New Tumor Inhibitor For Treatment Of Hereditary Breast Cancer Shows Promising Results In Mouse Model Nov 3, 2008
2, 2008) Researchers of the Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital used the novel inhibitor AZD2281 to target breast cancer, in which the BRCA1-gene plays a role, in a genetically engineered mouse model ... The researchers previously developed the mouse model to study BRCA1-associated breast tumors ... BRCA1 defects are often observed in so called triple-negative tumors. (Science Daily)
Men aren't excluded from breast cancer Oct 31, 2008
It is particularly striking when looking at the BRCA1 and BRCA2 genes that mean an increased risk of breast cancer, he said. "And actually if you look, a small percentage of female breast cancers are hereditary, but that percentage in men tends to be much higher," Dr. Keaton said. (The Augusta Chronicle)
A silent killer: Its symptoms are vague and common and there's no screening test, making ovarian cancer tricky to diagnose and harder to survive Oct 29, 2008
Combined with an ultrasound examination of the ovaries, the test can be useful for women at high risk for ovarian cancer: those with a family history of the disease; who carry the BRCA1 or BRCA2 gene; or who have had breast cancer ... She s 52 now, and a few years ago, she tested positive for the BRCA1 gene ... But most women don t have the BRCA1 or BRCA2 genes known to increase risk, and ovarian cancer can still swoop in out of the blue. (Racine Journal Times, WI)
When law is patent nonsense Oct 25, 2008
From November 6, the Melbourne company Genetic Technologies Ltd is insisting that public hospital laboratories no longer conduct their own testing for the inherited breast cancer gene mutations known as BRCA1 and BRCA2, implicated in up to 10 per cent of cases and associated with a younger age of onset ... Back in Australia, thousands of genetic samples are held in public laboratories in a data-bank built up since BRCA1 and BRCA2 testing began in 1995 ... Those skills could be lost from the... (Sydney Morning Herald)
Access to breast cancer test tightens Oct 24, 2008
The genes, known as BRCA1 and BRCA2, are linked to up to 10 per cent of breast cancer cases. Jan Murphy, of Macarthur, decided to lower her risk of getting breast cancer after 11 women on her mother's side of the family died from the disease. (The Canberra Times)
Labs ordered to stop breast cancer tests Oct 23, 2008
The genes in question - BRCA1 and BRCA2 - are implicated in up to 10 per cent of breast cancers ... - Between 5 and 10 per cent of breast cancer is linked to BRCA1 and BRCA2 gene mutations. (Sydney Morning Herald -- Australia)
THINK PINK: A family fights back. Oct 18, 2008
All five sisters have a mutation of the BRCA1 gene, a mutation that raises the risk of breast cancer to 85 percent, often at a young age ... The likely culprit: The BRCA1 mutation. (Florida Times-Union)
Uncertain Gene Test Result Can Feed Cancer Worries Oct 17, 2008
Mutations in the genes BRCA1 and BRCA2 are responsible for about 5 percent to 10 percent of breast cancers, and women with a strong family history of breast cancer can get BRCA testing to see whether they carry a mutation that raises their risk of the disease. However, the results of those tests are often not black-and-white. (MEDLINEplus)
'Pre-vivors' remove breast to avoid cancer Oct 16, 2008
With genetic testing more readily available, more women are learning if they have a defective BRCA1 or BRCA2 gene ... However, the risk of breast cancer in women who have mutations in the BRCA1 and BRCA2 genes can be reduced by a dramatic 90 percent through a bilateral mastectomy, a study published in the Journal of Clinical Oncology in 2004 found. (United Press International)
New Approach To Genetic Testing Could Halve Deaths From Inherited Bowel Cancer Oct 16, 2008
" Bowel cancer is one of the most common forms of cancer in Australia. There are about 1000 cases each year diagnosed in people under the age of 50, and about 10 per cent of these (100 per year) are the result of genetic fault that can now be detected. Professor Hopper says a similar approach could also be taken to improve genetic testing for breast cancer by studying the tumors of young women who developed the disease. "Breast cancers arising in young women with an inherited fault in BRCA1 have... (Science Daily)
Younger Breast Cancer Survivors Risk Disease in Other Breast Oct 15, 2008
The risk of contralateral breast cancer was also greatest when three or more family members had a history of breast cancer, indicating that some of the women in the study might have the risk-raising BRCA1 or 2 genetic mutations. These mutations weren't tested for in the study. (Washington Post)
Extra incentive to get screenings Oct 15, 2008
These women can now get genetic counseling to help them determine if a test is necessary to look for the presence of BRCA1 and BRCA2 mutations, which can signal an increased risk for developing breast cancer. 421-6968. (Herald & Review)
'Gossip Girl' Writer, Producer Removes Breasts to... Oct 14, 2008
In fact, parts of it actually served as the plot for an episode of ER." In 2005, Queller, a supervising producer and one of the head writers of the ultra-successful CW series Gossip Girl, opted to have a double mastectomy even though she didn t have breast cancer. And, in two years, she plans to have her ovaries removed even though she doesn t have ovarian cancer. Queller, now 38, made these radical decisions after watching her mother battle breast cancer and die from ovarian cancer. Then,... (Fox News)
THINK PINK: Men at risk for breast cancer, too Oct 14, 2008
Nevertheless, he got a blood test recently to see if he tests positive for the BRCA1 or BRCA2 genes, genetic alterations that increase the risk of developing breast cancer. The information isn't for him, he said. (Florida Times-Union)
New Findings May Improve Treatment Of Inherited Breast Cancer Oct 12, 2008
About 8% of breast cancer cases are caused by mutations in tumor suppressor genes, such as breast cancer associated gene-1 (BRCA1). BRCA1 is the most frequently mutated tumor suppressor gene found in inherited breast cancers and BRCA1 mutation carriers have a 50-80% risk of developing breast cancer by age 70 ... "Although work with animal models of BRCA1 mutation has provided some insight into the many biological processes linked with BRCA1, very little is known about the downstream mediators of... (Science Daily)
Breast cancer gene tests not worth the price? Oct 10, 2008
" They also claim that the average woman can reduce her risk of developing cancer through genetic testing.Myriad Genetics, the Salt Lake City biotechnology company behind the heavy ad push, charges about $3,000 for a complete risk-disposition test. Myriad, which holds a patent on the first breast cancer test, has been taking full advantage of the genetic testing monopoly it enjoyed until Wednesday when Decode entered the market with its new, more generalized test. To date, Myriad has been very... (MSNBC -- Politics)
deCODE Launches deCODE BreastCancer(TM), a Genetic Test to Screen for Risk of the Most Common Forms of Breast Cancer Oct 8, 2008
These are distinct from the rare and essentially purely inherited forms of the disease due to mutations in the BRCA1 and BRCA2 genes, which cause between 1 and 3 percent of breast cancers ... "We are very interested in all advances that could empower people to take charge of their health care and better understand their risk for developing breast cancer." Owen Winsett, M.D., founder and director of the Breast Center of Austin, Texas, commented: "I have followed closely the recent scientific... (PR Newswire)
Life After Double Mastectomy: New Mom Talks About Battling Breast ... Oct 5, 2008
In September, Patchen tested positive for a deleterious mutation of the BRCA1 gene. Woman who test positive for this mutated gene have an 87 percent chance of developing breast cancer, and a 40 percent of developing ovarian cancer, Coomer said. (FOXNews)
Breast Cancer Mutations Underestimated in Asians Oct 3, 2008
NEW YORK (Reuters Health) - Gene mutations that increase the risk of breast cancer, known as BRCA1 and BRCA2, may occur more commonly in Asian women than previously thought, new research suggests ... According to the report, two prediction models, which rely on a woman's personal and family history of breast and ovarian cancer, often fall short in identifying Asian women likely to have BRCA1 and BRCA2 mutations ... Only BRCAPRO discriminates between BRCA1 and BRCA2 mutation carriers, and genetic... (MEDLINEplus)
Study looks at psychological impact of gene test for breast cancer Oct 3, 2008
"Over 200,000 women will be diagnosed in the U.S. this year with breast cancer and a significant minority of them will have developed cancer because they harbor a BRCA1 or BRCA2 mutation," comments Dr. James P. Evans, Editor-in-Chief of Genetics in Medicine. "Sequencing of these genes has been a boon to patient management and to their family members but such testing comes with a psychological price. In the current issue of GIM, van Dijk et al. explore the psychological effect of discovering such... (EurekAlert!)
Patent system 'stifling science' Sep 25, 2008
" Fortress IP The traditional view is that strong patent protection stimulates innovation, reassuring companies that it is safe to invest in research without fear of being stung by rivals. Under this "old" model of intellectual property (IP), biotech firms raced to file a "fortress" of patents around newly discovered genes, closing off avenues of research for their competitors. But this strategy is ultimately counter-productive for both industry and consumers, argues the report, not least... (BBC News -- Health)
Hormone Therapy May Protect Women with Breast Cancer Gene Sep 25, 2008
The other women also carried the BRCA1 mutation but had no history of breast cancer. Women who had used HRT at some point in their lives had a 42 percent reduced risk of developing breast cancer compared with women who had never used hormone therapy, the researchers found. (MEDLINEplus)
New Computer-Based Tools Will Help Make Best Use of Genetic Breast Cancer Tests Sep 23, 2008
The first pair of tools will assess whether a woman with a family history of cancer should be tested for BRCA1 and BRCA2 gene mutations ... For instance, the AHRQ-sponsored U.S. Preventive Services Task Force has recommended that women whose family history is associated with an increased risk for BRCA1 or BRCA2 gene mutations are referred for genetic counseling and evaluation to measure the need for BRCA testing. (PR Newswire)
10 test for cancer genes Sep 18, 2008
While Lila was battling cancer, Jan had genetic testing to see if she was carrying cancer-causing mutations in two specific genes known as BRCA1 and BRCA2 ... It took 18 months for the results of the BRCA1 to come through and seven years for her to receive the outcome of the BRCA2 test by which stage she had gone ahead with her decision to have a double mastectomy ... While it turned out that I was negative for both BRCA1 and BRCA2, meaning something else had caused the cancer, the outcome would... (Belfast Telegraph)
10 test that can pinpoint your breast cancer risk in just one week Sep 17, 2008
The latest procedure would allow scientists to focus just on the two genes, BRCA1 and BRCA, cutting costs and time ... Women who carry a mutation in the BRCA1 or BRCA2 genes have up to an 80 per cent chance of developing cancer. (Daily Mail)
Breast, Ovarian Cancer Risk Underestimated for Asian Women Sep 13, 2008
By providing a woman's family history of these cancers, including the ages they were diagnosed, the programs calculate a probability that the patient carries a harmful mutation in BRCA1 or BRCA2 (genes involved in controlling malignant cell growth) ... Further research will be necessary to determine how often BRCA1 and BRCA2 mutations actually occur in Asian groups and what these mutations really mean for Asian women in terms of ... The only reason these models are even used, he notes, is... (Scientific American)
Risk of breast cancer mutations underestimated for Asian women, Stanford study shows Sep 12, 2008
Mutations in two genes - BRCA1 and BRCA2 - are strongly associated with the development of breast or ovarian cancer in carriers ... Those women deemed by the models to be likely carriers of these mutations are referred for testing of their BRCA1 and BRCA2 genes ... They sequenced the BRCA1 and BRCA2 genes of all of the study subjects and compared them to the models' predictions. (EurekAlert!)
Gaylord woman takes alternative path to treat cancer Sep 10, 2008
Upon doctor suggestion, Hansen went for genetic testing and found she carried the BRCA1 (breast cancer stage one) mutation gene. Her mother had previously been diagnosed with breast cancer. (Gaylord Herald Times, MI)
‘She had cancer, and I didn’t’: Family history of disease leads to genetic testing Sep 3, 2008
The cousin had genetic testing done and was positive for the BRCA1 breast cancer gene mutation ... They also had a 50 percent chance of inheriting one of the two mutated breast cancer genes, BRCA1 and BRCA2 ... Women diagnosed with breast cancer who have an abnormal BRCA1 or BRCA2 gene often have a family history of breast cancer, ovarian cancer, or both. (La Crosse Tribune, WI)
SUSAN REIMER: Cancer forces tough decisions on women Aug 31, 2008
More important, the young actress tested positive for a mutation in what is called the breast cancer gene, BRCA1 ... "There are ways to monitor for ovarian cancer -- ultrasound and testing for a marker in the blood -- but they are not as effective as the advances in mammography: digital pictures, ultrasounds and MRIs.Ovarian cancer is a silent stalker."She needs to deal with what she is dealing with right now, which is the breast cancer," Helzlsouer said.Research first identified the mutations... (Fresno Bee -- Opinion)
HEALTH BLOG: Digging into the latest cancer studies Aug 28, 2008
Ashkenazi Jews are 10 times more likely than the general population to carry mutations in the breast cancer genes called BRCA1 and BRCA2, and 90% of carriers have one of the three so-called Ashkenazi mutations ... Here's a National Cancer Institute about testing for BRCA1 and BRCA2 mutations. (USA Today -- Money)
Cancer Test for Women Raises Hope, and Concern Aug 26, 2008
These include carriers of mutations in genes called BRCA1 or BRCA2, as well as women with histories of ovarian or breast cancer. Dr. Gil Mor, the lead developer of the test at Yale, said the use of OvaSure might reduce ovarian surgeries, not increase them. (Atlanta Journal-Constitution -- Health)
High fiber bread, antioxidants help prevent breast cancer Aug 25, 2008
With a gene mutation in BRCA1, a woman like Applegate would be at a high risk for breast cancer for sure. But does that mean women with this or other mutations have to definitely get breast cancer. (Food Consumer)
Behind the screen Aug 23, 2008
Welcome to The Sydney Morning Herald. Peter and Renae Warne with PJ, 2, who has a neuroblastoma, but evidence shows such tumours in toddlers tend to disappear without treatment. (Sydney Morning Herald -- Australia)
Christina Applegate's Mastectomy: FAQ Aug 22, 2008
Before getting her preventive (prophylactic) double mastectomy three and half weeks ago, Applegate had two lumpectomies -- and only had cancer in one breast, according to Good Morning America -- and took a gene test that showed that she had the BRCA1 gene mutation, which makes breast cancer and more likely ... She said she based her choice on her family history -- her mother has had breast cancer and -- and her BRCA1 gene. (WebMD)
Entertainment Report Aug 21, 2008
Her mother battled breast cancer, and she tested positive for the BRCA1 gene mutation linked to breast and ovarian cancer. But the experience has been an emotional roller coaster, she said. (San Francisco Chronicle -- Entertainment)
Applegate, other high-risk women act fast against cancer Aug 20, 2008
Mutations in a gene called BRCA1 dramatically increase a woman's risk of cancer ... With BRCA1 mutations: 56% to 84 ... With BRCA1 mutations: 39% to 44. (USA Today)
Breast Cancer: Risks and Screening Aug 7, 2008
Mutations in certain genes, such as BRCA1 and BRCA2, increase a woman s susceptibility to breast cancer. Specialized tests are available to detect these abnormal genes. (Suite101.com)
The genetic testing revolution Aug 3, 2008
Genetic testing found Orlowski and her mother were both carriers of a mutated gene, BRCA1, that predisposed them to breast and ovarian cancer. Orlowski was granted insurance coverage for the hysterectomy as a result of her genetic test, but her concerns are more far-ranging. (Mason City Globe-Gazette, IO)
Know Your Genes? Jul 28, 2008
In the 1980s, scientists discovered that mutations in the BRCA1 and BRCA2 genes were linked to breast cancer risk. Women who carry a BCRA1 mutation have a 65 percent chance of developing breast cancer by age 70, and women with a BCRA2 mutation have a 39 percent risk. (KFOXTV.com, TX)
Women face tough decisions about breast cancer treatments Jul 25, 2008
Women newly diagnosed with breast cancer could be faced with the extra dilemma of having to decide whether to be tested for dangerous gene mutations, as evidence emerges that those with high-risk changes to the BRCA1 and BRCA2 genes may fare better with particular forms of chemotherapy. For women with several close relatives who had already had breast cancer, immediate testing might be warranted, Associate Professor Liz Lobb will tell the Sydney Cancer Conference today, because it could alter... (Sydney Morning Herald -- Australia)
Family Poor Predictor of Breast Cancer Jul 25, 2008
A family history of breast cancer is not the same as breast cancer risk associated with the inherited mutations of BRCA1 or BRCA2 genes. In an effort to better understand the predictive value of family breast cancer history, de Bock analyzed its impact in close to 2,000 women with and without breast cancer. (WebMD)
TG2 Identified As Potential Therapeutic Target In Chemo-resistant Ovarian Cancer Jul 18, 2008
21, 2006) BRCA1 and BRCA2 mutations may be more common in the general population than previously reported and may be associated with ovarian, breast, testicular and pancreatic cancers, according to a study in ... 18, 2002) Two new studies suggest that people who inherit BRCA1 mutations are at an increased risk of not only breast and ovarian cancer but a number of other cancers as well. (Science Daily)
'Smothered' Genes Combine With Mutations To Yield Poor Outcome In Cancer Patients Jul 16, 2008
21, 2006) BRCA1 and BRCA2 mutations may be more common in the general population than previously reported and may be associated with ovarian, breast, testicular and pancreatic cancers, according to a study in. (June 26, 2003) Researchers have peered inside breast cancer's toolbox and identified a set of rogue genes that accelerates the spread of cancer from its primary site in the breast to a secondary location in. (Science Daily)
Breast cancer tests 'will become costly' Jul 15, 2008
Melbourne-based company Genetic Technologies has said it will enforce patents that allow it to carry out all testing for the most common breast and ovarian cancer genes, BRCA1 and BRCA2, in Australia and New Zealand ... The test, available in Australia since the late 1990s, has allowed thousands of at-risk women to check if they have a mutation of the BRCA1 or BRCA2 genes, which would increase their risk of breast or ovarian cancer three to sevenfold. (Sydney Morning Herald -- Australia)
Gene Activity May Explain Deadlier Breast Cancers among Younger Women Jul 14, 2008
The gene sets activated in younger women regulated such things as immune function, breast cancer-related gene mutations such as BRCA1, stem cell biology, cell death and various cancer signaling pathways. Younger women were less likely to have estrogen-receptor-positive tumors (71 percent versus 80 percent in older women); more likely to have tumors which overexpress the protein HER2neu (52 percent versus 24 percent); more likely to have higher-grade tumors (56 percent versus 26 percent) and... (MEDLINEplus)
Herceptin Targets Breast Cancer Stem Cells Jul 14, 2008
1, 2008) A new study may explain why women with a mutation in the BRCA1 gene face up to an 85 percent lifetime risk of breast cancer. Researchers from the University of Michigan Comprehensive Cancer Center. (Science Daily)
Medical research is hindered by out-of-date laws Jul 5, 2008
Work on the BRCA1 and BRCA2 genes that can cause breast cancer, for example, has been held up in the United States by patents held by Myriad Genetics, a US company, and the University of Utah, though similar patents have been revoked in Europe. Patents have also delayed research into malaria and golden rice , a genetically modified variety that contains the precursor of vitamin A, Sir John said. (Times Online)
Swab for life Jun 29, 2008
The test, being developed by international scientists, identifies up to nine genes known to be linked to breast cancer, including BRCA1 and BRCA2. Researchers said women found to be "high risk" could be regularly screened while those at "low risk" could delay mammograms until older. (Herald Sun)
Experimental Imaging System Helps Detect Breast Cancer Jun 28, 2008
Last year, the American Cancer Society issued recommendations that women at high risk for breast cancer (such as those with the BRCA1 or BRCA2 gene mutation or a strong family history of the disease) have annual MRIs in addition to mammography. MRIs have "high sensitivity," meaning they pick up a lot of unusual spots in the breast, but those spots aren't always malignant. (MEDLINEplus)
A supercomputer takes on a killer Jun 28, 2008
For example, women can now be tested for mutations in the BRCA1 and BRCA2 genes that signal a higher chance of getting breast or ovarian cancer - and some with the mutation opt for preventive mastectomies or hysterectomies. But many women with the mutation do not develop cancer, and many women without the mutation do. (Globe and Mail)
Cancer gene test 'for all women' Jun 27, 2008
The best known of these are faults in the BRCA1 and BRCA2 genes, but there are several others. Researchers say that it is becoming feasible to work out whether a woman is at "low", "moderate" or "high" risk of cancer by looking at which combinations of these she has. (BBC News -- Health)
Caution on breast cancer predictor Jun 27, 2008
It would also test for the two high-risk genes, BRCA1 and BRCA2, discovered a decade ago. The researchers said women deemed high-risk could be advised to have regular mammograms or choose to have their breasts removed. (Sydney Morning Herald -- Australia)
Women in their 30's will be offered gene test to check risk of ... Jun 26, 2008
The primary genes involved include BRCA1 and BRCA2, but they occur only rarely in the general population and account for around 5 per cent of almost 46,000 breast cancer cases a year in the UK.. The latest research, funded by Cancer Research UK, analysed the effect of seven common 'modest risk' gene variants which increase the likelihood of developing breast cancer. (Daily Mail)
Gene test gives early alert for breast cancer Jun 26, 2008
In a paper published today in the New England Journal of Medicine, Pharoah and colleagues say that there are seven genetic variants - apart from the well-known, if rare, high-risk genes such as BRCA1 and BRCA2 - which have been discovered to increase a woman's risk of breast cancer, particularly if she has certain combinations of them. More are still being discovered. (guardian.co.uk)
Gene fuels deadly prostate cancer Jun 25, 2008
The latest study - based on 301 patients - examined two closely related faulty genes, BRCA1 and BRCA2, both of which greatly increase a woman's risk of breast cancer, and are linked to ovarian cancer. Both genes cut average survival times in men with prostate cancer who carried them - for men carrying BRCA1 the average survival time was eight years after diagnosis. (BBC News -- Health)
Personalized Medicine Jun 23, 2008
For example, a woman who has a mutation in her BRCA1 gene, a gene implicated in hereditary breast cancer, would learn she has an increased chance of developing the disease and could be screened more frequently and earlier. Since the earlier breast cancer is detected, the better the likelihood of being cured, close monitoring of such predisposed women could make a dramatic reduction in overall breast cancer deaths. (Suite101.com)
Mammogram Screening Day In Langford Jun 19, 2008
Genetic alterations (changes)-Specific alterations in certain genes (BRCA1, BRCA2, and others) increase the risk of breast cancer. These alterations are rare; they are estimated to account for no more than 10 percent of all breast cancers. (Marshall County Journal, SD)
Answers on cancer and genetics Jun 16, 2008
That's why my daughter, Gabrielle, shared the story of her BRCA1 mutation and the preventive double mastectomy she had six months ago to reduce her risk of getting breast cancer. Many asked questions that Dr. Georgia Wiesner, director of the Center for Human Genetics at University Hospitals, answered. (Cleveland.com)
KU Cancer Center director to speak at Relay For Life Jun 5, 2008
His laboratory was instrumental in demonstrating the role of BRCA1 in the growth control of normal and malignant cells and in how loss of BRCA1 function contributes to the development of breast cancer. Dr. Jensen was born in Gardner and earned his bachelor's degree in biology from Pittsburg State University. (Abilene Recorder Chronicle)
Cancer-blocking chemo not being offered Jun 3, 2008
Studies in 25,000 women have shown clear benefit for those with family risk, but it is less clear if it is effective for women carrying the specific high risk genes BRCA1 and BRCA2, because of the nature of the tumour types. The study questioned 23 specialists on their attitude towards the therapy and found nine "barriers" to offering the therapy. (Sydney Morning Herald)
Breast Cancer Gene Risk May Be Overstated Jun 2, 2008
Many women fear that breast cancer is inevitable if they are found to carry mutations in the genes BRCA1 and BRCA2 ... Some 181 carried mutations in either BRCA1 or BRCA2 genes, the team found ... Rather, it simply asserts greater variation in breast cancer risk among carriers of BRCA1 and BRCA2 which does not inherently say anything about overall risk (e. (Yahoo News -- Cancer)
Breast Cancer Rates Projected To Soar May 30, 2008
Professor Gareth Evans led the study of 1,442 women who carried the high-risk genes BRCA1 and BRCA2, on behalf of the Manchester-based Genesis Breast Cancer Prevention Centre. Around one in 500 people are said to carry the gene mutations which give women an 85-90% risk of breast cancer. (Sky News)
New Immunization Strategy Could Be Effective Against 10 To 15 Percent Of All Cancers May 28, 2008
15, 2007) Although defects in the "breast cancer gene," BRCA1, have long been known to increase the risk for breast cancer, exactly how the defects lead to tumor growth has remained a mystery. Now scientists. (Science Daily)
Personal Health: Red flags for hereditary cancers May 28, 2008
You might be familiar with the BRCA1 and BRCA2 mutations that are strongly linked to breast and ovarian cancer in women and somewhat less strongly to breast and prostate cancer in men. A woman with a BRCA mutation faces a 56 to 87 percent chance of contracting breast cancer and a 10 to 40 percent chance of ovarian cancer. (International Herald Tribune)
