New Pathway For Malaria Infection Discovered Sep 16, 2008
15, 2008) Cenix BioScience GmbH, a leading specialist in advanced RNA interference (RNAi)-based research services, Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, and the Lisbon-based biomedical research centre Instituto de Medicina Molecular (IMM), have announced the publication of their collaborative study in Cell Host & Microbe, describing the discovery and in vivo validation of scavenger receptor BI (SR-BI), a major regulator of cholesterol uptake by the... (Science Daily)
Gene linked to eye disease Aug 29, 2008
These experimental medications, which spur a phenomenon called RNA interference, or RNAi, may suppress a process that helps protect people from dry macular degeneration, Zhang said. Ironically in some individuals, using RNAi to cure wet age-related macular degeneration might actually increase the risk of getting dry macular degeneration, he said ... The release date was moved up from October because of the study's possible implications for the safety of the RNAi clinical trials. (San Diego Union-Tribune)
First Gene Associated With Dry Macular Degeneration Found Aug 29, 2008
Importantly, this research indicates that individuals with a genetic variant of TLR3 who undergo a new treatment called RNA interference (RNAi) could be at risk. A class of double-stranded RNA (like the genetic information carried by viruses), RNAi is used to turn off or silence other genes related to various diseases ... Several human clinical trials are currently using RNAi, including therapies to treat the "wet" form of AMD that occurs when abnormal blood vessels behind the retina start to... (Science Daily)
Cancer Gene Therapy Aug 29, 2008
It publishes original laboratory and clinical research papers, case reports and review articles on topics including RNAi approaches, drug resistance, hematopoietic gene transfer, homologous recombination, ribozyme technology, antisense technology, tumor immunotherapy and tumor suppressors,translational research, cancer therapy, gene delivery systems (viral and non-viral), anti-gene therapy (antisense, siRNA ymes), apoptosis; mechanisms and therapies , vaccine development, immunology and... (Nature News Service)
Application Notes Aug 29, 2008
A combination of RNA interference (RNAi) with fluorescence microscopy analysis is proving to be a very good solution to this problem. Here we show that the Olympus SZX stereo and upright BX microscopes, both with fluorescence illumination capabilities, are perfect for use in these situations. (Nature News Service)
Biopartnering Aug 29, 2008
Patent disputes haven't materialized in the RNAi field yet, but once products near the market, it might be a different story. Charlie Schmidt investigates. (Nature News Service)
Gene Linked to 'Dry' Macular Degeneration Aug 29, 2008
The treatment in question, known as "RNA interference," or RNAi, works by "silencing" genes that bring about wet AMD. Unfortunately, the treatment appears to simultaneously activate TLR3 -- resulting in a 60 percent spike in retinal cell death among mice and humans genetically susceptible to developing dry AMD. The result: RNAi may help protect against wet AMD while boosting the risk for dry AMD, the study authors said. "This raises particular concerns regarding RNAi therapy for wet AMD," Zhang... (MEDLINEplus)
Tekmira Pharmaceuticals Publishes Research That Addresses Critical Issue in the RNAi Field Aug 26, 2008
VANCOUVER, BRITISH COLUMBIA--(Marketwire - Aug. 26, 2008) - Tekmira Pharmaceuticals Corporation (TSX: - ) announced today that it has published new research that highlights proprietary technology developed by the company to modify small interfering RNA (siRNA) molecules to minimize the immune stimulation effects of siRNA while preserving their RNA interference (RNAi) activity ... 2008 Aug 19) highlights that a number of previously published studies reporting the therapeutic effects of siRNA are... (CCNMatthews Press Releases)
Specially Designed RNA Reduces Aug 20, 2008
The results showed that the RNA interference, or RNAi, mechanism could provide a new tactic for treating high cholesterol ... Horton said that the RNAi method also performed as well as cholesterol-lowering drugs currently on the market or in clinical trials. (Oneindia)
Tekmira Pharmaceuticals Corporation Announces Second Quarter 2008 Operating Results Aug 14, 2008
Dr. Mark J. Murray, Tekmira's President and CEO, said, "With the business combination of Tekmira and Protiva Biotherapeutics completed during the quarter, the new Tekmira is positioned to be a leader in the rapidly emerging field of RNAi therapeutics. The company has a clear strategy, a strong balance sheet and partnerships with some of the world's leading pharmaceutical companies.". "Our primary focus is on developing products exclusively in the RNAi therapeutics field and our secondary focus... (CCNMatthews Press Releases)
Tekmira Pharmaceuticals Announces RNAi Research Collaboration With Bristol-Myers Squibb Aug 13, 2008
The relationship between Tekmira and Bristol-Myers Squibb builds upon earlier work conducted at Bristol-Myers Squibb using siRNA delivery technology provided by privately held Protiva Biotherapeutics Inc. In May, Protiva and Tekmira combined their businesses to create a leader in the field of RNAi (RNA interference) therapeutics. Dr. Mark J. Murray, Tekmira's President and CEO, said, "Our relationship with Bristol-Myers Squibb is consistent with our strategy to work with global pharmaceutical... (CCNMatthews Press Releases)
Designer RNA Fights High Cholesterol, Researchers Find Aug 12, 2008
This result indicated that the RNA interference, or RNAi, mechanism could provide a new tactic for treating high cholesterol ... The RNAi method also performed as well as cholesterol-lowering drugs currently on the market or in clinical trials, Dr. Horton said ... Working with scientists at MIT and at Alnylam, an RNAi therapeutics company in Cambridge, Mass. (Science Daily)
RNA stops HIV in its tracks Aug 11, 2008
Priti Kumar from the Harvard Medical School in Boston, US, and colleagues from the US, Korea and Germany, used a technique called RNA interference (RNAi) to protect mice possessing a human immune system from infection by HIV.. RNAi works by using short strands of small interfering RNA (siRNA) to destroy targeted sequences of messenger RNA that are needed to manufacture proteins. (Chemistry World)
New Gene Technique Stops HIV In Its Tracks Aug 10, 2008
RNAi has great potential as an antiviral treatment. We think it has real promise, but there is a lot more to be done,'' Prof. (TopNews)
Researchers Silence HIV in Mice Engineered to Be Like Humans Aug 8, 2008
SILENCED: Researchers used RNAi to suppress genes that HIV needs to spread, effectively stopping the virus in its tracks ... They did so using a technique called , or RNAi, to clamp down on three genes found in infected cells, blocking the wily virus from moving to other cells ... RNAi works by flooding a cell with short segments of RNA the intermediate blueprint for building proteins from a gene's DNA. These segments disrupt the production of specific proteins, rendering a gene "silenced". (Scientific American)
AIDS Breakthrough? HIV Halted With RNAi In Mice Aug 8, 2008
Researchers Halt Spread Of HIV With RNAi In Animal Model ... Researchers Halt Spread Of HIV With RNAi In Animal Model ... "For the first time, we've used RNAi to dramatically suppress HIV infection in an organism," says corresponding author Premlata Shankar, who conducted the work while she was a junior investigator at the Harvard Medical School-affiliated Immune Disease Institute and an assistant professor at Harvard Medical School. (Science Daily)
Life Sciences 25 Jul 21, 2008
Biogen Idec's partner on the blockbuster drug Rituxan, , reported a sales surge; Alnylam Pharmaceuticals and decided to extend an RNAi therapeutics collaboration for another year. LAST. (Boston Globe)
Roche Makes Offer to Acquire All Outstanding Shares of Genentech for US$89.00 Per Share in Cash Jul 21, 2008
This, together with recent moves into RNAi (Ribonucleic Acid interference) and delivery technologies, as well as licensing activities, continues to provide a stimulating environment for the creation of medically differentiated medicines ... g. RNAi, novel protein architectures), assets (e. (PR Newswire)
Genes That Control Embryonic Stem Cell Fate Identified Jul 14, 2008
The scientists used a powerful technique known as RNA interference, or RNAi, to screen more than 1,000 genes for their role in mouse embryonic stem cells. The technique allows researchers to "knock down" individual genes, reducing their abundance in order to determine the gene's normal role. (Science Daily)
Fresenius Gobbles Up APP Pharma Jul 8, 2008
(See " ") The mutually beneficial relationship will allow Takeda non-exclusive rights to Alnylam's RNAi therapeutics platform technology and intellectual property in the fields of oncology and metabolic disease. Alnylam Pharmaceuticals will co-develop and co-commercialize Takeda's RNAi therapeutic products. (Forbes)
Researchers reveal types of genes necessary for brain development Jul 8, 2008
Researchers from Harvard Medical School and Brandeis University have successfully completed a full-genome RNAi screen in neurons, showing what types of genes are necessary for brain development ... A combination of live-cell imaging and quantitative analysis allowed Sepp et al to characterize neurons' morphological phenotypes in response to RNAi-mediated gene knockdown ... The researchers focused on 104 evolutionary conserved genes that, when downregulated by RNAi, have morphological defects. (EurekAlert!)
Inhalable Form Of Gene-therapy Takes Aim At Lung Cancer And Inflammatory Lung Disease Jun 11, 2008
In the article, Sally-Ann Cryan, Niamh Durcan, and Charlotte Murphy focus on research efforts to develop an inhalable form of RNA interference (RNAi), a gene-therapy technique that interferes with or "silences" genes that make disease-causing proteins. The authors explain that RNAi has advantages over other gene therapies ... They cite encouraging results with RNAi in laboratory studies in cells and animals with a range of lung diseases, including lung cancer, certain respiratory infections and... (Science Daily)
New Approach To Purifying Drinking Water Jun 9, 2008
The relatively new technology, known as RNA interference (RNAi), makes use of short snippets of genetic material that match -- like a lock and key -- a corresponding segment of a gene in the target ... "Our data showed that we could silence the action of a specific gene in a fungus in water, leading us to believe that RNAi shows promise as a gene-silencing tool for controlling the proliferation of waterborne bacteria and viruses." ... "We envision creating a system based on RNAi technology that... (Science Daily)
Eating and weight gain not necessarily linked, study shows Jun 4, 2008
They took advantage of a powerful and relatively new technique known as RNA interference, or RNAi, which allowed them to inactivate hundreds of genes one at a time to determine the effect of these gene inactivations on serotonin's actions on fat regulation. "Obesity and thinness are not solely determined by feeding behavior," the scientists conclude in their paper. (EurekAlert!)
Tekmira Pharmaceuticals and Protiva Biotherapeutics Announce Completion of Business Combination Jun 2, 2008
The combined company, which will retain the name Tekmira, will be a global leader in the field of RNA interference ("RNAi") therapeutics ... The new Tekmira will focus its business on advancing a pipeline of novel therapeutic products, including its lead RNAi therapeutic candidate, ApoB SNALP, as a treatment for hypercholesterolemia ... The company will have rights to develop a total of seven RNAi therapeutic products based on access to Alnylam's intellectual property. (CCNMatthews Press Releases)
New Insights Into Cellular Reprogramming Revealed By Genomic Analysis May 30, 2008
By identifying characteristic differences in the epigenetic maps and expression profiles of these partially reprogrammed cells, the researchers designed treatments using chemicals or RNA interference (RNAi) that were sufficient to drive them to a fully reprogrammed state. One of these treatments, involving the chemotherapeutic 5-azacytidine, could improve the overall efficiency of the reprogramming process by several hundred percent. (Science Daily)
Alnylam and Takeda strike $150m drug-licensing deal May 28, 2008
RNAi research stems in part from a 1998 discovery by Craig Mello, a researcher at the University of Massachusetts Medical School at Worcester, and Andrew Fire of Stanford University, who shared the 2006 Nobel Prize for medicine. Mello also helped found RXi Pharmaceuticals, a Worcester-based firm Simeonidis expects will reach its own RNAi licensing deal this year ... Other companies, including & Co., are also working on RNAi. (Boston Globe)
Alnylam May Gain $1 Billion From Takeda for Technology Licenses May 28, 2008
Our product portfolio will be enhanced by the addition of RNAi therapeutics to our current small molecule and antibody research platform,'' said Takeda President in a statement ... Takeda can choose to develop Alnylam's products in Asia, and the U.S. company will have an option to help develop and market medicines Takeda finds using RNAi technology for the U.S. ... Takeda recognized the future of medicine and innovation relies on RNAi therapeutics,'' said in an interview. (Bloomberg)
Another potential $1B deal for RNAi drug technology May 28, 2008
While the Takeda deal is more impressive for Alnylam in some aspects than the Roche deal, Simeonidis said investors are spoiled right now by advances at Alnylam, as well as a half-dozen other RNAi rivals, including San Francisco-based Sirna Therapeutics Inc. which was acquired in 2006 by Merck & Co. for $1 ... He said RNAi technology is seen as the big thirst-quencher for what is recognized widely as a major innovation gap in the pharmaceutical industry ... RNAi technology also known as... (San Diego Union-Tribune -- Business)
Biotech Reigns At Wharton's Business Plan Contest May 26, 2008
To prevent the gene from causing blindness, iTherapeutics' drug would harness a biological mechanism called RNA interference, also known as RNAi or gene silencing. (Two American scientists won the Nobel Prize in 2006 for their discovery of RNAi ... By manipulating the natural RNAi process, researchers can, in effect, turn genes off. (Forbes)
Gladstone scientists reveal the genetics of fat storage in cells May 22, 2008
To identify novel genes involved in fat storage, GICD scientist Dr. Yi Guo, and Dr. Tobias Walter, formerly of Dr. Walters laboratory and now of the Max Planck Institute of Biochemistry in Germany, initiated a major discovery project, in which they used RNAi screens to individually inactivate all the genes in cells from fruit flies. Basic cellular processes in humans are highly conserved in cells from fruit flies, so the results should mostly be applicable to human biology. (EurekAlert!)
UMass, China agree on online classes Apr 1, 2008
Mello shared the 2006 Nobel Prize in medicine for work on a gene-blocking technology called RNAi. Yan Jichang, vice chairman and general secretary of China's Continuing Education Association, said that "the importance of this strategic partnership cannot be overstated" and that it is crucial to "the future of China's place in the league of nations.". (Boston Globe)
Gene Silencing Therapies Could Have Harmful Side Effects, Research Suggests Mar 29, 2008
"My lab made the surprising discovery that siRNAs, including those in clinical trials, do not enter cells or trigger RNAi. Rather, we found that they generically, regardless of their sequence or target, bind a receptor known as TLR3 on cell surfaces and block blood vessel growth in the eye, skin and a variety of other organs.". Blocking blood vessel growth is beneficial in a variety of diseases. (Science Daily)
Tekmira Pharmaceuticals Presents Data on Improved Drug Delivery Technology at International RNAi Conference Mar 29, 2008
VANCOUVER, BRITISH COLUMBIA--(Marketwire - March 28, 2008) - Tekmira Pharmaceuticals Corporation ("Tekmira") (TSX: - ) announced today that a new second-generation formulation of the Company's liposomal drug delivery technology has the potential to bring a 10-fold increase in potency to RNA interference (RNAi) drugs that are administered intravenously ... The preclinical data are being presented at the "RNAi, MicroRNA, and Non-Coding RNA" Keystone Symposium held March 25-30, 2008 in Whistler,... (CCNMatthews Press Releases)
Neuronal Regulators Offer Potential Targets For Cancer Mar 22, 2008
After uncovering this role, Westbrook used a technique called RNA interference (RNAi) to search for proteins that reduce REST levels ... The RNAi screen netted a known tumor promoter called 2-TRCP. Further genetic tests revealed that 2-TRCP binds directly to REST, tagging it for destruction. (Science Daily)
New Strategy To Prevent Genetically Altered Rice From Uncontrolled Spreading Mar 22, 2008
The genes of interest in these transgenic rice plants will be linked with an RNAi cassette which suppresses the expression of the rice detoxification enzyme of Bentazon, rendering the transgenic rice to be sensitive to the herbicide. Conventional rice is highly tolerant to Bentazon. (Science Daily)
Chinese scientists' breakthrough in GM-modified rice Mar 22, 2008
"The principle beneath this strategy is simple: the genes of interest in these GM-modified rice plants are tagged with an RNAi cassette which suppresses the expression of the rice detoxification enzyme against a common herbicide, rendering the GM-modified rice to be sensitive to this herbicide," said Dr. Shen Zhicheng, the project leader. Shen said this strategy is reliable and inexpensive for implementation, and is particularly useful for development of GM-modified crops as bioreactor for... (Xinhuanet, China)
RNA Interference (RNAi) Mar 16, 2008
Future directions of RNAi therapy. The capacity of RNAi to effect changes in gene expression has been proven in laboratories over and over again. (Suite101.com)
Protein 'Shocks' Evolution Into Action Feb 27, 2008
In the current studies, Todd Sangster and his co-authors used inbred mustard plants (Arabidopsis thaliana) and simulated stress by inhibiting their HSP90 production with the chemical geldanamycin, a known, highly specific HSP90 inhibitor or by RNAi. The authors then examined the effects of stressing the plants. (Science Daily)
Director of Stem Cell Biology Feb 23, 2008
The Stem Cell Program expects to work closely with new programs in RNAi Therapeutics and Gene Therapy. Together, these programs will be an important component of UMMS commitment to clinical and translational science. (Nature News Service)
Mass. bill bolsters life sciences sector Feb 17, 2008
The bill calls for spending $95 million for the construction of a life science center at the University of Massachusetts in Amherst, and $90 million toward a $265 million RNAi and genetic therapy center on the UMass medical school campus in Worcester. UMass scientist Craig Mello's RNAi research at UMass Worcester earned him a Nobel Prize last year. (CNNMoney.com)
Tearless Onion Created In Lab Using Gene Silencing Feb 6, 2008
We have been using a gene-silencing technology, called RNAi, developed by Dr Peter Waterhouse at CSIRO in Australia, that allows us to retarget the plant s own natural regulation system without expressing foreign proteins in the plant, Dr Eady says. Through RNAi, genes can be specifically shut down or turned off. (Science Daily)
RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols Feb 2, 2008
The first protocol describes the use of RNAi to investigate gene function in fruit flies. Short RNA molecules are injected into fly embryos to disrupt the function of a specific gene. (EurekAlert!)
Gene Discovery Made Easier With Powerful New Networking Technique Jan 30, 2008
" To build the worm gene network, Lee, a postdoctoral researcher in Marcotte's group, synthesized data from about 20 million experiments from around the world. A visual representation of the network--which has the appeal of a work of modern art--is a complex web of lines interconnecting the worm's 16,000 genes. In one set of studies, the researchers looked for genes that cause tumors in the worms. The tumors are a model for human eye cancer (retinoblastoma) and appear as growths along the length... (Science Daily)
Genes Linked To Parkinson's Protection Identified Jan 26, 2008
Using a revolutionary technique known as RNA interference, or RNAi, Hamamichi removed, one at a time, the functions of each of the 867 genes from the tiny nematodes. This, Caldwell said, enabled the research team to investigate the impact the missing function would have on cellular processes. (Science Daily)
The RNA Drug Revolution: A New Approach To Gene Therapy Jan 24, 2008
23, 2008) RNA interference (RNAi) represents an innovative new strategy for using small RNA molecules to silence specific genes associated with disease processes, and a series of review articles describing the state-of-the-art and potential therapeutic applications of RNAi and microRNAs will begin with two review papers in the January 2008 issue of Human Gene Therapy ... At least six clinical trials using RNA interference (RNAi) have been approved, with many more coming down the pipeline,... (Science Daily)
Gene Responsible For Debilitating Blood Cell Disorder Discovered Jan 23, 2008
The RNAi Consortium, a collaboration among life science companies and academic institutions based at the Broad Institute, developed the reagents used in the current study. Indeed, a broader application of RNA interference may lead to the discovery that other diseases, particularly cancers, stem from subtle, single gene hits, instead of the dual hits of traditional scientific lore. (Science Daily)
Tracking down HIV propagation Jan 19, 2008
Using RNA interference (RNAi) to screen thousands of genes, researchers from Harvard Medical School have identified 273 human proteins required for HIV propagation. The vast majority had not been connected to the virus by previous studies. (Australian Life Scientist)
RNA Shown To Silence Cancer Suppressor Gene Jan 16, 2008
16, 2006) Researchers at The University of Texas M. D. Anderson Cancer Center say they have jumped a significant hurdle in the use of RNA interference (RNAi), believed by many to be the ultimate tool to both. (Jul. (Science Daily)
Nucleonics initiates hepatitis B clinical trial with expressed interfering RNA therapeutic Jan 12, 2008
HORSHAM, PA (January 11, 2008): Nucleonics, Inc., a privately held biotechnology company focused on the development of novel RNA interference (RNAi)-based therapeutics, announced today that the company has begun treating patients in a Phase 1 human safety study of its experimental treatment for chronic Hepatitis B virus (HBV) infection, NUC B1000 ... We are very pleased to initiate this clinical study, which represents one of the first systemic administrations of any RNAi-based therapeutic and... (EurekAlert! -- Business News)
UMMS and CIW grant key RNAi rights to Oxford Biomedica Jan 7, 2008
WORCESTER, MA, AND WASHINGTON, DCThe University of Massachusetts Medical School and the Carnegie Institution of Washington announced today that they have entered into licensing agreements with Oxford BioMedica (LSE: OXB), a gene therapy company, that grants the company rights to key RNA interference (RNAi) patent rights ... The process, called RNA interference (RNAi), can shut down disease-causing genes or direct researchers to pathways for effective drug development ... James P. McNamara, PhD,... (EurekAlert! -- Business News)
New Route For Heredity Bypasses DNA Jan 5, 2008
First, the researchers attempted to determine if the RNA cache idea was valid by directing specific RNA-destroying chemicals, known as RNAi, to the cell before fertilization. This gave encouraging results, disrupting the process of development, and even halting DNA rearrangement in some cases. (Science Daily)
New Gene Therapy Heals Growth Deficiency Disorder In Live Animal Dec 21, 2007
20, 2003) RNA interference (RNAi) has emerged as an extremely versatile and powerful tool in biomedical research. A new study published in the February issue of Nature Structural Biology reports the creation. (Science Daily)
Researcher Develops Test For Targeted Therapy In Acute Myeloid Leukemia Dec 13, 2007
"We were initially screening for these targets by doing large-scale DNA sequencing, looking for mutations. This strategy was not as successful as we had hoped, so we decided that an assay that could functionally screen cells and give us some idea based on what killed cells and what didn't kill cells would be a better place to start. We could then work backward to find the actual mutation underlying that phenotype. RNAi (the name of the technology we use) seemed an ideal platform for this because... (Science Daily)
Patrick invokes historic link to China Dec 4, 2007
Mello, who shared the 2006 Nobel Prize in medicine for work on a gene-blocking technology called RNAi, said he hopes to set up a facility in China to work with a new life science center planned for UMass ... "We're hoping that we can forge a real, meaningful alliance where Tsinghua and UMass would team up to develop RNAi therapeutics and develop new technology around RNAi, and maybe share intellectual property as well.". (Boston Globe)
Patrick, executives set for China trade trip Nov 29, 2007
Patrick will also be accompanied by a number of government and industry officials, including two Cabinet secretaries, University of Massachusetts president Jack Wilson, and UMass Medical School professor Craig Mello, who won a Nobel Prize for his research into a new way to silence genes called RNAi. Todd Wallack can be reached at. (Boston Globe)
Taconic Acquires 80% Stake in Artemis Nov 27, 2007
Models produced include knock out and humanization platforms, as well as inducible/reversible RNAi knock down models, and ASKA models for the inducible and reversible knock down of kinases. These platforms are being continually expanded, most recently with the addition of mouse models humanized for key drug metabolism enzymes (ADME mice). (BusinessWire)
New South S.F. center to help Pfizer find next biotech cure Nov 8, 2007
Jonathan MacQuitty, a partner in the health care investment firm Abingworth Management Inc. in Menlo Park, said Pfizer's money and drug development expertise could boost the growth of small companies, "sort of like putting a flower in a hothouse. "This will give Pfizer a window on how these (scientific) areas are developing, and also the opportunity to pounce when they want to make an acquisition," MacQuitty said. Pfizer recently recruited Goodman, the former chief executive and co-founder of... (San Francisco Chronicle)
Gene-block birth control 'on way' Oct 19, 2007
" However, the researchers estimate that it will be at least 10 years before clinical trials of an RNAi contraceptive would be possible. Off-target Dr Martin Fabani, a researcher in the technique at Cambridge University, said that obstacles would need to be overcome, and that there was no guarantee that side-effects could be avoided completely. He said: "RNA interference is fantastic and there was a big hype around it, but people are starting to see what we call 'off-target' effects - where the... (BBC News)
Biologists claim Nobel prize with a knock-out Oct 18, 2007
Last year s awarding of a Nobel Prize in Physiology or Medicine to discoverers of RNAi caused a surge of complaints because not only RNAi is a reinvention of RNA interference wheel but also a tiny aspect of the broad scope discovery on epigeneics ... prize for RNAi went to very early after the discovery and this is after 27 years. (Nature News Service)
Scientist launches new venture with same tech Oct 16, 2007
"They left large room for other areas using our technology," said Lu, Intradigm co-founder and Sirnaomics president and CEO. "RNAi is new technology. There are many areas that need to be developed. We're going to take this into new frontiers that Intradigm is not working on.". Still, both are tuning into a breakthrough technology called siRNA, when longer double-stranded RNA -- which transmit genetic information throughout the body -- are chopped into smaller chunks. (Washington Business Journal, DC)
YEAR OF MIRACLES Oct 15, 2007
These microRNAs then oversaw a whole new process, called RNA interference (RNAi), that served to modulate the expression of DNA.The good news was that RNAi could open up a whole new approach to biomedical therapy (more on that later). But RNAi also made it clear that the fundamental unit of heredity and genetic function is not the gene but the position of each individual DNA letter. (Indian Express)
Genes that both extend life and protect against cancer identified Oct 15, 2007
They did this using several techniques, including RNA interference or RNAi, a powerful tool that allows scientists to control the expression of just one kind of gene at a time. About half of the genes stimulated tumor growth and half suppressed it, they found. (EurekAlert!)
Carlsbad biotech goes on a tear Oct 14, 2007
under an agreement that allowed Alnylam to use Isis patents in a field of antisense called RNA interference, or RNAi. In return, Alnylam agreed to give Isis a cut of money earned from work using the patents. (North County Times)
Biofuel: The little shrub that could - maybe Oct 11, 2007
The poisons could all be removed using RNAi technology, and the meal would then be appropriate for animal feed, and not as a dangerous environmental pollutatnt. 1. (Nature News Service)
