Both Major Theories About Human Cellular Aging Supported By New Research Dec 31, 2008
The diet plus metabolic genes pattern is "a modular longevity network," says Vladimir Titorenko of Concordia University in Montreal, who studies baker's yeast, Saccharomyces cerevisiae, as a simpler model for the complex mechanisms of human cellular aging. Through the yeast model, Titorenko and colleagues identified five groups of novel anti-aging small molecules that significantly delayed aging. (Science Daily)
Misfolded Proteins Accelerate Yeast Evolution Nov 27, 2008
To test this hypothesis, the scientists first examined what genes might help to induce the prion state, plowing through the entire genome of Saccharomyces cerevisiae, the common baker's yeast that biologists have studied intensively for many years. Jens Tyedmers, a lead author on the paper published in PLoS Biology on November 28, tested 4700 yeast strains that each lacked one of the genes in the yeast genome, and then tested each strain's ability to create the prion. (Science Daily)
What The Social Lives Of Brewer’s Yeast Say About Evolution Nov 20, 2008
The researchers used common brewer's and baker's yeast (Saccharomyces cerevisiae) as a model for studying social behavior because yeast behavior is driven solely by genetics, without any input from cognitive learning or culture. Also, since S. cerevisiae has been widely studied and characterized, scientists are able to manipulate it with great precision. (Science Daily)
Genes That Prevent Changes In Physical Traits Due To Environmental Changes Identified Nov 6, 2008
The research, which studied the genetic makeup of baker's yeast, appears in the latest issue of the Public Library of Science's journal, PloS Biology ... 10, 2000) Using robots to monitor the goings-on of thousands of individual baker's yeast cells growing on a small plastic grid, scientists supported by the National Institutes of Health, in collaboration. (Science Daily)
Cells Coordinate Gene Activity With FM Bursts, Scientists Find Oct 3, 2008
The scientists looked specifically at the molecular changes within simple baker's yeast (Saccharomyces cerevisiae) cells after exposure to excess calcium, which increases in concentration in cells in response to stressful conditions such as high salt levels, alkaline pH, and cell wall damage ... While studying the molecular changes within simple baker's yeast (Saccharomyces cerevisiae) cells, scientists discovered that the cells tune the expression of groups of genes using discrete bursts of... (Science Daily)
When Cells Go Bad: Cells That Avoid Suicide May Become Cancerous Oct 3, 2008
To trigger telomere loss, the researchers inserted into the flies a gene from common baker's yeast. The gene makes an enzyme that breaks and rejoins DNA. When they turned on the enzyme, it led to the loss of a single telomere in each affected fruit fly cell. (Science Daily)
SCUD: Saccharomyces Cerevisiae Ubiquitination Database Sep 24, 2008
Description SCUD is a web-based database for the ubiquitination system in Saccharomyces cerevisiae (Baker's yeast). We first searched for all the known enzymes involved in the ubiquitination process in yeast, including E1, E2, E3, and deubiquitination enzymes. (BioMed Central)
Brewing A Great Beer: DNA Study Reveals Evolution Of Beer Yeasts Sep 12, 2008
11, 2008) Lager lovers convinced that their beer of choice stands alone should prepare to drink their words this Oktoberfest. New research by geneticists at the Stanford University School of Medicine indicates that the brew, which accounts for the majority of commercial beer production worldwide, owes its existence to an unlikely pairing between two species of yeast - one of which has been used for thousands of years to make ale. (Science Daily)
Engineers Build Mini Drug-producing Biofactories In Yeast Aug 19, 2008
Christina D. Smolke, an assistant professor of chemical engineering at Caltech, along with graduate student Kristy Hawkins, genetically modified common baker's yeast (Saccharomyces cerevisiae) so that it contained the genes for several plant enzymes ... Using baker's yeast as a surrogate disease model. (Science Daily)
Preventing Protein Clumping Characteristic Of Parkinson's Disease With Baker's Yeast Aug 16, 2008
15, 2008) Researchers at the University of Pennsylvania School of Medicine have identified a protein from a most unlikely source -- baker's yeast -- that might protect against Parkinson's disease. More than a million Americans suffer from Parkinson's disease, and no treatments are available that fundamentally alter the course of the condition. (Science Daily)
Caltech engineers build mini drug-producing biofactories in yeast Aug 16, 2008
Christina D. Smolke, an assistant professor of chemical engineering at Caltech, along with graduate student Kristy Hawkins, genetically modified common baker's yeast (Saccharomyces cerevisiae) so that it contained the genes for several plant enzymes. The enzymes allow the yeast to produce a chemical called reticuline, which is a precursor for many different classes of benzylisoquinoline alkaloid (BIA) molecules. (EurekAlert!)
Why Cells Starved Of Iron Burn More Glucose Jun 11, 2008
Thiele stressed that the findings show what happens during iron deficiency in baker's yeast cells, but probably in some way do extend to people. "Nearly 35 percent of all known human disease genes have a counterpart in the yeast genome. A scientist is always conservative about extrapolating. I think we can make predictions that the metabolic reshuffling that we observe in yeast, the same types of key proteins and enzymes that are involved during iron deficiency, are likely to follow similar... (Science Daily)
Protein Combination Triggers 9-1-1 To Make Cells Fight Cancer-causing agents May 20, 2008
The next step toward developing diagnostic tools and drug treatments is to test whether this model, which used genes from baker's yeast that have counterparts in people, can apply to human cells as well. Xiao will present his team's findings and future research directions at the Gordon Research Conference on Mutagenesis at Oxford University this summer. (Science Daily)
Humans, Flies Differ In How Proteins Interact May 15, 2008
This will be crucial in order to understand, for example, why some fungal species, such as baker's yeast are important in the production of bread and beer, while other closely related species cause fungal infections with high mortality rates. The study was carried out by scientists at Imperial College London, the Max-Planck-Institute for Molecular Biology in Germany and the University of Arhus in Denmark. (Science Daily)
Architecture For Fundamental Processes Of Life May 14, 2008
"Our team systematically analyzed the interactions of proteins of bakers yeast, a unicellular organism confirmed to provide insight into fundamental processes shared by most living cells including those of humans," explained Prof. Michnick. (Science Daily)
'Super Yeasts' Produce 300 Times More Protein Than Previously Possible May 14, 2008
23, 1998) A University of Florida chemist has borrowed a page from the Betty Crocker cookbook and found a way to use baker's yeast in making chemical products used in pharmaceuticals and. (Apr. (Science Daily)
Parkinson's damage under scrutiny May 14, 2008
Scientists may be able to use simple baker's yeast to recreate the destruction wreaked by Parkinson's disease in a test tube. It is hoped that the experiments will help them devise ways to halt the disease in its tracks. (Yahoo News -- Parkinson's Disease)
Key Roadblock To Gene Expression Identified: Implications For AIDS May 10, 2008
The scientists then compared these maps to the team's earlier maps of the baker's yeast Saccharomyces cerevisiae, revealing that evolution has organized nucleosomes differently in simple life forms compared to more complex organisms like the fruit fly. In yeast, a nucleosome sits on top of the transcription start site, so RNA polymerase must contend with that nucleosome as soon as it begins to transcribe the gene. (Science Daily)
Molecular Espionage Shows A Single HIV Enzyme's Many Tasks May 10, 2008
13, 2004) Studies on common baker's yeast have led to the discovery of what may be a long-sought mechanism in the life cycle of retroviruses, including the human immunodeficiency virus (HIV). Knowing the. (Science Daily)
Bloodless Worm Sheds Light On Human Blood, Iron Deficiency Apr 20, 2008
" Heme and Blood Heme is a critical molecule for health in all eukaryotes, organisms whose cells are organized into complex structures enclosed in membranes. Species of eukaryotes range from humans to baker's yeast. Heme makes blood red and binds to oxygen and other gases we need to survive. Heme is created in the mitochondria, then moves through pathways that connect other cells, where it is synthesized to form blood. Heme on its own, however, is toxic. "We wanted to find out how heme gets... (Science Daily)
Mechanism Underlying Multidrug Resistance In Fungi Discovered Apr 7, 2008
To better understand the molecular pathways controlling multidrug resistance in fungi, the research team first investigated drug resistance in baker's yeast, a common genetic model for observing biological processes. Using detailed genetic, biochemical, and molecular approaches, the researchers found that yeast induce multidrug resistance via a molecular switch similar to one that removes drugs and other foreign substances from human cells. (Science Daily)
Fasting May Bolster Healthy Cells' Resistance to Chemo Toxins Apr 3, 2008
Working with baker's yeast, he and other researchers found that the fungus sustains less cellular damage as it ages when deprived of key nutrients, allowing it to live longer. Mammalian cells have a version of the genetic pathway that controls this starvation response in yeast. (Scientific American)
New Way To Fight Cancer: Protect Healthy Cells With The Silver Shield Apr 2, 2008
The idea for the study came from the Longo group's previous research on aging in cellular systems, primarily lowly baker's yeast ... "We were able to reach a 1,000-fold differential resistance using a tumor model in baker's yeast. If we get to just a 10-20 fold differential toxicity with human metastatic cancers, all of a sudden it's a completely different game against cancer," Longo said. (Science Daily)
Starvation could kill tumours: study Apr 1, 2008
"In simple systems in the baker's yeast, we got to 1,000 fold separation between normal cells and cancer-like cells in the response to chemotherapy," he said. "So if we can just get to say 10 to 20 fold separation in clinical patients, you see how it is a completely different story for the toxicity of chemotherapy in humans, but also for the ability to go after more aggressive cancers that usually kill the patient.". (ABC Online)
On The Trail Of Rogue Genetically Modified Pathogens Mar 19, 2008
Using baker's yeast as a surrogate disease model. . (Science Daily)
Easter Menu: Italian Desserts Mar 10, 2008
cup fresh baker's yeast (or 5 tbsp active dry yeast). cup granulated sugar. (Suite101.com)
50 Years Ago in Biochemistry Feb 29, 2008
We also discovered that antimycin A blocked the respiratory system of bakers yeast and enhanced aerobic fermentation to the anaerobic rate. This information was passed on to Ahmad and Strong in the next laboratory, who were working intensively on antimycin. (The Scientist)
New Details Of A Gene-regulatory Network Governing Metabolism Discovered Feb 27, 2008
"S. cerevisiae, or common baker's yeast, can use any number of different types of sugar molecules for energy production," noted Dr. Joshua-Tor, a structural biologist. "Importantly, the yeast cell can rapidly respond to changes in its nutritional environment by altering the expression of specific genes that allow it to make use of those different energy sources.". (Science Daily)
Prions Link Cholesterol To Neurodegeneration Feb 13, 2008
6, 2007) Using baker's yeast and another fungus, researchers report the first successful propagation of a prion from one organism to another. Prions -- infectious, oddly-folded proteins that are the main. (Science Daily)
Plant Gene That Helps Plants Resist Environmental Stresses Identified Jan 29, 2008
Ten years ago, Xiao discovered a gene in baker's yeast that when inactivated causes cells to be more susceptible to DNA-damaging agents. His team then identified two similar human genes and found that when either of these was put into the yeast cells containing the inactivated gene, the problem was soon fixed and the cells grew normally. (Science Daily)
Yeast Life Extended Ten Times; Offers Hope for Humans Jan 29, 2008
The researchers achieved the feat by deleting two genes SCH9 and RAS2 from baker's yeast and then subjecting the yeast cells to extreme starvation by restricting their calorie intake. RELATED. (National Geographic)
Anthrax Cellular Entry Point Uncovered Jan 28, 2008
26, 2002) A compound from baker's yeast, used to make bread rise, may one day help protect people against deadly anthrax infections, according to researchers. In laboratory tests, the compound, called WGP. (Science Daily)
Limiting calories extends life of yeast Jan 21, 2008
Removal of certain genes combined with reduction in calorie intake could increase lifespan, new research on baker's yeast finds ... In one study, the researchers genetically modified baker's yeast by removing two genes responsible for aging and related diseases like cancer, and restricted the yeast's calorie intake. (Boston Globe)
Diet And Lifestyle Critical To Recovery, Says Study Jan 21, 2008
The team used baker's yeast -- a model organism studied by biologists to reveal molecular processes in higher organisms -- to explore the relationship between environment and genetic background. The large-scale study involved removing one of the two copies of all yeast genes -- similar to removing one parent's set of genes in a human -- and analysing the resulting fitness under different dietary restrictions. (Science Daily)
Lifestyle 'a big impact on drugs' Jan 19, 2008
The Manchester University researchers looked at the way that this drop in "gene dosage" worked using an experiment in baker's yeast, which shares many genes with humans. Every cell has two copies of each gene, but they changed the cell so that it had only one of each, then placed it in a number of different environments, rich or poor in different chemicals. (BBC News -- Health)
Life Expectancy Of Yeast Extended To 800 In Yeast Years, No Apparent Side Effects Jan 15, 2008
14, 2008) Biologists have created baker's yeast capable of living to 800 in yeast years without apparent side effects ... Longo's group put baker's yeast on a calorie-restricted diet and knocked out two genes, RAS2 and SCH9, that promote aging in yeast and cancer in humans ... Baker's yeast is one of the most studied and best understood organisms at the molecular and genetic level. (Science Daily)
“Store that fat” says new gene. Is obesity explained? Dec 21, 2007
Beyond the fact that we humans love a good sourdough, and baker's yeast helps raise that loaf, what else do we have in common with these lowly fungi ... The nucleus appears in baker's yeast, which separated from our lineage 2 ... After so much evolutionary divergence, we look kinda different from baker's yeast, but we share this essential trait: globs of stored fat inside our cells. (Why Files)
Malaria Parasite In Patient Blood Finds Distinct Physiological States Dec 5, 2007
The biological underpinnings of these groups were made clearer through a second innovative approach: systematically comparing P. falciparum -- whose genes and genome are poorly understood -- to the baker's yeast, an organism that has been extensively characterized at the genetic level. Since the malaria parasite and the baker's yeast are both single-celled eukaryotes, it is possible they may share some of the same cellular machinery and could also respond in some similar ways to their... (Science Daily)
Tim Hangarter Nov 6, 2007
Baker's yeast: Mrs. London's rep rises in magazine reviews - The Business Review (Albany) ... Baker's yeast: Mrs. London's rep rises in magazine reviews. (Albany Business Review, NY)
Baker's yeast: Mrs. London's rep rises in magazine reviews Nov 6, 2007
Members: Not Registered. for free extra services. (Albany Business Review, NY)
New magnetic separation technique might detect multiple pathogens at once Oct 30, 2007
As an initial demonstration of the concept, the researchers attached two "model pathogens," a baker's yeast and a soil bacterium, to magnetic beads, and used their technique to selectively isolate them. The magnetic separation method, which the researchers call magnetophoresis, uses a rotating magnetic field and a microchip containing an array of miniature magnets to separate tiny magnetic beads based on their size within a matter of minutes. (EurekAlert!)
How Hormones Achieve Their Effects Oct 24, 2007
24, 2006) Today researchers in Germany announce they have finished the first complete analysis of the "molecular machines" in one of biology's most important model organisms: S. cerevisiae (baker's yeast). The. (Science Daily)
NIEHS researchers identify enzyme critical in DNA replication Jul 6, 2007
The researchers used an innovative strategy to demonstrate that in bakers yeast, DNA polymerase epsilon has a primary role in replicating the leading strand of DNA. DNA polymerase epsilon was found to be a key determinant of genome stability and of cellular responses to DNA damage resulting from exposures to environmental stress ... However, humans and related higher organisms, such as bakers yeast, are much more complicated. (EurekAlert!)
Prion propagates in foreign host Jul 6, 2007
Previously, Liebman focused her studies on prion-forming proteins found in baker's yeast, while Saupe's research looked at prion protein in another fungus. A key difference between the two is that the yeast prion proteins are rich in the amino acids glutamine and asparagine in the regions of the protein used to transform them into a prion. (EurekAlert!)
Scientists Closer to Unfolding Mysteries of Prion Formation in Mad Cow Disease May 18, 2007
Biology professor Susan Lindquist and postdoctoral researcher Peter Tessier examined the behavior of prions in baker's yeast (Saccharomyces cerevisiae) ... If cultured with peptides from both species, the researchers discovered that they could bias which yeast species it could infect by adjusting environmental conditions: At a temperature of four degrees Celsius, it sought out the baker's yeast's recognition element; at 37 degrees C, it was activated by C. albicans peptides ... The pair also... (Scientific American)
Reconstruction of human protein interolog network using evolutionary conserved network May 11, 2007
The predicted human protein-protein interactions associated with confidence scores are derived from six eukaryotic organisms - rat, mouse, fly, worm, thale cress and baker's yeast. Conclusions. (BioMed Central)
Scientists Identify Prion's Infectious Secret May 10, 2007
Tessier covered the array with peptides from baker's yeast and then added prion protein to the array, also from the same yeast species ... The baker's yeast prion could not recruit peptides from the pathogenic fungi cells, and vice versa ... To further verify these results, Tessier accessed a synthetic yeast prion, one that another research group had assembled from pieces of both the baker's yeast and the pathogenic fungi prion. (Science Daily)
Scientists Reveal Structure Of Gateways To Gene Control Mar 31, 2007
"To obtain their high-resolution map, the researchers first isolated 322,000 nucleosomes from the 6,000 regions that control gene transcription in the DNA of baker's yeast, S.cerevisiae, an organism widely studied as a model of how human cells work. These promoter nucleosomes are the only ones in the yeast DNA that contain in their core a histone protein called H2A.Z. Led by Pugh and Stephan Schuster, associate professor of biochemistry and molecular biology, the Penn State research team then... (Science Daily)
DNA Ends: Common Tool, Different Job Feb 22, 2007
In certain cells, such as our germ cells or baker's yeast cells, which need to divide indefinitely, an enzyme called telomerase elongates telomeres to compensate for the continual attrition at chromosome ends ... About 10 years ago, Lundblad discovered that Cdc13, a protein that binds single-stranded telomeric DNA, plays a central role at the telomeres of baker's yeast. (Science Daily)
Using the sense of smell to change hormone levels Feb 15, 2007
Researchers gave 21 women 20 sniffs from a bottle containing 30 milligrams of androstadienone, and then, on a different day, had them sniff an identical bottle that contained baker's yeast, a similar-smelling substance. Neither the researchers nor the subjects knew which bottle was being presented. (International Herald Tribune -- Health)
Smell of Male Sweat May Arouse Women Feb 11, 2007
Next, they sniffed a jar that contained pure AND (which smells "vaguely musky," according to the UC Berkeley news release) or baker's yeast, which doesn't contain AND. ... When the women smelled AND, their mood, sexual arousal, and cortisol levels were higher than when they smelled the baker's yeast ... The women rated the smell of AND and baker's yeast comparably. (WebMD)
Rhizomania resistance keeps sugarbeets safe Feb 8, 2007
The Prairie Star: Updates. Wednesday, February 7, 2007 9:20 PM MST. (Great Falls Prairie Star, MT)
