Inhibition of the Bcl-xL Deamidation Pathway in Myeloproliferative Disorders Dec 27, 2008
Address reprint requests to Dr. Zhao at the Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB2 4AT, United Kingdom, or at rui. zhao{at}bbsrc. (New England Journal of Medicine)
Genetic Variants in Diabetes and Celiac Disease Dec 27, 2008
Address reprint requests to Dr. Todd at the Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0XY, United Kingdom, or at john. todd{at}cimr. (New England Journal of Medicine)
Could Marijuana Substance Help Aging Brain? Nov 23, 2008
With the same intervention technique, the researchers also determined that WIN acts on receptors known as CB1 and CB2, leading to the generation of new brain cells a process known as neurogenesis. Those results led the scientists to speculate that the combination of lowered inflammation and neurogenesis is the reason the rats memory improved after treatment with WIN.. (Science Daily)
Alemtuzumab vs. Interferon Beta-1a in Early Multiple Sclerosis Oct 23, 2008
Coles and Compston at the Department of Neurology, Box 165, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom, or at ajc1020{at}medschl. cam. (New England Journal of Medicine)
Cannabinoid Drugs Oct 7, 2008
CB2 receptors, located primarily in immune cells. Synthetic cannabinoids can target one or both CB receptors, either by acting with them or blocking them. (Suite101.com)
Pot-Like Drugs Could Stop Pain, Not Brain Sep 16, 2008
Researchers from looked at two kinds of receptors in the nervous system, known as CB1 and CB2 ... Blocking the CB2s could stop pain without clouding thinking or leading to abuse and dependency, researchers wrote ... "Our new study is very promising because it suggests that we could alleviate pain by targeting the cannabinoid receptor CB2 without causing the kinds of side-effects we associate with people using cannabis itself.". (NBCSandiego.com, CA)
Drug From Pot Could Slow Pain, Not Brain Sep 16, 2008
Researchers from Imperial College London looked at two kinds of receptors in the nervous system, known as CB1 and CB2 ... Blocking the CB2s could stop pain without clouding thinking or leading to abuse and dependency, researchers wrote ... "Our new study is very promising because it suggests that we could alleviate pain by targeting the cannabinoid receptor CB2 without causing the kinds of side-effects we associate with people using cannabis itself.". (Click2Houston, TX)
New cannabis-like drugs could block pain without affecting brain, says study Sep 13, 2008
The research demonstrates for the first time that cannabinoid receptors called CB2, which can be activated by cannabis use, are present in human sensory nerves in the peripheral nervous system, but are not present in a normal human brain. Drugs which activate the CB2 receptors are able to block pain by stopping pain signals being transmitted in human sensory nerves, according to the study, led by researchers from Imperial College London ... The new research indicates that drugs targeting CB2... (EurekAlert!)
Nature Biotechnology Aug 29, 2008
Medical Research Council Cambridge CB2 0QH Britain. Lincoln University Chiristchurch New Zealand. (Nature News Service)
SciBX: Science-Business eXchange Aug 29, 2008
Using CB2 agonists to treat pain. And more. (Nature News Service)
From a costume party to CB2 Aug 21, 2008
CB2 at last: Crate and Barrel offshoot CB2, the latest home furnishings store in the Bay Area, may also be among the most affordable ... Some of these designers are indeed mentioned in the store's latest catalog, where CB2 alludes to Emeco's midcentury classic aluminum chair designed for the Navy ... "We don't have a design team as such," said Ryan Turf, a textile and accessories buyer and developer for CB2. (San Francisco Chronicle)
Around the House: Affordable desks Aug 10, 2008
-- CB2 has priced its Graph desk at just $299 ... com or look for the desk upstairs at the new CB2 showroom at Union Square. (San Francisco Chronicle)
Turned-off Cannabinoid Receptor Turns On Colorectal Tumor Growth Aug 5, 2008
The team also analyzed the other main cannabinoid receptor, CB2, and found no role for it in colorectal cancer. They also treated the mice with a CB1 antagonist, a compound that binds to the receptor but does not activate it. (Science Daily)
Salutary Pizza Spice: Oregano Helps Against Inflammations Jun 27, 2008
Beta-caryophyllin docks on specific receptor structures in the cell membrane - the so-called cannabinoid-CB2 receptors, and produces a change in cell behaviour: for example, it will inhibit the cell ... But it has a further advantage in that, in contrast to other substances which affect the CB2 receptors, beta-caryophyllin does not lead to intoxication ... For this CB2 receptor has a "brother" by the name of CB1, which is best known to drug researchers. (Science Daily)
Opioids And Cannabinoids Influence Mobility Of Spermatozoids Jun 25, 2008
Dr. Agirregoitia has used a number of techniques to find three opioid receptors (DELTA, KAPPA and MU) and two cannabinoid receptors (CB1 and CB2) in the human sperm ... As regards the cannabinoid system, the activation of the CB1 y CB2 receptors causes the percentage of spermatozoids with rapid and progressive mobility to be reduced ... Even so, as a consequence of the activation of the CB1 receptor, the number of slow spermatozoids rises, while the activation of CB2 increases the number of... (Science Daily)
At Vintage Suites Jun 7, 2008
CB2 Architect and Construction of Portland, Ore. is the general contractor for the project, but a host of local sub-contractors have been hired to do the majority of the work. (Montana Standard, MT)
Japan's daily life Mar 3, 2008
A "toddler robot" called "Child-Robot with a Biomimetic Body," or "CB2," looks around the room. Hooked up to a database of words clustered by association, the robot -- dubbed Kansei, or "sensibility" -- responds to the word "war" by quivering in what looks like disgust and fear. (CNN -- International)
Should we take brain enhancing drugs? Dec 22, 2007
Barbara Sahakian and Sharon Morein-Zamir are at the University of Cambridge, Department of Psychiatry and the MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, Cambridge CB2 2QQ, UK.. Abstract. (Nature News Service)
Medical Marijuana Growers Payback Dec 6, 2007
Another cannabinoid was found to attach to the CB2 receptor found on osteoclasts and osteoblasts, which are the cells reponsible for regulating bone density, and reduced bone loss in mice with induced mouse osteoporosis. It was also found that mice and humans with mutations to their CB2 receptors had three times more likelihood of contracting osteoporosis. (Washington Post)
The endocannabinoids: Functional roles and therapeutic opportunities Oct 15, 2007
Mice whose CB1 receptors are knocked out display slower functional recovery after TBI and do not respond to treatment with 2-AG. Over the last few years several groups have noted that CB2 receptors are also formed in the brain, particularly as a reaction to numerous neurological diseases, and are apparently activated by the endocannabinoids as a protective mechanism ... Activation of the CB2 receptor by a selective agonist also improved the neurological score ... Modulation of this system either... (EurekAlert!)
Complement C3 and Age-Related Macular Degeneration Aug 9, 2007
Box 139, Addenbrooke's Hospital, Cambridge CB2 0XY, United Kingdom, or at jrwy1{at}cam. ac. (New England Journal of Medicine)
Baby robot that can walk, talk and feel Jun 14, 2007
Built by Japanese scientists Minoru Asada and Hiroshi Ishiguro (who famously created an android twins of himself), the robot called CB2 weighs 33kg and stands 130cm tall ... When CB2's shoulders are tapped, it blinks as if surprised, stops moving, and turns its gaze toward the person who touched it ... Future research at the Japanese Science and Technology Agency in Osaka will attempt to improve the body functions of CB2 - whose full name is 'Child-robot with Biomimetic Body. (Yahoo News -- Robots and Robotics)
Marijuana Compound May Fight Lung Cancer Apr 20, 2007
In the new study, the researchers first showed that two different lung cancer lines, as well as samples from patient lung tumors, produced the cannabinoid receptors CB1 and CB2. Endocannabinoids -- cannabinoids produced naturally in the body -- are thought to have an effect on pain, anxiety and inflammation when they bind to cannabinoid receptors. (Forbes)
Marijuana Cuts Lung Cancer Tumor Growth In Half, Study Shows Apr 18, 2007
THC that targets cannabinoid receptors CB1 and CB2 is similar in function to endocannabinoids, which are cannabinoids that are naturally produced in the body and activate these receptors ... Acting through cannabinoid receptors CB1 and CB2, endocannabinoids (as well as THC) are thought to play a role in variety of biological functions, including pain and anxiety control, and inflammation ... In the present study, the researchers first demonstrated that two different lung cancer cell lines as... (Science Daily)
New JAK2 Mutations and Erythrocytosis Feb 1, 2007
Address reprint requests to Dr. Anthony R. Green at the Department of Haematology, Cambridge Institute for Medical Research, Hills Rd., Cambridge CB2 2XY, United Kingdom, or at arg1000{at}cam. ac. (New England Journal of Medicine)
Prevalence and Effects of Mutations in the Leptin-Receptor Gene Jan 18, 2007
Address reprint requests to Dr. Farooqi at the University Department of Clinical Biochemistry, Addenbrooke's Hospital, Hills Rd., Box 232, Cambridge CB2 2QQ, United Kingdom, or at isf20{at}cam. ac. (New England Journal of Medicine)
