New Migraine Drug Shows Promise Nov 25, 2008
"One potential benefit of the new CGRP receptor antagonist class of acute migraine treatments is the absence of vasoconstriction, a liability of the triptans, which may allow for the safe administration of telcagepant in patients with migraine with cardiovascular disease," the study authors wrote. "However, such patients were excluded from the present study because of the contraindication for zolmitriptan, and further studies are necessary to determine the safety of telcagepant in patients with... (Washington Post)
Phase II Results of COL-144 Presented at European Headache and Migraine Trust International Congress 2008 Sep 7, 2008
COL-144 is a first-in-class Neurally Acting Anti-Migraine Agent (NAAMA), which unlike triptans, exhibits anti-migraine activity without causing vasoconstriction. COL-144 is a highly potent and selective 5HT1F receptor agonist. (PR Newswire)
Even low levels of air pollution may pose stroke risk May 31, 2008
Some research has shown that particulate air pollution is associated with acute artery vasoconstriction and with increased thickening of the blood, which may enhance the potential for blood clots. However, this requires further study. (EurekAlert!)
Treximet(TM) (Sumatriptan and Naproxen Sodium) Tablets Approved by FDA for Acute Treatment of Migraine Apr 16, 2008
Treximet contains sumatriptan that mediates vasoconstriction, which correlates with the relief of migraine headache. It also contains naproxen, an anti-inflammatory agent. (PR Newswire)
Lungs' Mast Cells Could Provide New Treatment Target For Asthma, Other Respiratory Disease Jan 31, 2008
"We're interested in any disease in which we can also detect local renin/angiotensin production because it appears to be linked to fibrosis, vasoconstriction, and now bronchoconstriction," Dr. Silver explains. The goal of all this research: new treatment targets for a range of illnesses. (Science Daily)
Diabetics Most At Risk From Neglected Post Meal Sugar Peak Dec 19, 2007
Numerous studies support the hypothesis of a causal relationship between hyperglycaemia and oxidative stress leading to vasoconstriction (a narrowing of the blood vessels) and thus high blood pressure. Acute glycaemic variability appear to play particular important roles in this mechanism. (Science Daily)
Canadian Health Authority Approves THELIN (Sitaxsentan Sodium) for Pulmonary Arterial Hypertension May 31, 2007
Selective endothelin A receptor antagonism has been shown to increase blood flow and reverse vasoconstriction in human clinical pharmacology studies. For more information, please visit. (Primezone Releases)
Encysive Pharmaceuticals Previews European Union Activities for 2007 May 1, 2007
Highly selective endothelin A receptor antagonism has been shown to increase blood flow and reverse vasoconstriction in human clinical pharmacology studies. In August 2006, the European Commission granted marketing authorization for THELIN 100 mg tablets in all 27 member states of the European Union. (Primezone Releases)
Roustabout's rescuers battle brutal cold Apr 21, 2007
Shaw figured Tim's legs might be badly cut, and vasoconstriction -- the body's ability to constrict blood flow to traumatized limbs -- was helping keep him alive. He'd also been given a powerful painkiller. (Anchorage Daily News)
LOL - Laughing Out Loud Mar 31, 2007
Vasoconstriction and vasodilation, and hence the control of blood pressure. Blood clotting (thrombosis and fibrinolysis). (Suite101.com)
THELIN (sitaxentan sodium) Receives Australian Marketing Approval Mar 7, 2007
Highly selective endothelin A receptor antagonism has been shown to increase blood flow and reverse vasoconstriction in human clinical pharmacology studies. Pulmonary arterial hypertension (PAH) is a condition that involves high blood pressure and structural changes in the walls of the pulmonary arteries, which are the blood vessels that connect the right side of the heart to the lungs. (Primezone Releases)
