Genetic Engineering & Biotechnology News reports on the trend toward predictive toxicogenomics Nov 20, 2008
"Toxicogenomics, which is essentially gene-expression profiling, is the next step up from basic toxicology studies," says John Sterling, Editor-in-Chief of GEN. "It is a more complex approach, and it will take some time before it becomes a regular tool in the technology armentarium of drug discovery and pharmaceutical scientists.". So far most companies are focusing on toxicogenomics primarily as a method to explore mechanisms of action rather than to predict toxicity. (EurekAlert!)
Gene Signatures for Liver-Cancer Recurrence Nov 6, 2008
Methods We aimed to demonstrate the feasibility of gene-expression profiling of more than 6000 human genes in formalin-fixed, paraffin-embedded tissues. We applied the method to tissues from 307 patients with hepatocellular carcinoma, from four series of patients, to discover and validate a gene-expression signature associated with survival. (New England Journal of Medicine)
Gene Signature for Liver Cancer Recurrence Found Oct 17, 2008
Most gene-expression profiling studies use tissue samples that have been flash frozen. But tissues taken in biopsies are usually chemically fixed and embedded in wax. (MEDLINEplus)
New Electrostatic-based DNA Microarray Technique Could Revolutionize Medical Diagnostics Jul 2, 2008
Often referred to as "gene chips," DNA microarray assays and their RNA counterparts have become one of the most powerful tools for gene-expression profiling, the identification of mutations, and the detection of multiple pathogens in patients afflicted either by multiple diseases or drug-resistant strains of diseases. Aside from their potential future role in personalized medicine, the widespread use of DNA microarray assay devices could have an immediate and profound impact on the treatment of... (Science Daily)
Molecular Science Could Further Improve Leukemia Survival, Say St. Jude Researchers Mar 21, 2008
One is gene-expression profiling, which measures the amount of messenger RNA made by different genes in different cell types; and the other is pharmacogenetics. RNA is the decoded form of genes and is a signal that those genes have been active. (PR Newswire)
Immune Cells Fighting Chronic Infections Become Progressively 'Exhausted,' Ineffective Oct 22, 2007
Using a technique called gene-expression profiling, Wherry and his colleagues identified 490 genes whose activity in T cells is altered during a chronic viral infection. Closer study at different time points using a 22-gene subset of the larger group of genes provided molecular signatures of progressive T-cell exhaustion. (Science Daily)
How phytol suppresses arthritis May 10, 2007
The aim of this study was to use gene-expression profiling to understand the protective effect against arthritis of activation of NADPH oxidase in the immune system ... Hence, global gene-expression profiling on inguinal lymph nodes was performed 10 days after the induction of pristane-induced arthritis (PIA) and phytol administration. (BioMed Central)
Models of Breast Cancer Feb 11, 2007
In fact, gene-expression profiling can be used to predict which tumour is likely to be metastatic. Some have even proposed that tissue-specific profiles can predict the site of metastasis. (Suite101.com)
