Viral DNA In Bacterial Genome Could Hold Key To Novel Cystic Fibrosis Treatments Dec 3, 2008
Winstanley et al. Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa. Genome Research, 2008; DOI. (Science Daily)
Hana Biosciences to Present Data On Marqibo, Its Lead Novel Anti-Cancer Compound, At 2008 American Society of Hematology (ASH) Meeting Dec 1, 2008
In Vivo Anti-Tumor Efficacy of Vincristine Sulfate Liposomes Injection (VSLI, Marqibo) in Multiple Myeloma (abstract #2760; Sunday, Dec. 7, 6:00 PM) * Peripheral Neuropathy Profile of Vincristine Sulfate Liposomes Injection (VSLI, Marqibo), a Nanoparticle Vincristine Formulation, in Adult Subjects with Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) and Non-Hodgkin's Lymphoma (NHL) (abstract #2928; Monday, Dec. 8, 5:30 PM) * Phase 1 Study of Weekly Vincristine Sulfate (VCR) Liposomes... (Primezone Releases)
Marijuana-inspired Painkiller? New Chemical Pathway Discovered Nov 28, 2008
However, FAAH does not control 2-AG metabolism in vivo, and therefore, the potential biological functions and therapeutic potential of this second endocannabinoid have remained largely unknown. Teasing out 2-AG's specific impacts have proven challenging. (Science Daily)
Scientists Identify 13 New Tumor-suppressor Genes In Liver Cancer Nov 28, 2008
Zender et al. An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer. Cell, 2008; DOI. (Science Daily)
Fate and effects of the drug Tamiflu in the environment Nov 27, 2008
This research project is interdisciplinary and will combine studies on the environmental fate of the drug with in vivo studies of the development of Tamiflu resistant viruses say the project leader Bjrn Olsen at the Department of Medical Sciences Uppsala University ... Detected environmental levels will then be used in an in vivo Mallard infection model for detailed studies on the development of Tamiflu resistance in low pathogenic avian viruses. (EurekAlert!)
New Diabetes Treatment? New Source Of Insulin-producing Cells Identified Nov 26, 2008
She concluded: "Our identification of a differentiated pancreatic cell type as an in vivo progenitor for all differentiated pancreatic cell types has implications for a potential expandable source for new islets for replacement therapy for diabetes. While the ideal therapy would be to have those with diabetes regenerate their own islet cells, that is still a long way off.". This study was supported by grants from the National Institutes of Health/National Institute of Diabetes and Digestive and... (Science Daily)
Cytoplasmic CXCR4 expression in breast cancer: induction by nitric oxide and correlation with lymph node metastasis and poor prognosis Nov 24, 2008
The relationship between nitrotyrosine levels (a biomarker for peroxynitrate formation from NO in vivo) and lymph node status, CXCR4 immunoreactivity, and other established clinico-pathological parameters, as well as prognosis, was analyzed ... Formation of the biomarker nitrotyrosine was also correlated with CXCR4 expression and lymph node metastasis in vivo. (BioMed Central)
Codon Switching to Attenuate Viral Replication Nov 20, 2008
First, the creation of a strain of virus that can be grown readily and replicates well enough in vivo to stimulate a protective immune response and yet does not cause disease is more art and guesswork than science. Indeed, vaccines. (New England Journal of Medicine)
How Cancer Spreads: Signaling Between Protein, Growth Factor Is Critical For Coordinated Cell Migration Nov 19, 2008
Cell migration, though central to the development and maintenance of multicellular organisms, is not well understood, particularly in vivo or in live models. Researchers already knew the Wnt pathway has a role in embryogenesis and cancer by regulating cell-to-cell communication and that the Fgf pathway influences embryogenesis, wound healing, and cell proliferation. (Science Daily)
Common anesthetic induces Alzheimer's-associated changes in mouse brains Nov 13, 2008
"These are the first in vivo results indicating that isoflurane can set off a time-dependent cascade inducing apoptosis [cell death] and enhanced levels of the Alzheimer's-associated proteins BACE and A-beta," says Zhongcong Xie, MD, PhD, of the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) and the MGH Department of Anesthesia and Critical Care, the study's lead and corresponding author. "This work needs to be confirmed in human studies, but it's looking like isoflurane may not... (EurekAlert!)
Identifying Positioned Nucleosomes with Epigenetic Marks in Human from ChIP-Seq Nov 13, 2008
In vivo positioning and covalent modifications of nucleosomes play an important role in epigenetic regulation, but genome-wide studies of positioned nucleosomes and their modifications in human still remain limited. Results. (BioMed Central)
Key Mechanism That Regulates Development Of Stem Cells Into Neurons Identified Nov 12, 2008
Researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC analyzed sections of the forebrain in animal model embryos to investigate Ryk's function in vivo. They found that during neurogenesis, when neural stem cells start to grow into neurons, Ryk protein is cleaved and translocates to the cell nucleus to regulate neuronal differentiation. (Science Daily)
Brain imaging study supports the 'cognitive reserve' hypothesis Nov 12, 2008
"Based on autopsy data, there may be a ceiling effect when extensive beta-amyloid pathological burden is present as in late-stage dementia of the Alzheimer type. Presumably, as the Alzheimer disease pathological burden increases, a greater proportion of highly educated participants reaches the threshold for dementia and the initial advantage provided by cognitive reserve decreases. Longitudinal imaging of beta-amyloid pathology in vivo will soon allow us to determine whether these inferences... (Hindu)
New laser method reproduces art masterworks to protein patterns Nov 12, 2008
According to a new study published in the journal Lab on a Chip, scientists from Universit de Montral, the Maisonneuve-Rosemont Hospital Research Centre, McGill University and the Montreal Neurological Institute have developed a laser technology that can mimic the protein patterns that surround cells in vivo and that could lead to great advances in neuroscience. To illustrate the precision of their protein patterning technique, the research team reproduced a masterwork of Dutch painter... (EurekAlert!)
Research On Breathing Disorders And Congenital Heart Defects Nov 11, 2008
In vivo spectral domain optical coherence tomography volumetric imaging and spectral Doppler velocimetry of early stage embryonic chicken heart development. J. Opt. (Science Daily)
NC State finds new nanomaterial could be breakthrough for implantable medical devices Nov 11, 2008
We anticipate that this novel membrane material could find use in immunoisolation devices, kidney dialysis membranes and other medical devices encountering biocompatibility issues that limit in vivo function. . (EurekAlert!)
Raptor Pharmaceuticals to Collaborate with Centre Hospitalier Universitaire d'Angers for Phase II Clinical Trial in Huntington's Disease Nov 10, 2008
Sandrine Humbert and Frederic Saudou from the Curie Institute demonstrated a potential mechanism for cysteamine in an in vivo preclinical Huntington's model that showed increased brain and blood levels of BDNF. The Curie Institute will participate in the clinical trial by determining the BDNF levels in the patients. About Huntington's Disease Huntington's is a rare, progressive, and hereditary neurological disease that often leads to death within 15 to 20 years after diagnosis. (PR Newswire)
SemBioSys announces third quarter 2008 financial and operational results Nov 7, 2008
"We have completed all necessary steps to start clinical trials with our safflower-produced insulin this year and have begun plaque remodeling and regression studies in mice using our safflower-produced Apo AI(Milano), after obtaining positive results from an initial in vivo study. We have also taken the appropriate measures to allow Botaneco to operate independently of SemBioSys with its own source of capital," said Andrew Baum, president and chief executive officer of SemBioSys. "In response... (Canada Newswire)
Seeing A Brain As It Learns To See Nov 7, 2008
The measurements were made using something called "in vivo two-photon laser scanning microscopy," which allows researchers to focus on a virtual slice of living tissue a few microns thick, and up to 300 microns below the surface of the brain. By scanning at multiple depths, the researchers were able to examine the properties of hundreds of neurons in a single animal. (Science Daily)
Selective Reprogramming Of General Cells? Compounds For Stem-cell Production From Adult Cells Identified Nov 7, 2008
Ding went on to suggest that this drug discovery approach could be used to identify additional small molecules, which could not only provide insights into the reprogramming process, but also become useful in in vivo stem cell biology and, ultimately, the development of novel therapeutics ... In vitro and in vivo characterizations confirmed that transduction of only two factors with simultaneous treatment with small molecules BIX and BayK was sufficient to reprogram general cells to become... (Science Daily)
New advancements in the use of adult, embryonic stem cells for tissue regeneration Nov 7, 2008
The ability to reprogram adult somatic cells to ESCs in culture has led the authors to the concept that it may be possible to use natural or synthetic molecules to reprogram adult somatic cells in vivo to adult stem cells that will recapitulate the development of a tissue, organ or appendage, or to stimulate resident adult stem cells to do so. They argue that strong regenerators, such as fish and amphibians know how to do this naturally, and should be studied to learn what molecules are required... (EurekAlert!)
Metabolism of no-carrier-added 2-[18F]fluoro-L-tyrosine in rats. Nov 7, 2008
Several fluorine-18 labelled fluoroamino acids have been evaluated as tracers for the quantitative assessment of cerebral protein synthesis in vivo by positron emission tomography (PET) ... The present in vivo study was carried out in normal awake rats using no-carrier-added 2-[18F]Tyr. (BioMed Central)
Genetic noise control via protein oligomerization Nov 4, 2008
We have developed a fully stochastic model for the positive feedback control of a single gene, as well as a pair of genes (toggle switch), integrating quantitative results from previous in vivo and in vitro studies. In particular, we explicitly account for the fast binding-unbinding kinetics among proteins, RNA polymerases, and the promoter/operator sequences of DNA. We find that the overall noise-level is reduced and the frequency content of the noise is dramatically shifted to the... (BioMed Central)
Transplantation: 'molecular miscegenation' blurs the boundary between self and non-self Oct 31, 2008
Extensive and bidirectional transfer of major histocompatibility complex class II molecules between donor and recipient cells in vivo following solid organ transplantation. FASEB J. 2008 22: 3776-3784. (EurekAlert!)
OSA's ISP launches with research on breathing disorders and congenital heart defects Oct 31, 2008
A. M. Davis, F. G. Rothenberg, N. Shepherd, and J. A. Izatt, "In vivo spectral domain optical coherence tomography volumetric imaging and spectral Doppler velocimetry of early stage embryonic chicken heart development," J. Opt. Soc. (EurekAlert!)
Tenants claim landlord gave them injections Oct 30, 2008
In the same questionnaire, Cunningham said his "doctors' license was revoked for 'in vivo' stem cell therapy also known as prolotherapy.". Yesterday Cunningham said he only used the injections on people if they asked and if they were under a doctor's supervision. (Honolulu Advertiser)
Cold Virus Found To Manipulate Genes Oct 28, 2008
Proud et al. Gene Expression Profiles during In Vivo Human Rhinovirus Infection: Insights into the Host Response. American Journal of Respiratory and Critical Care Medicine, 2008; 178 (9): 962 DOI. (Science Daily)
BiPar Sciences' Lead Compound Selected as Top 10 Oncology Drug Candidate Oct 28, 2008
D., contributing writer to Windhover's In Vivo and Start Up publications, and Ben Bonifant, vice president and head of the Business Development Practice, Campbell Alliance, a leading business development strategy consulting firm ... Windhover Information, Inc., an Elsevier company, has led the field in providing analysis of the healthcare industry to decision-makers at all levels since the founding of its flagship publication, IN VIVO, the Business & Medicine Report, in 1983. (Primezone Releases)
Moderate use averts failure of type 2 diabetes drugs in animal model Oct 28, 2008
Remedi SM, Nichols CG. Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells. Public Library of Science Medicine, October 2008. (EurekAlert!)
BioAtom Inc. To Present at BIOCOM Investor Conference 2008 Oct 27, 2008
Its ONCOSENSOR(TM), a nanotechnology probe, will undergo in vivo evaluation at Center for Functional Onco Imaging, UC Irvine, in collaboration with Radiation Oncology Group, Long Beach Memorial Hospital. From Bomb Detector to Cancer Diagnostic Probe. (PR Newswire)
Building the blood-brain barrier Oct 27, 2008
Activation of the Wnt signaling pathway in vivo and in vitro promoted BBB development, and inactivation prevented it. In vitro increasing Wnt signaling also strengthened junctions between non-brain endothelial cells. (EurekAlert!)
An evolutionarily conserved intronic region controls the spatiotemporal expression of the transcription factor Sox10 Oct 27, 2008
We have combined in vivo testing of DNA fragments in zebrafish and computational comparative genomics to identify key regulatory regions of the zebrafish sox10 gene. Both approaches converged on the 3' end of the conserved 1st intron as being critical for spatial patterning of sox10 in the embryo. (BioMed Central)
FDA advisory panel today with Bayer, GE Healthcare on imaging biomarkers in Alzheimers will affect disease modification drug trials Oct 24, 2008
The availability of a non-invasive, imaging biomarker capable of detecting amyloid-beta in the brain to facilitate early and accurate in vivo disease detection of AD is a major unmet medical need ... I think with amyloid imaging and ancillary CSF tests, we can identify now those who have AD pathology in vivo without a biopsy. (FT.com -- Markets)
Oncolytics Biotech Inc. Collaborators Present Reovirus and Melanoma Research at EORTC-NCI-AACR Symposium Oct 23, 2008
CALGARY, Oct. 23 /CNW/ - Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ONCY) announced today that Dr. Shizuko Sei of SAIC-Frederick, Inc., delivered a poster presentation entitled "In Vivo Efficacy and Replication Dynamics of Intravenously Administered Oncolytic Reovirus in Nude Mice Bearing Human Melanoma Xenografts" at the 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. SAIC-Frederick is the prime contractor to the National Cancer Institute at Frederick (NCI-F) in the... (Canada Newswire)
A new relationship between brain derived neurotrophic factor and inflammatory signaling Oct 23, 2008
The senior authors recent publication associates the marked rise in BDNF that accompanies prolonged seizures with a specific decrease in the levels of alpha 1 that is reversed upon in vivo delivery of a JAK/STAT pathway inhibitor. Alpha 1 gene regulation is dependent upon the induction of a transcriptional repressor called inducible cAMP early repressor (ICER) that binds to the alpha 1 gene in coordination with the cAMP regulatory element binding protein (CREB). (EurekAlert!)
Miss Conceptions, Confirmed Oct 21, 2008
Their research "opens the way for a range of new procedures using animal parts." So while tissue regeneration in vivo reduces the need to repeat each transplant, it will apparently increase "use of animal tissue such as blood vessels, tendons and bladders" overall, according to the BBC. The point of all this work, according to Tissue Regenix, is to "address the .". We're not talking anymore about killing animals for food. (Slate)
Scripps research team sheds light on immune system suppression Oct 18, 2008
"It's the first demonstration that a virus causes suppression of the interferon response in vivo," says the paper's senior author Michael Oldstone, a Scripps Research professor and a pioneer in immune system studies. "This model explains how a secondary infection can be caused by a normal virus infection and this provides the guide for what to do and where to look in human diseases, which are of course more difficult.". (EurekAlert!)
Desensitization during Renal Transplantation Oct 16, 2008
The efficacy of different intravenous immune globulin preparations may vary substantially in vitro2 and probably in vivo. This might be why. (New England Journal of Medicine)
Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system Oct 15, 2008
The paper, "In Vivo Activation of Midbrain Dopamine Neurons via Sensitized, High-Affinity 6* Nicotinic Acetylcholine Receptors," was published in the October 9 issue of the journal Neuron. This work was supported by grants from the National Institutes of Health, the Moore Foundation, the Croll Research Foundation, California's Tobacco-Related Disease Research Program, a Caltech alumnus, and the Howard Hughes Medical Institute. (EurekAlert!)
ATL1101 suppresses tumours in prostate cancer animal study Oct 15, 2008
"Importantly, ATL1101 injection inhibited both aspects of tumour growth." "To our knowledge, this is the first demonstration of systemic efficacy in a prostate cancer model with an RNA-silencing IGF-I receptor drug. Our study clearly shows that ATL1101 is an effective inhibitor of IGF-IR signalling in vivo, and that its pharmacological mechanism is highly relevant in the control of prostate tumour growth." ANP CEO, Mark Diamond said "This project is a very exciting opportunity for ANP. By our... (Sydney Morning Herald)
Embryonic heart exhibits impressive regenerative capacity Oct 14, 2008
"To the best of our knowledge, this represents the first in vivo demonstration of selection against diseased tissue during embryonic heart development." The work also suggests that some cell populations within the heart are better able to regenerate than others and that those others are likely to be the source of later pathology. . (EurekAlert!)
Two Luminaries Join Cequent Scientific Advisory Board: Judy Lieberman, M.D. Ph.D., and Patrice Courvalin, M.D. Oct 7, 2008
Dr. Lieberman and her colleagues are currently working to harness RNAi for use against HIV and other viruses and they have developed novel strategies for cell-specific targeting of small interfering RNAs to confer in vivo protection from viral disease. In related work, Dr. Lieberman's laboratory is also working in the emerging field of miRNAs by developing their potential as diagnostic and therapeutic tools. (PR Newswire)
Obesity Clue: Newly Identified Cells Make Fat Oct 4, 2008
Rodeheffer et al. Identification of White Adipocyte Progenitor Cells In Vivo. Cell, October 2008; DOI. (Science Daily)
Why Calories Taste Delicious: Eating and the Brain Oct 3, 2008
To address this important question, the authors showed that calorie load increases dopamine levels in an area of the brain called the nucleus accumbens independent of taste in genetically altered mice using a technique known as in vivo microdialysis. Although both sucrose and sucralose increased dopamine above baseline in normal mice, genetically altered mice only showed an increase in dopamine with real sugar, indicating that caloric load (and not the taste of sweetness) was triggering their... (Scientific American)
Colon Cancer: Researchers Take Important Steps Forward In Understanding Cause Oct 3, 2008
Milicic et al. Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo. Cancer Research, 2008; 68 (19): 7760 DOI. (Science Daily)
Bordetella pertussis Isolates in Finland: Serotype and Fimbrial Expression Sep 25, 2008
Results of serotype-specific antibody responses suggest that Fim2 strains could express Fim3 during infection, showing a difference in fimbrial expression between in vivo and in vitro. The complete article is available as a. (BioMed Central)
Keratin 8 Expression in Head and Neck Epithelia Sep 22, 2008
K8 is an excellent marker for head and neck malignancies, which allows for early detection as well as for visualisation of potentially disseminating tumour cells in vivo. The complete article is available as a. (BioMed Central)
Prosthetic Vein Valve Designed To Direct Blood Flow Shows Promising Pre-clinical Results Sep 21, 2008
The researchers will begin conducting preclinical animal trials at Emory University in October to test the in vivo biocompatibility and performance of the prosthetic vein valve prototype in sheep. Sheep were chosen because their cardiovascular geometry and physiology are similar to those of humans. (Science Daily)
Genes Capable Of Regulating Stem Cell Function Identified Sep 20, 2008
In recent years, planarians have been recognized as a powerful model system in which to molecularly dissect conserved stem cell regulatory mechanisms in vivo ... "Our findings demonstrate that important signaling pathways regulating adult stem cell proliferation, migration and differentiation are evolutionarily and functionally conserved between planarians and mammals. Planarians are poised to not only advance the understanding of how diverse adult tissues are functionally maintained in vivo,... (Science Daily)
Sun-damaged Skin Does Not Improve With Estrogen Treatments, Study Finds Sep 17, 2008
Induction of Collagen by Estradiol: Difference Between Sun-Protected and Photodamaged Human Skin In Vivo. Arch Dermatol. (Science Daily)
New Pathway For Malaria Infection Discovered Sep 16, 2008
15, 2008) Cenix BioScience GmbH, a leading specialist in advanced RNA interference (RNAi)-based research services, Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, and the Lisbon-based biomedical research centre Instituto de Medicina Molecular (IMM), have announced the publication of their collaborative study in Cell Host & Microbe, describing the discovery and in vivo validation of scavenger receptor BI (SR-BI), a major regulator of cholesterol uptake by the... (Science Daily)
3-D MRI technique helps radiologists detect high-risk carotid disease Sep 16, 2008
"Intraplaque Hemorrhage: In Vivo 3D High-Spatial Resolution MR Imaging." Collaborating with Dr. Moody were Richard Bitar, M.D., M.Sc. General Leung, M.Sc. (EurekAlert!)
Nano-sized 'Cargo Ships' To Destroy Tumors Sep 12, 2008
While hybrids have been used for various laboratory applications outside of living systems, said Sailor, there are limited studies done in vivo, or within live organisms, particularly for cancer imaging and therapy. That s because of the poor stability and short circulation times within the blood generally observed for these more complicated nanostructures, he added. (Science Daily)
First Prognosticator Of Survival In Aggressive Cancer Revealed Sep 9, 2008
22, 2007) A small molecule derived from the spacer domain of the tumor-suppressor gene Rb2/p130 has demonstrated the ability to inhibit tumor growth in vivo and could be developed into an anti-cancer. (Feb. (Science Daily)
Gene Therapy Prevents Blindness In An Animal Model Of Mitochondrial Dysfunction Sep 9, 2008
"These data represent the 'proof of principle' that optimized allotropic expression is effective in vivo and can be envisaged as a therapeutic approach for mtDNA-related diseases," concludes Dr. Corral-Debrinski. "The next step towards our goal of clinical trials for preventing blindness in patients suffering from LHON disease will be to assess the long-term safety of our approach in large animals.". (Science Daily)
MMP-28 as a regulator of myelination Sep 9, 2008
MMP-28 is upregulated in conditions of demyelination in vivo, induces signaling in vitro consistent with myelination inhibition and, neutralization of MMP-28 activity can enhance myelination in vitro. These results suggest inhibition of MMP-28 may be beneficial under conditions of dysmyelination. (BioMed Central)
Neurogenesis In Adult Brain: Association With Stress And Depression Sep 3, 2008
2, 2008) The brain is the key organ in the response to stress. It reacts in a complex, orchestrated manner that is related to the activation and inhibition of neural structures involved in sensory, motor, autonomic, cognitive and emotional processes. (Science Daily)
Cellvizio Imaging System Improves Bile Duct Cancer Detection According to a New Study in Clinical Gastroenterology and Hepatology Sep 3, 2008
Cellvizio Inc. leads the growing in vivo cellular imaging market enabling physicians to visualize, diagnose and treat pathologies that can not be seen using other imaging techniques. The Cellvizio(r) system provides microscopic visualization of mucosal tissue and improves clinical outcomes by increasing the diagnostic yield of existing endoscopic procedures. (Primezone Releases)
Artificial bones blend with tendons Sep 1, 2008
Garcia and former graduate student Jennifer Phillips, along with other researchers, were not only able to create artificial bone that melds into softer tissues, but were also able to implant the technology in vivo for several weeks. More Health/Sci. (India Times, India -- Health/Science)
Neurogenesis in the adult brain: The association with stress and depression Sep 1, 2008
Up to now, neural networks in adults have been thought to be fixed and immutable, without the potential to regenerate: This assumption was prominently pronounced by the famous Spanish neuroscientist Santiago Ramon y Cajal, who postulated that everything may die, nothing may regenerate" (Cajal, 1928). Current research has overcome this view and has shown that the formation of new nerve cells (=neurogenesis) also takes place in the adult brain. Neurogenesis can be modified by positive modulators... (EurekAlert!)
Engineers Make Bone That Blends Into Tendons Aug 31, 2008
Garcia and former graduate student Jennifer Phillips, along with research technician Kellie Burns and their collaborators Joseph Le Doux and Robert Guldberg, were not only able to create artificial bone that melds into softer tissues, but were also able to implant the technology in vivo for several weeks ... Now that they have been able to demonstrate that they can implant the tissue in vivo for several weeks, the team s next step is to show that the tissue can handle weight for an even longer... (Science Daily)
Application Notes Aug 29, 2008
0, software that automates collection, calibration and analysis of multimodal images both in vivo and in vitro, the screen enables accurate fluorescence measurement of samples placed anywhere on the imaging surface, improving quantitative accuracy and overall throughput. Proteins are the principal active engines of biology. (Nature News Service)
Nature Methods Aug 29, 2008
Noninvasive, in vivo quantification of asthma severity using fluorescence molecular tomography. See a 00004000 lso this month. (Nature News Service)
Biopartnering Aug 29, 2008
In addition, a wide range of support services are offered from biosafety, through GLP immunoassay testing to in vivo studies. Web. (Nature News Service)
The transcriptional cofactor MIER1-beta negatively regulates histone acetyltransferase activity of the CREB-binding protein Aug 23, 2008
Functional analysis, using HEK293 cells, shows that the CBP bound to MIER1 in vivo has no detectable HAT activity. Histone 4 peptide binding assays demonstrate that this inhibition of HAT activity is not the result of interference with histone binding. (BioMed Central)
