Second Chance For Dangerous T-cells Jun 27, 2009
Since T-cell receptors are all randomly constructed, there is also a constant production of T-cells in the thymus that may recognize and attack the body's own structures ... While these still possess a T-cell receptor that targets the body's own structures, they have been reprogrammed during their development in the thymus so that they can no longer cause any damage. (Science Daily)
Ortho Biotech Oncology Research & Development announces collaboration with National Cancer Institute to develop novel cell therapies to treat cancer Jun 5, 2009
The other part of the CRADA will focus on a collaborative effort on a T-Cell Receptor (TCR) research program. "This public-private partnership represents an extraordinary opportunity to bring together complementary and substantial expertise and resources from two groups with the common goal of advancing a highly promising new modality of therapy for patients with cancer," says Jay P. Siegel, M.D., chief biotechnology officer of Johnson on's Pharmaceuticals and Medical Devices ostics businesses. (EurekAlert! -- Business News)
First Genome-wide Expression Analysis Yields Better Understanding Of How Leukemia Develops Feb 12, 2009
Among them, a ribosome and T-cell receptor signaling pathway emerged as new players in the regulation of cancer stem cells. The direct comparison of leukemic stems cells (obtained by consent from patients) to normal blood stem cells, also provides critical insight into the differences found in malignancy that may be used to develop targeted therapy, said Michael W. Becker, M.D., an assistant professor at the James P. Wilmot Cancer Center at the University of Rochester Medical Center. (Science Daily)
