Chemical In Gut May Help Fight Obesity Dec 3, 2008
They used a detailed blood-screening test called LC tandem mass spectrometry to find the NAPE group of molecules. For the study, rats were given NAPE for five days and there was a continuous reduction in food intake and body weight. (InjuryBoard.com)
Appetite-suppressing hormones could fight obesity Dec 1, 2008
One of the sensitive tests used by researchers - the LC tandem mass spectrometry - was responsible for identifying the NAPE group of fat sensing molecules. Dr. Gerald Shulman, senior author of a study in rats published in the November 26 issue of the journal Cell, said: "We're excited but we have to be cautious. We would love to be able to take this to man tomorrow because we need effective ways to treat obesity and, right now, we have very few agents that work effectively. But we have much work... (TopNews)
World's Smallest Hand-held Instrument For Detecting Health And Safety Threats Oct 31, 2008
Laboratory tests showed that the Mini 11 could accurately identify the chemical composition of three commonly used commercial drugs within just one minute using tandem mass spectrometry. Unlike previous portable mass specs, this new instrument is capable of analyzing a wider variety of molecules, including large proteins, the scientists say. (Science Daily)
High-tech protection Oct 3, 2008
The state contracts with the Wisconsin state laboratory for the tandem mass spectrometry tests. Beischel said there is now a big push to screen for more conditions, and some states screen for more than the 29 recommended by the American Academy of Pediatricians and the American College of Medical Genetics. (Helena Independent Record, MT)
Estrogen 'Flooding Our Rivers,' Montreal Study Finds Sep 22, 2008
Lajeunesse, A., Gagnon, C., and Sauve%u0301, S. Determination of Basic Antidepressants and Their N-Desmethyl Metabolites in Raw Sewage and Wastewater Using Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry. Analytical Chemistry, 2008; 80 (14): 5325 DOI. (Science Daily)
Frost & Sullivan Recognizes Waters Corporation for Its Pioneering, High Customer Value Analytical Instrumentation Product, SYNAPT HDMS Aug 19, 2008
This is for its breakthrough SYNAPT(TM) High Definition Mass Spectrometry(TM) (HDMS(TM)) system, the first commercial instrument that combines ion mobility (IMS) based measurements and separations with high resolution tandem mass spectrometry. Waters develops a number of high-performance analytical solutions, including liquid chromatographs and related chemistries, mass spectrometers, and laboratory informatics that are used by scientists to separate and identify chemical compounds for a wide... (PR Newswire)
Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients Aug 16, 2008
To identify novel potential biomarkers for PDAC from pancreatic juice, we carried out difference gel electrophoresis (DIGE) and tandem mass spectrometry (MSMS) to compare the pancreatic juice profiling from 9 PDAC patients and 9 cancer-free controls. Of the identified differently expressed proteins, three up-regulated proteins in pancreatic cancer juice, matrix metalloproteinase-9 (MMP-9), oncogene DJ1 (DJ-1) and alpha-1B-glycoprotein precursor (A1BG), were selected for validation by Western... (BioMed Central)
Waters Corp. offers US water agencies complimentary testing for the presence of drugs Mar 21, 2008
In December 2007, EPA published Method 1694 Pharmaceuticals and Personal Care Products in Water, Soil, Sediment, and Biosolids by HPLC/MS/MS. Using Waters chemistry products, Method 1694 identifies pharmaceuticals and personal care products in environmental samples by high performance liquid chromatography combined with tandem mass spectrometry (HPLC/MS/MS) using isotope dilution and internal standard quantification techniques. This method has been developed for use with aqueous, solid, and... (EurekAlert! -- Business News)
Discovery Could Lead To Urine Test To Detect Cancer Early, Better Prevention Feb 8, 2008
It involves testing a one-ounce sample of urine using a sophisticated method called tandem mass spectrometry, which analyzes about 40 estrogen-related compounds, including estrogen-DNA adducts formed by a chemical reaction of estrogen metabolites and DNA.. Researchers say the results are exciting because they show women at high risk of breast cancer can be identified by the level of adducts in a urine sample. (Science Daily)
Manure Management Reduces Levels Of Antibiotics And Antibiotic Resistance Genes Dec 4, 2007
During this time, the levels of antibiotics were monitored using high-performance liquid chromatography (HPLC) and tandem mass spectrometry (MS/MS). In addition, two types of ARG that confer resistance to tetracycline, tet(W) and tet(O), were monitored using quantitative polymerase chain reaction (Q-PCR). (Science Daily)
Faster, More Efficient Method For Detecting Illegal Steroids In Urine Oct 17, 2007
Zheng Ouyang, R. Graham Cooks, and colleagues developed a new steroid-testing method that combines two state-of-the-art testing techniques called desorption electrospray ionization (DESI) and tandem mass spectrometry. In laboratory studies, the researchers used it to analyze fresh urine samples for the presence of tiny amounts of seven different anabolic steroids. (Science Daily)
Illegal drug use may be tracked with toilet waste Sep 18, 2007
But the process -- tandem mass spectrometry -- is a lengthy one that requires concentrating the samples to be able to detect any drug they might contain, according to the release. The new method has modified the existing process, which originated in Italy last year for similar screening processes, and involves the ability to use samples with lower concentrations to complete the testing in just 25 minutes, Field said. (Daily Collegian, PA)
At S$70, TMS test can save a baby Aug 31, 2007
Doctors are now urging for broader adoption of the non-compulsory tandem mass spectrometry (TMS) test, which screens for 29 inborn defects, to avoid potentially tragic scenarios. Associate Professor Roy Joseph, consultant paediatrician of the National University Hospital (NUH), said the rate of testing, which can detect blood disorders like thalassaemia, is low. (Channel NewsAsia, Singapore)
Sewage Tells Tales About Community-wide Drug Abuse Aug 23, 2007
Tandem mass spectrometry, for example, is a laboratory method routinely used to identify the unique by-products of various drugs by determining their molecular weight. The problem is, the method frequently requires a time-consuming off-line process to concentrate the samples. (Science Daily)
City Research Scientist Aug 5, 2007
PREFERRED SKILLS Prior experience with human DNA/RNA based testing on pathology specimen, micro array technology, proteomic study using tandem mass spectrometry, or working experiences in an accredited clinical genetics laboratory is highly desired. Successful candidate should possess the following; excellent communication skills and a strong sense of team work, excellent IT skills; excellent analytical and conceptual thinking; Microsoft Windows, Microsoft Word, Excel, and PowerPoint. (Nature News Service)
Accuracy Of Thyroid Hormone Testing Improved With State-of-the-art Test Jul 30, 2007
The test to measure thyroid hormones, which uses tandem mass spectrometry, was developed by Steven Soldin, Ph ... Soldin came to GUMC in 2002 to design such state-of-the-art tests, and now, versions of the same tandem mass spectrometry technology that can measure free thyroxine (FT4) levels in blood are already in use at a number of medical centers, says Dr. Soldin, a co-author ... The investigators used three different tests -- immunoassay, the Georgetown tandem mass spectrometry, and the gold... (Science Daily)
New Information About Old Proteins Offers Researchers Shortcuts To Study Disease Apr 26, 2007
"Phosphorylation is essential for controlling chemical reactions in our cells' protein factories, and phosphorylation gone awry has been implicated in several diseases. The ability to study more than one phosphorlyation at a time will help us understand some of these diseases - including cancers - sooner. "What we have here is about 20 years' worth of lots of work in one searchable list," says Pandey. A report on all of the newly identified protein alterations is published in the Feb. 13 issue... (Science Daily)
MWH Laboratories Introduces Testing of Perfluorochemicals (PFCs) Apr 24, 2007
MWH Laboratories' proprietary method can measure the chemicals down to 50 parts per trillion (50 ppt) using an online enrichment preparation technique followed by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). This method eliminates some of the sources of contamination ubiquitous in lab settings when doing conventional solid phase extraction by relying on the sensitivity of the lab's state-of-the-art API 4000 LC-MS/MS and online pre-concentration. (Yahoo! Wire -- Entertainment News)
