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    News and Articles on ACE inhibitor



    'Off-Label' Drug Use Is Common  Nov 26, 2008
    The ACE inhibitor Prinivil or Zestril (lisinopril), most commonly used off label for coronary artery disease. The drug Procrit or Epogen (epoetin alfa), approved for anemia in patients with kidney failure, but widely used in patients with other chronic diseases. (CBS News)

    Without enzyme, biological reaction essential to life takes 2.3 billion years  Nov 11, 2008
    His work has also influenced rational drug design, and findings from his laboratory helped spur development of ACE inhibitor drugs, now widely used to treat hypertension and stroke. Research on enzymes as proficient catalysts also led to the design of protease inhibitors that are used to treat HIV infection. (EurekAlert!)

    Protect your heart: Know your blood pressure  Nov 5, 2008
    Now she's on two blood pressure medications -- an ACE inhibitor that lowers levels of blood vessel-tightening chemicals and a beta-blocker that slows heart rate -- and her pressure's normal ... Her blood pressure is now under control thanks to an ACE inhibitor, a diuretic, and some overdue diet changes. (CNN -- Health)

    African-American Canadians Who Receive Kidney Transplants Fare Better Than Those In US  Nov 3, 2008
    3, 2008) African American kidney disease patients in both Canada and the United States are less likely than Caucasian Americans to have access to kidney transplants, but only African-Americans in the United States have worse health outcomes than Caucasians after a transplant is performed, according to a new study. The results could further open the debate about what has driven the disparities seen only in the United States. (Science Daily)

    Cell Changes Leading To Impaired 'Artificial Kidney' Function Identified  Nov 2, 2008
    1, 2008) Molecular targets identified by a Spanish research team may hold the key to freedom for some sufferers of kidney disease. A new study published in Disease Models & Mechanisms (DMM) reveals the cellular signals which cause one treatment for kidney failure to lose its usefulness over time. (Science Daily)

    ACE Inhibitor Drugs Okay with Venom Therapy  Oct 30, 2008
    In a report published in the medical literature this month, Dr. Kevin M. White and Dr. Ronald W. England of Wilford Hall Medical Center, San Antonio, note that there have been several case reports of severe system-wide reactions in venom allergic and other patients taking ACE inhibitors who have been stung or exposed to venom immunotherapy. Their current findings are "preliminary evidence that patients who receive life-saving venom immunotherapy can safely continue or start ACE inhibitors,"... (MEDLINEplus)

    Chicken reduces high blood pressure, research shows  Oct 16, 2008
    Last Updated: Thursday 16 October 2008 07:22 GMT. by Published on October 15, 2008 - 0 comments. (TheMedGuru)

    Angiotensin II Blockade in Marfan’s Syndrome  Oct 16, 2008
    NEJM -- Angiotensin II Blockade in Marfan's Syndrome. Volume 359:1732-1734. (New England Journal of Medicine)

    Heart problems May Be Solved by A Single "Polypill"  Oct 8, 2008
    MONDAY, October 6, (News Locale) - A single polypill that combines blood-thinning aspirin, a cholesterol-lowering statin, and an ACE inhibitor and a thiazide to lower blood pressure is being tested in a pilot study. The study of 700 volunteers will test the safety and efficacy of the polypill, manufactured by Dr Reddy's of Hyderabad, India. (News Locale)

    Polypill pilot finally takes off  Oct 8, 2008
    The "Red Heart" pill contains the blood-thinner aspirin, a cholesterol-lowering statin, and an ACE inhibitor and a diuretic to combat high blood pressure. Researchers believe the once-a-day pill would cost as little as 70 cent per month and could halve the number of deaths from cardiovascular disease and stroke, realising a long-held dream of many doctors, according to a report in the Guardian newspaper. (Irish Times)

    A single pill 'to tackle all heart problems soon'  Oct 6, 2008
    According to them, the red heart pill to be priced at USD one for a month's supply, blends blood-thinning aspirin, a cholesterol-lowering statin, an ACE inhibitor and a thiazide to lower blood pressure. Trials in thousands of people could start next year, said the researchers led by Anthony Rodgers at the University of Auckland in New Zealand. (Hindu)

    High Blood Pressure Takes Big Toll On Small Filtering Units Of The Kidney  Sep 25, 2008
    24, 2008) Take a kidney out of the body and it still knows how to filter toxins from the blood. But all bets are off in the face of high blood pressure. (Science Daily)

    What You Need to Know About Heart Failure Medications  Sep 23, 2008
    ACE Inhibitor Pills - These medicines work by blocking the effects of harmful stress hormones ... They have actions similar to those of ACE inhibitors and may be recommended for people who can not tolerate an ACE inhibitor. (Pekin Times, IL)

    Al Dente: When mouth pain is not dental pain  Sep 19, 2008
    The blood pressure lowering ACE inhibitor medications and others may cause this burning sensation. However, the cause may not be found; medicine refers to this as primary or idiopathic burning mouth syndrome. (Malden Observer, MA)

    Newly Found Gene Variants Account For Kidney Diseases Among African-Americans, Studies Show  Sep 16, 2008
    15, 2008) For the first time, researchers have identified variations in a single gene that are strongly associated with kidney diseases disproportionately affecting African-Americans. This work was conducted by researchers at the National Institutes of Health (NIH) and by NIH-funded investigators at the Johns Hopkins University. (Science Daily)

    The Pitfalls of Linking Doctors' Pay to Performance  Sep 10, 2008
    For example, doctors receive bonuses if they prescribe ACE inhibitor drugs to patients with congestive heart failure. Hospitals get bonuses if they administer antibiotics to pneumonia patients in a timely manner. (Atlanta Journal-Constitution -- Health)

    TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet  Sep 1, 2008
    Landmark ARB trial investigated Micardis(R) (telmisartan) against placebo in reducing the composite endpoint of cardiovascular death, myocardial infarction, stroke and hospitalization for congestive heart failure in ACE inhibitor intolerant high-risk patients receiving current standard of care RIDGEFIELD, Conn ... "Previously, the ONTARGET trial showed that telmisartan was as effective as the ACE inhibitor ramipril in reducing the risk of cardio- and cerebrovascular events, but with a lower rate... (PR Newswire)

    Duct-tape treatment can cure some warts  Aug 26, 2008
    " A small piece of duct tape is placed over the wart for a week. Remove the tape, soak the wart in warm water, file it down with an emery board and put on a fresh piece of duct tape the next day. Repeat this for up to two months. More wart remedies can be found at www.peoples pharmacy.com. About 40 years ago, a doctor told me to increase my potassium intake. A few years later, I found Morton Salt Substitute. I sprinkle about 1/8 teaspoon on my food about once a week, and I haven't had a muscle... (Athens Banner-Herald)

    Targeted Drug Therapy Found Effective In Patients With Common Form Of Immune-mediated Kidney Disease  Aug 19, 2008
    18, 2008) The drug rituximab causes considerable kidney injury healing in patients with membranous nephropathy, a common form of kidney disease, according to a new study. The results suggest that this condition, previously destined to progress to kidney failure in 30-40 percent of cases, can actually be healed in some patients. (Science Daily)

    Treating Blood Pressure May Help Prevent Dementia  Jul 8, 2008
    That study found patients whose high blood pressure was treated with a diuretic, with or without a second blood pressure drug called an ACE inhibitor, had a reduced risk of death from stroke and death from any cause. Several studies have found a link between high blood pressure and dementia, which is marked by a loss of memory and other cognitive abilities, including the ability to speak, identify objects or think abstractly. (Newsmax)

    Goodbye to high BP and obesity  Jun 15, 2008
    The 'polypack' contains a combination of five drugs in eight different formulations (three blood pressure lowering agents, an antiplatelet drug, a beta blocker, an ACE inhibitor, a diuretic and a statin) for treating cardio-vascular conditions such as reducing blood pressure and lowering cholesterol levels. Simply put, the polypack includes blood pressure lowering combinations, aspirin (blood thinner) and a statin, which is a cholesterol lowering agent. (India Times, India -- Health/Science)

    New Molecular Link Between Diabetes And Kidney Failure  Jun 10, 2008
    9, 2008) Diabetes is an increasingly common cause of kidney failure in developed countries. It is thought that activation of a hormone system known as the renin-angiotensin system (RAS) early in the course of diabetes has an important role in the development of kidney disease. (Science Daily)

    New Kidney Protein Speeds, Improves Diagnosis Of Failing Kidneys  Jun 6, 2008
    6, 2008) Walk into any emergency department complaining of chest pain and you are likely to have blood drawn. Within hours it should be clear whether you've had a heart attack, based on enzyme levels in your blood and whether those levels reveal the tissue damage normally associated with a heart attack or other major cardiac event. (Science Daily)

    Tests start on low-cost combo heart drug  May 20, 2008
    The polypill contains three established drugs aspirin, a cholesterol-lowering statin and an ACE inhibitor for reducing blood pressure and is intended to prevent heart attack patients from suffering a recurrence. At the moment, such patients are often required to take multiple drugs, which is expensive. (MSNBC -- Health)

    Kidney Disease Worsens In A Fourth Of African-Americans Despite Therapy For Hypertension  May 6, 2008
    Study participants were initially recruited beginning in 1995 for the , which concluded in 2001 that an ACE inhibitor medication protected the kidneys better than two other classes of blood pressure drugs. During the Cohort Study, nearly 9 out of 10 participants were taking an ACE inhibitor or an angiotensin receptor blocking drug, and average blood pressure was 133/78 mmHg, close to national guidelines for high blood pressure in people with chronic kidney disease. (Science Daily)

    Scientists make weight loss claim  May 2, 2008
    He also said that although ACE inhibitor drugs were widely used to treat high blood pressure, there was nothing to indicate that, even at high doses, they encouraged weight loss in humans. In addition, although the drugs were generally safe, they did carry a risk of side effects, such as kidney damage. (BBC News -- Health)

    Way to increase metabolism for weight loss  May 2, 2008
    "ACE inhibitor and Angiotensin Receptor Blocker (ARB) drugs are already widely available to treat hypertension and have been found to have this same effect on fat and glucose metabolism, but many people using these drugs may not have noticed any significant weight loss because their lean body mass could have increased. "It is possible that the ACE inhibitor and ARB drugs could be adapted to become specific weight loss drugs it may be a question of the correct dosage. "However, such a weight... (Health Newstrack)

    Blood pressure drug aid in weight loss  May 2, 2008
    The group was using an ACE inhibitor with animals to study the effects of a complex biochemical pathway called the renin-angiotensin system on blood pressure. Unexpectedly, the mice and rats got skinnier. (Australian Migration News)

    New guidelines issued for treating resistant hypertension  Apr 8, 2008
    Thus, a triple drug regimen of an ACE inhibitor or angiotensin receptor blocker, calcium channel blocker and a thiazide diuretic is effective and generally well-tolerated. Ultimately, however, combinations of three or more drugs must be tailored to the individual, considering prior benefit, history of adverse events, additional medical conditions such as chronic kidney disease or diabetes, and patient financial limitations. (EurekAlert!)

    Two-drug Blood Pressure Therapy Dramatically Lowers Cardiovascular Risk  Apr 2, 2008
    One group received a tablet containing benazepril, which is a type of drug called an ACE inhibitor, and amlodipine, which belongs to a class of drugs known as calcium channel blockers or CCBs. The other pill combined benazepril and hydrochloro-thiazide, a type of diuretic or "water pill." The 20 percent reduction in cardiovascular events was observed with the ACE/CCB combination tablet. (Science Daily)

    Significant Reductions In Mortality Shown Using Blood Pressure-lowering Treatment In Very Elderly  Apr 2, 2008
    5mg, with the addition of the ACE inhibitor perindopril in tablet form once a day ... 23, 2007) The blood pressure-lowering drugs called ACE inhibitors provide almost ten percent greater protection against coronary heart disease, compared with angiotensin receptor blockers, says new research. (Science Daily)

    Cheap combo pills can aid heart  Apr 1, 2008
    He led a study testing a single daily pill combining a diuretic and the ACE inhibitor benazepril versus a daily pill containing benazepril and a calcium channel blocker, amlodipine. ACE inhibitors dilate blood vessels to lower pressure ... His study assigned 3,845 older people in Europe, China and several other countries to take the diuretic or dummy pills plus the ACE inhibitor perindopril as needed to reach a goal of 150/80 from an average starting pressure of 173/91. (MSNBC -- Race)

    Hypertension: Never too old to benefit from treatment  Apr 1, 2008
    Starting treatment for high blood pressure with a combination of an ACE inhibitor and a calcium channel blocker may be more effective than the one-pill regimen now called for in medical guidelines, Kenneth Jamerson of the University of Michigan reported. Ramipril, an ACE inhibitor, and telmisartan, an angiotensin II receptor blocker, or ARB, are equally effective, Salim Yusuf of McMaster University in Hamilton, Ontario, reported. (USA Today)

    ACE Inhibitor as Effective as More Expensive Blood Pressure Drug  Apr 1, 2008
    MONDAY, March 31 (HealthDay News) -- Treatment with an ACE inhibitor drug was as effective in reducing deaths, heart attacks and stroke in a high-risk group of patients as a newer and more expensive angiotensin-receptor blocker (ARB) drug, a large international study has found ... The study of more than 17,000 people with coronary artery disease or diabetes found no major differences between those treated with the widely used ACE inhibitor ramipril (Altace) and those given the ARB telmisartan... (U.S. News & World Report)

    Blood-pressure drugs work at any age, studies say  Apr 1, 2008
    He led a study testing a single daily pill combining a diuretic and the ACE inhibitor benazepril vs. a daily pill containing benazepril and a calcium channel blocker, amlodipine. ACE inhibitors dilate blood vessels to lower pressure. (AZCentral -- News)

    Combo Pill Cuts Blood Pressure and Heart Risks  Apr 1, 2008
    While both pills helped control blood pressure, people who took the Novartis AG drug Lotrel -- a pill containing an angiotensin-converting enzyme, or ACE, inhibitor plus a calcium channel blocker -- had 20 percent fewer heart events such as heart attacks and strokes than those who took an ACE inhibitor and diuretic, or "water pill," combination ... Both pills contained the ACE inhibitor benazepril, known by the brand name Lotensin. (Newsmax)

    New weapon in heart attack war  Apr 1, 2008
    The ONTARGET trial compared the effectiveness of a common type of blood pressure drug known as an ACE inhibitor, a newer class of drug known as an ARB, and the use of both drugs together in patients who were at high risk of cardiovascular disease but were otherwise healthy. It found the newer drug, telmisartan, matched the older drug, ramipril, with fewer side-effects. (Melbourne Herald Sun)

    Novel Discovery Could Lead To Much-needed Kidney Failure Treatment  Mar 17, 2008
    16, 2008) The unwanted activation of an important cell-signaling pathway may play a role in two kidney problems that are major causes of end-stage renal disease, scientists at the Albert Einstein College of Medicine of Yeshiva University have found. Their research, which opens up a novel approach for treating kidney failure, is described in the March issue of Nature Medicine. (Science Daily)

    Elderly Hispanics face disparity in health care  Mar 15, 2008
    Also at Community, according to the government benchmark data, an ACE inhibitor -- a common medication for a particular type of heart attack -- was being given only 76% of the time, Jha said ... "We know that an ACE inhibitor is a common medication with a particular kind of heart attack; everyone agrees this is the right thing to do and hospitals should be doing it 100% of the time," he said. (Fresno Bee -- Business)

    Half Of Heart Patients Significantly Underuse Effective Heart Medications, Many Because Of Cost  Feb 23, 2008
    At present, patients under the Part D program take some combination of beta blockers, ACE inhibitors or ARBs, statins and aspirin. Some patients take only one of these drugs; others use several, but on average patients are 50 percent adherent, researchers said. (Science Daily)

    Cardiologist says diet exercise are the best medicine to ward off heart disease  Feb 16, 2008
    Ace inhibitors work by expanding blood vessels to decrease resistance and allow blood to flow more easily. Mantle also touched on some unique challenges that face different groups of people in terms of heart disease. (Demopolis Times, AL)

    Major International Diabetes Study Does Not Confirm Increased Risk Of Death Reported By US Trial  Feb 16, 2008
    Blood pressure treatment comprised a blood pressure lowering treatment regimen including the ACE inhibitor, perindopril, and the diuretic, indapamide. This treatment was shown to reduce mortality in patients with diabetes and the results were reported last year in The Lancet. (Science Daily)

    Protein Loss In Urine Predicts Effectiveness Of Hypertension Medication  Feb 13, 2008
    In addition, these new data suggest that if you want to prevent cardiovascular disease the best medication for people with more protein loss is perhaps a so-called ACE inhibitor (a specific antihypertensive). Screening. (Science Daily)

    Drug Combo Tied to Kidney Risk with Some Cardiac Surgeries  Feb 9, 2008
    Aprotinin plus ACE inhibitor associated with renal woes during off-pump surgery, U.K. study finds ... Among patients who had on-pump surgery, there was no significant association between aprotinin and postoperative renal dysfunction, irrespective of ACE inhibitor use ... However, aprotinin was associated with a more than twofold increased risk of renal dysfunction among the 848 patients who had off-pump cardiac surgery and received both aprotinin and ACE inhibitors. (MEDLINEplus)

    New finding may help explain development of preeclampsia  Feb 9, 2008
    ACE inhibitor drugs are currently used to lower Ang II in non-pregnant women with hypertension, but these drugs cannot be given to pregnant women. The study authors suggest that other therapies aimed at regulating blood pressure might be beneficial if they target the chorionic villi rather than the system as a whole. (EurekAlert!)

    Bayer's Trasylol, Taken Off Market in November, Is Safe in Some Surgeries  Feb 8, 2008
    In surgery without a pump, Trasylol used in combination with the ACE inhibitor class of blood-pressure drugs led to a two-fold increase in kidney dysfunction, a serious complication with a high death-rate, the study said ... In the 848 patients given the drug during off-pump surgery, the presence of an ACE inhibitor was linked to higher kidney dysfunction ... ACE inhibitors are often used in cardiac surgery to protect the kidneys by reducing blood pressure. (Bloomberg -- Germany)

    Diuretics Best for Hypertension and Metabolic Syndrome  Jan 30, 2008
    It included 42,418 people with hypertension and at least one other risk factor for cardiovascular disease who were randomly assigned to take either the diuretic chlorthalidone (15,255), the calcium channel blocker amlodipine besylate (9,048), the alpha-blocker doxazosin mesylate (9,061), or the ACE inhibitor lisinopril (9,054) ... Patients who took the ACE inhibitor and the alpha-blocker also had an increased risk of combined cardiovascular disease ... "The lack of benefit of the agents with the... (MEDLINEplus)

    Gene Variations Associated With Effectiveness Of Blood Pressure Medications  Jan 25, 2008
    The researchers found evidence of a pharmacogenetic association of the NPPA T2238C variant with coronary heart disease (CHD), stroke, all-cause death, combined CHD, and combined CVD when comparing the chlorthalidone (diuretic) group with the amlodipine (calcium channel blocker) group, and for stroke when comparing the chlorthalidone group with those receiving amlodipine or lisinopril (ACE inhibitor). The association was consistent for all outcomes: those with at least one copy of the minor C... (Science Daily)

    Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure  Jan 21, 2008
    Tell your doctor if you take lithium or cyclosporine or if you have ever had a reaction called angioedema to ACE inhibitor medicine. In clinical studies, the most common side effect experienced by more patients taking TEKTURNA than patients taking a sugar pill was diarrhea. (PR Newswire)

    Blood Pressure Drug Telmisartan Shows Powerful Activity Against Stroke, Study Suggests  Dec 18, 2007
    In this case, his team tested two drugs telmisartan and an ACE inhibitor, ramipril (Altace) in a rat model long favored by stroke researchers. In this approach, rats are fed what's known as a "stroke-prone diet," meaning they get lots of salt in both their food and water. (Science Daily)

    Drug May Limit Radiation Kidney Damage In Bone Marrow Transplantation Patients  Nov 20, 2007
    19, 2007) Researchers at the Medical College of Wisconsin in Milwaukee have found that the risk of radiation injury in normal tissue after exposure may be reduced by a drug in common use. It suggests that long-term administration of the drug captopril, starting at three weeks after patients receive total body irradiation in preparation for bone marrow transplantation (BMT), showed a favorable trend for better long-term kidney function and better long-term patient survival. (Science Daily)

    Urine Test Results Can Point to Heart Dangers  Nov 20, 2007
    He and his colleagues also found that the hypertension drug trandolapril (an ACE inhibitor) lowered albumin levels in patients' urine. The findings of this study and previous research by the same team indicate that "we cardiologists need to pay more attention to kidney function in our patients, and we need to look at two aspects -- filtration and albuminuria," Solomon said. (Health-Finder)

    Medical College of Wisconsin study finds drug may limit radiation kidney damage in BMT patients  Nov 15, 2007
    Public release date: 14-Nov-2007. Contact: Toranj Marphetia. (EurekAlert!)

    Probing The Link Between Kidney Disease And Heart Disease  Nov 9, 2007
    8, 2007) Kidney disease isn t just about kidneys: Research has shown that people with kidney abnormalities have a dramatically increased risk of heart disease. But by studying blood samples from patients with early-stage kidney disease, researchers at The Rockefeller University Hospital hope to better define the connection. (Science Daily)

    Following Heart Disease Guidelines Saves Lives, According to a Kaiser Permanente Abstract Presented at AHA Scientific Sessions  Nov 5, 2007
    For example, 92 per cent of Kaiser Permanente patients with ACS were discharged with an ACE inhibitor(3) or angiotensin-receptor blocker (ARB)(4), recommended in the guidelines as an effective therapy for reducing mortality from heart attacks. By comparison, only 61 per cent of eligible patients in non-KP hospitals in the CRUSADE database and 55 per cent in the NRMI database received an ACE inhibitor or ARB. On admission, 97 per cent of eligible KP patients received beta blockers compared with... (PR Newswire)

    Heart drug 'boosts' OAP fitness  Oct 11, 2007
    Researchers discovered older people became more active when they were given an ACE inhibitor called perindopril ... The study follows on from previous research by her team, which found that heart failure patients were able to walk further after being prescribed ACE inhibitors. (BBC News -- Health)

    Blood Pressure Drugs Cut Death Rate in Diabetes  Sep 6, 2007
    New Delhi, Delhi, India -- The George Institute for International Health (Business Wire India). The largest-ever study of treatments for diabetes has shown that a fixed combination of two blood pressure lowering drugs reduces the risk of death, as well as the risks of heart and kidney disease. (NDTV.com)

    Blood Pressure Drug Combo Helps Diabetic Hearts  Sep 3, 2007
    Large, long-term global study shows diuretic plus ACE inhibitor reduced risk of dying from heart disease ... SUNDAY, Sept. 2 (HealthDay News) -- Using a combination of diuretics and ACE inhibitors to manage blood pressure in people with type 2 diabetes can help protect against heart disease, according to new data released Sunday ... The participants, all 55 or older, received either a combination of the ACE inhibitor perindopril and the diuretic indapamide or a placebo. (Health-Finder)

    Diabetes treatment that could save 100000 lives  Sep 3, 2007
    At present, only those with high blood pressure are offered medication such as ACE inhibitor and diuretic drugs ... Half received daily blood pressure-lowering treatment with Coversyl Plus, a combination of the ACE inhibitor perindopril, which works by relaxing the blood vessels, and the diuretic indapamide. (Daily Mail)

    Mysteries surround how diabetes works through system  Sep 2, 2007
    Dr. Yorek's team found it could block much of the nerve damage in Zucker rats by using either a blood pressure medication known as an ACE inhibitor or a cholesterol-lowering drug called a statin, but it also discovered that those treatments and others had much less effect on reversing nerve and vessel damage in the rats if it already had occurred. And that poses a problem for human drug trials, Dr. Yorek said. (Pittsburgh Post-Gazette, PA)

    Blood-Pressure Lowering Medication Significantly Reduced Stroke and Death Risk In Elderly  Aug 10, 2007
    5mg SR), and an additional ACE inhibitor (perindopril), in tablet form once a day. Emeritus Professor Chris Bulpitt, HYVET Principal Investigator from the Care of the Elderly Department at Imperial College London, said: "It was not clear prior to our study whether the over-80s would benefit from blood pressure lowering medication in the same way as younger people. Our results are great news for people in this age group because they suggest that where they have high blood pressure, such treatment... (Science Daily)

    Antihypertension Drugs Help People Over 80  Aug 9, 2007
    5 mg SR), and an additional ACE inhibitor (perindopril), in tablet form once a day. The study was halted in July. (Forbes)

    Meda AB (publ.) January - June 2007, H1 Interim Report  Aug 8, 2007
    The product comprises the well-known substances lercanidipine (a calcium antagonist) and enalapril (an ACE inhibitor). The product is indicated for high blood pressure treatment. (BusinessWire)

    Hypertension drugs 'aid elderly'  Aug 7, 2007
    In the latest trial which began in 2001, patients with high blood pressure were either given a low dose diuretic and an ACE inhibitor called perindopril in tablet form once a day, or a dummy pill. Lead researcher Professor Chris Bulpitt said: "Our results are great news for people in this age group because they suggest that where they have high blood pressure, such treatment can cut their chances of dying as well as stroke.". (BBC News -- UK)

    Meda Expands the Collaboration with Recordati  Jul 31, 2007
    The combination product consists of lercanidipine (calcium antagonist) and enalapril (an ACE inhibitor) two well-known pharmaceutical substances. The product is indicated for the treatment of high blood pressure. (BusinessWire)

    Trial of Blood Pressure Drug Offers Hopeful Early Results  May 23, 2007
    Lotrel combines a calcium channel blocker, amlodipine besylate, with an ACE inhibitor, benazepril. In the trial, the drug was compared with a different combination medication that combined benazepril with a diuretic, which makes the body lose water. (MEDLINEplus)

    Health Highlights: May 15, 2007  May 18, 2007
    Women were also less likely to be prescribed ACE inhibitor drugs for chronic heart failure or to be prescribed beta blocker drugs after a heart attack, the study said. The RAND Corporation study is published in the May/June issue of the journal Women's Health Issues. (Forbes)

    Heart-failure Patients Benefit From Pharmacist Care  May 16, 2007
    For example, heart patients taking an ACE inhibitor received their pills in a bottle marked with an ace of hearts sticker. A corresponding information sheet, designed to be easy to read and understand, was also marked with the ace-of-hearts. (Science Daily)

    Women Less Likely to Get Treatment After Heart Tests  May 16, 2007
    In the six months following the exercise stress testing, women were less likely than men to have coronary angiography or revascularization and were also less likely to be prescribed statin, ACE inhibitor, or beta-blocker drugs. "Future studies should further investigate whether these management differences explain sex differences in cardiovascular disease outcomes," the study authors wrote. (MEDLINEplus)

    RAND study finds women with heart disease and diabetes less likely to receive proper care  May 14, 2007
    Other types of care women received less often than men included being prescribed ACE inhibitor drugs for chronic heart failure and receiving prescriptions for beta blocker drugs following a heart attack. Women with diabetes in both Medicare and commercial health plans were more likely to have received eye exams than their male peers. (EurekAlert!)

    8 plants from South Africa may hold potential for treating high blood pressure  May 2, 2007
    The study, entitled ACE Inhibitor Activity of Nutritive Plants in Kwa-Zulu Natal, was conducted by Irene Mackraj and S. Ramesar, both of the Department of Physiology and Physiological Chemistry; and H. Baijnath, Department of Biological and Conservation Sciences; University of Kwa-Zulu Natal, Durban, South Africa ... In an effort to identify indigenous plants consumed by the local population in Kwa-Zulu Natal that hold potential antihypertensive properties, the researchers examined 16 plants to... (EurekAlert!)

    New Hope For Stroke Victims  Apr 26, 2007
    "The ACE inhibitor class of blood pressure lowering drugs, of which Lisinopril is a member, have been shown in studies to lower blood pressure but preserve the blood flow to the brain which may be all important after stroke. This study compared the use of blood pressure lowering with Lisinopril versus placebo treatment within a few hours of acute stroke in patients presenting to University Hospitals Leicester. The results showed that blood pressure was effectively lowered in the treated group... (Science Daily)

    Protein Monitoring Improved Heart Failure Treatment  Apr 20, 2007
    The major difference in medical treatment was use of higher doses of beta-blocker and ACE inhibitor drugs in the BNP-monitored group, the researchers said. BNP is a protein produced by the muscle cells of the heart ventricles as a response to excess stretching of those cells. (MEDLINEplus)

    Blood Pressure Keeps Even Keel With Daily Chocolate  Apr 12, 2007
    Rationally applied, daily chocolate may contribute to normal blood pressure on a par with beta-blocker or ACE inhibitor monotherapy, according to a meta-analysis by Dirk Taubert, M.D., Ph. D., of University Hospital here, and colleagues. (MedPage Today)

    Ibuprofen Risky for Heart Patients?  Apr 5, 2007
    The problem with that is Grandma Jones has to take a statin drug, an ACE inhibitor, and beta-blockers, too. Now you tell her to take a white pill hours before she takes the green pill -- it isn't going to work," he says. So what is a person who needs low-dose aspirin supposed to do for arthritis pain? For those at low risk of stomach and gut side effects, Farkouh recommends taking naproxen at the lowest helpful dose -- and avoiding ibuprofen. Nissen says there's far too little evidence to advise... (WebMD)

    Calpis and Marukome Develop Miso with Blood Pressure Lowering Effect  Mar 28, 2007
    Casein miso is made by adding fermented casein in the process and has 8 times more ACE inhibitor effect than normal miso. A clinical trial conducted on mice proved its antihypertensive effect. (JCN Network, Japan)

    A Compelling Case for King Pharma  Feb 27, 2007
    We believe new management at King Pharmaceuticals (: $19) has done an admirable job so far in rectifying the company's past woes, defending its key franchises, and expanding the product portfolio. While King is expected to eventually face significant patent erosion on key products in the years ahead, we believe new product development projects, especially in the area of pain management, bode well for long-term growth. (BusinessWeek)

    Combo Drugs Best for Lowering Blood Pressure  Feb 9, 2007
    The subjects were randomly allocated to take one of four agents -- a calcium channel blocker, a beta-blocker, a diuretic, or an ACE inhibitor -- or a capsule containing all four drugs at one quarter of the dose used for single-drug therapy. After 4 weeks, the reduction in pressure with the combination treatment was 19 points, significantly greater than the 6 to 11 points seen with the various individual agents. (MEDLINEplus)

    Quinine is unsafe for leg cramps  Jan 30, 2007
    Altace (ramipril) is an ACE inhibitor. Such blood pressure medicines are less likely than many others to cause sexual dysfunction, but not all patients can tolerate them. (Newsday -- Health)

    New treatment is a godsendfor ulcerative colitis patient  Jan 25, 2007
    Lisinopril (Zestril) is an ACE inhibitor, and felodipine (Plendil) is a calcium channel antagonist. Both are blood pressure medicines. (The Standard-Times, MA)

    United States Beats Europe For Hypertension Treatment, But Room For Improvement Remains  Jan 24, 2007
    By starting treatment for high blood pressure earlier and being more aggressive, physicians in the United States control hypertension significantly better than their counterparts in western Europe report researchers from Temple, the University of Chicago, and Stanford in the Jan. 22, 2007, issue of the Archives of Internal Medicine. In a study based on clinic visits of more than 21,000 patients with hypertension, the researchers found that 63 percent of U.S. patients had their blood pressure... (Science Daily)

    Active Ingredient In Common Chinese Herb Shown To Reduce Hypertension  Jan 20, 2007
    Some 50 million Americans have hypertension, that is, blood pressure measuring above the normal range (less than 120/80 mmHg). If untreated, it can lead to heart attacks, strokes, or kidney disease. (Science Daily)

    Researchers Identify Gene Associated With Severe Kidney Failure In Diabetes  Jan 11, 2007
    A research team at Wake Forest University Baptist Medical Center and the University of Heidelberg has proven that a gene protects some people with diabetes from developing severe kidney failure or "end-stage renal disease.". Diabetes is the leading cause of end-stage kidney disease worldwide, an illness that requires either kidney dialysis treatments or a kidney transplant for survival. (Science Daily)

    Most hospital performance measures for heart failure not linked to improved patient outcomes  Jan 3, 2007
    Public release date: 2-Jan-2007. Contact: Waddell Albin 310-794-8672. (EurekAlert!)

    Study finds limitations in publicly reported quality-of-care indicators for heart-failure patients  Jan 3, 2007
    The study determined that none of the five standard measures were significantly associated with reduced early mortality risk and only ACE inhibitor or ARB use modestly affected mortality or rehospitalization outcomes. Prescribing a beta-blocker in eligible patients, however, was strongly associated with lower mortality risk and lower death/rehospitalization risk. (EurekAlert!)


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