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News and Articles on APOBEC3G
New Evidence Of Battle Between Humans And Ancient Virus Jul 24, 2008
One of those proteins, called APOBEC3G, leaves a tell-tale signature behind: It mutates virus DNA in a recognizable pattern and is one our cells use to attack modern retroviruses ... What emerged were two copies of HERV-K that had clearly been mutated, and thus inactivated, by the APOBEC3G protein ... "But these sorts of ancient interactions may have influenced how humans are able to combat these retroviruses today. These proteins help protect us against current retroviruses." Indeed, HERV-K may... (Science Daily)
U of M researchers determine structure of protein that mutates DNA of the AIDS virus HIV-1 Feb 21, 2008
D., co-investigators of the research and assistant professors in the Department of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota have determined the structure of APOBEC3G a protein that inhibits the AIDS virus, HIV. This discovery is the first to shed light on the atomic structure of the protein ... The APOBEC3G machine is capable of modifying HIV DNA so that the virus is no longer infectious ... HIV-1, however, has unfortunately developed a way to evade this... (EurekAlert!)
New Protective Action For Powerful Anti-HIV Factor Identified Oct 31, 2006
Scientists at the Gladstone Institute of Virology and Immunology (GIVI) have identified a previously unknown function of APOBEC3G (A3G), a protein that acts against HIV, a finding that may lead to new approaches for controlling HIV infection. The work is published today, Oct. 2, 2006, in Proceedings of the National Academy of Sciences, USA.. (Science Daily)
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