Never give up Oct 25, 2009
At first, doctors believed she had ductal carcinoma in situ (DCIS), the most common type of non-invasive breast cancer. With DCIS, the cancer has not spread beyond the walls of the ducts into the tissue of the breasts. (Ellensburg Daily Record, WA)
Lexington breast cancer survivor sees reason for hope Oct 16, 2009
That mammogram showed that Lisa had DCIS, or ductal carcinoma in situ. DCIS is an early form of breast cancer confined to the milk ducts. (Lexington Minuteman, MA)
'New' type of breast cancer, DCIS, can put life on hold Oct 12, 2009
New' type of breast cancer, DCIS, can put life on hold - USATODAY.com ... New' type of breast cancer, DCIS, can put life on hold ... She had a double mastectomy after being diagnosed with DCIS: "I didn't want to worry.". (USA Today -- News)
Research needed to learn which DCIS patients may be candidates for less invasive therapy Sep 26, 2009
Ductal carcinoma in situ (DCIS), the most common non-invasive lesion of the breast, presents unique challenges for patients and providers largely because the natural course of the untreated disease is not well understood. Because most women diagnosed with DCIS are treated, it is difficult to determine the comparative benefits of different treatment strategies versus active surveillance, meaning systematic followup ... "Instead of treating all women diagnosed with DCIS, we need to determine which... (EurekAlert!)
Early Form of Breast Cancer May Need New Name Sep 26, 2009
CHICAGO (Reuters) - A common, nonmalignant tumor of the breast called ductal carcinoma in-situ or DCIS may need a name change because the word "carcinoma" scares so many women, a U.S. panel of experts said on Thursday. They said the term carcinoma creates a lot of worry in women who fear they will develop cancer, even though long-term survival rates for DCIS are excellent, approaching 100 percent ... DCIS is a condition in which abnormal cells accumulate in the breast duct, but have not spread... (MEDLINEplus)
Specialists want carcinoma out of diagnosis Sep 25, 2009
More than 50,000 women a year are diagnosed with DCIS, or ductal carcinoma in situ ... Only about 2 percent of DCIS patients die of breast cancer in the next 10 years ... The problem: Doctors do not have a good way to tell which women are at risk of DCIS returning as true cancer and which are not. (MSNBC -- Health)
Overexpressed protein converts noninvasive breast cancer into invasive disease Sep 9, 2009
ErbB2, an oncoprotein that promotes metastasis, is overexpressed in 50 to 60 percent of the noninvasive breast cancer known as ductal carcinoma in situ (DCIS) ... In a series of lab experiments, Yu and colleagues showed that overexpression of ErbB2 accompanied by overexpression of 14-3-3 can change DCIS into invasive breast cancer ... This only occurs in about half of ErbB2-overexpressing DCIS, the team found, explaining the numerical puzzle. (EurekAlert!)
International Medical Device Maker; Four Executives Charged in Connection With Unlawful Clinical Trials Jun 17, 2009
against Norian Corporation (Norian), Synthes, Inc. (Synthes), and four top Synthes executives, Michael D. Huggins (Huggins), Thomas B. Higgins (Higgins), Richard E. Bohner (Bohner) and John J. Walsh (Walsh), charging them for their involvement in conducting clinical trials of a medical device without the authorization of the FDA. Joining in today's announcement were Food and Drug Administration (FDA) Office of Criminal Investigations Special Agent-in-Charge Kim A. Rice; Department of Health and... (PR Newswire)
Protein Predicts Development Of Invasive Breast Cancer In Women With Ductal Carcinoma In Situ May 27, 2009
ScienceDaily (May 27, 2009) Women with ductal carcinoma in situ (DCIS) who exhibit an overexpression of the protein HER2/neu have a six-fold increase in risk of invasive breast cancer, according to a new study from the University of Pennsylvania School of Medicine. The results, published in the May issue of the journal Cancer Epidemiology, Biomarkers and Prevention, may help clinicians distinguish between DCIS that requires minimal treatment and DCIS that should be treated more aggressively ...... (Science Daily)
Preventive mastectomies on the rise May 9, 2009
The rate of so-called "contralateral prophylactic mastectomy" surgery among U.S. women with early breast cancer called ductal carcinoma in situ (DCIS) increased by 188 percent between 1998 and 2005, Dr. Todd Tuttle, from the University of Minnesota, Minneapolis, and colleagues found ... "The 10-year survival rate for women with DCIS is 98 percent to 99 percent," Tuttle notes in a university-issued statement ... The findings, reported in the Journal of Clinical Oncology, stem from a study of... (MSNBC -- Health)
New universal breast cancer marker predicts recurrence and clinical outcome May 7, 2009
In an additional study, published online in Cancer Biology py, the researchers also found that the loss of stromal caveolin-1 in ER-positive non-invasive breast cancers called ductal carcinoma in situ (DCIS) serves as a biomarker for progression to invasive breast cancer. "This marker was highly predictive of development of invasive breast cancer in patients with DCIS," said Gordon Schwartz, M.D., a professor of Surgery at Jefferson, who was involved with the DCIS study ... "We have been... (EurekAlert!)
More Women Opt For Double Breast Removal Apr 11, 2009
5 percent of women in a study of 51,000 with DCIS had both breasts removed ... "The 10-year survival rate for women with DCIS is 98 to 99 percent," Tuttle said ... A news release on the work described DCIS as the earliest stage of breast cancer, when the cancer is small and confined. (Click2Houston, TX)
More women with early-stage breast cancer choosing double mastectomies Apr 10, 2009
The rate of contralateral prophylactic mastectomy (CPM) surgery among U.S. women with ductal carcinoma in situ (DCIS) increased by 188 percent between 1998 and 2005, according to Todd Tuttle, M.D., lead researcher on this study ... "The 10-year survival rate for women with DCIS is 98 to 99 percent," Tuttle said ... This new study indicates the same attitude among women with DCIS, described as the earliest stage of breast cancer when the cancer is small and confined within a duct area of the... (EurekAlert!)
Breakthrough model for human cancer may improve development of cancer drugs; study in PNAS Apr 7, 2009
D., member, Whitehead Institute and professor of biology, MIT. "In contrast, tumor development in the HIM model proceeds through defined histological stages of hyperplasia, from ductal carcinoma in situ (DCIS) to invasive carcinoma. Moreover, HIM tumors display characteristic responses to a targeted therapy known to be effective in humans, specifically Herceptin. This represents a big step forward in developing xenograft models that will accurately predict patient responses to agents that are in... (EurekAlert!)
Cancer screening: Doing more harm than good? Mar 13, 2009
Fortunately, the surgeon told her, it had been caught early: She had ductal carcinoma in situ, or DCIS, which meant that the cancer was still confined to a single milk duct. And it might well stay there, he added, since DCIS generally doesn't become invasive ... That all sounded great, Bull recalls, until the surgeon told her that there was no way to know whether her cancer would turn out to be the lazy, nonthreatening type of DCIS or the potentially invasive kind. (MSNBC -- Health)
Cancer screening 'blights ten lives for every one saved' Feb 20, 2009
Inevitably, DCIS or non-invasive tumours will be found. But people have the right to choose whether they want screening and whether they want treatment for any abnormalities found. (Daily Mail)
Radiation Benefits Women with Early Breast Cancer Feb 7, 2009
NEW YORK (Reuters Health) - A review of published studies confirms that the addition of radiation therapy to breast-conserving surgery in the treatment of a noninvasive early form of breast cancer called ductal carcinoma in situ (DCIS) substantially decreases the risk of recurrence of either DCIS or invasive breast cancer in the affected breast ... Specifically, the data suggest that the addition of radiation therapy after breast conserving surgery reduces the risk of recurrence of either DCIS... (MEDLINEplus)
