Breast Cancer Genome Shows Evolution, Instability Of Cancer Dec 25, 2008
"This is the first study to comprehensively map these genomic translocations to base pair resolution," Lee said ... This study of the genome sequence refined the understanding of aberrant genomic rearrangements to the base pair level of resolution, said Milosavljevic. (Science Daily)
Techno-Creativity Will Save Us Dec 16, 2008
When the Human Genome Project began in the early 1990s, sequencing one DNA base pair cost about $10 ... Today sequencing one base pair costs a tenth of a cent, and by 2024--just 16 short years from today's presidential transition--we'll sequence an entire human genome (yours, if you'd like) for $100. (Forbes -- Technology)
Is Bigfoot Real? Dec 2, 2008
com, states, with its one deviating base pair, this sample is almost human. Another guest of the Snelgrove Lake cabin claims that in 2006, whilst asleep inside, the porch table was overturned and a fishing pole case was thrown against the cabin. (Suite101.com)
DNA and Genealogy Oct 8, 2008
Matching base pairs interlocked in the middle of the double helix and each strand of the DNA molecule is the template for the other ... Sir Alec Jeffreys developed a DNA fingerprinting technique that looked for mutations in DNA called stutters, where a sequence of base pairs is repeated several times ... DNA or deoxyribonucleic acid is the sequence of base pair chemicals that define each human being as a unique individual. (Suite101.com)
Simplest Animal's Genome Reveals Complexity Aug 23, 2008
The analysis of the 98 million base pair genome of Trichoplax (literally "hairy-plate") illuminates its ancestral relationship to other animals. Trichoplax is the sole member of the placozoan ("tablet," or "flat" animal) phylum, whose relationship to other animals, such as bilaterians (humans, flies, worms, snails, et al) and cnidarians (jellyfish, sea anemones, corals, et al), and sponges is contentious. (Science Daily)
Gene Variant May Decide Who Smokes and for How Long Aug 9, 2008
The regular smokers were far more likely than never-smokers to have less common form of the CHRNA5 gene in which just one base pair in the gene sequence is different from the more common form of the gene. Smokers were also eight times more likely than never-smokers to have got a pleasurable buzz when they tried their first cigarette. (Health-Finder)
Blocking HIV Multiplication: Structure Elucidation Of 'Kissing Complex' Aug 8, 2008
To understand the role of this base pair and to permit synthesis of RNAs capable of binding more effectively to the viral regulator sequence, it was necessary to precisely elucidate how this binding takes place and define the essential parameters for its stabilization. By developing innovative NMR tools for the structural study of RNAs in solution, IBS and Ottawa University scientists determined with a very high precision the structure of the complex formed by the two RNAs in solution and... (Science Daily)
New research on mutation in yeast can enhance understanding of human diseases Jun 20, 2008
While C. elegans mutations were largely the result of inserting or deleting base pairs of DNA, yeast's patterns of mutation were characterized by changing one base pair for another ... He adds that the consequences of inserting and deleting base pairs can be much more dramatic than substituting one base pair for another ... This way, the yeast accumulate mutations that might otherwise make them "bad yeast" the weak survive and look for them across the entire 10 million base pair genome. (EurekAlert!)
Is ADHD An Advantage For Nomadic Tribesmen? Jun 11, 2008
A study led by Dan Eisenberg, an anthropology graduate student from Northwestern University in the US, analyzed the correlates of body mass index (BMI) and height with two genetic polymorphisms in dopamine receptor genes, in particular the 48 base pair (bp) repeat polymorphism in the dopamine receptor D4 (DRD4) gene. The DRD4 gene codes for a receptor for dopamine, one of the chemical messengers used in the brain. (Science Daily)
ASU researcher working to strengthen DNA Jun 10, 2008
Serving Arizona State University Online Since 1995. Current Issue: Monday, June 09, 2008. (Web Devil, AZ)
Eight New Human Genome Projects Offer Large-scale Picture Of Genetic Difference May 2, 2008
The researchers created what's called a clone map, taking multiple copies of each of the eight genomes and breaking them into numerous segments of about 40,000 base pairs, which they then fit back together based on the human reference genome. They searched for structural differences that ranged in size from a few thousand to a few million base pairs ... Base pairs are one of the basic units of information on the human genome. (Science Daily)
Gene Variant Increases Risk Of Asthma Apr 15, 2008
That variation changes one DNA base pair, out of the 3 billion in the human genome, at a location in the CHI3L1gene known as -131C/G. Those with asthma were more likely to have a cytosine (C), rather than guanine (G) at this location. Those inheriting two copies of a C at -131 had higher YKL-40 levels and an asthma prevalence of 0. (Science Daily)
Discussion to focus on women in medical field Apr 8, 2008
Five women physicians who are alumnae of Jackson Public Schools and Base Pair the research mentorship program between JPS and the University of Mississippi Medical Center will share their perspectives today on Recruiting the Next Generation: Women in Biomedicine ... JPS students enrolled in Base Pair and Student Oriented Academic Research (SOAR) programs have organized the panel as their spring 2008 community science forum ... Panelists are: Dr. Ayanna Jenkins, Jackson-Hinds Comprehensive... (The Clarion-Ledger)
UCLA researchers examine human embryonic stem cell genome Mar 28, 2008
Forms of variation include single DNA base pair alterations, duplications or deletions of genes or sets of genes, and translocations, a chromosomal rearrangement in which a segment of genetic material from one chromosome becomes heritably linked to another chromosome. These changes can be benign, but they can also promote diseases such as certain cancers, or confer increased risk to other diseases, such as HIV infection or certain types of kidney ailments. (EurekAlert!)
Of the Pills We Take Mar 23, 2008
Dr. Bustamante compared 10,000 genes shared by 15 African-Americans and 20 European-Americans and found nearly 40,000 individual differences in which a gene's smallest structural unit -- a single DNA base pair -- had been altered. Half of them had no measurable effect. (Wall Street Journal)
Bogue Chitto eyes cutting-edge research class Mar 22, 2008
The method of introduction between student and researcher began as a program called Base Pair ... "It is a very close association that mimics the binding of base pairs fundamental to the structure of DNA." ... The catalyst for the Base Pair system is proximity. (Brookhaven Daily Leader, MS)
Education briefs Mar 2, 2008
Applications are being accepted for teacher professional development workshops, a component of the Base Pair/SOAR program funded by the Howard Hughes Medical Institute ... For additional information, call (601) 815-1269, send an e-mail to Donna C. Sullivan at or Gail Howell at )or visit the Base Pair Web site at http:// basepair. (The Clarion-Ledger)
A little less than perfect Feb 28, 2008
It's nothing extraordinary -- just one or two base pairs, if you are biologically inclined. But base pair inversions are easier to explain, and no one's surprised when they happen, time to time. (The Cavalier Daily, VA)
New Way To Store Information Via DNA Discovered Feb 26, 2008
Given the size of the DNA fragments (one base pair of DNA is 0. 33 nanometers), one could store a large amount of information in a very small space. (Science Daily)
Ancient Impact Seen In Modern European Diversity Feb 22, 2008
The researchers focused on single nucleotide polymorphisms (SNPs), where a single DNA base pair (the smallest structural unit) in a gene's sequence had been altered. Genetic variations were classified as to whether a SNP was found in one or both populations. (Science Daily)
Please sequence my eel Feb 9, 2008
The only way to get at those genes is to sequence every last base pair of the genome, says James Albert, one of the papers authors and a fish biologist at the University of Louisiana at Lafayette. Many applications. (Nature News Service)
Washington University increases fleet of Roche Genome Sequencer FLX Systems Feb 8, 2008
The Centers system improvements will include an increase in sequence read length beyond 400 base pairs and a dramatic increase in the number of sequencing reads per instrument run ... With the longer 400 base pair read lengths, we can start to assemble the genomes using a de novo approach, eliminating the need to remap the sequences to a reference genome that can lead to errors. (EurekAlert! -- Business News)
DNA does the work: Building new gold crystals Feb 1, 2008
The idea takes advantage of the molecular biology of DNA, in which one strand of DNA forms a bond with a complementary strand to make what is called a base pair. Mirkin and colleagues simply design the specific genetic code using the four building blocks of DNA -- adenine, guanine, cytosine and thymine or A, G, C and T -- and attach the gold particles to those strands. (Reuters UK)
Carolyn Abraham on creating artificial life Jan 29, 2008
"The feat marks a historic and controversial milestone in the fledgling field known as synthetic biology. A team of 17 researchers at the J. Craig Venter Institute (JCVI) has created the largest man-made DNA structure by synthesizing and assembling the 582,970 base pair genome of a bacterium, Mycoplasma genitalium JCVI-1.0. (Credit: www.jcvi.org) Related Articles Recent Internet Links "It uses chunks of synthetic DNA like Lego blocks, with an aim to create life forms that can be genetically... (Globe and Mail)
Scientists create man-made DNA map Jan 26, 2008
The researchers at the J Craig Venter Institute in Rockville created the artificial genome code - the chemical blueprint of life - by synthesising and assembling 582,970 base pair genome of bacterium Mycoplasma genitalium JCVI-1. 0. (India Times, India -- Health/Science)
Lab-made genome gives life to ethics debate Jan 26, 2008
Dr. Venter noted that having commercial labs synthesize the pieces cost less than a dollar for each base pair of nucleotides. Robert Holt, a scientist at the Genome Science Centre of the BC Cancer Agency, and a former collaborator with the Venter group, called the report an important technical accomplishment because the size of the DNA molecule constructed dwarfs previous efforts. (Globe and Mail)
Longest Piece of Synthetic DNA Yet Jan 25, 2008
"The 582,970 base pair M. genitalium bacterial genome is the largest chemically defined structure synthesized in the lab," lead author Daniel Gibson told ScientificAmerican ... (Base pairs are complementary linked nucleotide bases, such as adenine thymine. (Scientific American)
Scientists Create First Synthetic Bacterial Genome -- Largest Chemically Defined Structure Synthesized In The Lab Jan 25, 2008
24, 2008) A team of 17 researchers at the J. Craig Venter Institute (JCVI) has created the largest man-made DNA structure by synthesizing and assembling the 582,970 base pair genome of a bacterium, Mycoplasma genitalium JCVI-1 ... Prior to today s publication the largest synthesized DNA contained only 32,000 base pairs ... Thus, building a synthetic version of the genome of the bacteria M. genitalium genome that has more than 580,000 base pairs presented a formidable challenge. (Science Daily)
NEJM editorial on significance and limitations of new lupus gene expression research Jan 21, 2008
The new research looks at how variations in a single DNA base pair, called single nucleotide polymorphisms (SNP), can be used to identify genetic variations among individuals that are associated with a diagnosis of lupus. In some cases, the SNPs call attention to important genes but have no apparent functional importance themselves. (EurekAlert!)
Using Genes to Fight Pine Beetle Jan 17, 2008
" To find out, Aukema and fellow researchers at UNBC are collecting as many pine beetle samples as they can, looking at the insect in all its life stages -- from larvae to adult. The genes in each beetle sample are exposed to various chemicals, like pheromones or the chemicals in tree sap to determine what makes them "switch" on or off. "We're not sequencing every single base pair in the DNA," says Dezene Huber, a Canada Research Chair and associate professor at UNBC. "We're looking at these... (TheTyee.ca)
Study puts doctors closer to genetic prostate-cancer test Jan 17, 2008
" The research team, from Johns Hopkins, Wake Forest University and the Karolinska Institute in Stockholm, drew blood from 2,893 prostate cancer patients and 1,781 matched "controls" who did not have the disease. Using DNA from blood cells, they sifted through variations in chemicals called nucleotides that pair up to form the DNA. These "single nucleotide polymorphisms," or SNPs (pronounced "snips"), occur when one chemical base pair is swapped for another, altering the information in the DNA... (Chicago Tribune)
Scientists Discover Remarkable Editing System For Protein Production Jan 4, 2008
In addition to Beebe, Mock, and Schimmel, Eve Merriman was an author on the new Nature paper, entitled "Distinct domains of tRNA synthetase recognize the same base pair." All authors are from The Scripps Research Institute. The study was funded by the National Institutes of Health, the Skaggs Foundation, and the National Foundation for Cancer Research. (Science Daily)
Are Humans Evolving Faster? Dec 11, 2007
Chromosomes are made of DNA, a twisting, ladder-like structure in which each rung is made of a "base pair" of amino acids, either G-C or A-T. Harpending says that about every 1,000 base pairs, there will be a difference between the two chromosomes. That is known as a SNP.. (Science Daily)
Will nanobots help us to live forever? Nov 22, 2007
For example, the amount of genetic data collected has doubled every year since 1990, and the cost has come down from $10 per base pair to a fraction of a penny. As a result, technologies to literally reprogramme the "software" (ie the genes) that underlie human biology will be a thousand times more powerful than they are today in a decade, and a million times more powerful in two decades. (Guardian Unlimited -- Life)
Localization of TFIIB binding regions using serial analysis of chromatin occupancy Nov 13, 2007
GSTs are 20-22 base pair fragments that are derived from TFIIB bound chromatin. TFIIB localized to both non-protein coding and protein-coding loci. (BioMed Central)
Creationist draws on Bible to explain place in universe Nov 11, 2007
Eddie wrote on Nov 10, 2007 10:32 PM:" Phil, you're (not "your") quite mistaken. You need to educate yourself about basic biology. Mutations are changes to the base pair sequence of the genetic material of an organism. There are several types of mutations, and they can be advantageous, disadvantageous, or neutral towards an organism's survival. Speciation has been observed numerous times; fruit flies, African frogs, and especially the human-initiated creation of domestic sheep are prime... (La Crosse Tribune, WI)
If mutations occur at random over the entire sequence of a species' genome, how can a complex organ such as an eye evolve? How can all the mutations that direct the development of that organ be concentrated in the right places? Nov 1, 2007
At more than six billion individuals, the human species is now so large that every single base pair of the three billion in the genome is mutated several times, somewhere in the population, every generation. Some of these mutations are so harmful that they're eliminated before their carriers are even born. (Scientific American)
Masquerading for money: Tougaloo, Rust get ball rolling with scholarship event Nov 1, 2007
But science was her favorite subject, and good grades led to her three-year participation in Murrah's Base Pair program. The research mentorship program, funded by the Howard Hughes Medical Institute, annually matches 15 high school students with University of Mississippi Medical Center faculty members for in-depth science experiences. (The Clarion-Ledger)
Were Neandertals the Original Redheaded Strangers? Oct 27, 2007
A 128 base pair fragment of MC1R was isolated from the Italian sample. (For reference, there are estimated to be 250,000,000 base pairs in the entire Neandertal genome. (Scientific American)
SPECIAL REPORT: So similar, yet so different Oct 18, 2007
The new, more thorough version finds surprisingly high diversity in single nucleotide polymorphisms (SNPs) parts of the genome marked out by specific changes in a single DNA base pair. Bill Clinton: impressed by the revelatory power of DNA.R. EDMONDS/AP. (Nature News Service)
IBM Opens New Doors to Quantum Computing Sep 3, 2007
Scientists from IBM have managed to partially confirm Feynmans theory and to give God his share of the glory and greatness for his inventiveness: our DNA uses 32 atoms to store information in one half of the chemical base pair that is the fundamental unit that makes up genetic information. With further work it may be possible to build structures consisting of small clusters of atoms, or even individual atoms, that could reliably store magnetic information. (eFluxMedia (press release))
Scientists Find Clue To Mechanisms Of Gene Signaling And Regulation Aug 24, 2007
DNA methylation occurs across the animal genomes, almost always at the C base position of a CG dinucleotide (sequence of two base pairs) in the genetic sequence ... In the regions of the genome where genes are imprinted, called differentially methylated regions, they found a repeat pattern (periodicity) of 8 to 10 base pairs between two CG dinucleotides ... "We believe that this repeating pattern of 8 to 10 base pairs between CGs provides a signal for where the differential methylation should... (Science Daily)
Genetic Phonetics Could Be The Trick To Sounding Out DNA's Meaning Aug 22, 2007
Most modern attempts to decipher how portions of genetic code are translated into physical characteristics are akin to a first-grader trying to sound out a word letter by letter or, in this case, base pair by base pair. But University of Florida researchers have developed a computational method that s more like reading whole words at a time. (Science Daily)
New genetic risk factors for multiple sclerosis found Jul 30, 2007
The three research teams analyzed thousands of patients of European descent, and found that a single base pair difference in the IL7R gene increased the risk of having MS by about 20. That risk is too low to make IL7R useful for a genetic test, cautions Margaret Pericak-Vance, a geneticist at the University of Miami in Florida, and an author on one of the studies. (Nature News Service)
Mouse genome will help identify causes of environmental disease Jul 30, 2007
57 billion base pair of their standard reference strain. The data were then used to develop the haplotype map which contains 40,898 segments. (EurekAlert!)
Hepatitis C helicase unwinds DNA in a spring-loaded, 3-step process Jul 27, 2007
What they found was that the DNA unwound in discrete jumps: Three nucleotide pairs (base pairs) had to be unhitched from one another before an unwinding event occurred ... You are loading the spring with small mechanical movements until finally you have accumulated enough tension on the DNA-protein complex to cause the rapid unwinding of three base pairs ... The researchers observed that three ATP molecules were consumed in each unwinding reaction, indicating that three hidden steps, each... (EurekAlert!)
Semiconductor membrane mimics biological behavior of ion channels Jul 13, 2007
Since each base pair carries a different electrical charge, we could use the membrane as a p-n junction to detect the changing electrical signal. . (EurekAlert!)
First Bacterial Genome Transplantation Changes One Species To Another Jun 30, 2007
Venter, Smith and Hutchison made the first significant strides in the development of a synthetic genome by their work in assembling the 5,386 base pair bacteriophage X174 (phi X). They did so using short, single strands of synthetically produced, commercially available DNA (known as oligonucleotides) and using an adaptation of polymerase chain reaction (PCR), known as polymerase cycle assembly (PCA), to build the phi X genome. (Science Daily)
Going beyond X and Y May 21, 2007
In 1990, while at the University of Cambridge, Peter Goodfellow discovered SRY, a gene on the Y chromosome hailed as the "master switch." Just one base pair change in this sequence would produce a female instead of a male. And when researchers integrated SRY into a mouse that was otherwise chromosomally female, an XX fetus developed as a male. (Scientific American)
Cataloging The Structural Variations In Human Genetics May 11, 2007
We know there is a genetic factor, but what is the role of single base pair changes versus structural changes. The project Eichler and his colleagues describe in their paper will help answer this question. (Science Daily)
New Genetic Risk Factors For Type 2 Diabetes Identified Apr 29, 2007
This means researchers often need to take additional steps, such as sequencing every DNA base pair in that particular region of the genome, to identify the exact genetic variant that affects disease risk. In the latest work, researchers began by scanning the genomes of more than 2,300 Finnish people who took part in the Finland-United States Investigation Of NIDDM Genetics (FUSION) and Finrisk 2002 studies. (Science Daily)
A cricket Gene Index: A genomic resource for studying neurobiology, speciation, and molecular evolution Apr 26, 2007
In addition, a set of unique 70 base pair oligomers that can be used for DNA microarrays was developed. All Gene Index information is posted at the DFCI Gene Indices web page. (BioMed Central)
Two-step Process Filters Evolution Of Genes Of Human And Chimpanzee Mar 7, 2007
They focused their analysis on the simplest and most common mutations, those that alter just one letter, a single base pair, of DNA.. DNA uses a three-letter code to designate the 20 types of amino acids that are strung together in specific order to create a protein. (Science Daily)
Your scent and your sex life Feb 22, 2007
"It was remarkably precise. ... A mouse can discriminate a mouse that differs by one DNA base pair mutation in one MHC gene," says Monell director Gary Beauchamp. Other studies showed that when it came to mating, opposites attracted -- in both mice and men. (Seacoast New Hampshire)
New Technique Assesses Effects Of Multiple Copies Of Genes On Disease Risk Feb 1, 2007
"The copy number variants we describe in this paper are numerous and fairly large they vary in length between two thousand and two million DNA base pairs," Graubert says ... -- The Human Genome Project (HGP) endeavoured to map the human genome down to the nucleotide (or base pair) level and to identify all the genes present in ... It is made up of 23 chromosome pairs with a total of about 3 billion DNA base pairs. (Science Daily)
