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News and Articles on Haploinsufficiency
Study finds brain chemical underpinning human obesity Aug 28, 2008
Researchers hypothesized that the subphenotype of obesity in the WAGR syndrome is attributable to deletions that induce haploinsufficiency of BDNF. ... Among them, BDNF haploinsufficiency was associated with lower levels of serum BDNF and with childhood-onset obesity. (Xinhuanet, China)
Brain-Derived Neurotrophic Factor and Obesity in WAGR Syndrome Aug 28, 2008
Heterozygous, variably sized, contiguous gene deletions causing haploinsufficiency of the WT1 and PAX6 genes on chromosome 11p13, approximately 4 Mb centromeric to BDNF (11p14 ... We hypothesized that the subphenotype of obesity in the WAGR syndrome is attributable to deletions that induce haploinsufficiency of BDNF. ... Conclusions Among persons with the WAGR syndrome, BDNF haploinsufficiency is associated with lower levels of serum BDNF and with childhood-onset obesity; thus, BDNF may be... (New England Journal of Medicine)
Rheb's Role In Cancer Aug 20, 2008
Nardella et al. Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. Genes & Development, 2008; 22 (16): 2172 DOI. (Science Daily)
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