Salk researchers develop novel glioblastoma mouse model Jan 5, 2009
"They displayed all the characteristics of cancer stem cells, and less than 100 and as few as 10 cells were enough to initiate a tumor when injected into immunodeficient mice," says Friedmann-Morvinski. Most xenograft models for brain tumors using tumor cell lines require at least 10,000 cells. (EurekAlert!)
Newly Discovered Esophagus Stem Cells Grow Into Transplantable Tissue, Study Finds Dec 25, 2008
When the tissue-engineered patches were transplanted under the skin of immunodeficient mice, the cells formed epithelial structures. Additionally, in a mouse model of injury of the esophagus in a normal mouse, which mimics what happens during acid reflux, green-stained stem cells migrated to the injured lining cells and co-labeled with the repaired cells, indicating involvement of the stem cells in tissue repair and regeneration. (Science Daily)
Study sheds light on causes of HIV dementia Dec 4, 2008
To find out, the researchers injected either clade B or clade C HIV into the brain of a special strain of immunodeficient mice. After six days--enough time for the viruses to cause neurologic damage--the mice were tested in a complex water maze that challenged their long term memory as well as their short term working memory (the type that temporarily stores and manages the information needed to carry out complex cognitive tasks, such as learning, reasoning, and comprehension). (EurekAlert!)
Hope in HIV battle Aug 8, 2008
Even with primate models, you are forced to use simian immunodeficiency virus instead, which is closely related to HIV, or artificial viruses that contain parts of both SIV and HIV. But we had a group of immunodeficient mice to study. They lack their own immune system, so you can introduce human T cells into these mice and they don't regard those cells as foreign or reject them. (MSNBC -- Health)
Novel Ways To Boost Vaccination Or Natural Defenses Jul 13, 2008
"Without IL-21, we probably wouldn't be completely immunodeficient, just severely compromised. In addition to the high affinity antibodies we're talking about, our bodies also produce a lot of low affinity antibodies for mopping up infection. That low level response happens around-the-clock and is one of our body's first lines of defence.". "You could say that IL-21 directs the most finely-tuned aspect of our immune response. The highly specialised weaponry developed on-the-spot to target... (Science Daily)
Cells That Initiate A Common Infant Tumor Identified Jun 10, 2008
After each cell had been grown long enough for it to have given rise to a large population of cells, the cells were transplanted into immunodeficient mice, where they generated human blood vessels ... Joyce Bischoff et al. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. (Science Daily)
Neurologically Impaired Mice Improve After Receiving Human Stem Cells Jun 6, 2008
Immunodeficient mice were used to minimize the rejection of the transplanted cells. The researchers found that the new transplant procedure resulted in infiltration of human glial progenitor cells throughout the brain and spinal cord. (Science Daily)
Pox protection May 28, 2008
It may be fatal in newborns, senior citizens and those who are immunodeficient. Deaths from varicella in healthy adults are 30 to 40 times more than that of children aged five to nine years. (The Star Online, Malaysia -- News)
Stem Cell Researchers Demonstrate Safety Of Gene Therapy Using Adult Stem Cells May 8, 2008
In the current study, 630 immunodeficient mice received mesenchymal stem cells from one human bone marrow donor and hematopoietic stem cells from another. Mesenchymal stem cells are a type of cell found in bone marrow that support the function of hematopoietic stem cells, and can give rise to bone, cartilage, fat, and muscle. (Science Daily)
2 microRNAs promote spread of tumor cells Jan 29, 2008
When the scientists injected MCF-7 cells without CD44 into immunodeficient mice, the mice developed bone and lung tumors, while mice receiving MCF-7 cells with CD44 did not. We found that miR-373 and miR-520c interfered with the expression of CD44 in MCF-7 cells, Huang says. (EurekAlert!)
Boy in a bubble gets leukaemia after gene therapy Dec 20, 2007
A child who was born with a rare immunodeficient condition has developed leukaemia as a result of gene therapy he received at Great Ormond Street children's hospital in London. The boy who is now three was born with rare X-linked severe combined immunodeficiency, (SCID-X1), a condition which only affects males. (News-Medical.net)
New Chimeric Mouse Model For Human Liver Diseases, Drug Testing Dec 6, 2007
They developed a simple system that allows them to transplant human hepatocytes into immunodeficient mice, which can now be used to test how drugs affect the liver. "Rodents are often used as model organisms to study the efficacy and toxicity of drugs," says lead author Karl-Dimiter Bissig, M.D. Ph. (Science Daily)
UV rays to check waterborne disease Oct 20, 2007
WASHINGTON: French researchers have found that extremely chlorine-resistant parasites called Cryptosporidium, which cause a diarrhoeal disease in humans and can lead to significant mortality in immunodeficient patients, become virtually inactive when exposed to industrial UV reactors. Human contamination of the waterborne disease called cryptosporidiosis occurs by ingestion of the resistant form of the parasite, either directly through person-to-person and animal-to-person routes or indirectly... (India Times, India -- Health/Science)
UCLA and Orthopaedic Hospital Unveil Innovative Research Complex UCLA, Sep. 25 Sep 26, 2007
Research will address crippling diseases of children and adults, including cancer, bone and cartilage disorders, drug-resistant infections, severe combined immunodeficient diseases, diabetes, lupus, rejection syndromes associated with solid-organ transplantation, and more. WHO: Some of the world's leading researchers and doctors will be on hand to explain their efforts on the frontiers of orthopaedic medicine, microbiology, immunology, transplantation, AIDS research, embryonic stem cell... (University of California Newswire, CA)
Testes May Provide Plentiful Source of Adult Stem Cells Sep 21, 2007
When the stem cells were implanted in immunodeficient mice used for cancer research, the cells developed into teratomas in every case that showed differentiation into multiple types of cells. In the same mouse model, the stem cells formed teratomas that contained functional blood vessels that joined up with the "host" circulation system. (MedPage Today)
Human Source Of Stem Cells With Potential To Repair Muscle Identified Sep 6, 2007
A thousand myoendothelial cells transplanted into the injured skeletal muscle of immunodeficient mice produced, on average, 89 muscle fibers, compared with 9 and 5 muscle fibers for endothelial and satellite cells, respectively. Myoendothelial cells also showed no propensity to form tumors, a concern with other stem cell therapies. (Science Daily)
OHSU turns mouse into factory for human liver cells Aug 10, 2007
Early results since 2004 showed it could be done, but the mice were difficult to breed, the time window for transplanting human liver cells into the mice was narrow, and the mouse liver, despite efforts to make the animal immunodeficient, often rejected the human cells ... It has created a severely immunodeficient mouse strain that develops liver disease only when the animals don't receive a protective drug called NTBC, allowing liver disease to be turned on and off. (EurekAlert!)
Infection-Related Cancers Elevated Among the Immunodeficient Jul 7, 2007
Coverage of HIV/AIDS Supported by an educational grant from. " Historically, only Kaposi's sarcoma, non-Hodgkin's lymphoma, and cervical cancer have represented AIDS-defining illnesses. Increased incidence of other cancers has been reported, but this was judged to be the result of lifestyle and other risk factors rather than immunodeficiency by investigators in the largest study to look at the issue, the AIDS-Cancer Match Registry Study published in the Journal of the American Medical... (MedPage Today)
Scientists Identify A Mouse Embryonic Stem Cell More Like Our Own Jul 3, 2007
When injected into immunodeficient mice, they formed teratomas large tumors containing bits of cartilage, muscle, fat, skin and other tissues. Other experiments revealed how similar the epiblast stem cells are to human ES cells, and how different those two cell types are from the classic mouse ES cell. (Science Daily)
Kefir: A Food for Longevity Mar 23, 2007
This could be important to those who suffer immunodeficient diseases and the elderly. Kefir has been shown to guard against illnesses such as cancer, chronic fatigue and herpes and due to its nutritious nature, has been shown to decrease food cravings in many individuals, by balancing blood sugar. (Suite101.com)
Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo Mar 18, 2007
In 10 male severe combined immunodeficient (SCID) mice, pieces of SW 1353 chondrosarcomas were implanted into a cranial window preparation where the calvaria serves as the site for the orthotopic implantation of bone tumors. From day 7 after tumor implantation, five animals were treated with SU6668 (250 mg/kg body weight, s.c.) at intervals of 48 hours (SU6668), and five animals with the equivalent amount of the CMC-based vehicle (Control). (BioMed Central)
New Source of Stem Cells: Amniotic Fluid Jan 8, 2007
In addition to laboratory experiments, the team studied AFS cells in mouse models, grafting neural stem cells into the brains of mutant mice with disrupted neural development and growing bone tissue in another set of immunodeficient mice. "It adds t o the list of pluripotent stem cells that have already been identified in other sources and tissues," says Willem Fibbe, an immunohematologist at Leiden University Medical Center in the Netherlands. (Scientific American)
