Europe Seeks Alternatives to Natural Latex from Asia Feb 5, 2010
(June 9, 2005) The source tree for natural rubber, Hevea brasiliensis, is frequently affected by a bark necrosis syndrome, which has been observed since the 1980s. The disease leads to sharp falls in latex. (Science Daily)
Making Macrophages Protect Against Effects of Obesity Feb 4, 2010
In this state, the macrophages secrete cytokines, such as tumor necrosis factor (TNF) alpha, that encourage the development of insulin resistance, diabetes, and heart disease. The Gladstone team hypothesized that enhancing the capacity of macrophages to store dietary fats might alter this process. (Science Daily)
Biomarker could help doctors tailor treatment for rheumatoid arthritis Jan 30, 2010
Investigators have identified a biomarker that could help doctors select patients with rheumatoid arthritis who will benefit from therapy with drugs such as Enbrel, a tumor necrosis factor (TNF)-antagonist drug. The study, led by researchers at Hospital for Special Surgery in collaboration with rheumatologists at University of Southern California, appears in the February issue of the journal Arthritis atism. (EurekAlert!)
Blood test may predict rheumatoid arthritis Jan 30, 2010
Rheumatoid arthritis drugs target some of the inflammatory markers that were elevated, such as tumor necrosis factor (TNF). When all 30 of the markers that the researchers measured are taken into account, the test would correctly predict 86 percent of the time the individuals who would ultimately develop rheumatoid arthritis, according to the study. (CNN -- Health)
Inflammation 'on Switch' Also Serves as 'Off Switch' Jan 27, 2010
Normally, TAB2 can be counted on to bring a protein called TAK1 close to tumor necrosis factor, or TNF, a circulating molecule that is a normal component of the immune system. Bringing TAK1 close to TNF activates TAK1, thereby starting the inflammatory response. (Science Daily)
Immune Response May Worsen Alzheimer's Jan 19, 2010
The answer lies in the body s immune response, which launches an attack on invading pathogens, releasing inflaming proteins such as tumor necrosis factor, or TNF. This molecule causes the vagus nerve, which extends from the brain to the abdomen and controls vital functions such as heartbeat, to send an electrical im-pulse to the brain, thereby directing the brain to secrete its own immune messengers. In people with healthy brains, this chain of events merely leads us to feel under the for a few... (Scientific American)
Researchers Tackle Ductal Carcinoma in Situ and Its Many Unanswered Questions Jan 19, 2010
Efforts should also be made to make full use of biomarkers, such as HER2 status and necrosis, to determine risk status, according to the paper. "This would allow for focusing aggressive treatment on those who have the greatest probability of benefit," the authors write. (Science Daily)
Lung Cancer: Drug With Unique Disruption of Tumor Blood Flow Shows Promise Jan 18, 2010
"ASA404 has been shown to cause selective disruption of the established tumor vasculature, inhibition of tumor blood flow and tumor necrosis.". This unique mechanism of action could provide an option for patients with either squamous or non-squamous NSCLC. Treatment options for patients with advanced stage NSCLC are limited, particularly for those with squamous histology where some treatments exhibit limited efficacy or serious side effects. (Science Daily)
Heart Attack Jan 17, 2010
Feature Article of Sunday, 17 January 2010. You are here: Article 175226. (Ghana Web, Ghana)
Newer Drug More Effective in Psoriasis Treatment Jan 15, 2010
Enbrel blocks tumor necrosis factor alpha, while Stelara inhibits interleukin-12 and interleukin-23 ... These results show that "the optimal approach to treating psoriasis may be via the targeting of the chemical messengers interleukin-12 and interleukin-23 as exemplified by ustekinumab as opposed to the chemical messenger tumor necrosis factor alpha targeted by etanercept," Griffiths said. (MEDLINEplus)
Ustekinumab versus Etanercept for Moderate-to-Severe Psoriasis Jan 14, 2010
We compared two biologic agents, ustekinumab (an interleukin-12 and interleukin-23 blocker) and etanercept (an inhibitor of tumor necrosis factor. for the treatment of psoriasis. (New England Journal of Medicine)
Rheumatologists Advance Genetic Research Related to Disabling Form of Arthritis Jan 11, 2010
(June 12, 2008) Adalimumab therapy is effective and well-tolerated in ankylosing spondylitis, rheumatoid arthritis and psoriatic arthritis patients with a previously inadequate response to anti-tumour necrosis. . (Science Daily)
Nature Reviews Endocrinology (formerly Nature Clinical Practice Endocrinology & Metabolism) Jan 10, 2010
Diabetic angiopathy, the complement system and the tumor necrosis factor superfamily. Allan Flyvbjerg. (Nature News Service)
Rheumatoid Arthritis Treatment Doesn't Promote Cancer Jan 10, 2010
THURSDAY, Oct. 29 (HealthDay News) -- Treatment with tumor necrosis factor (TNF) blockers doesn't increase rheumatoid arthritis patients' risk of cancer, new research has found. TNF is a substance secreted by immune cells that regulates the immune system and plays a role in inflammation. (MEDLINEplus)
