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Kranzler and his colleagues used data collected through Project MATCH, a multi-center randomized clinical trial evaluating the efficacy of three types of psychosocial treatment for alcoholism: Cognitive Behavioral Therapy (CBT), Motivational Enhancement Therapy (MET), and Twelve Step Facilitation (TSF). The researchers collected DNA samples from 812 European-American subjects (596 men, 216 women), and followed their passage through 12 weeks of treatment and a 12-month post-treatment period. (Science Daily)
Ore. prep athletes say drug testing does not deter Oct 19, 2007
The study involved roughly 1,400 teenagers and was the first randomized clinical trial to determine the deterrent effects of drug testing on high school athletes. The study comes at a time when an increasing number of high schools are testing for drugs -- a controversial practice. (KGW Northwest NewsChannel 8, OR -- Sports)
Random drug testing not reliable in keeping teen athletes from using Oct 19, 2007
The study, named SATURN (Student Athlete Testing Using Random Notification), is the first-ever prospective, randomized clinical trial to assess the deterrent effects of drug and alcohol testing among high school athletes. Prior to this study, there was little research and no randomized trials to establish whether student-athlete drug and alcohol testing is an effective deterrent, said Linn Goldberg, M.D., F.A.C.S.M., principal investigator, professor of medicine and head of the Division of... (EurekAlert!)
OrbusNeich's Genous(TM) Bio-Engineered R Stent(TM) is Subject of Sessions on Innovation at TCT 2007 Oct 18, 2007
Latest Randomized Clinical Trial Results of First Pro-Healing Stent Also Featured at Annual Symposium HONG KONG, Oct. 18 /PRNewswire/ -- OrbusNeich's Genous(TM) Bio-engineered R stent(TM) is the subject of several sessions about innovation in interventional cardiology strategies and device design at this year's Transcatheter Cardiovascular Therapeutics symposium, TCT 2007, which is set for Oct. 20-25 at the Washington Convention Center in Washington, D.C. The line-up of sessions that feature the... (PR Newswire)
New cervix test improves finding of pre-cancer cells Oct 18, 2007
In a blind, randomized clinical trial, Canadian researchers showed that a test that identifies the DNA of the human papillomavirus, the virus believed to cause cervical cancer, appears to be exquisitely sensitive, identifying nearly 95 percent of the women who have pre-cancerous or cancerous cells. In combination with the standard Pap smear, that number became 100 percent. (AZCentral -- News)
Banked Blood Loses Ability To Deliver Oxygen To Tissues Almost Immediately Oct 13, 2007
"Both McMahon and Stamler believe that a large-scale randomized clinical trial in humans is needed, arguing that blood has both benefits and risks, and therefore should be evaluated in the same manner as medications."There is little doubt that transfused blood can be harmful," said Stamler. "We are only uncertain about how serious the problem is. The availability of a potential solution will hopefully focus the attention of the medical community on the potential magnitude of this problem. (Science Daily)
Crucial factor declines in banked blood Oct 11, 2007
Both research teams believe that a large-scale randomized clinical trial in humans is needed, arguing that blood has both benefits and risks, and therefore should be evaluated in the same manner as medications. Editor: Liu Dan. (Xinhua)
Long-Term Follow-up of the West of Scotland Coronary Prevention Study Oct 11, 2007
Background The West of Scotland Coronary Prevention Study was a randomized clinical trial comparing pravastatin with placebo in men with hypercholesterolemia who did not have a history of myocardial infarction, with an average follow-up of approximately 5 years. The combined outcome of death from definite coronary heart disease or definite nonfatal myocardial infarction was reduced from 7. (New England Journal of Medicine)
Banked Blood Could Do More Harm Than Good Oct 10, 2007
A large-scale randomized clinical trial in humans is needed, said McMahon and Stamler. These studies show that donated blood has risks as well as benefits, and therefore should undergo clinical trials in the same way as drugs and medication. (Medical News Today)
'Eat all you want and still lose weight!' Oct 8, 2007
It goes on to say that the research study was a "controlled, randomized clinical trial.". The site does not name the research study, but statistics it mentions match those in a report featured in 2001 by the Journal of Human Nutrition and Dietetics, a publication of the British Dietetic Assn.. (Los Angeles Times)
Acupuncture: it doesn't matter where you stick the needle Sep 26, 2007
To investigate the effectiveness of acupuncture at healing back pain, the researchers carried out a randomized clinical trial that consisted of over 1,000 patients. Each participant had experienced chronic back pain for a minimum of eight years and underwent a series of ten 30-minute sessions for treatment of their pain. (Ars Technica)
Acupuncture Treats Back Pain Sep 25, 2007
D., M.D., of the University of Regensburg, Bad Abbach, Germany, and colleagues conducted a randomized clinical trial involving 1,162 patients (average age 50) who had experienced chronic low back pain for an average of eight years. Patients underwent ten 30-minute sessions (approximately two sessions per week) of verum acupuncture (387 patients), sham acupuncture (387 patients) or conventional therapy (388 patients). (Newsmax)
Two Drugs Equally Effective For Heart Patients Undergoing Angioplasty, Study Finds Sep 16, 2007
"It is not likely that there will ever be a randomized clinical trial comparing the two drugs, as it would require over 30,000 patients," says Henry Ting, M.D., Mayo Clinic cardiologist and co-author. "Our study fills an evidence gap by providing data to help guide treatment decisions.". (Science Daily)
Sometimes hyperactive kids are just seeing double Sep 13, 2007
Next spring, the U.S. National Eye Institute will announce the results of a $6 million randomized clinical trial measuring the benefits of vision therapy in a doctor's office versus home-based therapy. For Raea Gragg, the treatment was relatively simple. (International Herald Tribune)
2 drugs equally effective for heart patients undergoing angioplasty, Mayo study finds Sep 11, 2007
-- In lifesaving procedures to open blocked heart arteries a key question has persisted for years: Is use of the more expensive drug, abciximab, justified over use of the less-expensive eptifibatide" A new Mayo Clinic study to be published in the current edition of Value in Health, Volume 11, Issue 4 and now available as an e-publication, offers clinicians the first large-scale contemporary study to help answer the question. The study found no significant difference between the drugs in the... (EurekAlert!)
Researchers must try harder to recruit minorities to trials Sep 7, 2007
This report describes the successful strategies of recruitment and retention of African Americans and Latinos in a randomized clinical trial to reduce smoking, depression and intimate partner violence during pregnancy. Socio-demographic characteristics and risk profiles of retained vs. non-retained women and lost to follow-up vs. dropped-out women are presented. (BioMed Central)
Cholesterol Drug Change May Be Risky Sep 6, 2007
Cholesterol Management Health Center. Study by Maker of Statin Drug Lipitor Raises Questions About Switching to Generic Versions By WebMD Medical News Reviewed by. (WebMD)
New Study Findings Confirm CLEXANE(R)/LOVENOX(R) Long-Term ... Sep 5, 2007
ExTRACT TIMI 25 was a major randomized clinical trial thatsupported the worldwide submission and subsequent approval by the FDAand some European countries of the new Lovenox(R) indication for thetreatment of patients with acute ST-segment elevation myocardialinfarction (STEMI). STEEPLE (SafeTy and Efficacy of Enoxaparin in PercutaneousCoronary Intervention Patients) trial one year follow up shows thatthe composite of all cause death at 1 year and major bleeding was3. (Juraforum.de)
Avigen Initiates European Multi-Center AV650 Phase II Spasticity Trial in Patients with Multiple Sclerosis Sep 5, 2007
This double blind, randomized clinical trial will be conducted in 25 MS centers in Germany and other European countries. It will evaluate safety, tolerability, pharmacokinetics and efficacy in up to 150 MS patients suffering from spasticity. (Primezone Releases)
Cypher(R) Sirolimus-Eluting Coronary Stent Demonstrates Sustained Clinical Benefits Compared to Bare Metal Stents in Five-Year Randomized Clinical Trial With No Differences in Long-Term Safety Sep 3, 2007 Hypnosis - Effective Pain Reliever for Breast Cancer Surgery Sep 1, 2007 Hypnosis Reduces Pain And Costs In Breast Cancer Surgery Aug 31, 2007 Hypnosis eases breast cancer surgery pain: study Aug 29, 2007 Migraine trial under way Aug 29, 2007 FDA Gives Medtronic Cervical Disk Green Light Aug 28, 2007 It smells fishy - and that's good Aug 20, 2007 Sirr: Women's Health in Venezuela Aug 16, 2007 DNA Vaccine Against Multiple Sclerosis Appears Safe, Potentially Beneficial Aug 15, 2007 DNA vaccine could help MS sufferers: study Aug 14, 2007 New Study Questions Avandia's Heart Risk Aug 9, 2007 Inhaled nitric oxide safe for tiny preemie lungs, UCSF study finds Aug 7, 2007 Africa: Daily HIV/Aids Report Jul 26, 2007 Treating HIV-infected Infants Early Helps Them Live Longer Jul 26, 2007 Eating Fish Urged to Counter Binge-Drinking Effects on Fatty Acids Jul 26, 2007 Early treatment sees more HIV babies survive Jul 24, 2007 Study confirms that NSAIDs treatment can reduce colorectal cancer risk Jul 24, 2007 Study: Zocor May Prevent Alzheimer's, Parkinson's Jul 20, 2007 Exceeding '5 A Day' Guide For Veggie, Fruit Intake Doesn't Reduce Chance Of Breast Cancer Recurrence, Study Finds Jul 19, 2007 Selenium Supplements May Increase The Risk Of Type 2 Diabetes Jul 16, 2007 Tomatoes show little effect in reducing cancer risk Jul 12, 2007 Glaxo's Avandia stirs debate at diabetes meeting Jun 26, 2007 New Study Shows A1c Reduced Safely By Patients With Type 2 Diabetes Using Self-Adjusted Dosing Starting With Once-Daily Insulin Treatment Levemir(R) Jun 25, 2007 University of Zurich announces worldwide clinical trial of Cardiac Resynchronization Therapy Jun 23, 2007 One-step Breast Cancer Treatment Combines Radiation, Surgery Jun 21, 2007 Estrogen Therapy and Coronary-Artery Calcification Jun 21, 2007 Folic Acid Does Not Prevent Colorectal Tumours New Study Suggests Jun 6, 2007 Dasatinib shows high early response rate as first treatment for chronic myelogenous leukemia Jun 3, 2007 Doctors Conclude Temsirolimus Is Effective New Treatment For Advanced Renal Cell Carcinoma Jun 1, 2007 Dietary vitamin B6. B12 and folate, may decrease pancreatic cancer risk among lean people Jun 1, 2007 FDA approves new kidney cancer drug May 31, 2007 Effect of Burch Colposuspension versus Fascial Sling to Reduce Urinary Stress Incontinence May 22, 2007 Reducing Cardiovascular Disease Risk Factors When Discontinuing Hormone Replacement Therapy May 17, 2007 Coenzyme Q10 Does Not Improve Parkinson's Disease Symptoms May 16, 2007 Infants with bronchiolitis may benefit more from albuterol May 16, 2007 Data Show Low Incidence of Breakthrough Bleeding With ORTHO TRI-CYCLEN(R) LO In a Broad Range of Women May 9, 2007 Aspirin: A wonder drug for women? May 2, 2007 Novel transfusion strategy for pediatric patients in intensive care Apr 20, 2007 Survival Data Available From ERBITUX(R) Study in First-Line Treatment of Advanced Head and Neck Cancer Apr 4, 2007 Dark chocolates perk up blood vessel function: Study Mar 27, 2007 Studies explore lifestyle choices and heart risks Mar 25, 2007 Degrees in homeopathy slated as unscientific Mar 22, 2007 Obesity May Up Prostate Cancer Deaths Mar 17, 2007 Tykerb (lapatinib) - new anti-cancer treatment approved Mar 15, 2007 Viagra Drug May Help Improve Exercise Capacity In Pulmonary Fibrosis Patients Mar 14, 2007 Taking AIM at post-stroke depression Feb 17, 2007 More doubt cast on value of drug-coated stents Feb 13, 2007 Celexa Effective Against Depression with Heart Patients Jan 24, 2007 Prostate Cancer Trial Halted Due to 3 Cases of Leukemia Jan 21, 2007 New international study to test exercise in heart failure patients Jan 20, 2007 Combined Heart and Stroke Prevention Surgery Ups Death Risk Jan 16, 2007 Low-dose Aspirin Offers Lower Chance Of Asthma Jan 16, 2007
VIENNA, Austria, Sept. 3 /PRNewswire/ -- Clinical investigators at the European Society of Cardiology Congress 2007 (ESC Congress 2007) reported today that the CYPHER(R) Sirolimus-eluting Coronary Stent continued to provide clinical benefits compared to a bare metal stent in the E-SIRIUS Trial out to five years of follow-up with no differences in safety. At five-year follow-up, the patients in the CYPHER(R) Stent arm of the study continued to be significantly less likely than the patients in the... (PR Newswire)
New Study Findings Confirm CLEXANE(R)/LOVENOX(R) Long-Term Clinical Benefit in Patients Suffering From Acute Coronary Syndrome Sep 3, 2007
ExTRACT TIMI 25 was a major randomized clinical trial that supported the worldwide submission and subsequent approval by the FDA and some European countries of the new Lovenox(R) indication for the treatment of patients with acute ST-segment elevation myocardial infarction (STEMI). STEEPLE (SafeTy and Efficacy of Enoxaparin in Percutaneous Coronary Intervention Patients) trial one year follow up shows that the composite of all cause death at 1 year and major bleeding was 3. (PR Newswire)
" In a randomized clinical trial, 200 women scheduled for a breast biopsy or lumpectomy [removal of tumor without mastectomy] underwent a 15-minute hypnosis session before they went into the operating room. Others just had a consultation with a psychologist. While hypnosis has been studied before, this was the first time it was part of breast cancer treatment. Helen Dorman describes the pain of her surgery: "You sort of feel like you've been rolled over by a Mack [a brand of large truck] truck... (Voice of America)
Article: Montgomery GH, Bovbjerg DH, Schnur JB, David D, Goldfarb A, et al. A Randomized Clinical Trial of a Brief Hypnosis Intervention to Control Side Effects in Breast Surgery Patients. J Natl Cancer Inst 2007; 99:1304-1312. (Science Daily)
"This is a randomized clinical trial of 200 patients that really showed beneficial effects for patients," said Guy Montgomery of Mount Sinai School of Medicine in New York. "It really works well.". (Scientific American)
San Diego-based CryoCor said it has enrolled more than 170 patients in a randomized clinical trial of its ablation system for treating atrial fibrillation. Santarus signs a deal. (San Diego Union-Tribune -- Business)
The Prestige Cervical Disc underwent a prospective, multi-center, randomized clinical trial to assess its safety and effectiveness based on comparisons between data collected from patients with single-level symptomatic cervical DDD at one level between C3-C7. The investigational group of 276 patients received the Prestige Cervical Disc device while the 265 patients in the control group received an anterior plated surgical fusion utilizing bone graft and plate stabilization. (dBTechno)
The reliability of many of these studies is limited by small sample sizes, animal-only subjects or the observational (rather than randomized clinical trial) design of the research. Within these limitations, some results are encouraging. (San Francisco Chronicle)
Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: a randomized clinical trial. Hogewoning CJ; Bleeker MC; van den Brule AJ; Voorhorst FJ; Snijders PJ; Berkhof J; Westenend PJ; Meijer CJ Int J Cancer. (Zmag.org)
Based on these results, a phase 2b trial--a randomized clinical trial in approximately 290 patients--of BHT-3009 is already under way. "If successful in MS, antigen-specific DNA vaccines can be developed for prevention or treatment of related diseases, such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and myasthenia gravis," the authors conclude. (Science Daily)
But based on the findings, a randomized clinical trial involving administering BHT-3009 to approximately 290 patients is underway with hopes that successful treatment of MS sufferers could pave the way for the development of similar vaccines to prevent or treat related diseases such as Type 1 diabetes, lupus and rheumatoid arthritis, researchers concluded. "Eventually, and this is a goal for farther down the road, we believe that the targets of these diseases may not be identical across... (CTV.ca)
That means their data fall short of the gold standard -- a randomized clinical trial -- so they "will neither solve the overriding problems of drug safety nor ultimately help a chronically underfunded federal agency," he said. More information. (Health-Finder)
The controlled, randomized clinical trial of nitric oxide was headed by Roberta Ballard, MD, UCSF professor emeritus of neonatology who coordinated the trial while serving as chief of the division of neonatology at Childrens Hospital of Philadelphia. The trial included 582 very premature infants who were enrolled between 2000 and 2005 in the study at 7 to 21 days old at 21 hospitals around the country. (EurekAlert!)
He added, "This is the first randomized clinical trial that shows that infants treated before three months of age will do better than infants who have their treatment delayed.". Anthony Fauci, director of NIAID, said, "The results of this trial could have significant public health implications worldwide because these findings will cause experts to consider changes in standards of care in many parts of the world" (Reuters, 7/24). (AllAfrica.com)
This trial, called the "Children with HIV Early Antiretroviral Therapy" (CHER) study, is a phase III, randomized clinical trial led by Avy Violari, M.D., FCPaed (SA), of the University of the Witwatersrand in Johannesburg, South Africa, and Mark Cotton, MBChB, MMed, of the University of Stellenbosch in Cape Town, South Africa ... "Children with HIV infection frequently show rapid disease progression within the first year of life due to their developing immune systems and susceptibility to other... (Science Daily)
Note that the findings came from a retrospective review of data, not a randomized clinical trial. As alcohol consumption increased in men, dietary intake of total saturated fatty acids, total monounsaturated fatty acids (MUFA), and total polyunsaturated acids (PUFA) decreased significantly (P=0. (MedPage Today)
"This is the first randomized clinical trial that shows that infants treated before 3 months of age will do better than infants who have their treatment delayed," Zerhouni said in a statement. The study of 337 babies aged 6 to 12 weeks was initially aimed at examining whether early antiretroviral drug therapy over a limited period would delay HIV progression. (Scientific American)
It would be ideal to conduct a randomized clinical trial in which half the patients receive NSAIDs at doses higher than those used in prior trials and half receive placebos and follow both groups for many years for evidence of cancer. But such trials are expensive, time consuming, and could present real health risks to participants. (EurekAlert!)
This was a broad observational study rather than a gold-standard randomized clinical trial, in which all the variables are carefully controlled. "At least one, sometimes two, randomized clinical trials would be required before the FDA would approve marketing the drug for Alzheimer's or dementia," says Dr. Samuel Gandy, chair of the Alzheimer's Association's medical and scientific advisory council. (MSNBC -- Health)
The study is the largest-ever randomized clinical trial to assess the connection between diet and breast cancer recurrence. Stanford was one of seven sites for the trial. (Science Daily)
Results of a randomized clinical trial using 200 micrograms of selenium alone showed that 55 percent more cases of type 2 diabetes developed among participants randomized to receive selenium than in those who received a placebo pill. Results will appear in print in the August 2007 issue of Annals of Internal Medicine and were posted online on July 10. (Science Daily)
Others point out that this was a review of previous studies, not a large, randomized clinical trial, which could have yielded stronger results. "It reaffirms what we keep learning over and over again," said Dr. David Katz, director of the Prevention Research Center at Yale University School of Medicine. (abc13.com)
One audience member called the publication of the study irresponsible, in light of an ongoing randomized clinical trial looking at heart effects of the drug. That elicited applause from the audience; but Nissen's response that he had an ethical obligation to publish his findings also drew applause. (Scientific American)
"The study is a testament to the safety of Levemir(R), as patients were able to adjust their basal insulin dose on their own and achieve the same level of glycemic control as when guided by their doctor, while reducing the risk of hypoglycemia," said Luigi Meneghini, MD, MBA, Associate Professor of Clinical Medicine and the Director of the Eleanor and Joseph Kosow Diabetes Treatment Center at the Diabetes Research Institute, Miami, FL. "Since having type 2 diabetes requires a great deal of... (PR Newswire)
The worldwide study, called "Echocardiography guided Cardiac Resynchronization Therapy (EchoCRT)", is the first prospective randomized clinical trial to evaluate the impact of cardiac resynchronization therapy in patients with advanced heart failure (NYHA Class III) and a narrow QRS complex who show mechanical dyssynchrony as assessed by echocardiography. "It is established that CRT provides clinical benefit for heart failure patients with wide QRS," said Johannes Holzmeister, MD, University of... (EurekAlert!)
McCready and Fyles will join a randomized clinical trial to further study the results of using this procedure. The study participants from PMH will generally be older patients with small, early-stage tumours (less than 2 cm). (Science Daily)
We examined the relationship between estrogen therapy and coronary-artery calcium in the context of a randomized clinical trial. Methods In our ancillary substudy of the Women's Health Initiative trial of conjugated equine estrogens (0. (New England Journal of Medicine)
"Folic Acid for the Prevention of Colorectal Adenomas: A Randomized Clinical Trial." Bernard F. Cole; John A. Baron; Robert S. Sandler; Robert W. Haile; Dennis J. Ahnen; Robert S. Bresalier; Gail McKeown-Eyssen; Robert W. Summers; Richard I. Rothstein; Carol A. Burke; Dale C. Snover; Timothy R. Church; John I. Allen; Douglas J. Robertson; Gerald J. Beck; John H. Bond; Tim Byers; Jack S. Mandel; Leila A. Mott; Loretta H. Pearson; Elizabeth L. Barry; Judy R. Rees; Norman Marcon; Fred Saibil; Per... (Medical News Today)
The comparison to historical data provides insight into dasatinib's effect, but a randomized clinical trial comparing medications directly would present a more detailed picture. Imatinib, known commercially as Gleevec and produced by Novartis Pharmaceuticals, was the first drug to target the fusion protein BCR-ABL that causes the disease. (EurekAlert!)
The results of a phase III, randomized clinical study involving patients with advanced renal cell carcinoma and poor prognostic features show temsirolimus improved overall survival when compared to the current treatment for this stage of disease. The study, led by Gary R. Hudes, M.D., director of the Genitourinary Malignancies Program at Fox Chase Cancer Center, is published in the May 31 issue of the New England Journal of Medicine. (Science Daily)
The researchers say their study cannot definitively say that one carbon nutrients either pose a benefit or a hazard to most people, but they note that it is the best analysis that can be performed outside of a randomized clinical trial. . (EurekAlert!)
"It would be reasonable to hypothesize that temsirolimus could provide greater benefit to patients with less extensive metastatic disease. Only a randomized clinical trial will give us that definitive knowledge," Hudes said. More information. (Atlanta Journal-Constitution)
Background Many surgical procedures are available for women with urinary stress incontinence, yet few randomized clinical trials have been conducted to provide a basis for treatment recommendations. Methods We performed a multicenter, randomized clinical trial comparing two procedures the pubovaginal sling, using autologous rectus fascia, and the Burch colposuspension among women with stress incontinence. (New England Journal of Medicine)
Participants were part of the five-year Women On the Move through Activity and Nutrition (WOMAN) study, a randomized clinical trial of CVD prevention. The focus of this investigation was 240 women who were taking HRT at baseline; 134 of these women were randomized to the lifestyle intervention and the remaining 106 were randomized to the health education group. (Science Daily)
Alexander Storch, M.D., of the Technical University of Dresden, Germany, and colleagues conducted a randomized clinical trial of a 300-milligram dose of CoQ10 in 131 patients with Parkinson's disease who did not have changes in motor functions and were on stable treatment for their condition. Those assigned to the treatment group took 100 milligrams of CoQ10 three times daily for three months, followed by a two-month "washout" period. (Science Daily)
In a paper to be presented at the 2007 Society for Academic Emergency Medicine (SAEM) Annual Meeting, a double-blind randomized clinical trial involving over 700 infants over a three year period showed a clear advantage for albuterol in successful discharges from the Emergency Department. Although many smaller studies have shown either no difference or an advantage to epinephrine, this surprising result of a small but real advantage in using albuterol may force physicians to reassess their... (EurekAlert!)
The findings are based on a retrospective analysis of data from a randomized clinical trial evaluating the safety and efficacy of ORTHO TRI- CYCLEN LO compared to Loestrin(R) Fe 1/20 (norethindrone acetate/20 mcg ethinyl estradiol) tablets. The study evaluated the incidence of breakthrough bleeding and spotting in 1,506 women using ORTHO TRI-CYCLEN LO versus 1,057 women using norethindrone acetate/20 mcg ethinyl estradiol tablets for up to 13 continuous menstrual cycles. (PR Newswire)
Experts agree that the Nurses Health Study has considerable statistical power because of its size and the 24 years of follow-up, but they also note its limitations as an observational study, which isn't as reliable as a randomized clinical trial. John Baron, an epidemiologist at Dartmouth Medical School who comments on Chan's study in the same issue of the Archives of Internal Medicine, says the response to the findings should be cautious. (Orlando Sentinel)
Montreal, April 19th, 2007 -- In its April 19th, 2007 edition, the New England Journal of Medicine published an article about the findings of a multi-center randomized clinical trial that compared transfusion strategies for patients in pediatric intensive care units. The study, led by Dr. Jacques Lacroix, a full professor in the Department of Pediatrics at the Universit de Montral and a pediatric intensivist as well as researcher at the CHU Sainte-Justine, a university hospital center, was... (EurekAlert!)
"We are excited by the results of this study, as it is the first large, randomized clinical trial to examine the impact of ERBITUX treatment in combination with platinum-based chemotherapy on overall survival in metastatic head and neck cancer," said Eric Rowinsky, M.D., Chief Medical Officer and Senior Vice President of ImClone Systems. "ERBITUX has already demonstrated improved survival when combined with radiation in locoregionally advanced head and neck cancer." "When ERBITUX was approved... (PR Newswire)
"In this group of healthy adults with BMI between 25 and 35 kg/m2, dark chocolate ingestion over a short period of time was shown to significantly improve endothelial function, leading our team to believe that greater benefit may be seen through a long-term, randomized clinical trial," co-investigator, Dr. Valentine Yanchou Njike of Yale Prevention Research Center said. However, cautioning against chocolate overdoing, researchers called for larger studies to generate confirmed results. (The Money Times)
"In this sample of healthy adults with BMI between 25 and 35 kg/m2, dark chocolate ingestion over a short period of time was shown to significantly improve endothelial function, leading our team to believe that greater benefit may be seen through a long-term, randomized clinical trial," said Valentine Yanchou Njike, M.D., of Yale Prevention Research Center, and co-investigator on this study. "While the findings from this study do not suggest that people should start eating more chocolate as part... (EurekAlert!)
For advocates of evidence-based medicine, the double-blind randomized clinical trial (in which neither the doctor nor the patient knows who is getting active treatment and who is getting a placebo) is the best form of evidence available to practitioners ... "I definitely think homeopathy can, and should, be evaluated within the context of double-blind, placebo-controlled, randomized clinical trials," says Ellen Hughes, who teaches complementary therapies to medical students at the University of... (Nature News Service)
"Although one would need a randomized clinical trial to definitively determine whether weight loss could be an effective complementary treatment for obese men diagnosed with prostate cancer, these results offer yet another good reason for men to achieve and maintain a healthy weight," Kristal says. By Miranda Hitti Reviewed by Louise Chang 2005-2006 WebMD, Inc. All rights reserved. (CBS News)
The approval of Tykerb was based on a randomized clinical trial in about 400 women with advanced or metastatic breast cancer that was also HER2 positive. In the trial, half the patients received Tykerb with capecitabine and half received capecitabine alone. (News-Medical.net)
"The next step is to confirm this finding in a large, randomized clinical trial." The study was funded by the National Institutes of Health. Other authors include: Dr. Harold R. Collard, department of medicine, San Francisco General Hospital, University of California, San Francisco; Kevin J. Anstrom, Ph. (Science Daily)
INDIANAPOLIS Activating patients and developing a monitoring and evaluation system was highly effective in ending or reducing post-stroke depression in patients enrolled in the largest randomized clinical trial to date for this prevalent and disabling consequence of stroke. Researchers from the Richard L. Roudebush Veterans Administration Medical Center, the Regenstrief Institute and the Indiana University School of Medicine report in the March issue of the journal Stroke, that AIM, a new... (EurekAlert!)
A company executive singled out the Swedish study as "far from definitive" because it was an uncontrolled registry of patients rather than a randomized clinical trial. Both Boston Scientific and Johnson & Johnson, the other major stent maker, are sponsoring further trials to assess the safety and effectiveness of stents in more complex cases. (Boston Globe)
Point out that a large randomized clinical trial is still necessary to determine whether treatment of depression in these patients has beneficial effects on the occurrence of cardiovascular events ... "For that a large, randomized clinical trial is urgently needed.". (MedPage Today)
"Of importance, this possible increase in risk would not have been identified so early without a randomized clinical trial that allowed comparison between a group receiving standard treatment and a group receiving a novel therapy approach," Glode added. One expert thinks the decision to end the trial was correct. (Forbes)
The new trial, called Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) "is the largest randomized clinical trial of exercise training ever performed," Kitzman said. "The trial represents a critical step in establishing exercise as a therapy for patients with left ventricular dysfunction" (reduced heart contractions). (EurekAlert!)
"Given this significant increase in postoperative stroke and death, a randomized clinical trial of the combined surgery is needed to determine the benefit, if any, compared to performing the operations in separate hospitalizations.". RELATED LINKS. (Scientific American)
(July 8, 2005) -- The Women's Health Study (WHS) -- the largest randomized clinical trial to investigate the impact of aspirin and vitamin E on the primary prevention of cardiovascular and cancer risk -- has helped. . (Science Daily)
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