Gene That Regulates Breast Cancer Metastasis Identified Oct 8, 2009
To examine the effect of Id1 upregulation in tumor metastasis in vivo, the team generated tagged mouse and human cell lines expressing mouse or human Id1, respectively. Following transplantation back into the mice, lung metastasis developed from Id1-upregulated cells but not in controls, demonstrating that Id1 expression promotes tumor metastasis in vivo. (Science Daily)
Researchers identify protein involved in causing gum disease, osteoporosis, arthritis Aug 31, 2009
This makes sense given that upregulation of NFATc1 is involved in triggering osteoclast precursor cells to turn into osteoclasts. "This is the first paper to identify that IRF-8 is a novel key inhibitory factor in osteoclastogenesis [production of osteoclasts]," said Dr. Zhao. (EurekAlert!)
Recognizing Obesity in Dogs & Cats ... Jul 27, 2009
NGF gene expression and secretion by canine adipocytes in primary culture: upregulation by the inflammatory mediators LPS and TNFalpha. V H Ryan et al. Hormone Metabolic Research. (Suite101.com)
Carbohydrates 'can suppress tumours' Jul 8, 2009
"These results indicate that certain carbohydrates on normal cells and enzymes that synthesise those glycans, such as 3GnT1, function as tumor suppressors. And, upregulation of 3GnT1 may become a novel way to treat cancer," Prof Minoru Fukuda, who led the team, said. In fact, in their study, the researchers showed that 3GnT1 controls the synthesis of laminin-binding glycans in concert with the genes LARGE/LARGE2. (India Times, India)
Carbohydrate acts as tumor suppressor Jul 7, 2009
" Upregulation of 3GnT1 may become a novel way to treat cancer.". Using antibodies, the team investigated the expression of both -DG and its associated glycans in both normal and cancerous cells. (EurekAlert!)
Level Of Cellular Stress Determines Longevity Of Retinal Cells May 10, 2009
The antioxidant upregulation is one way neurons have evolved to protect themselves from exogenous stress and it s especially important in the eye, which receives damaging UV energy from the sun. But while the loss of NinaA delays the cell death cascade, this protection is lost when rhodopsin is absent from retinal cells, suggesting that it s actually the loss of NinaA and the resulting ER stress, and not the loss of rhodopsin s function, that makes the cells live longer. (Science Daily)
Sanofi-aventis to Acquire BiPar Sciences, a US Biopharmaceutical Company Apr 15, 2009
The company also presented gene expression data that confirmed significant upregulation of PARP in the tumors of the first 50 patients enrolled in the Phase 2 trial. Results were presented at the recent annual CTRC-AACR San Antonio Breast Cancer Symposium (SABCS) in December 2008. (Primezone Releases)
Insight Into The Way Nicotine Works In The Brain Mar 30, 2009
4, 2008) Following chronic nicotine exposure, nicotine receptors increase in number, an upregulation that contributes to nicotine's addictive properties. While a current belief is that this process is. (Science Daily)
Cellular discovery may lead to targeted treatment for rare form of anemia Mar 16, 2009
"Previous studies suggested L11 was passively coming out of the nucleolus when ribosome production was disrupted. Our study actually showed that the nucleolus stayed intact as ribosomes were still being produced, suggesting selective upregulation of L11," explains Thomas, the John and Gladys Strauss endowed professor of cancer biology at UC and scientific director at UC's Genome Research Institute. "If we can target the L11 interaction, we might be able to spare other stress pathways that... (EurekAlert!)
Transcriptional Factor SOX9 Renders Melanomas Sensitive To Retinoic Acid And Stops Tumor Growth Mar 11, 2009
Passeron et al. Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid. Journal of Clinical Investigation, 2009; DOI. (Science Daily)
Shades Of 1918? Comparing Avian Flu With A Notorious Killer From The Past Feb 16, 2009
As Baskin notes, referring to the group's measurements of Tissue Culture Infectious Dose or TCID over the course of H5N1's infection, "the take home message is that for H5N1 there is hardly any viable tissue left to infect by day 7, yet there is still very strong viral replication." Further, despite the broad and sustained upregulation of inflammatory genes, they were of no use in limiting the H5N1 infection. While the new study found that the 1918 ressortant strains and H5N1 each attacked... (Science Daily)
