Myelodysplastic Syndromes Nov 5, 2009
Volume 361:1872-1885. Ayalew Tefferi, M.D., and James W. Vardiman, M.D.. (New England Journal of Medicine)
A Common Genetic Mechanism in Malignant Bone Marrow Diseases May 28, 2009
The myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia (AML) are seemingly unrelated diseases except for their origin in hematopoietic precursor cells in bone marrow ... By contrast, a prominent feature of the myelodysplastic syndromes is a reduction in the number of one or more cells in the hematopoietic lineage. (New England Journal of Medicine)
Cyclacel Pharmaceuticals Announces Suspension of Quarterly Dividend On 6% Convertible Exchangeable Preferred Stock Apr 8, 2009
Sapacitabine (CYC682), a cell cycle modulating nucleoside analog, is in Phase 2 studies for the treatment of acute myeloid leukemia in the elderly, myelodysplastic syndromes, cutaneous T-cell lymphoma and lung cancer. Seliciclib (CYC202 or R-roscovitine), a CDK (cyclin dependent kinase) inhibitor, is in Phase 2 for the treatment of lung cancer and nasopharyngeal cancer. (Primezone Releases)
Menlo Park's ChemGenex focuses on rare diseases Mar 18, 2009
An orphan drug is one developed to treat a rare medical condition, such as myelodysplastic syndromes or MDS, a group of bone marrow disorders, which is one area ChemGenex is pursuing. The company s drug has also been developed to combat two other rare cancers. (San Jose Business Journal, CA)
Doctor gives dogs with cancer a new lease on life Mar 3, 2009
Learn about myelodysplastic syndromes - causes, types and more. Fred Hutchinson Cancer Research Pioneering New Treatments and Care. (Yahoo News -- Top Stories)
Symptomsof anemiavary by type Feb 17, 2009
Dear Reader: Myelodysplastic syndromes are a group of disorders that affect the bone marrow and stem cells. There are eight subtypes but because of space restrictions, I can't list and explain each type. (Erie Times-News, PA)
• Patient needs more information about myelodysplastic anemia Feb 17, 2009
DEAR READER: Myelodysplastic syndromes are a group of disorders that affect the bone marrow and stem cells ... There also may be a link between myelodysplastic syndromes and long-term exposure to pesticides, heavy metals, herbicides and chemical fertilizers ... Once you have been diagnosed with one of the myelodysplastic syndromes, it is important to be careful. (Burley South Idaho Press, ID)
Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Feb 7, 2009
Nplate is the first treatment specifically developed for ITP. It is also being investigated for potential use in paediatric ITP, myelodysplastic syndromes (MDS) and chemotherapy-induced thrombocytopenia (CIT) ... Thrombotic/thromboembolic complications, progression of existing haematopoietic malignancies or myelodysplastic syndromes (MDS), and effects on red and white blood cells are all potential risks associated with romiplostim treatment ... Additional risks include bone marrow fibrosis,... (PR Newswire)
