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News and Articles on JAK3
Rigel Announces Third Quarter 2008 Financial Results and Clinical Update Nov 3, 2008
R348 Moving forward, Rigel plans to focus on psoriasis and possible topical applications with its Jak3 inhibitor, R348, and to do so with a collaboration partner. Rigel will move forward with another selective Jak3 inhibitor compound for transplant rejection ... Rigel expects to select this new Jak3 inhibitor compound by the end of 2008. (PR Newswire)
Key Step In Programmed Cell Death Discovered Mar 3, 2008
For example, they demonstrated earlier that most cytokines controlling hematopoietic cells require an enzyme called Jak2, or Jak3 in lymphocytes, at the receptors where cytokines attached to the cell. In screening for components that are regulated by the Jak enzymes, the St. Jude team found the Hax1 protein. (Science Daily)
STAT3 Signaling and the Hyper-IgE Syndrome Oct 18, 2007
The human genome encodes four JAK family members JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2) and seven STAT proteins. 1 JAKs are protein tyrosine kinases that interact with the intracellular domains of cytokine receptors (Figure 1) and that have enhanced catalytic activity toward substrate proteins after receptor activation. (New England Journal of Medicine)
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