CombiMatrix Announces Positive Results From Expanded HerScan Study Dec 18, 2008
These data further validate that when chromosome resolution is insufficient to fully elucidate causality, or in breast cancers where cell culture conditions preclude effective chromosomal preparations, our array CGH tests provide a robust clinical tool for capturing the genomic equivalent of an incredibly high resolution chromosome karyotype,'' said Dr. Mansoor Mohammed, President and CEO of Combimatrix Molecular Diagnostics (CMDX) ... Rather, it provides a comprehensive molecular cytogenetic... (Primezone Releases)
Microarray Analysis Improves Prenatal Diagnosis Nov 26, 2008
"The array enables you to detect smaller deletions or duplications of genetic material that would not be seen on a regular karyotype (a depiction of the size, shape and number of chromosome and any abnormalities in them)," said Dr. Ignatia B. Van den Veyver, associate professor of obstetrics and gynecology and molecular and human genetics at BCM and first author of the report ... In 15 cases when the array detected something that was significant for patient care, the finding was either suspected... (Science Daily)
Chromosomal Abnormalities Jun 14, 2008
If a karyotype reveals a numerical abnormality, it is most likely random ... If, however, a fetal karyotype reveals a structural abnormality, a parental karyotype should be performed to determine or rule out a hereditary condition. (Suite101.com)
Chromosome Analysis Jun 7, 2008
The Karyotype or Comparative Genomic Hybridization of Fetal Matter ... Two techniques, karyotype and comparative genomic hybridization (CGH), are currently used to assess the tissue ... To perform the karyotype, a specialized lab technician will. (Suite101.com)
UCLA researchers examine human embryonic stem cell genome Mar 28, 2008
Clinical specialists commonly generate a karyotype to examine the chromosomes of cancer cells or for amniocentesis in prenatal diagnosis, which has a much lower resolution than Array CGH, said Michael Teitell, a researcher with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and the senior author of the study ... His team found CNV differences between the two lines in at least seven different chromosome locations below the level of detection using standard... (EurekAlert!)
First Diploid Human Genome Sequence Shows We're Surprisingly Different Sep 5, 2007
Spectral karyotype analysis. (Credit: J. Craig Venter Institute). (Science Daily)
Drug Resistance Argues Against Mutation Theory Of Cancer Jun 29, 2007
The chromosomal fingerprint, or karyotype, of a normal human cell (left), includes 46 paired chromosomes. The distinctive karyotype of an aneuploid breast cancer cell, however, (right) includes duplicates of entire chromosomes, missing chromosomes, and chromosome stubs ... "Why aren't we all getting resistant to any toxic drug we are exposed to" Why does it happen only in cancer cells" Why do cancer cells become resistant and the patients don't""In his experiments, Duesberg and his colleagues... (Science Daily)
Support for chromosomal theory of cancer found in cancers' development of drug resistance Jun 28, 2007
"Why aren't we all getting resistant to any toxic drug we are exposed to" Why does it happen only in cancer cells" Why do cancer cells become resistant and the patients don't"" In his experiments, Duesberg and his colleagues focus on the chromosomal fingerprint of a cell, its karyotype. For decades, physicians have known that cells of a particular cancer have the same set of marker chromosomes, a rogues gallery of normal chromosomes and stumps of chromosomes. Duesberg and UC Berkeley... (EurekAlert!)
When a Person Is Neither XX nor XY: A Q&A with Geneticist Eric Vilain Jun 7, 2007
Now in 1959 when the karyotype of Klinefelter [a male who is XXY] and Turner [a female who has one X] syndromes was discovered, it became clear that in humans it was the presence or the absence of the Y chromosome that's sex determining. Because all Klinefelters that have a Y are male, whereas Turners, who have no Y, are females. (Scientific American)
