Bernard Ackerman, skin specialist Dec 15, 2008
His laboratory there was one of the first to screen for early signs of Kaposi's sarcoma, a fatal skin cancer now understood to have been closely linked to the AIDS epidemic. In 1992, he moved to Philadelphia to teach at Jefferson Medical College. (Boston Globe)
Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer Dec 15, 2008
DOXIL is also indicated for the treatment of AIDS-related Kaposi's sarcoma in patients after failure of prior systemic chemotherapy or intolerance to such therapy. IMPORTANT SAFETY INFORMATION. (PR Newswire)
HIV & AIDS Dec 10, 2008
If you're infected with HIV, you're also more likely to develop certain cancers, especially Kaposi's sarcoma, cervical cancer and lymphoma, although improved treatments have reduced the risk of these illnesses ... It often resembles Kaposi's sarcoma, but it can cause disease in other parts of your body, including your liver and spleen ... Kaposi's sarcoma is a tumor of the blood vessel walls. (CNN -- Health)
Despite US Drop, Cancer Rates Grow Worldwide Dec 10, 2008
In Africa, for example, the three most common cancers are Kaposi's sarcoma (related to HIV infection) and liver and cervical cancer. In China, liver cancer is a huge problem. (Time.com)
Reprogrammable Cell Type Depends On Single Gene To Keep Its Identity Dec 8, 2008
(June 29, 2004) Blood-vessel-lining cells that are infected with the virus that causes the skin tumor Kaposi's sarcoma (KS) appear to transform into the type of cells that usually line lymphatic vessels, report. . (Science Daily)
Individuals With HIV Have Higher Risk Of Non-AIDS Cancers Nov 20, 2008
Although some cancers are known to be associated with HIV, such as Kaposi's sarcoma, non-Hodgkin's lymphoma and cervical cancer, limited research has been conducted on risk of non-AIDS cancers. Shiels and her colleagues analyzed data from 11 U.S. and international studies comparing cancer incidence in individuals with HIV with the general population. (Science Daily)
Non-AIDS Cancer Risk Higher for Those with HIV Nov 20, 2008
While some cancers have been linked to HIV, such as Kaposi's sarcoma, non-Hodgkin lymphoma and cervical cancer, not much is known about ties to non-AIDS cancers. When gender and study design are accounted for, the risk of non-AIDS cancer was about two times greater for HIV-infected individuals, both with and without AIDS, than the public at large. (MEDLINEplus)
AIDS: A timeline Oct 7, 2008
- 1981: Eight young homosexuals in New York are diagnosed with Kaposi's Sarcoma, a skin cancer that usually occurs in older people, while five Los Angeles gays fall sick with a rare form of pneumonia. These clusters alert US authorities to a new disease that wrecks the immune system and exposes the body to opportunistic disease. (India Times, India -- Health/Science)
Natural History of HIV Sep 14, 2008
For cancer in AIDS patients, the most common is Kaposi's sarcoma, a tumor that can appear in the skin, oral cavity, gastrointestinal tract, or respiratory tract. AIDS also increases the likelihood of lymphoma and cervical cancer. (Suite101.com)
Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway Jul 25, 2008
Imiquimod (Aldara, R-837, S26308), the best characterized and most widely used, is highly efficacious in the treatment of external genital and anal warts, basal cell carcinoma, actinic keratoses, Kaposi's sarcoma, chronic hepatitis C infection, and intraepithelial carcinoma. Therefore, the underlying mechanism of imiquimod action is of clinical importance. (EurekAlert!)
Growing older with HIVVirus presents special risks as it accelerates effects of aging Jul 13, 2008
The first cases of AIDS were associated with cancers such as a rare skin lesion known as Kaposi's sarcoma. But while AIDS-related malignancies seem to be declining in this country, other types of cancer -- lung, rectal and gastrointestinal malignancies -- seem to be disproportionately affecting the HIV population, said Dr. Robert Kalayjian, a longtime infectious-disease specialist at Cleveland's MetroHealth Medical Center. (Kalamazoo Gazette, MI)
Cancer risk soars in HIV-infected people: study May 21, 2008
Some types of cancers like Kaposi's sarcoma and non-Hodgkin lymphoma have long been associated with people infected by the AIDS virus ... Many early AIDS patients developed Kaposi's sarcoma, a cancer previously associated with older people or people receiving immunosuppressant medications following an organ transplant. (Scientific American)
Starting Point Of Sun-induced Skin Cancer Discovered: Molecular 'Hooks' Also Pull Compounds From Marijuana From Bloodstream May 17, 2008
2, 2007) The major active component of marijuana could aid the Kaposi's sarcoma virus in infecting cells and multiplying, according researchers at Harvard Medical School. They report that low doses of THC. (Science Daily)
The Moral Scales May 14, 2008
Maintaining weight becomes difficult with vomiting and diarrhea, with tuberculosis and fungal infections, with cancers such as Kaposi's sarcoma and lymphoma. Even so, you'd think that a few million of these wasting bodies would weigh more on the moral balance than seven senators. (Townhall.com)
Cloning Of A Key Group Of Human Genes, The Protein Kinases, Reported May 6, 2008
ivi Ojala, University of Helsinki, they identified a novel kinase required for activation of Kaposi's sarcoma herpesvirus. "The isolated kinase genes form a resource that scientist can now use to systematically map kinase signaling networks in different cellular disease models. The kinases are also promising targets for therapeutic intervention in the treatment of various cancers", Professor Taipale states. (Science Daily)
Leukemia Therapy During Pregnancy May Cause Infant Abnormalities, Study Suggests Mar 8, 2008
13, 2004) A new clinical study has shown that imatinib mesylate (Gleevec) has activity in AIDS-related Kaposi's sarcoma (KS). Imatinib inhibits important pathways that spur cancer growth, resulting in the. (Science Daily)
The New Age of Molecular Diagnostics for Microbial Agents Mar 6, 2008
In recent years, molecular techniques have been applied successfully in the identification of infectious agents such as Borna virus, Kaposi's sarcoma associated herpesvirus (human herpesvirus 8), West Nile virus, and the severe acute respiratory syndrome (SARS) coronavirus. 1 Currently, the majority of surveillance and discovery efforts use methods based on sequences of known agents namely, competitive polymerase chain reaction (PCR) and microarrays. (New England Journal of Medicine)
Single MicroRNA Fine-tunes Innate Immune Response Feb 25, 2008
19, 2007) Researchers have discovered that the virus which causes Kaposi's Sarcoma encodes a molecule for controlling gene regulation nearly identical to one found normally in human cells. Both versions of the. (Science Daily)
More on HIV-Associated Kaposi’s Sarcoma Jan 31, 2008
NEJM -- More on HIV-Associated Kaposi's Sarcoma ... More on HIV-Associated Kaposi's Sarcoma ... To the Editor: The AIDS Malignancy Consortium, a multicenter cooperative group funded by the National Cancer Institute, has enrolled 442 patients who have human immunodeficiency virus (HIV) infection and measurable Kaposi's sarcoma in a series of therapeutic trials since 1996 (Table 1). (New England Journal of Medicine)
Newly Discovered Virus Linked To Deadly Skin Cancer Jan 20, 2008
19, 2008) A new strategy to hunt for human viruses described in this week's issue of the journal Science by the husband-and-wife team who found the cause of Kaposi's sarcoma has revealed a previously unknown virus strongly associated with another rare but deadly skin cancer called Merkel cell carcinoma ... Moore and Chang, a husband-and-wife research team who also discovered Kaposi's sarcoma-associated herpesvirus (KSHV) in 1993 ... KSHV, which causes Kaposi's sarcoma, is the most common... (Science Daily)
Documenting the toll of AIDS Jan 2, 2008
The history is contained in dry records compiled, for example, by the California Department of Health Services and in passionate protest fliers from groups that include Mobilization Against AIDS. It is found in diaries and in old copies of Diseased Pariah News, a gallows-humor magazine that outrageously suggested giving Boy Scout merit badges for Kaposi's sarcoma and thrush infections. No matter the source, nearly every file carries an emotional wallop: Often it was panic and outrage as the... (Los Angeles Times)
Virus Discovered Using Same Tools As Host Cell Dec 20, 2007
19, 2007) Duke University Medical Center researchers have discovered that the virus which causes Kaposi's Sarcoma encodes a molecule for controlling gene regulation nearly identical to one found normally in human cells ... One such virus is Kaposi's Sarcoma Associated Herpesvirus (KSHV) which causes a rare skin cancer that disproportionately affects HIV-infected individuals ... "The viral microRNA expressed by Kaposi's Sarcoma Associated Herpesvirus (KSHV), is remarkably similar in both... (Science Daily)
Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal Dec 20, 2007
In both cases, the hybrid molecules had a profound effect on the size of tumors in mouse modelsXshrinking tumors of both Kaposi's sarcoma and colon cancer. "We were able to show the chemically programmed complex had at least 1,000-fold increase in the therapeutic effect compared with the small molecule alone," said Barbas. (EurekAlert! -- Business News)
First Global Cancer Figures Released Dec 19, 2007
A trusted source of newsand information since 1942. like the HPV vaccine, where we can easily prevent [cervical] cancer, and then start looking at hepatitis vaccination and trying to prevent some liver cancers," he explained. "Those are the things we can positively affect in the shortest amount of time. (Voice of America)
Hanford man and family live with impact of HIV Dec 1, 2007
By 1987 he was becoming progressively sick with various illnesses, such as throat cancer and Kaposi's sarcoma, a type of skin cancer common in HIV-positive men. That's when he was diagnosed with AIDS, acquired immunodeficiency syndrome, resulting from the damage to the immune system caused by human immunodeficiency virus (HIV). (Hanford Sentinal, CA)
How One Virus Uses Mimicry To Replicate Successfully: Related Mechanisms May Trigger Some Cancers Nov 5, 2007
20, 2007) Researchers have identified a new strategy that Kaposi's Sarcoma Associated Herpesvirus uses to dupe infected cells into replicating its viral genome. This is the first study to directly show that a. (Science Daily)
New Theory Of How Viruses May Contribute To Cancer Oct 25, 2007
The paradigm was developed based on a study of cells infected with the Kaposi's sarcoma associated herpesvirus, or KSHV, also known as human herpesvirus 8 (HHV-8). The researchers examined a gene called K13 that activates a pathway previously implicated in cancer development. (Science Daily)
Transparent Zebrafish Help Researchers Track Breast Cancer Oct 24, 2007
21, 2004) In studying a virus that causes the skin cancer Kaposi's sarcoma, University of North Carolina at Chapel Hill scientists have identified a viral gene that switches on cellular genes involved in. . (Science Daily)
Unsettling re-emergence of 'gay cancer' Oct 13, 2007
San Francisco doctors have reported a cluster among gay men of unusual cases of Kaposi's sarcoma, the cancer-like skin disease whose disfiguring purple lesions were a terrifying signature of a bygone era of the AIDS epidemic ... The new cases of Kaposi's sarcoma have not been aggressive, invasive or lethal - the way the disease behaved in patients with uncontrolled HIV during the 1980s ... "This could either be the canary in the coal mine, or it could just be a collection of rare events that... (San Francisco Chronicle)
An AIDS-related Virus Reveals More Ways To Cause Cancer Oct 11, 2007
Researchers at the University of Pennsylvania School of Medicine have shed new light on how Kaposi's Sarcoma-associated Herpes Virus (KSHV) subverts normal cell machinery to cause cancer ... Kaposi's sarcoma and primary effusion lymphoma are two of the viral-associated cancers that are common in immune-compromised patients. (Science Daily)
DNA Damage Response Confers A Barrier For Viral Tumorigenesis Oct 2, 2007
Kaposi's sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi's sarcoma (KS) ... 2007: Viral oncogene-induced DNA damage response is activated in Kaposi's sarcoma tumorigenesis. (Science Daily)
Doctors See Return of Kaposi's Sarcoma in Handful of AIDS Patients Sep 28, 2007
WEDNESDAY, Sept. 26 (HealthDay News) -- San Francisco doctors say they've seen a small number of longtime HIV patients with mild cases of Kaposi's sarcoma, a potentially dangerous condition that once plagued people with AIDS.. It's not clear why Kaposi's sarcoma is making a comeback, or whether it may pose a significant health threat to AIDS patients ... Kaposi's sarcoma, a type of skin cancer that causes disfiguring lesions, was largely limited to Mediterranean men before the AIDS epidemic. (MEDLINEplus)
HIV-Associated Kaposi’s Sarcoma with a High CD4 Count and a Low Viral Load Sep 27, 2007
NEJM -- HIV-Associated Kaposi's Sarcoma with a High CD4 Count and a Low Viral Load ... HIV-Associated Kaposi's Sarcoma with a High CD4 Count and a Low Viral Load ... To the Editor: Kaposi's sarcoma associated with HIV infection has been decreasing in incidence and severity since the introduction of antiretroviral therapy. (New England Journal of Medicine)
Pregnancy May Slow -- Not Accelerate -- Progression To AIDS Sep 22, 2007
Disease progression was defined as experiencing an AIDS-defining event such as Kaposi's sarcoma, Pneumocystis carinii pneumonia, or Candida fungal infection of the esophagus; or death. Of the 759 women studied, 71 percent (540) were receiving HAART. Eighteen percent (139) of women studied had one or more pregnancy during this study. (Science Daily)
Marijuana Component Opens The Door For Virus That Causes Kaposi's Sarcoma Aug 3, 2007
The major active component of marijuana could enhance the ability of the virus that causes Kaposi's sarcoma to infect cells and multiply, according to a team of researchers at Harvard Medical School ... While most people are not at risk from Kaposi's sarcoma herpes virus (KSHV), researchers say those with lowered immune systems, such as AIDS patients or transplant recipients, are more susceptible to developing the sarcoma as a result of infection ... While previous studies indicated that... (Science Daily)
Infection-Related Cancers Elevated Among the Immunodeficient Jul 7, 2007
" Historically, only Kaposi's sarcoma, non-Hodgkin's lymphoma, and cervical cancer have represented AIDS-defining illnesses. Increased incidence of other cancers has been reported, but this was judged to be the result of lifestyle and other risk factors rather than immunodeficiency by investigators in the largest study to look at the issue, the AIDS-Cancer Match Registry Study published in the Journal of the American Medical Association in 2001. With publication of two large cohort studies... (MedPage Today)
HIV Patients at More Risk of Developing 20 Cancers, Australian Doctors Say Jul 6, 2007
In addition to cancers known to be linked to HIV, including non-Hodgkin's lymphoma, Kaposi's sarcoma and cervical cancer, the study group was more likely to develop tumors linked to infections such as human papillomavirus, including those of the mouth, penis, anus, liver, stomach, esophagus, larynx and eye, the researchers said. The risk of developing cancers not linked to infection, such as tumors of the breast and prostate, was the same as for the general population, they said. (Bloomberg -- Germany)
HIV/AIDS pioneer named chief medical officer at Presidio Pharmaceuticals Jun 22, 2007
He identified the first cases of Kaposi's sarcoma in San Francisco in 1991 and started the Kaposi's Sarcoma Clinic at the University of California San Francisco. He also created The HIV/AIDS Clinic, which has the largest private AIDS clinic in San Francisco. (San Francisco Business Times, CA)
Styx bassist writes about secret gay life Jun 12, 2007
Panozzo was diagnosed with AIDS in 1998 and had most of the symptoms: Kaposi's sarcoma, anemia, thrush. His weight dropped to 130 pounds. (AZCentral -- Entertainment)
SAN FRANCISCOPeru trekker's mystery bug is new to science Jun 8, 2007
During the worst years of the AIDS epidemic in San Francisco, Koehler first encountered the Bartonella when HIV infected patients sought treatment for disfiguring purple lesions that doctors initially thought were Kaposi's sarcoma. But these tumors were actually different from that common opportunistic infection that felled thousands of AIDS patients in the early years of the epidemic. (San Francisco Chronicle)
CAELYX(R) Delays Time to Disease Progression as Maintenance Therapy in Patients with Metastatic Breast Cancer Jun 4, 2007
CAELYX is also approved in the EU for the treatment of advanced ovarian cancer in women who have failed first-line, platinum-based therapy and for the treatment of AIDS-related Kaposi's sarcoma in patients with low CD4 counts. SOURCE Schering-Plough Corp.. (PR Newswire)
Cancer Virus' Genetic Targets Identified May 14, 2007
University of Florida researchers have identified specific human genes targeted by a virus believed to cause Kaposi's sarcoma, a rare form of cancer associated with AIDS and with organ transplants that causes patches of red or purple tissue to grow under people's skin ... Scientists believe that with the regulatory genes sidelined, blood vessel growth runs rampant, resulting in the typical markings of Kaposi's sarcoma ... "The hallmarks of Kaposi's sarcoma are red spots full of blood vessels on... (Science Daily)
Scientists find clues to AIDS-cancer link May 12, 2007
Researchers say they've identified specific human genes targeted by the virus behind Kaposi's sarcoma, a rare cancer often found in AIDS patients ... Kaposi's sarcoma is typically seen in people with weakened immune systems, such as those with AIDS and organ transplant patients ... The virus believed to cause Kaposi's sarcoma has "mini-molecules" called microRNAs that silence genes that suppress tumor cells and limit vascular growth. (Atlanta Journal-Constitution -- Health)
Africa facing major cancer blight May 11, 2007
" In some parts of Africa, the increased incidence of cancer is a consequence of economic development and populations that are living longer. But in other parts, where HIV/Aids is slashing longevity, cancer rates may be rising directly as a result of the HIV/Aids epidemic with cancers such as Kaposi's sarcoma, tumours which appear under the surface of the skin or on mucous membranes, becoming increasingly common. "HIV/Aids lowers the immunity of a patient and you know that throughout your... (BBC News -- Africa)
Enhancing Chemotherapy's Efficacy: New Agent Has Synergistic Effect With Standard Drugs Apr 17, 2007
This synergistic effect--in which the effect of two agents is greater than the sum of their individual effects--appeared when using the combination of MCP110 and Taxol on laboratory cell cultures of human Kaposi's sarcoma and mouse models carrying human lung and colon cancer cells. "Together, these findings indicate that MCP compounds have potential to be effective in combination with other anticancer agents," the authors concluded. (Science Daily)
- Germaine Greer Apr 9, 2007
It is his belief that the real cause of the occurrence of Kaposi's sarcoma among gay men is not a retrovirus, but their frequent recourse to amyl nitrite inhalants (poppers). Sadly for Mr Lauritsen, nobody has been paying attention to his howling in the wilderness on these topics and so he has been forced to search out another dead horse and give it a good flogging instead. (Guardian Unlimited)
Cancer cases 'will double by 2030' Apr 6, 2007
The study also found that the commonest type of cancer for men in Africa was Kaposi's sarcoma, which is directly linked to the Aids/HIV epidemic there. The agency also found that there were commonly more people in the world who died of cancer than those who died of tuberculosis, Aids and malaria combined. (Channel 4 News)
World cancer cases to double: expert Apr 5, 2007
In Africa, the most common type of cancer among men is Kaposi's sarcoma, which is linked to the HIV and AIDS epidemic, Boyle said. In the United States, a vaccine being developed for cervical cancer costs $US350 ($A433), but in Europe it is twice as expensive, he said. (The Age)
Epiphany Biosciences builds its board Mar 31, 2007
The San Francisco company is working on a treatment for Kaposi's sarcoma and other infectious diseases. The members of its board are. (San Francisco Business Times, CA)
Molecularly targeted therapy for Kaposi's sarcoma in a kidney transplant patient: case report, "what worked and what did not" Mar 27, 2007
Molecularly targeted therapy for Kaposi's sarcoma in a kidney transplant patient: case report, "what worked and what did not" Patricia Volkow , Juan W Zinser and Ricardo Correa-Rotter ... Imatinib is a tyrosine-kinase inhibitor; for which there is limited information regarding its effects on AIDS Kaposi's sarcoma and none in patients with transplant-associated Kaposi's sarcoma ... Sirolimus, an immunosuppressive drug used for kidney transplant, exhibits antiangiogenic activity related to... (BioMed Central)
Read More: FYI: Groopman Mar 17, 2007
Dr. Groopman's research has focused on the basic mechanisms of cancer and AIDS. He did seminal work on identifying growth factors which may restore the depressed immune systems of AIDS patients and on treatment for AIDS-related neoplasms, particularly Kaposi's sarcoma and lymphoma. His book, "How Doctors Think," is a journey into the medical mind, showing how doctors arrive at the correct diagnosis and why sometimes they detour and fail to. (CBS News -- Evening News)
Finnish Scientists Discover New Approach To Treat Virus-induced Lymphomas Mar 16, 2007
Kaposi's sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi's sarcoma and primary effusion lymphoma (PEL) ... PEL is a non-Hodgkin type lymphoma latently infected with KSHV, and it manifests as an effusion malignancy in Kaposi's sarcoma patients. (Science Daily)
Epiphany Biosciences hires hepatitis expert as scientific chief Feb 23, 2007
Epiphany is working on a blood test for Kaposi's Sarcoma Associated Herpes Virus. Fred Volinsky, M.D., is the company's CEO.. (San Francisco Business Times, CA)
Scientists Uncover Enzyme's Dual Role In Cancer Metastasis Feb 3, 2007
(April 21, 2004) -- In studying a virus that causes the skin cancer Kaposi's sarcoma, University of North Carolina at Chapel Hill scientists have identified a viral gene that switches on cellular genes involved in. . (Science Daily)
Coping with HIV| Jan 11, 2007
Kaposi's sarcoma was one of the first illnesses noticed among San Francisco gay men in the early 1980s. It was then a little-known disease of elderly European men and young Africans, which tended to be chronic and rarely spread through the body. (iAfrica.com)
Epiphany Biosciences finishes license deal for Kaposi's sarcoma patents Jan 11, 2007
said Wednesday it completed a licensing deal with Columbia University that gives it exclusive rights to diagnostic and therapeutic uses of some patents related to Kaposi's sarcoma ... It seeks to develop diagnostic tests for the virus that causes Kaposi's sarcoma, a serious cancer common in HIV-positive patients. (East Bay Business Times, CA)
Synthetic Peptide Targets Latent Papilloma Virus Infections Jan 6, 2007
The strategy the researchers used to block HPV spread might also prove useful against other infectious viruses, such as the related Epstein-Barr virus, the cause of mononucleosis and an aggressive form of lymphocytic leukemia called Burkitt's leukemia, and the Kaposi's sarcoma virus, which can develop to cancer in those with AIDS.. The work was supported by the National Institutes of Health. (Science Daily)
AIDS drug on track for FDA approval Jan 2, 2007
Kaposi's sarcoma, the early AIDS epidemic's portentous and deadly calling card, was overwhelming him. "Warren really couldn't qualify for the drug, because his Kaposi's was progressing and because he had pretty significant side effects from the chemotherapy," Deeks said. (Los Angeles Times)
