Nicotine Linked To Breast Cancer Growth And Spread, Study Suggests Oct 20, 2008
4, 2008) Following chronic nicotine exposure, nicotine receptors increase in number, an upregulation that contributes to nicotine's addictive properties. While a current belief is that this process is. (Science Daily)
Researchers discover that growing up too fast may mean dying young in honey bees Sep 25, 2008
The diurnal upregulation of antioxidants and antioxidation capacity in flight muscle disappeared with age, which may explain the impairment of flight muscle mitochondrial function (elevated H2O2 production and reduced aconitase Vmax) and flight capacity observed in foragers. Conclusions. (EurekAlert!)
Connexin-43 upregulation promotes tumor cell adhesion Jul 23, 2008
Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium ... Upregulation of connexin-43 was observed in tumor cell-endothelial cell contact areas in vitro and in vivo, and in areas of intratumor blood vessels and in micrometastatic foci ... The marked upregulation of connexin-43 in tumor cell-endothelial cell contact areas, whether in preexisting 'homing' vessels or in newly formed tumor vessels, suggests that connexin-43... (BioMed Central)
New Cancer Clue: MicroRNA Controls Expression Of Oncogenes Jun 11, 2008
The researchers went on to show that transcriptional silencing of miR-203 lead to upregulation of the oncogene ABL1 and the BCR-ABL1 oncogenic fusion protein in various mouse and human hematopoietic malignancies. Further, restoration of miR-203 resulted in a subsequent reduction of ABL1 and BCR-ABL1 and in decreased proliferation of tumor cells. (Science Daily)
'PLoS ONE' STUDY: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice Jun 4, 2008
Age-related changes in gene expression that are prevented by CR would be expected to show opposite directions of change (upregulation vs. downregulation). As previously reported , we observed a large effect of CR in opposing age-related changes: CR reduced 921 (90%) age-related alterations in gene expression and 536 of these represented highly significant differences (P0. (USA Today -- Tech)
Mouse Model Might Help Individuals With The Genetic Disorder Costello Syndrome May 21, 2008
The high blood pressure was caused by abnormal upregulation of a protein known as Ang II and was prevented by treatment with a drug used to treat individuals with high blood pressure that inhibits the generation of Ang II. As some of the heart defects were also less severe after treatment with the drug, the authors suggested that some of the heart defects might be secondary changes in Ang II expression rather than direct effects of mutation of the H-RAS gene. Journal reference. (Science Daily)
Immune system pathway identified to fight allergens, asthma May 8, 2008
Dual upregulation of c-Kit and stem cell factor has been noted in some cancers, such as small cell lung cancer. IL-6 has been associated with cancers such as multiple myeloma, said Dr. Anuradha Ray. (EurekAlert!)
Brain Study May Lead To Improved Epilepsy Treatments Apr 17, 2008
Journal reference: Bauer B, Hartz AM, Pekcec A, Toellner K, Miller DS, Potschka H. Seizure-Induced Upregulation of P-glycoprotein at the Blood-Brain Barrier through Glutamate and COX-2 Signaling. Molecular Pharmacology. (Science Daily)
Experts Speak On Vytorin Study Apr 2, 2008
In addition, they make the comment along the lines that benefit may depend on "not how low you go" but "how you get there"--this conveniently ignores the fact that the ultimate pathway for LDLc lowering with statins, ezetimibe and even bile acid sequestrants is identical--all lower intracellular content of cholesterol, mainly in the liver, which results in upregulation of the LDL receptor and enhanced removal of apo B (LDL) containing lipoproteins. They also ignore decades of prior clinical end... (Forbes -- Business)
Unsuspected Protein Determines Resistance To Breast Cancer Treatment Feb 6, 2008
Examination of signaling molecules downstream of CDK10 led the authors to propose that CDK10 normally represses the ETS2 transcription factor and that the loss of CDK10 expression results in relief of ETS2 repression and upregulation of c-RAF transcription. Enhanced c-RAF activation results in activation of mitogen-activated protein kinase and increased cyclin D1 expression, both previously linked to tamoxifen resistance. (Science Daily)
Epilepsy And Brain Pathology Linked Together By The Protein ADK Jan 8, 2008
The authors observed in a mouse model of epilepsy that ADK upregulation and spontaneous seizures occurred in the region of the brain affected by astrogliosis ... Furthermore, as ADK-deficient ES cell--derived implants protected normal mice from chemical-induced astrogliosis, ADK upregulation, and seizures, it was suggested that ADK-based treatment strategies might provide a new approach for the treatment of individuals with epilepsy. (Science Daily)
Plant Study Reveals New Insights Into How Genomes Work Jan 7, 2008
The embryo is overlaid on a genome browser image of tiling expression data from an intergenic region that exhibits strong upregulation of a cluster of novel tandem repeat-associated, exosome-regulated transcripts. (Credit: Image courtesy of Dr. Brian Gregory, Salk Institute for Biological Studies). (Science Daily)
Key Genetic Trigger Of Acute Myeloid Leukemia Identified Nov 29, 2007
When N-Myc is overexpressed, this pathway is activated and triggers cell death, preventing the onset of AML. But when upregulation of Twist suppresses this pro-apoptosis mechanism, the cell continues to multiply. Upregulation is the increased activity of a gene caused by a specific signal. (Science Daily)
Searching For Biomarkers For Early Detection Of Colorectal Cancer Sep 27, 2007
Western-blot analysis clearly validated 2 differentially expressed proteins, mimecan downregulation and TXNDC5 upregulation in colorectal adenomas and cancers. "Adenoma is a very important step in the development of cancer. Discovering the biomarker of adenoma will improve the early detection and prevention of cancer," said Lai. (Science Daily)
A search for biomarkers for early detection of colorectal cancer Sep 25, 2007
Western-blot analysis clearly validated 2 differentially expressed proteins, mimecan downregulation and TXNDC5 upregulation in colorectal adenomas and cancers. Adenoma is a very important step in the development of cancer. (EurekAlert!)
Panel reports on gene therapy death Sep 18, 2007
In patients where the TNF-alpha upregulation is not due to an underlying infection, (i. e. not associated) then gene therapy should be effective for its intended purpose. (The Scientist)
Parasitic Battles Can Involve Gene Transfer That Aids Evolution Sep 9, 2007
The upregulation of so many host genes during infection is a phenomenon unseen before in the world of bacteriology ... Lindell and Chisholm believe the most plausible scenario to explain the gene upregulation and gene trading is that the bacterium activates certain genes in response to infection as a means of self-protection. (Science Daily)
Diesel Fumes Team Up With Cholesterol for Atherosclerosis Jul 28, 2007
The synergistic upregulation was confirmed by quantitative polymerase chain reaction (qPCR). Finally, the researchers showed that these pathways were activated in vivo. (MedPage Today)
Daily pill to beat genetic diseases Apr 26, 2007
In the UK boys with Duchenne Muscular Dystrophy are being registered for PTC-124 as well as exon skipping and other potential drugs such as Utrophin upregulation on the DMD Registry (http://www. dmdregistry. (Times Online)
Potentia Pharmaceuticals Announces Initiation of Phase I Clinical Trials to Evaluate its Lead Compound for Age-Related Macular Degeneration Mar 20, 2007
POT-4 is a complement inhibitor, which shuts down the complement activation system that could lead to local inflammation, tissue damage and upregulation of angiogenic factors such as vascular endothelial growth factor (VEGF) ... As C3 is the central component of all major complement activation pathways, its inhibition effectively shuts down all downstream complement activation that could otherwise lead to local inflammation, tissue damage and upregulation of angiogenic factors such as vascular... (Canada Newswire)
Researchers find predictor of mortality in cardiac patients Feb 21, 2007
The authors propose several potential explanations for this somewhat paradoxical observation, including potential upregulation of the RANTES receptor, the CCR5 receptor, which is known for its proatherosclerotic properties. Alternatively, lower levels of RANTES may simply reflect greater deposition of RANTES on atherosclerotic arteries with less circulating levels available for measurement by routine ELISA testing. (EurekAlert!)
New Anti-angiogenesis Treatment: Combination Therapy Obliterates New Vessel Growth In Tumors And Retinopathy Jan 11, 2007
Importantly, Friedlander notes that the use of single therapies can result in the activation of alternative compensatory pro-angiogenic pathways designed to stimulate new vessel growth, while the combination approach significantly reduced such compensatory upregulation ... "The point of the study was to show proof-of-concept that targeting multiple angiogenic pathways will be more effective than inhibiting single ones due to potential compensatory upregulation," Friedlander said. (Science Daily)
