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News and Articles on SNCA
Genetic association study of synphilin-1 in idiopathic Parkinson's disease Mar 22, 2008 With the discovery of missense and multiplication mutations in the alpha-synuclein gene (SNCA) in familial parkinsonism, Lewy inclusions were found to stain intensely with antibodies raised against the protein. Yeast-two-hybrid studies identified synphilin-1 as an interacting partner of alpha-synuclein, and both proteins show co-immunolocalization in a subset of Lewy body inclusions. (BioMed Central)
Treatment For Alcoholism Could Be Selected Based On Genetics Oct 26, 2007 27, 2007) The protein alpha synuclein (SNCA) plays an important role in the regulation of dopamine function. Craving is a common symptom in alcoholics. (Science Daily)
Tumor-free Breast Tissue Can Have Precancerous Changes Jan 13, 2007 In addition, the researchers identified three other genes (called CYP26A1, KCNAB1 and SNCA) that were highly methylated in about one-third to nearly one-half of the breast tumors. Again to our surprise, we found that in 70 percent of cases, when these genes were highly methylated in tumor cells, they were also highly methylated in the adjacent normal tissue, says Yan. (Science Daily)
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