys have something called vasopressin. Less is known about vasopressin, says Haltzman, but it does tend to make the male of the species more territorial. Also, he says the male brain structure contributes to why guys are less into sharing emotions, more into watching sports on a flat-screen TV with surround sound. Enough talk. Let the construction begin. First, it should be known that Brookins isn't some regular joe who has taken it upon himself to build a free-standing man cave. Brookins,... (The Daily Reflector)
NDA accepted for tolvaptan, investigational drug for worsening heart failure and hyponatremia Dec 22, 2007
PRINCETON, NJ, Dec. 21, 2007-- Otsuka Pharmaceutical Development rcialization, Inc. announced today that the U.S. Food and Drug Administration has accepted a new drug application (NDA) for the companys investigational oral once-daily medication tolvaptan, a selective V2-vasopressin receptor antagonist, for two indications: treatment of adults with worsening heart failure and treatment of hyponatremia1 ... Tolvaptan is a novel, investigational small molecule designed to be an antagonist of the... (EurekAlert! -- Business News)
Vasopressin Caution In Septic Shock, Animal Study Suggests Dec 14, 2007
14, 2007) Vasopressin should be used with great caution for the treatment of hypotension in septic shock, according to new results from an international research team ... The peptide hormone vasopressin is being developed as a new therapy for the hemodynamic support of septic shock and vasodilatory shock due to systemic inflammatory response syndrome ... However, the safety of vasopressin treatment in humans with septic shock is yet to be proven. (Science Daily)
Generosity 'may be in the genes' Dec 10, 2007
The gene AVPR1a plays a key role in allowing a hormone called arginine vasopressin to act on brain cells. Vasopressin, in turn, has been implicated in social bonding. (BBC News -- Health)
Read the interview Nov 13, 2007
Men secrete a particular hormone, vasopressin. Both men and women, when they are doing something pleasurable, secrete dopamine, which is a rewards signal -- it means, "I like this. I want to do this again." So, our drive to have sex again with this person is neurochemically driven. (CNSnews.com)
The Syndrome of Inappropriate Antidiuresis Aug 30, 2007
If one continuously administers vasopressin in dogs maintained on zero salt and normal water intake, volume expansion with urinary salt loss occurs initially. This period is followed by an "escape" water diuresis, resulting in a reduction. (New England Journal of Medicine)
our opinion: Recent events spotlight previously discussed concerns Jul 31, 2007
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Strange but True: Drinking Too Much Water Can Kill Jun 28, 2007
Produced by the hypothalamus and secreted into the bloodstream by the posterior pituitary gland, vasopressin instructs the kidneys to conserve water ... If that same person is running a marathon, however, the stress of the situation will increase vasopressin levels, reducing the kidney's excretion capacity to as low as 100 milliliters per hour. (Scientific American)
Runners -- Let Thirst Be Your Guide Jun 20, 2007
Many people are drinking too much water, including sports drinks, when exercising, a practice that could put some individuals engaging in prolonged types of endurance exercise at risk of potentially lethal water intoxication, say international experts who study disorders of water metabolism. Such exercise includes marathons, triathlons, and long distance cycling. (Science Daily)
The Devout Doctor's Prescription Jun 17, 2007
A few years later, Dr. Landry showed that a hormone, vasopressin, can reverse clinical shock in patients, a condition of extremely low blood pressure that is fatal in most cases. "Not many of us invent something that allows people to walk out of an intensive-care unit," says Qais Al-Awqati, a professor of medicine at Columbia, who has known Dr. Landry for nearly three decades. (Wall Street Journal)
Stretch Marks for Dads: Jun 15, 2007
The neurons also had more receptors for vasopressin, a hormone that has been shown to prompt animal fathers to bond with offspring. (Receiving an injection of vasopressin, for instance, prompts a male prairie vole to cuddle and groom a youngster. (Slate)
Letters to the Editor Apr 11, 2007
Numerous published studies scattered throughout medical journals confirm that soy phyto-estrogens are capable of causing abnormal hormone fluctuations that target the brain, especially influencing changes in vasopressin and oxytocin during a most important period of time when hormone balance is most critical for normal fetal and early childhood brain development. It took more than 60 years for the FDA to include a variety of fatal drug warnings for female hormone estrogen/progestin drugs that... (Washington Times, DC)
Drug Provides Short-Term Relief of Heart Failure Symptoms Mar 27, 2007
The first study looked at 4,133 hospitalized heart failure patients in Europe, North America and South America who took part in the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study With Tolvaptan (EVEREST) trial. The patients received either 30 milligrams of tolvaptan or a placebo once a day for a minimum of 60 days. (MEDLINEplus)
EVEREST Data on Short- and Long-Term Use of Otsuka's Investigational Novel Treatment, Tolvaptan, Published in Journal of the American Medical Association and Featured in ACC's Late Breaking Clinical Trials Mar 26, 2007
PRINCETON, N.J., March 25 /PRNewswire/ -- Once-daily dosing with Otsuka's investigational oral medication tolvaptan, a vasopressin receptor antagonist, was associated with improvements in signs and symptoms of acutely decompensated heart failure (ADHF) in hospitalized patients receiving conventional care, without an adverse effect on their long-term survival versus placebo. (1) These data are from the short- and long-term analyses of the international landmark trial Efficacy of Vasopressin... (PR Newswire)
Heart failure medication provides some symptom relief Mar 26, 2007
Marvin A. Konstam, M.D., of Tufts - New England Medical Center, Boston, and colleagues with the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study With Tolvaptan (EVEREST) trial, examined the long-term clinical outcomes of the heart failure medication tolvaptan. The trial, comprised of two short-term clinical status studies, included 4,133 patients hospitalized with heart failure at 359 North American, South American, and European sites between October 2003 and February 2006, and... (EurekAlert!)
Why God lies and sex objects object to sex Mar 20, 2007
And feelings of attachment are produced primarily by the hormones oxytocin and vasopressin, which at elevated levels can actually suppress the circuits for lust. I'm not so sure that sex drive diminishes when most people believe it does. (Asia Times Online)
Psychologist Explains The Neurochemistry Behind Romance Feb 15, 2007
"Two related brain peptides, vasopressin and oxytocin, have been shown to be involved in both the permanent or long-term social bonding that underlies mating," Kristal says. "The neurotransmitter dopamine, in a part of the brain called the VTA, is certainly involved in the rewarding properties of love and sex.". (Science Daily)
Sanofi-aventis 2006: In a Difficult Environment, Another Year of Growth in Adjusted EPS Excluding Selected Items Feb 13, 2007
Satavaptan (SR121463), a vasopressin V2 receptor antagonist, confirms in study DFI4522 that a pure aquaretic agent has therapeutic interest in the reduction in the number of paracentesis in recurrent ascites. Ferroquine (SR97193), studied in the treatment of malaria entered into phase IIb. (PR Newswire)
Dont let Valentines Day scare you » Feb 13, 2007
Stage 3Attachment There are two hormones involved in the feeling of attachment: oxytocin and vasopressin ... Vasopressin Another hormone in the longterm commitment stage, this is also released after sex. (Hindustan Times, India)
