Hybrid Molecules Show Promise For Exploring, Treating Alzheimer's Nov 7, 2009
"We found molecules known for amyloid-beta recognition and then attached metal binding sites to them." In collaboration with Ayyalusamy Ramamoorthy, professor of chemistry and associate professor of biophysics, Lim then used NMR spectroscopy to confirm that the new, hybrid molecules still interacted with amyloid-beta ... In addition to Lim and Ramamoorthy, coauthors include postdoctoral fellow Sarmad Hindo, graduate students Allana Mancino and Joseph Braymer, lab technician Yihong Liu, and NMR... (Science Daily)
Trembling hands and molecular handshakes Oct 24, 2009
Scientists at the Institute for Structural Biology use NMR spectroscopy and X-ray diffraction to determine the three-dimensional structures of biologically relevant proteins and nucleic acids, and to probe their behaviour in aqueous solution ... Efforts are now underway to optimize NMR so that the technique can be applied to larger proteins and protein complexes (consisting of several subunits). (EurekAlert!)
A brave new brand of science Oct 17, 2009
"Ramachandran can be credited for bringing together into the one field of molecular biophysics the then disparate fields of X-ray crystallography, peptide synthesis, NMR and other optical studies and physicochemical experimentation," added Brahmachari who began as a physical chemist from Calcutta University and morphed into a molecular biophysicist at IISc. "Today, there's no LoC (line of control) between physics and biology," said TIFR physicist Deepak Mathur, who heads the Centre for... (India Times, India -- Community News)
New Link Between Pre-eclampsia And Diet Aug 27, 2009
Imidazole-Based Erythrocyte Markers of Oxidative Stress in Preeclampsia-An NMR Investigation. Reproductive Sciences, 2009; DOI. (Science Daily)
Urine Samples Could Be Used To Predict Responses To Drugs, Say Researchers Aug 13, 2009
The new study looked at 99 healthy male volunteers aged between 18 and 64, taking one dose of the commonly used painkiller acetaminophen, widely known as paracetamol in the UK. The researchers took urine samples from the men before they took the paracetamol dose and for six hours afterwards and analysed the metabolites in the samples using 1H NMR spectroscopy. The results revealed that a compound called para-cresol sulphate, which is derived from para-cresol produced by bacteria in the gut, was... (Science Daily)
Evotec Announces Research Agreement On Fragment Based Screening Drug Discovery With Cubist Pharmaceuticals Jul 14, 2009
EVOlution(tm) combines biochemical, nuclear magnetic resonance (NMR) and surface plasmon resonance (SPR) screening technologies for the screening of low molecular weight compounds and fragments ... About NMR and SPR Screening Technologies ... NMR and SPR screening technologies are used to study the interaction of small molecules, such as drug candidates, with their targets. (Primezone Releases)
Not just the party of no, the party of hell, no! May 11, 2009
NMR, as it was originally called, was used for a type of Chemical analysis called NMR Spectrocopy , in which the image was captured by photography ... No, the MRI or NMR had been around since the 1930 s used for chemical spectroscopy ... In the period between 1950 and 1970, NMR was developed and used for chemical and physical molecular analysis. (Atlanta Journal-Constitution -- Opinion)
American Chemical Society Weekly PressPac -- April 15, 2009 Apr 20, 2009
Using a high-tech instrument termed solid-state NMR spectroscopy, the scientists discovered that molecules of curcumin act like a biochemical disciplinarian ... ARTICLE #3 FOR IMMEDIATE RELEASE "Determining the Effects of Lipophillic Drugs on Membrane Structure by Solid-State NMR Spectroscopy the Case of the Antioxidant Curcumin". (EurekAlert!)
Biocompatible Materials For Rapid Prototyping Apr 19, 2009
The chemical composition, purity and molecular weight distribution of the synthesized oligomers were proven by means of 1H NMR, IR spectroscopy and gel permeation chromatography. The conversion of (meth)acrylate functions after the photo-curing process was estimated by FT-IR. Standard mechanical tests were performed on 40 mm long tensile bars produced by Envisiontec perfactory machine. (Science Daily)
New MRI Signaling Method Could Picture Disease Metabolism In Action Apr 6, 2009
Unlike carbon-12, carbon-13 emits an NMR signal like hydrogen atoms do. Using this room-temperature DNP, the biological molecule pyruvate can retain its MRI signal for as long as 40 seconds -- long enough to observe it undergoing rapid chemical change. (Science Daily)
'Holy powder' ingredient makes membranes behave for better health Mar 7, 2009
Now as researcher he is fascinated with proteins that are associated with biological membranes, and he uses a technique called solid-state NMR spectroscopy to reveal atom-level details of these important molecules and the membranous milieu in which they operate ... His research group recently developed the two-dimensional solid-state NMR technique that they used to probe curcumin-membrane communication in this study. (EurekAlert!)
Paradigm Shift In MRI Detection Results In Broad Images, Crystal Clear Mar 6, 2009
Magnetic resonance imaging (MRI) is the imaging variant of nuclear magnetic resonance (NMR) ... The foundations of MRI were laid over 60 years ago by the American Edward M. Purcell and ETH Zurich graduate Felix Bloch through their discovery of NMR. ... NMR went on to revolutionize chemistry and structural biology, including key developments for which the Zurich-based scientists Richard R. Ernst and Kurt W. (Science Daily)
Building A Better Protein: Researchers Use Computers To Find Keys To Stabilizing Proteins Feb 27, 2009
Makhatadze was assisted in his research by post-doctoral researcher Mayank Patel, graduate student Jiajing Liu, NMR Core Director Scott McCallum, and Assistant Professor of Biology Chunyu Wang, all of Rensselaer, as well as former graduate student Alexey Gribenko, who is currently a member of the faculty at the University of Texas Medical Branch. In addition, the structure of one the proteins used in the study, acylphosphatase (AcPh), was actually solved at Rensselaer using the sophisticated... (Science Daily)
New Johns Hopkins imaging center to widen windows on the brain Feb 10, 2009
Sites include the F.M. Kirby Research Center for Functional Brain Imaging at the Kennedy Krieger Institute, the Molecular Imaging Center in the Broadway Research Building, the Department of Radiology's PET Center, Radiology's MRI Service Center and its Animal NMR Service Center. Once high-quality images are generated, the core serves as a bridge to analysis in several ways. (EurekAlert! -- Business News)
