New Treatment Option Emerging For Some With Early Stage Lung Cancer Nov 7, 2009
Each patient's "forced expiratory volume in 1 second" or FEV1 was measured. "We use the FEV1 to grade the severity of a patient's COPD," says Eric D. Anderson, MD, a pulmonologist at Georgetown University Hospital and presenting author of the abstract ... For patients with a better FEV1, survival was 100 percent. (Science Daily)
MediciNova Announces Initiation of a Phase Ib Clinical Trial for MN-221 in Patients With Stable, Moderate to Severe Chronic Obstructive Pulmonary Disease Nov 4, 2009
In addition to the preclinical data described above, MN-221 has been shown to produce significant improvements in mean change in post-infusion (15 minute) forced expiratory volume in one second (FEV1) from baseline (objective measure of lung function) at doses of 3 ... Administration of MN-221 at a dose of approximately 1,100 micrograms over intervals of one or two hours also produced marked improvement in FEV1 in patients with moderate-to-severe stable asthma (MN-221-CL-005) ... Based on an... (Primezone Releases)
Triple therapy halves exacerbations in moderate-to-severe COPD Oct 8, 2009
After one week, patients on triple therapy increased their pre-dose FEV1 clinic values by six percent over than patients on tritropium alone. There was an even greater improvement in post-dose readings among triple-therapy patients, which were about 12 percent better than those on tiotropium alone. (EurekAlert!)
MediciNova to Evaluate MN-221 for the Treatment of Chronic Obstructive Pulmonary Disease Exacerbations Jul 21, 2009
In addition to the data described above MN-221 has been shown to produce significant improvements in mean change in post-infusion (15 minute) FEV1 from baseline (objective measure of lung function) at doses of 3 ... Administration of MN-221 at a dose of approximately 1,100 micrograms over intervals of one or two hours also produced marked improvement in FEV1 in patients with moderate-to-severe stable asthma (MN-221-CL-005) ... Based on an analysis of the data from the recently completed Phase II... (Primezone Releases)
Alpha1-Antitrypsin Deficiency Jun 25, 2009
There is no family history of COPD. Severe airflow obstruction is seen on spirometry, with a forced expiratory volume in 1 second (FEV1) that is 40% of the predicted value. . (New England Journal of Medicine)
Obesity Does Not Worsen Asthma, But May Reduce Response To Medications Jun 5, 2009
" Previous studies have suggested that obesity predisposes people to developing asthma, to suffer more severe asthma symptoms, and to respond less to medications. However, the exact mechanism for these links has been unclear, and the studies have generally relied upon patients' reports of their diagnosis and symptoms rather than using more precise tools to characterize patients. Dr. Sutherland and his colleagues decided to examine the issue in a well characterized group of 1,256 patients who had... (Science Daily)
Three years of pulmonary rehabilitation: inhibit the decline in airflow obstruction, improve exercise endurance time, and body-mass index, in chronic obstructive pulmonary disease May 31, 2009
In addition, current views are that pulmonary rehabilitation does not improve FEV1 or even slow its decline in COPD patients ... Eighty patients with moderate to severe COPD (age 63 7 years; FEV1 48% 14) were recruited ... These groups were matched for age, sex, BMI, FEV1% and number of pack-years smoked. (BioMed Central)
Perforomist Inhalation Solution data to be presented today at American Thoracic Society conference May 20, 2009
The primary efficacy endpoint was standardized absolute FEV1 AUC0-3 ... Subgroups with a significant difference in pre-treatment FEV1 on Day 14 favoring Perforomist Inhalation Solution were older, ( 65 years), severe to very severe COPD. (EurekAlert!)
Women More Susceptible To Harmful Effects Of Smoking, Study Finds May 19, 2009
Examining the total study sample, there were no gender differences with respect to lung function (FEV1) and COPD severity, but the women were on average younger and had smoked significantly less than men. To explore these differences further, they also analyzed two subgroups of the study sample: COPD subjects under the age of 60 (early onset group) and COPD subjects with less than 20 pack-years of smoking (low exposure group). (Science Daily)
New therapies mean HIV patients gain longer lives, face new challenges May 18, 2009
The patients, mostly men in their 40s, half of whom were smokers, were assessed at baseline for two measures of respiratory status, FEV1 and DLCO, and had been followed for two years at the time of reporting. FEV1 is a measure of expiratory flow in one second, a standard gauge of lung capacity, whereas DLCO is a measurement of diffusing capacity of the lungs and is decreased in patients with emphysema ... At the end of two years, the 63 patients displayed marked declines in lung function, going... (EurekAlert!)
Gene Variants May Determine Lung Function And Susceptibility To Maternal Smoking Mar 29, 2009
The lung function measurements used were maximal mid expiratory flow rate (MMEF), forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). "FEV1 is a measure of large airways, FVC of total lung volume and MMEF of smaller airways, so they measure slightly different things and we wouldn't necessarily expect to see all outcomes behaving the same," said Dr. Breton ... Finally, another haplotype in GSTM4, occurring in 16-22% of the population, showed significantly decreased... (Science Daily)
Love handles put the squeeze on lungs Mar 6, 2009
The study analyzed health information on more that 120,000 people from the Paris Investigations Preventives et Cliniques Center, and assessed demographic background, smoking history, alcohol consumption, as well as lung function, including FEV1 (forced expiratory volume in one second) and FVC (forced vital capacity, or the total expiratory volume) with respect to BMI, waist circumference and other measures of metabolic health. The results were published in the second issue for March of the... (EurekAlert!)
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma Mar 5, 2009
5 unit considered to be clinically important), forced expiratory volume in 1 second (FEV1) after use of a bronchodilator, airway hyperresponsiveness, and eosinophil counts in the blood and sputum ... There were no significant differences between the groups with respect to symptoms, FEV1 after bronchodilator use, or airway hyperresponsiveness. (New England Journal of Medicine)
