Did your doctor get it right? Nov 3, 2008
Ask for a forced expiratory volume (FEV1) test, a lung-function screen. Abnormal results indicate asthma, and using a bronchodilator inhaler can help. (MSNBC -- Health)
New Test Promises Quicker, More Accurate Evaluation For Cystic Fibrosis Patients Oct 29, 2008
Currently, response to medication is measured by how much air a person can rapidly exhale: forced expiratory volume in one second or FEV1. FEV1 cannot be performed effectively for all patients, especially young and very sick patients ... Generally patients FEV1 does improve when inflammation is reduced, but not all patients FEV1 improves significantly, and changes can take weeks to months to show up. (Science Daily)
A 4-Year Trial of Tiotropium in COPD Oct 10, 2008
The patients were at least 40 years of age, with a forced expiratory volume in 1 second (FEV1) of 70% or less after bronchodilation and a ratio of FEV1 to forced vital capacity (FVC) of 70% or less. Coprimary end points were the rate of decline in the mean FEV1 before and after bronchodilation beginning on day 30 ... Results Of a total of 5993 patients (mean age, 65 8 years) with a mean FEV1 of 1. (New England Journal of Medicine)
COPD and Declining FEV1 — Time to Divide and Conquer? Oct 10, 2008
NEJM -- COPD and Declining FEV1 -- Time to Divide and Conquer ... COPD and Declining FEV1 Time to Divide and Conquer. (New England Journal of Medicine)
Spiriva Safe, Effective for COPD Patients Oct 7, 2008
However, treatment with tiotropium did not improve forced expiratory volume (FEV1), which is a measure of breathing and a marker for the progression of COPD. Throughout the study, FEV1 continued to decline in both groups ... "Tiotropium, when added to usual therapy, did not demonstrate a reduction in the normal decline in FEV1," Make said. (MEDLINEplus)
Link between asthma and sweating Sep 10, 2008
Airway narrowing is measured using the FEV1 a test of how fast and hard a patient can breathe out. People with asthma react to a lower dose of inhaled methacholine than those without asthma; and those who had a 20% or more fall in their FEV1 over baseline after breathing in the methacholine, were classified as having a positive result ... The researchers divided the subjects into those whose maximum reduction in FEV1 was less than 20% and those in whom the reduction was greater. (NHS Choices)
Sweating, Crying May Help Prevent Exercise-Induced Asthma In Athletes Sep 9, 2008
Lockette and colleagues analyzed the relationship between fluid secretion rates (sweat, saliva, and tears) in 56 athletic subjects suspected of having EIA. Air movement through the lungs, i.e., the FEV1, was measured in otherwise healthy volunteers before and after the administration of methacholine, a drug that can cause airways to constrict in patients with EIA. ... Individuals who were most sensitive to methacholine, i.e., who had the greatest fall in FEV1, were the least sensitive to... (Science Daily)
Hope for patients with COPD Aug 16, 2008
The Toward a Revolution in COPD Health (TORCH) study investigated the effects of combined salmeterol, a -agonist, and fluticasone propiniate, an inhaled cortical steroid, either alone or in combination, on mortality, exacerbations, health-related quality of life and rate of decline in lung function as measure by forced expiratory volume in one second (FEV1) in patients with COPD. ... "Pharmacotherapy with salmeterol plus fluticasone propionate, or the components, reduces the rate of decline on... (EurekAlert!)
Bronchitol Cystic Fibrosis Dose Trial Results Positive Aug 12, 2008
The trial achieved its primary end point of demonstrating a dose dependent improvement in lung function as measured by FVC (forced vital capacity) and FEV1 (the amount of air that can be forcibly exhaled in 1 second). At the end of the two-week Bronchitol treatment periods, changes in lung function were as follows: -- 400 mg treatment group: FEV1 increased by 8 ... 0006 vs 40 mg) -- 240 mg treatment group: FEV1 increased by 4. (PR Newswire)
Cystic Fibrosis Foundation Hosts Quality Improvement Summit - Caregivers from 15 States and Canada Gather in Hartford for Intensive Learning May 31, 2008
At the start of the collaborative, average lung function for CF patients at the pediatric center (measured by FEV1) was 89 percent. Using quality improvement techniques, today average lung function has jumped to 98 percent, making it among the best centers in the country. (PR Newswire)
Oxidative Stress May Predict Later Lung Trouble In Young Adults May 23, 2008
"Our principle finding was that the highest levels of oxLDL at year 15 of the cohort were associated with the lowest forced expiratory volume in one second (FEV1) at year 20, which is a measure of airflow obstruction, one of the defining features of COPD and lower forced vital capacity (FVC), a measure of total lung capacity," said Ravi Kalhan, M.D., M.S., assistant professor of medicine and director of the COPD program at Northwestern University Feinberg School of Medicine, senior author of the... (Science Daily)
Concomitant treatment with nebulized formoterol fumarate & tio-significant improvements -- COPD May 21, 2008
Following randomization, subjects entered a six-week treatment period to evaluate the safety and efficacy of formoterol fumarate inhalation solution (FFIS; Perforomist, 20 g/2mL) while maintaining once-daily treatment with TIO. The primary efficacy endpoint was standardized area under the curve for FEV1 over three hours (FEV1 AUC0-3) at the last visit (week 6). The standardized absolute AUC0-3 for FEV1 following the first dose of study medication at Day 1 was statistically significantly... (EurekAlert!)
Perforomist-comparable pharmacokinetic and pharmacodynamic profile to DPI formulation May 21, 2008
Mean FEV1 AUC0-12 (standardized area under the curve for FEV1 over twelve hours) following FFIS treatment ranged from 1. 3 to 3. (EurekAlert!)
Passion fruit peel relief for asthmatics May 16, 2008
In addition, the objective measure of asthma that was used, FEV1, actually showed a significant improvement in the placebo group after four weeks, but not in the group that took the PFP. ... To be eligible for inclusion they had to have a forced expiratory volume (FEV1), the volume of air that can be forcibly exhaled in the first second after breathing in as much as possible, of between 30 and 75% of the predicted normal for their age, sex and height ... However, FEV1 was reported as being... (NHS Choices)
Cystic Fibrosis Trial In Children Returns Positive Data Apr 4, 2008
At the end of the treatment period, lung function as determined by measuring FEV1 (the amount of air that can be forcibly exhaled in 1 second) improved by: -- 7% while the subjects were on Bronchitol -- 7% while subjects were on rhDNase and -- 2% while subjects were on both agents together ... People affected by cystic fibrosis typically experience a decline in lung function of 1-2% every year of their life, as measured by FEV1 ... Name of Trial DPM - CF-203 (A phase II study with Bronchitol)... (PR Newswire)
Aridol(TM) Endorsed by International Olympic Committee Mar 28, 2008
"Long-term intense endurance training and environmental factors, such as allergens, chlorine derivatives, pollutants or cold air can increase the risk of developing exercise induced asthma. A simple-to-use airways inflammation test, Aridol is a dry powder administered to patients' lungs via a small hand-held inhaler. Doctors can use the results of this test to identify airway hyperresponsiveness C a hallmark of asthma. Medications can be adjusted according to the severity of the disease. (see... (PR Newswire)
GSK Data Suggests Efficacy of Advair(R) and Serevent(R) is Not Impacted by Genetic Profile Mar 17, 2008
There was also no difference between the improvement recorded for each of the three groups on the secondary endpoints of forced expiratory volume in 1 second (FEV1), symptom-free days or use of a rescue inhaler. A sub-analysis of that trial was also presented today at the AAAAI meeting (abstract #509) by Harold Nelson, M.D., professor of medicine at National Jewish Medical and Research Center in Denver. (PR Newswire)
Telling Smokers How Old Their Lungs Are Works Mar 17, 2008
BMJ, smokers whowere told their lung age were significantly more likely to quit thanthose who did not receive the information (Medical News Today)
Sirolimus for Angiomyolipoma in Tuberous Sclerosis or Lymphangioleiomyomatosis Jan 10, 2008
During the period of sirolimus therapy, among patients with lymphangioleiomyomatosis, the mean forced expiratory volume in 1 second (FEV1) increased by 118 330 ml (P=0 ... One year after sirolimus was discontinued, the FEV1 was 62 411 ml above the baseline value, the FVC was 346 712 ml above the baseline value, and the residual volume was 333 570 ml below the baseline value; cerebral lesions were unchanged. (New England Journal of Medicine)
Air Quality and Attenuated Age-Related Decline in Lung Function Dec 6, 2007
g., forced vital capacity [FVC], forced expiratory volume in 1 second [FEV1], FEV1 as a percentage of FVC, and forced expiratory flow between 25 and 75% of the FVC [FEF25 75]), smoking habits, and spatially resolved concentrations of particulate matter that was less than 10 m in aerodynamic diameter (PM10) from a validated dispersion model assigned to residential addresses for 4742 participants at both the 1991 and the 2002 assessments and in the intervening years ... In mixed-model regression... (New England Journal of Medicine)
Respiratory Effects of Exposure to Diesel Traffic in Persons with Asthma Dec 6, 2007
Walking for 2 hours on Oxford Street induced asymptomatic but consistent reductions in the forced expiratory volume in 1 second (FEV1) (up to 6 ... 4%) that were significantly larger than the reductions in FEV1 and FVC after exposure in Hyde Park (P=0. (New England Journal of Medicine)
Ozone can affect heavier people more Nov 27, 2007
When subjects were put into categories of body fatness defined by the US Centers for Disease Control based on their BMI, the ozone-related drops in lung function, particularly the forced expiratory volume in one second (FEV1), were lowest in underweight people (BMI less than 18. 5), greater in normal weight people (BMI 18. (EurekAlert!)
New Guideline Targets Treatment of Stable COPD Nov 13, 2007
Treatment of stable COPD should be limited to patients who have respiratory symptoms and forced expiratory volume in one second (FEV1) less than 60 percent predicted, as documented by spirometry. Patients with COPD and FEV1 less than 60 percent predicted should be prescribed long-acting inhaled-agonists, long-acting inhaled anticholinergics, or inhaled corticosteroids. (Health-Finder)
Breastfed Babies Breathe Better, Except When Mom Has Asthma Nov 7, 2007
The researchers measured lung volume [forced vital capacity (FVC)] and airflows [forced expiratory volume in one second (FEV1) and FEV1/FVC. When analyzed as a whole, the group found that FEV1/FVC was lower in breastfed children. (Science Daily)
Long-acting Inhaled Therapies, Supplemental Oxygen, Pulmonary Rehabilitation, Benefit COPD Patients, Report States Nov 4, 2007
Treatment of stable COPD should be reserved for patients who have respiratory symptoms and forced expiratory volume in one second (FEV1) less than 60 percent predicted, as documented by spirometry. For symptomatic patients with COPD and FEV1 less than 60 percent predicted, clinicians should prescribe long-acting inhaled -agonists, long-acting inhaled anticholinergics, or inhaled corticosteroids. (Science Daily)
Summary for Patients Nov 2, 2007
Spirometry is a breathing test that can diagnose COPD on the basis of a measurement called FEV1 (forced expiratory volume in 1 second), which estimates the amount of air that a person exhales in 1 second compared with that of a typical healthy person of the same age and size. A person with a FEV1 of 60% exhales about 60% the amount that a typical healthy person the same age and size exhales in 1 second ... The authors found strong evidence for a benefit of inhaled beta-agonists,... (Annals of Internal Medicine)
Pitrakinra May Significantly Reduce Asthma Symptoms Oct 20, 2007
The primary endpoint for the first trial was a maximum percentage drop in forced expiratory volume (FEV1)** in one second over 4-10 hours after receiving the allergen. In the second study the primary endpoint was average percentage fall in FEV1 over 4-10 hours after being given the allergen ... If smaller falls in FEV1 during the asthma attack for the Pitrakinra group compared to the placebo group were detected, this would indicate that the allergic response had been reduced by Pitrakinra. (Medical News Today)
Statins reduce loss of function, keeping old lungs young - even in smokers Oct 13, 2007
Both forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were measured ... In FEV1, statin users lost 10 ... Within each smoking group, those not taking statins were estimated to experience faster declines in FEV1 and FVC than those taking statins, wrote Dr. Schwartz, noting that the size of the effect varied a bit with smoking status. (EurekAlert!)
Menstrual irregularity linked with lung function Oct 10, 2007
Forced vital capacity, a measure of lung function, was significantly lower in women with menstrual irregularity, but there was only an insignificant association between menstrual irregularities and forced expiratory volume in one second (FEV1). The effects of menstrual irregularity on asthma symptoms were additive to those of BMI, the researchers note in the September issue of the Journal of Allergy and Clinical Immunology. (Scientific American)
Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study Oct 9, 2007
At baseline, FEV1 was inversely associated with serum SPD levels (P = 0. 045) but not with CC16 (P = 0. (BioMed Central)
Keeping Lungs Young Sep 24, 2007
Measures commonly used to assess lung function include FEV1 (forced expiratory volume at 1 second - volume exhaled in the first second of a forced exhalation from maximal inhalation) and DLCO (diffusing capacity of the lung for carbon monoxide - gas exchange capacity) ... A 5-foot-5-inch white woman could be expected to have an FEV1 of 3 ... In nonsmokers, once lung function begins to decline, FEV1 decreases at a rate of 20-30 mL/year and DLCO 0. (San Francisco Chronicle)
Asthma Flares Harm Lung Function Sep 21, 2007
2 percent) experienced at least one severe asthma exacerbation -- defined as being admitted to the hospital for worsening asthma or as a significant and reversible reduction in FEV1 -- a standard measure of lung function. Decline in lung function was much more pronounced in those individuals with frequent asthma attacks relative to individuals with infrequent asthma attacks, Bai and colleagues report. (MEDLINEplus)
Asthma flares harm lung function: study Sep 20, 2007
2 percent) experienced at least one severe asthma exacerbation -- defined as being admitted to the hospital for worsening asthma or as a significant and reversible reduction in FEV1 -- a standard measure of lung function. ADVERTISEMENT (article continues below) Decline in lung function was much more pronounced in those individuals with frequent asthma attacks relative to individuals with infrequent asthma attacks, Bai and colleagues report. (Scientific American)
Flavorings-Related Lung Disease Sep 10, 2007
Also, higher cumulative exposure to diacetyl in this plant was associated with having a lower level of forced expiratory volume in 1 second (FEV1), an important measure of lung function ... People who had ever worked as mixers had more chest symptoms and poorer lung function as measured by lower FEV1 than people who had never worked as mixers ... People who had worked as mixers for more than 12 months had more shortness of breath with exertion and lower FEV1 than people who had worked as mixers... (Food Consumer)
Brochiolitis Obliterans Pops Up in Home Microwave Sep 8, 2007
The man has also shown a progressive decline in one-second forced expiratory volume (FEV1) despite treatment with oral corticosteroids. Dr. Rose said measurements in the man's home during microwave popcorn preparation showed levels "similar" to those seen in the plant where the affected workers were first described. (MedPage Today)
Treatment For COPD May Need To Start Before Birth Sep 5, 2007
The measurements used were of forced expiratory volume in one second (FEV1)*, forced vital capacity (FVC)*, and forced expiratory flow between 25% and 75% of FVC (FEF25-75)*, both before and after treatment with a bronchodilator (180 g albuterol). The researchers found that participants who were in the lowest quartile for maximum expiratory flows as infants also had lower values for FEV1,FVC, and FEF25-75 up to age 22, after adjustment for height, weight, age, and sex, as compared with those in... (Science Daily)
Dirty City Air Stunts Kids' Lungs Aug 17, 2007
They noted that the effect of air pollution on forced expiratory volume in one second (FEV1) -- a measure of lung function -- among children in the study was greater than the effect of exposure to mothers' smoking among children in the United States. HealthDay. (MEDLINEplus)
Sex Differences Found In COPD Aug 6, 2007
However, even after controlling for age, FEV1% predicted (a standard measure of lung function), smoking history and severity of emphysema, the researchers found that women reported more breathlessness, higher depression, lower mental health and lower overall quality of life than men. "These data showing greater breathlessness in women relative to men at similar degrees of airflow obstruction and emphysema severity imply that sex-specific anatomic differences must be considered in models of COPD... (Science Daily)
One Cannabis Joint Equals Smoking Up to Five Cigarettes Aug 1, 2007
A dose-response relationship was found between cannabis smoking and reduced forced expiratory volume (FEV1) to forced vital capacity ratio and specific airways conductance, and increased total lung capacity. For measures of airflow obstruction, one cannabis joint had a similar effect to 2. (MedPage Today)
Papworth Exercises Help Asthmatics Breathe Easier Jun 30, 2007
Secondary outcomes included scores on the Hospital Anxiety and Depression Scale and the Nijmegen dysfunctional breathing questionnaire, as well as objective measures of respiratory function, such as forced expiratory volume in one second (FEV1) ... There were no differences in FEV1, vital capacity, forced vital capacity, or peak expiratory flow. (MedPage Today)
FDA approves Dey, L.P.'s Perforomist inhalation solution for maintenance treatment of COPD May 12, 2007
The study's results showed that Perforomist Inhalation Solution 20 mcg/2 mL taken twice daily was statistically superior to placebo for the primary endpoint, FEV1 AUC 0-12. The safety and efficacy of Perforomist Inhalation Solution observed in this study were comparable to those of Foradil. (EurekAlert! -- Business News)
Promising Drug Fails To Improve COPD Symptoms May 5, 2007
There were also no differences among the three groups in secondary efficacy endpoints as measured by FEV1, 6-minute walk distance, the transition dyspnea index and the number of exacerbations requiring a doctor or hospital visit. According to the authors, the results of the study were surprising for a number of reasons. (Science Daily)
May 1 is World Asthma Day May 2, 2007
- Normal (or near-normal) lung function test results (PEF and FEV1). - No (or very infrequent) asthma attacks. (Kewanee Star Courier, IL)
'Popcorn Lung' Erupts in Flavor Industry Apr 30, 2007
Spirometry showed severe obstructive lung disease, with a forced expiratory volume in 1 second (FEV1) of 28% of the predicted normal value ... Spirometry showed severe obstructive lung disease, with an FEV1 of 18% of the predicted normal value, without bronchodilator response ... FEV1 ranged from 17% to 44% of predicted normal value for age, height, race, and sex. (MedPage Today)
Hot Bronchi Bring a Breath of Fresh Air to Severe Asthmatics Mar 29, 2007
The patients also had airflow obstruction, defined as pre-bronchodilator forced expiratory volume in 1 second (FEV1) of 60% to 85% of the predicted value, and airway hyper-responsiveness, defined by a challenge dose of methacholine required to lower the FEV1 by 20% (PC20) of less than 8 mg/mL. ... There were no significant effects of bronchial thermoplasty on either FEV1 or airway hyper-responsiveness however. (MedPage Today)
Inhaled Steroids Do Not Alter Course of COPD Mar 27, 2007
While inhaled steroids do not slow the decline in FEV1 seen with COPD, Soriano cited three interventions that do: smoking cessation, lung surgery, and oxygen therapy. SOURCE: Chest, March 2007. (MEDLINEplus)
Kids' Chest Illness Not Tied to Later Lung Trouble Feb 27, 2007
Between age 35 and 45, the amount of air that could be expelled in 1 second after taking the biggest breath possible, a parameter that doctors refer to as the forced expiratory volume in 1 second, or "FEV1," fell by 35 milliliters each year. The rate of decline in lung function was not significantly affected by wheezing, pneumonia, or whooping cough in childhood. (MEDLINEplus)
Data show significant asthma control and improved lung function with Symbicort Feb 25, 2007
Bronchodilatory response was measured by the median time to achieve 15% improvement in forced expiratory volume in one second (FEV1) how much air a person can exhale during a forced breath in the first second of exhalation, which is a measure of how well the lungs are functioning after medication was taken. Results showed that after the first dose of treatment (day of randomization), the median time to 15% FEV1 improvement was significantly earlier (P ... Results showed SYMBICORT provided... (EurekAlert!)
MediciNova Reports 2006 Financial Results Feb 16, 2007
The primary endpoint is the change from baseline in mean forced expiratory volume in one second (FEV1); there are a number of secondary endpoints. MN-029. (Primezone Releases)
Traffic pollution harms children's lungs - study Jan 27, 2007
Children who lived within 500 meters of a freeway or motorway had substantial deficits in eight-year growth of forced expiratory volume in 1 s (FEV1), 81 ML less than that in children who lived at least 1,500 meters away from a freeway, the researchers found ... In addition, at age 18, children who lived within 500 m of a freeway had pronounced deficits in attained lung function with mean percent-predicted 97 0 percent for FEV1 relative to that for those who lived 1,500 m or farther away from a... (Food Consumer)
Living Near a Busy Highway Impedes Children's Lung Growth Jan 27, 2007
Residential proximity to freeway traffic was associated with smaller eight-year increases in FEV1 and maximum midexpiratory flow rate (MMEF), which translated into pronounced deficits in percent-predicted lung function at age 18, the researchers said ... For example, children who lived within 500 meters of a freeway had substantial decreases in eight-year growth of forced expiratory volume in 1s (FEV1-81 mL, P=0 ... The association between FEV1 growth and distance to a freeway was significant in... (MedPage Today)
