Breast Cancer Cells Recycle To Escape Death By Hormonal Therapy Oct 6, 2008
A University of Pennsylvania team led by Dr. Craig Thompson reported in 2007 in The Journal of Clinical Investigation that chloroquine increased death of suicide-resistant lymphoma cells being treated with chemotherapy. Dr. Schoenlein will give chloroquine along with an antiestrogen and measure cell death. (Science Daily)
New Class of Drugs Might Cause Congenital Heart Defects Oct 4, 2008
"We have no idea if there will be any risk, but the study suggests we should be aware of the possibility," said Dr. Thomas Force, a professor of medicine at Thomas Jefferson University in Philadelphia and lead author of an online report in the October issue of the Journal of Clinical Investigation. The drugs are aimed at a gene that produces a protein called glycogen synthase kinase-3 (GSK-3). (MEDLINEplus)
Loss Of The Protein Target Of Lithium Disrupts Normal Mouse Embryonic Heart Development Oct 3, 2008
Journal of Clinical Investigation, (in press). Adapted from materials provided by , via , a service of AAAS.. (Science Daily)
When Healing Turns To Scarring: Research Reveals Why It Happens And How To Stop It Sep 25, 2008
The study, led by Andrew Leask of the CIHR Group in Skeletal Development and Remodeling, is published in the Journal of Clinical Investigation. See also. (Science Daily)
Mother's Diet And Allergic Asthma In Offspring Sep 19, 2008
The results of the study are being published Sept. 18, 2008, in the online version of the Journal of Clinical Investigation and will appear in the October print issue ... Journal of Clinical Investigation, 2008; DOI ... Journal of Clinical Investigation, 2008; DOI. (Science Daily)
* Engineered enzyme protects against herpes: report Sep 19, 2008
5 percent of all patients able to reestablish normal neural functions, the researchers said in a scientific paper published on Sept. 2 in the Journal of Clinical Investigation. While about 80 percent of young adults worldwide have been infected by HSV-1, surveys in the past indicated that every year one in 200,000 patients develop encephalitis, they said. (Taipei Times, Taiwan -- World)
Stem Cell Regeneration Repairs Congenital Heart Defect Sep 13, 2008
5, 2004) In the February 2 issue of the Journal of Clinical Investigation, Pritinder Kaur and colleagues at the Peter MacCallum Cancer Centre, Australia, demonstrate that both epidermal stems cells and their. (June 16, 2005) Mutations in a critical gene that controls heart and blood vessel development in mouse embryos mimics a type of congenital heart disease in humans, according to new research by researchers at the. (Science Daily)
Advanced blood analysis may speed diagnosis of heart attacks Sep 10, 2008
The report will appear in the October Journal of Clinical Investigation and has received early online release. "Right now there are no blood markers for reversible myocardial injury in clinical use, and the only available markers are not detectable until hours after the onset of tissue damage. Because our treatments for heart attacks are most effective in the first hours after symptoms occur, these newly identified markers could help us apply treatments sooner and help more patients," says the... (EurekAlert!)
Anti-tumor Effects Are Enhanced By Inhibiting Two Pathways Rather Than One Aug 26, 2008
Journal of Clinical Investigation, 2008; DOI ... Journal of Clinical Investigation, 2008; DOI ... 23, 2007) In a study appearing online in the Journal of Clinical Investigation, researchers in China report using mouse models of tuberous sclerosis complex to provide a potential explanation for the fact that. (Science Daily)
Novel Mechanism That Controls The Development Of Autoimmunity Discovered Aug 15, 2008
6, 2004) In the February 2 issue of the Journal of Clinical Investigation Mark Peakman and colleagues from King's College London suggest a mechanism for the specificity of the immune regulation that. (Feb. (Science Daily)
Protein key to control, growth of blood cells Aug 14, 2008
Her study appeared online July 10 in the Journal of Clinical Investigation. Hematopoietic stem cells (HSCs) develop into all types of blood cells: red blood cells, platelets and immune cells. (EurekAlert!)
New Panel Of Mice Helps Predict How Drugs Are Broken Down In Humans Aug 5, 2008
The researchers report their findings in the Aug. 1 issue of the Journal of Clinical Investigation. In the study, four types of mouse were generated: mice that lacked PXR, mice that lacked CAR, mice that expressed human PXR in place of mouse PXR, and mice that expressed human CAR in place of mouse CAR. In addition, breeding these different mice in various combinations led to the generation of mice expressing both human PXR and human CAR and mice lacking both PXR and CAR.. (Science Daily)
Cigarette smoke worsens flu Jul 26, 2008
Ads By Google Indo-Asian News ServiceWashington, July 25, 2008First Published: 17:23 IST(25/7/2008)Last Updated: 17:43 IST(25/7/2008). Cold and flu virus symptoms often mild in non-smokers can seriously hit smokers, according to a study by Yale School of Medicine. (Hindustan Times)
Smokers Struck by Influenza Face Higher Mortality Rates Jul 25, 2008
(SOURCE: Journal of Clinical Investigation, news release, July 24, 2008) ... The study was published in the current issue of the Journal of Clinical Investigation. (Health-Finder)
Yale study shows why cigarette smoke makes flu, other viral infections worse Jul 25, 2008
Published in the Journal of Clinical Investigation, the study also identified the mechanism by which viruses and cigarette smoke interact to increase lung inflammation and damage ... Citation: The Journal of Clinical Investigation, Vol. 118, No. 8 (August 2008). (EurekAlert!)
Minimally Invasive Treatment Improves Male Fertility Jul 23, 2008
2, 2006) Although it had previously been thought that a protein known as GBA2 was important for bile acid metabolism, a new study appearing in the November issue of the Journal of Clinical Investigation shows. (Nov. (Science Daily)
Scientists identify how gastric reflux may trigger asthma Jul 22, 2008
"This is the first experimental evidence in a controlled, laboratory setting linking these two very common conditions in humans," says Lin, the senior author of the study published online in the European Journal of Clinical Investigation. "These data suggest that chronic micro-aspiration of gastric fluid can drive the immune system toward an asthmatic response.". (EurekAlert!)
A Potential Metastatic Disease Target? Jul 21, 2008
The study's results were released as a special "highlighted" article in a recent issue of the Journal of Clinical Investigation. Adapted from materials provided by. (Science Daily)
Bone Marrow Transplants: Cancer Drug Shows Promise Against Graft Vs. Host Disease Jul 17, 2008
Journal citation: Journal of Clinical Investigation, Vol. 118, no. 7, July 2008. Funding: National Institutes of Health, Doris Duke Clinical Scientist Development Award, Amy Strelzer Manasevit-National Marrow Donor Program. (Science Daily)
Overcoming Resistance To A Cancer Drug Jun 25, 2008
Journal of Clinical Investigation, 2008; DOI ... Journal of Clinical Investigation, 2008; DOI. (Science Daily)
Certain anticancer agents could be harmful to patients with heart disease Jun 24, 2008
The research was reported June 20, 2008, in advance online publication in the Journal of Clinical Investigation ... Journal of Clinical Investigation June 20, 2008 (advance online publication). (EurekAlert!)
How Measles Virus Spreads: Discovery May Rewrite Textbooks Jun 23, 2008
Journal of Clinical Investigation, 2008 DOI. Adapted from materials provided by. (Science Daily)
Hormone may help dieters keep weight off: U.S. study Jun 21, 2008
"When you lose weight you've created about the perfect storm for regaining weight," said Michael Rosenbaum of Columbia University Medical Center in New York, whose research appears in the Journal of Clinical Investigation. After weight loss Rosenbaum said the metabolism not only becomes more efficient, so the body needs fewer calories, but the brain becomes more vulnerable to tasty-looking treats. (Scientific American)
The cause of all hereditary sensory and autonomic neuropathy type II cases has been established Jun 11, 2008
A major discovery that details the existence of a neuronal specific form of the WNK1 gene, henceforth referred to as the WNK1/HSN2 isoform, was recently completed by the research group of Dr. Guy A. Rouleau and published in the scientific journal The Journal of Clinical Investigation. The group led by Dr. Rouleau is part of the University of Montreal Hospital Centre (CHUM), the CHUM Research Centre (CRCHUM) and the Sainte-Justine University Hospital Centre. (EurekAlert!)
Scientists ID Gene Regulating Blood Glucose Levels Jun 7, 2008
The study is published in the July issue of The Journal of Clinical Investigation. "Genetics is identifying a whole new set of genes, proteins and pathways that are related to diabetes and blood sugar control. Our next challenge is to figure out how these genes work," study co-author Dr. Thomas A. Buchanan, professor of endocrinology at Keck, said in a prepared statement. (Health-Finder)
Link Between Inflammation, Cancer Confirmed Jun 4, 2008
The researchers published evidence of the long-suspected link in the Journal of Clinical Investigation ... Journal of Clinical Investigation, 2008; DOI. (Science Daily)
Gene That Regulates Glucose Levels Identified Jun 4, 2008
The detailed results will be published in the July issue of the Journal of Clinical Investigation and are currently available online. The research was funded by the American Diabetes Association, the National human Genome Research Institutes, the National Institutes of Diabetes, Digestive and Kidney Diseases, the National Institutes on Aging, the National Heart, Lung and Blood Institute, Medical Research Council of the United Kingdom, the European Union, Lundbeck Foundation Center of Applied... (Science Daily)
Chronic Stomach Inflammation Boosts Cancer Risk Jun 3, 2008
Their findings, confirmed in two studies the researchers did on mice, were published in the June 2 online issue of the Journal of Clinical Investigation. Researchers have long known that inflammation caused by infectious agents, such as Helicobacter pylori and hepatitis C, produces cytokines -- chemicals that can foster cancerous cell proliferation and suppress cell death. (Health-Finder)
Protein May Be Key To New Therapies For Elevated Triglycerides May 28, 2008
Results of their study are published in the June issue of the Journal of Clinical Investigation. Heart disease is the leading cause of death in the United States and is a major cause of disability, according to the Centers for Disease Control and Prevention. (Science Daily)
Immune system protein could help develop cancer vaccine: study May 27, 2008
The research was published Friday in The Journal of Clinical Investigation. Story Tools: | | Text Size. (CBC.ca)
Cancer vaccine target pinpointed May 24, 2008
The research is published in the Journal of Clinical Investigation. The protein is unique to a type of immune cell called a dendritic cell, which is responsible for triggering the body's defence system. (BBC News -- Health)
Pittsburgh scientists find protein may be key to new therapies for elevated triglycerides May 24, 2008
Results of their study are published in the June issue of the Journal of Clinical Investigation. Scientists in the Division of Immunogenetics at Childrens Hospital studied the role of a protein known as Forkhead Box O1 (FoxO1) that mediates the metabolism of glucose and cholesterol. (EurekAlert!)
New Drug Reduces One Cause Of Vision Loss May 20, 2008
Journal of Clinical Investigation, May 15, 2008. Adapted from materials provided by , via , a service of AAAS.. (Science Daily)
Novel Insight Into Cardiac Arrhythmias, Sudden Cardiac Death May 12, 2008
Their findings, published online in the Journal of Clinical Investigation, could pave the way for the development of new, genetically-targeted therapies to treat and prevent fatal arrythmias. See also. (Science Daily)
Study Offers Clues to Link Between Arrhythmia, Sudden Death May 10, 2008
The study was published online Thursday in The Journal of Clinical Investigation. "We are still struggling to understand why arrhythmia causes sudden cardiac death in some patients, but not others, and what underlying molecular mechanisms or abnormalities may be at play," study senior author Dr. Gideon Koren, director of the cardiovascular research center at Rhode Island Hospital and a professor of medicine at Brown University's medical school, said in a prepared statement. (MEDLINEplus)
Scientists Discover How Stomach Tumors Form May 2, 2008
The findings were published online April 22 in The Journal of Clinical Investigation. The study shows that IL-11 promotes chronic inflammation and the formation of tumors in the stomach by increasing activation of the Stat3 protein, a known player in inflammation-associated carcinogenesis. (MEDLINEplus)
Enzyme Beneficial to Alzheimer's Plays Darker Role in Other Dementia May 2, 2008
The surprising findings, published in the April 22 online issue of The Journal of Clinical Investigation, are significant, because individuals with frontotemporal dementia with parkinsonism-17 -- a relatively rare hereditary form of dementia -- are often used as models for studying Alzheimer's disease. Alzheimer's disease and frontotemporal dementia each develop as a result of too many tau proteins accumulating and causing tangled lesions in the brain's neurons. (MEDLINEplus)
Regenerative Medicine To Repair Wounded Warriors Apr 23, 2008
5, 2004) In the February 2 issue of the Journal of Clinical Investigation, Pritinder Kaur and colleagues at the Peter MacCallum Cancer Centre, Australia, demonstrate that both epidermal stems cells and their. (Nov. (Science Daily)
Scan Detects Oxygen Levels in Tumors Apr 23, 2008
April 22, 2008, Journal of Clinical Investigation) ... "If successful, [the trend] will revolutionize the way that we treat cancer," said Dewhirst, who co-wrote a commentary accompanying the new study, published April 22 in the Journal of Clinical Investigation. (Health-Finder)
World-first Discovery Could Help Treat Life-threatening Tumors Apr 20, 2008
19, 2008) WA researchers investigating how blood vessel growth keeps cancers alive have made a world-first discovery that could boost the chances of successfully treating life-threatening tumours. Western Australian Institute for Medical Research (WAIMR) Associate Professor Ruth Ganss and her team have found that a gene called RGS5 can reverse angiogenesis -- the growth of blood vessels inside the tumour. (Science Daily)
Hepatitis B Virus Triggers Cell 'Suicide' In Patients With Chronic Infection Apr 10, 2008
Their findings are published today in the Journal of Clinical Investigation ... Journal reference: 'Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control hepatitis B virus' is published online ahead of print in the Journal of Clinical Investigation and is embargoed to Tuesday 8th April 2008 at 9pm GMT (5pm Eastern). (Science Daily)
A Random Analysis Apr 3, 2008
Journal of Clinical Investigation 107: 657-662. For genome defense in Neurospora, see Galagan, J. E. and Selker, E. U. 2004. (New York Times)
Korean scientists find gene promoting liver cancer growth Mar 24, 2008
The paper about the research was published in Journal of Clinical Investigation on Friday. "We are now searching for a business partner to conduct clinical research into liver cancer drugs," the daily quoted the team as saying. (Xinhuanet, China)
Parkinson's Disease Drug Might Work In Cancer Patients Mar 19, 2008
This research was published in the March 13 online issue of The Journal of Clinical Investigation. Other authors include: Chandrani Sarkar, Ph. (Science Daily)
Clues To Prevent Spread Of Ovarian Cancer Mar 19, 2008
In the April issue of the Journal of Clinical Investigation, the researchers show that an enzyme known as MMP-2 is necessary for ovarian cancer to attach itself to the sites where it tends to spread. Several drugs known as MMP inhibitors (for example, marimastat or prinomastat) inhibit the enzyme, dramatically reducing the tumor's ability to establish itself at sites beyond the ovary. (Science Daily)
Pinpointing When A Fetus Develops Male Genitalia, And Birth Defects Related To Male Sex Organs Mar 18, 2008
Journal of Clinical Investigation ... 2, 2006) Although it had previously been thought that a protein known as GBA2 was important for bile acid metabolism, a new study appearing in the November issue of the Journal of Clinical Investigation shows. (Science Daily)
New Drug Protects Nerve Cells From Damage In Mice Mar 18, 2008
Journal of Clinical Investigation. March 12, 2008. (Science Daily)
Male fertility decided in womb by hormones Mar 18, 2008
This measurement could be an early warning system of future reproductive problems in baby boys, the researchers reported in the latest edition of the Journal of Clinical Investigation. "We know from other studies that androgens work during foetal development to programme the reproductive tract. But our assumption was that it would be much later in pregnancy," said the study's lead author, Michelle Welsh. (Times of India)
Male fertility 'set in the womb' Mar 17, 2008
The results are published online in the Journal of Clinical Investigation. Problems with reproductive development such as the testes not descending properly into the scrotum (cryptorchidism) or the urinary tract opening in the wrong place on the penis (hypospadias) are fairly common in young boys. (BBC News -- UK)
Relief for priapism sufferers Mar 15, 2008
The study is published in the Journal of Clinical Investigation. Get personalised news stories on mobile. (India Times, India -- Health/Science)
Parkinson's Drug May Fight Cancer Mar 15, 2008
The findings were published in the online edition of the Journal of Clinical Investigation. "Researchers can now test this concept in solid tumors where angiogenesis (formation of new blood vessels) plays a critical role in the growth and progression of these cancers," Dr. Sujit Basu, a Mayo Clinic oncologist, said in a prepared statement. (Health-Finder)
Parkinson's Drug May Fight Cancer Mar 15, 2008
A study published in the March 13 online issue of The Journal of Clinical Investigation shows that dopamine, a drug currently used to treat Parkinsons disease and other illnesses, also might work in cancer patients. The study, which was done in mouse and laboratory models, shows that dopamine could possibly prevent new blood vessels from growing and as a result, slow cancer progression. (Newsmax)
Rare Syndrome Provides Clues On Obesity, Blood Pressure Mar 5, 2008
The study appeared online March 3 in the Journal of Clinical Investigation. The study was supported in part by grants from the American Heart Association, the National Institutes of Health and the Howard Hughes Medical Institute. (Science Daily)
Hormones could save hearing Mar 5, 2008
Their findings were published in the Journal of Clinical Investigation this week. "The alpha (oestrogen) receptor has no affect on hearing loss when you don't have the beta receptor you get more of a hearing loss. We're seeing the same effect in the males and the females," Canlon told AFP.. (iAfrica.com)
Sticky blood protein yields clues to autism Mar 5, 2008
In an advance online publication in the Journal of Clinical Investigation, Ana Carneiro, Ph. D., and colleagues report that a well-known protein found in blood platelets, integrin beta3, physically associates with and regulates the serotonin transporter (SERT), a protein that controls serotonin availability. (EurekAlert!)
Curry Spice May Thwart Heart Failure Feb 27, 2008
The studies "came to nearly identical conclusions," says an editorial published with the studies in February's edition of The Journal of Clinical Investigation. But editorialist Jonathan Epstein, MD, cautions against counting on curcumin to prevent heart failure in people, since the findings in rodents may not apply to people. (CBS News)
Gene Defect Causes Immune Deficiency And Balance Disorder Feb 26, 2008
The study, published online Feb. 21 in the Journal of Clinical Investigation, examined a specialized strain of Jackson Laboratory mice with a mutation that eliminates the production a protein called p22phox. Disruption of this protein causes a form of chronic granulomatous disease (CGD) -- a severe immune deficiency -- in humans. (Science Daily)
The cat's out of the bag: Felines stave off heart disease Feb 26, 2008
This latest research, published in the Journal of Clinical Investigation, adds to a growing body of medical literature indicating that curcumin has a broad range of biological properties. It is currently being tested as a possible treatment for cancer, Alzheimer's disease and various skin disorders. (Globe and Mail)
Study: genetic defect may produce balance disorders Feb 26, 2008
A study by researchers at the University of Iowa, the Jackson Laboratory in Maine and East Carolina University was funded in part by grants from the National Institutes of Health, and published online Friday in the Journal of Clinical Investigation. The study examined a specialized strain of Jackson Lab mice that eliminates production a protein called p22phox. (Muscatine Journal, IO)
Stimulating Thymus Reactivates T-Cell Production Feb 24, 2008
The results are published in the March issue of the Journal of Clinical Investigation. "These results represent new proof-of-principle findings that thymic involution can be reversed in humans," study author Dr. Laura Napolitano, an assistant investigator at Gladstone and an assistant professor of medicine at UCSF, said in a prepared statement. (Health-Finder)
Immune System Reactivated In Adults With HIV Feb 22, 2008
It should be noted that in an accompanying commentary in the Journal of Clinical Investigation, Kiki Tesselaar and Frank Miedema, at University Medical Center Utrecht, The Netherlands, warn that the long-term immunological and clinical benefits of growth hormone administration need to be thoroughly determined before this approach can be used more widely in the clinic ... Journal reference: Growth hormone resurrects adult human thymus during HIV-1 infection, Journal of Clinical Investigation. (Science Daily)
Curcumin May Prevent Heart Failure Feb 22, 2008
In a study entitled, Curcumin prevents and reverses murine cardiac hypertrophy, published in the February edition of the Journal of Clinical Investigation, researchers found when the herb is given orally to a variety of mouse models with enlarged hearts (hypertrophy), it can prevent and reverse hypertrophy, restore heart function and reduce scar formation. The healing properties of turmeric have been well known in eastern cultures for some time. (Newsmax)
Transplanted Cells May Hold The Key To Curing Hemophilia A Feb 20, 2008
The study appears online February 14 in the Journal of Clinical Investigation. Daniel Benten and Phyllis Novikoff of Einstein were also involved in this study. (Science Daily)
Early Detection Of Cerebral Malaria Possible, Animal Study Indicates Feb 20, 2008
Journal reference: A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI. Journal of Clinical Investigation. February 14, 2008. (Science Daily)
Urinary Incontinence In Women: Gene Shows Its Strength In Pelvis Feb 19, 2008
Journal article: HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse, Journal of Clinical Investigation. February 14, 2008. (Science Daily)
