Chronic Inflammation Can Help Nurture Skin Cancer, Study Shows Oct 24, 2008
"Inflammation should really help prevent a tumor," says Dr. Andrew Mellor, director of the MCG Immunotherapy Center and Georgia Research Alliance Eminent Scholar in Molecular Immunogenetics. In fact, there is strong evidence that inflammation triggers the immune response. (Science Daily)
'NATURE' ARTICLE: Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors Aug 19, 2008
The isotype and subclass of secreted antibodies were determined by ELISA. Nucleotide sequences of variable gene segments were determined by automated sequence analysis of cloned cDNA. The identity of the gene segments and mutations from the germline sequences were determined by alignment using the ImMunoGeneTics database ... Ruiz, M. et al. IMGT, the international ImMunoGeneTics database ... Identity of the gene segments and mutations from the germline sequences were determined by alignment... (USA Today -- Tech)
LABS Inc. to test organ donor eligibility in new St. Louis location Jul 14, 2008
LABS Inc. has tested tissue and organs for transplants for 25 years in the areas of infectious disease, immunogenetics and microbiology. The company employees more than 100 people and plans to open additional regional centers nationwide. (St. Louis Business Journal, MO)
New Vaccine Approach Prevents, Reverses Diabetes In Lab Study May 30, 2008
"The microspheres prevented the onset of type 1 diabetes and, most importantly, exhibited a capacity to reverse hyperglycemia, suggesting a potential to reverse type 1 diabetes in new-onset patients," said Dr. Trucco, chief of the Division of Immunogenetics at Children's. "This novel microsphere approach represents for the first time a vaccine with the potential to suppress and reverse diabetes. This finding holds true promise for clinical testing in people with type 1 diabetes.". (Science Daily)
New vaccine approach prevents/reverses diabetes in lab study at Children's Hospital of Pittsburgh May 29, 2008
The microspheres prevented the onset of type 1 diabetes and, most importantly, exhibited a capacity to reverse hyperglycemia, suggesting a potential to reverse type 1 diabetes in new-onset patients, said Dr. Trucco, chief of the Division of Immunogenetics at Childrens ... Dr. Trucco, an international leader in the field of immunogenetics, has dedicated his lifes work to finding a cure for diabetes. (EurekAlert!)
Pittsburgh scientists find protein may be key to new therapies for elevated triglycerides May 24, 2008
Scientists in the Division of Immunogenetics at Childrens Hospital studied the role of a protein known as Forkhead Box O1 (FoxO1) that mediates the metabolism of glucose and cholesterol ... Our latest findings suggest that we may eventually be able to develop drug therapies that inhibit FoxO1, which would thereby inhibit the production of proteins that lead to elevated triglyceride levels in people who are obese and/or who suffer from type 2 diabetes, said Henry Dong, PhD, a diabetes... (EurekAlert!)
An Immunodeficiency Disease with RAG Mutations and Granulomas May 8, 2008
From the Departments of Pediatrics and Adolescent Medicine (C.S., A.S., W.F.) and Internal Medicine (B.M.) and the Institute for Transfusion Medicine (U.P.), University Hospital Ulm, and the Institute for Clinical Transfusion Medicine and Immunogenetics (K.S.) all in Ulm; the Department of Pediatric Oncology, Hematology, and Clinical Immunology, Children's Hospital, Universit. ts Klinikum D. (New England Journal of Medicine)
InNexus sells royalty interests in two proposed drugs May 5, 2008
InNexus also named to its scientific advisory board Tom Kindt, who has served for the past two decades as chief of laboratory of immunogenetics at the National Institutes of Health in Bethesda, Md. GCU graduates 410 nurses. (Phoenix Business Journal, AZ)
Improving The Quality Of Laboratory Data With Computer Modeling Mar 3, 2008
Therefore, knowing which HLA proteins a person has is vital in transplant medicine, finding immunogenetic risk factors for disease, and understanding the way viruses like HIV mutate inside their host and evade the immune system. The model uses a large set of previously measured, high-quality HLA data to find statistical patterns in this type of data. (Science Daily)
India, France in health sector soon Jan 13, 2008
In the last JWG meeting, it was agreed that both the countries finalise a topic out of four areas already identified viz transnational research, chikungunya, cancer and immunogenetics. Loading. (India Times, India -- Intl Business)
India, France to cooperate in health sector Jan 12, 2008
In the last JWG meeting, it was agreed that both the countries finalise a topic out of four areas already identified viz transnational research, chikungunya, cancer and immunogenetics. Other stories in this section. (Economic Times)
New Strategies Work To Put Cancer On The Firing Line Jan 5, 2008
Dr. Andrew Mellor, director of the Immunotherapy Center and Georgia Research Alliance Eminent Scholar in Immunogenetics, and Dr. David Munn, pediatric hematologist-oncologist, showed in work published in 1998 in Science that fetuses use the enzyme IDO indoleamine 2,3-dioxygenase to locally disable a pregnant woman s immune system and avoid rejection. Subsequent studies demonstrated that tumors also use IDO for protection by activating regulatory T cells, which has a suppressive effect on the... (Science Daily)
Arthritis causing genes discovered Oct 23, 2007
Professor Brown's work was assisted by Professor John Reveille from the Division of Rheumatology and Clinical Immunogenetics at the University of Texas, and involved a team of researchers in Australia, England and North America. The identification of the two new genes will assist doctors to identify those people at high risk of developing ankylosing spondylitis, Professor Brown said. (ScienceAlert)
Will MICA Glitter for Recipients of Kidney Transplants? Sep 27, 2007
From the Institute for Clinical Transfusion Medicine and Immunogenetics, and the Institute for Transfusion Medicine, University Hospital both in Ulm, Germany. . (New England Journal of Medicine)
Tumors use enzyme to recruit regulatory T-cells and suppress immune response Aug 17, 2007
IDO inhibitors potential against tumors as well persistent viruses such as HIV arose out of work MCG scientists, led by Dr. Munn and his long-time collaborator Dr. Andrew L. Mellor, director of the MCG Immunotherapy Center and Georgia Research Alliance Eminent Scholar in Immunogenetics. Their work published in Science in 1998 showed fetuses use IDO indoleamine 2,3-dioxygenase to locally disable a pregnant womans immune system and avoid rejection. (EurekAlert!)
Recent Valley promotions and hires Aug 11, 2007
Kindt, a member of InNexus' scientific-advisory board, most recently was director of intramural research and chief of laboratory of immunogenetics at the National Institutes of Health in Bethesda, Md. CopperKey, Inc., a Web-based predictive-marketing software and solutions company, announce that Chris Lynde has been appointed president. (AZCentral -- Business)
Edward Boyse dies Aug 2, 2007
"He founded the field of immunogenetics," , a collaborator of Boyse's from the Monell Chemical Senses Center in Philadelphia, told The Scientist. Boyse and Beauchamp studied odor recognition in mice, that mice choose mates based on their body odor types. (The Scientist)
InNexus appoints former NIH director as commercialization guru Jul 6, 2007
He has been a member of InNexus' scientific advisory board and most recently was director of intramural research and chief of the laboratory of Immunogenetics at the National Institutes of Health in Bethesda, Maryland. InNexus (OTCBB: IXSBF) is a drug development company commercializing what are called monoclonal antibodies based on "Dynamic Cross Linking" technology, or DXL. Kindt replaces Dr. Heinz Kohler who remains a consultant to the company. (Phoenix Business Journal, AZ)
Fever After Smallpox Vaccination Tied To Individual Genetic Variations Jun 20, 2007
Reference: Stanley S, Frey S, Taillon-Miller P, Guo J, Miller R, Koboldt D, Elashoff M, Bhristensen R, Saccone N and Belshe R. The Immunogenetics of Smallpox Vaccine. The Journal of Infectious Diseases, online edition. (Science Daily)
Teaching the Body to Fix Itself Apr 24, 2007
"We are opening a new field," argued panel member Dr. Francesco Marincola, director of the Immunogenetics Laboratory at the National Institutes of Health. "There is much to learn by starting to see patients being treated with this.". (BusinessWeek)
InNexus Biotechnology Announces Appointment of J. Donald Capra, MD, Chairman of Scientific Advisory Board Apr 10, 2007
In addition to his current duties as President Emeritus, he continues his research projects in the laboratory as Member and Head of the Molecular Immunogenetics Research Program at OMRF. Prior to OMRF, he served as professor of microbiology and internal medicine and was the Edwin L. Cox Distinguished Chair in Immunology and Genetics of University of Texas Southwestern Medical Center and Director of Southwestern s Molecular Immunology Center. Dr. Capra is also well known for his studies of... (BusinessWire)
