Colorectal Cancer Awareness: Screening saves lives Nov 29, 2008
Genetic syndromes such as familial adenomatous polyposis (FAP) or hereditary nonpolyposis colon cancer (HNPCC). More than 90 percent of colorectal cancers are diagnosed in people aged 50 or older. (Princeton Bureau County Republican, IL)
'1-hit' event provides new opportunity for colon cancer prevention, say Fox Chase researchers Sep 15, 2008
The Fox Chase researchers studied patients with familial adenomatous polyposis (FAP), an inherited disorder that also serves as a classic model in support of the two-hit hypothesis. Patients with FAP, which predisposes people to colon cancer, carry mutations in one of their two copies of the adenomatous polyposis coli (APC) tumor-suppressor gene. (EurekAlert!)
Here comes the bride – no matter what Jun 14, 2008
Genetic testing would reveal that Ms. Heller had familial adenomatous polyposis (FAP), usually a hereditary illness, although neither of Ms. Heller's parents has the gene. Like 20 to 30 per cent of patients, Ms. Heller had a spontaneously occurring mutation. (Globe and Mail)
Fight corectal cancer, here's what you need to know May 20, 2008
Certain rare but high-risk genetic syndromes, including familial adenomatous polyposis and Lynch syndrome, caused by gene mutations that can now be detected with DNA testing, account for about 10 percent of the total cases, and as many as 30 percent are linked to family histories of colorectal cancer or inflammatory bowel diseases, says Dr. Keith Argenbright, medical director UT Southwestern Moncrief Cancer Resources. Q: Can colorectal cancer be prevented. (Atlanta Journal-Constitution -- Health)
Health Matters: Make colo-rectal screening a priority Feb 19, 2008
A family history or familial adenomatous polyposis, Gardner s syndrome, and hereditary nonpolyposis colon cancer are three conditions that carry a high risk of colorectal cancer. If polyposis or colorectal cancer seems to run in a family, members should talk to their doctors. (Needham Tab, MA)
Patient Zero for a Colon Cancer Gene Jan 22, 2008
The Fry family's mutation causes a relatively rare syndrome known as attenuated familial adenomatous polyposis (AFAP). Without proper clinical care, people with AFAP who account for less than 1% of the 153,000 colorectal cancer cases in the U.S. every year have a greater than two-in-three risk of developing cancer, compared with a one-in-24 chance in the general population. (Time.com)
US study shows English settlers to New World brought colon cancer Jan 7, 2008
The people in these two families have a slightly more than two out of three risk (69%) of getting colon cancer specifically, attenuated familial adenomatous polyposis (AFAP), a form of inherited colon cancer from the adenomatous polyposis coli (APC) gene that can lead to AFAP characterized by less than one hundred adenomatous polyps in the colon and rectum, by the age of 80 years. The general population in the United States has a slightly less than one in twenty-four chance (about 4%). (iTWire)
Colon Cancer Gene Traced to Arrival in United States Jan 4, 2008
The ACP gene mutation identified by Neklason and her colleagues causes attenuated familial adenomatous polyposis (AFAP), a condition which results in a 69 percent greater risk of developing colon cancer by the age of 80. This is compared to a roughly one in 24 chance for the general population. (MEDLINEplus)
Colon cancer risk traced to common ancestor Jan 3, 2008
In the study, the team identified the mutation that causes a condition called attenuated familial adenomatous polyposis (AFAP), which makes people more prone to developing polyps that can cause colon cancer. Without proper treatment, people with this mutation have a greater than 2 in 3 risk of developing colon cancer by age 80, compared to about 1 in 24 for the general population. (MSNBC -- Environment)
U.Va. hospital performs first intestinal transplant Oct 25, 2007
"She has a syndrome called FAP, or familial adenomatous polyposis, which made her predisposed to early colon cancer," he explained. Theoretically, doctors could have removed Wagner's small intestine and avoided the transplant, but Schmitt said this would have greatly reduced her quality of life. (The Cavalier Daily, VA)
Impaired DNA Repair Jul 20, 2007
These cancers differ from those due to mutations in the APC gene resulting in Familial Adenomatous Polyposis, in that they lack the gross chromosomal abnormalities associated with the latter. This is because they involve more discrete lesions resulting from mismatched bases. (Suite101.com)
Colorectal Cancer Summary Apr 7, 2007
Familial Adenomatous Polyposis (FAP) associated with several genetic abnormalities including mutations in the APC gene and later on, the p53 gene. Hereditary Non-Polyposis Colorectal Cancer (HNPCC) associated with various DNA mismatch repair gene mutations. (Suite101.com)
Web Extra: Colorectal cancer is serious disease in the United States Mar 29, 2007
Also, there are certain genetic factors that increase the likelihood of having colon cancer, including conditions called familial adenomatous polyposis (FAP), Gardner's syndrome, hereditary non-polyposis colorectal cancer, and being of Ashkenazi Jewish descent. Race: African-Americans have the highest colorectal cancer rates and the highest rate of death from the disease of any racial or ethnic group in the United States. (Sun Herald, MS -- Living)
People With Genetic Predictors Of Colorectal Cancer Are Not Getting Screened Feb 26, 2007
We studied families with a history of familial adenomatous polyposis, a condition that very often leads to colorectal cancer, says study author Dr. Anita Kinney. Unfortunately, only about half of those diagnosed with the condition had been tested for cancer recently, and even fewer of their at-risk relatives had been screened. (Science Daily)
Jessica tugs heart strings Jan 29, 2007
Sharing Jessica's wish was her 11-year-old sister, Emma, who also suffers from familial adenomatous polyposis, an inherited bowel cancer syndrome. Jessica said breakfasts with Chambers, Cole and Sarah Storer were amazing, but nothing compared with meeting Kernaghan as he added another four Golden Guitars to his collection. (Melbourne Herald Sun)
