Ernest Beutler, 80, pioneer in bone marrow transplants Oct 11, 2008
Dr. Beutler was a pioneer in bone marrow transplantation for fighting cancer; made key discoveries about the role of the X chromosome in women; helped discover G6PD deficiency, the most common clinically significant enzyme deficiency of humans; improved the diagnosis and treatment of Gaucher disease; and developed cladribine, a treatment for leukemia and multiple sclerosis ... He demonstrated that some black women who inherited the defective gene for G6PD deficiency from only one parent had some... (Boston Globe)
QLT announces FDA filing and review of Aczone(TM) labeling supplement for removal of blood screening requirement Jul 23, 2007
The Phase IV clinical trial of Aczone was performed to meet a post-approval commitment requested by the FDA. The purpose of this study was to gather more information about the safety of Aczone, a prescription topical medicine, in treating patients with acne who have G6PD deficiency. During a six-month period, patients were treated with both Aczone and the Aczone-vehicle (control group) in a cross-over design. (PR Newswire)
QLT USA, Inc. files Aczone(TM) labeling supplement for removal of blood screening requirement May 29, 2007
"This filing represents a significant milestone in our Aczone program and in our efforts to bring the first new compound in a decade for the treatment of acne to patients in the U.S.," said Bob Butchofsky, President and Chief Executive Officer of QLT. "If the FDA approves the label revision we believe Aczone could be a key contributor to our growth strategy with a potential launch of Aczone in 2008." The Phase IV clinical trial of Aczone was performed to meet a post-approval commitment requested... (PR Newswire)
G6PD Deficiency Is Associated With Significant Protection Against Severe, Life-threatening Malaria Mar 14, 2007
G6PD deficiency is also known as "favism" after the Italian word for broad beans (fava) which cause a classic reaction when eaten by people with G6PD deficiency. In males, who have only one X chromosome, mutations in the gene for G6PD on the X chromosome cause G6PD deficiency ... G6PD deficiency is associated with protection against malaria, notably in Africa where one form of G6PD deficiency (G6PD A-) is widespread. (Science Daily)
