Molecular Trigger Helps Prevent Aging, Disease Nov 19, 2009
(May 13, 2009) Cell biologists have found a more filling substitute for caloric restriction in extending the life span of simple organisms. Researchers show that yeast cells maintained on a glycerol diet live twice. (Science Daily)
'Escaped' proteins add to hearing loss in elderly, UF researchers find Nov 11, 2009
Caloric restriction, another way to reduce oxidative damage, has previously been shown to extend life and prevent age-related hearing loss in the type of mice used in the study ... "This extends research into life extension by caloric restriction into a whole new area that hasn't been looked at before," said Huber Warner, Ph ... "The work shows that rather than caloric restriction just having an overall effect on metabolism of nutrients, bak modulation can have segmental effects on particular... (EurekAlert!)
No funerals, no kids, no wrinkles Oct 29, 2009
Aubrey DeGrey's scientific proposals have nothing to do with CR (which means Caloric Restriction, not 'Reduction), for one thing. Whatever moral queasiness the concept may arouse in people like Ms Farrelly, the fact is that aging research is a perfectly credible and rapidly accelerating field of medicine. (Sydney Morning Herald -- Opinion)
SIU faculty gets $2.6M in stimulus grants Oct 22, 2009
Andrzej Bartke, professor and SIUC distinguished scholar of internal medicine and physiology, Interaction of Caloric Restriction with Longevity Genes, $60,952. Dr. Carol Bauer, professor of otolaryngology head and neck surgery, Features of Chronic Tinnitus in Animal Model as Indicated by MEMRI and MRS, $181,492. (St. Louis Business Journal, MO)
'Anti-Atkins' Low Protein Diet Extends Lifespan In Flies Oct 3, 2009
6, 2007) Caloric restriction in non-obese people translates into less oxidative damage in muscle cells, according to a new study by Anthony Civitarese, Eric Ravussin and colleagues (Pennington Biomedical. (June 28, 2009) Experiment after experiment confirms that a diet on the brink of starvation expands lifespan in mice and many other species. (Science Daily)
Scientists Find Gene Linked to Longer Life Oct 3, 2009
The results seen by deleting the S6K1 gene mimic the anti-aging effects of caloric restriction seen in lab tests on animals -- but without dieting, Selman and colleagues observed. The researchers conclude that thwarting the S6K1 gene might lead to treatments for aging-related diseases. (CBS News)
Fasting Prolongs Reproductive Life Span Aug 29, 2009
"For many, it has been assumed that cells and organs remain relatively stable during periods of starvation or caloric restriction," said Van Gilst, an assistant member of the Hutchinson Center's Basic Sciences Division, who authored the study with postdoctoral research fellow Giana Angelo, Ph. D. "The idea that an entire system would kill itself off during starvation and then regenerate upon food restoration was very surprising. The fact that extremely old worms could generate new eggs and... (Newsmax)
Turning Back The Clock: Fasting Prolongs Reproductive Life Span Aug 29, 2009
"For many, it has been assumed that cells and organs remain relatively stable during periods of starvation or caloric restriction," said Van Gilst, an assistant member of the Hutchinson Center's Basic Sciences Division, who authored the study with postdoctoral research fellow Giana Angelo, Ph ... However, Van Gilst is quick to point out that even if this mechanism is conserved in humans, it is still unknown what degree of caloric restriction would be required to impact egg production in humans... (Science Daily)
* Tests begin on drugs that may slow aging Aug 20, 2009
In experiments with mice and other laboratory animals, certain chemicals, caloric restriction and the change of single genes have all brought noticeable increases in life span ... Excitement among researchers on aging has picked up in the last few years with the apparent convergence of two lines of inquiry: single gene changes and the diet known as caloric restriction ... In caloric restriction, mice are kept on a diet that is healthy but has 30 percent fewer calories than a normal diet. (Taipei Times, Taiwan -- World Business)
Calorie restriction may cut breast cancer risk Aug 5, 2009
This study "contributes to accumulating evidence that caloric restriction acts by altering hormone levels rather than by directly starving cancers of energy," Dr. Michael Pollak, a professor of oncology at McGill University in Montreal, wrote in an accompanying editorial. "In particular, lower levels of insulin are associated with reduced food intake, and this may be protective," he said. (Xinhuanet, China)
The way you eat may affect your risk for breast cancer Aug 4, 2009
In an accompanying editorial also published in Cancer Prevention Research, Michael Pollak, M.D., stated that some major challenges of pharmacologic approaches to cancer prevention and/or treatment include defining the underlying causes and determining the relevance of these caloric restriction methods ... This study "contributes to accumulating evidence that caloric restriction acts by altering hormone levels rather than by directly starving cancers of energy. In particular, lower levels of... (EurekAlert!)
New Doubts About Fasting Leading To Longer Lives Based On Study In Flies Jul 16, 2009
Many studies indicate that caloric restriction extends life spans in fruit flies, mice and, most recently, rhesus monkeys, apparently by slowing the aging process ... Working with fruit flies, Schneider and his graduate student Janelle Ayres have shown that caloric restriction can indeed alter the flies' response to infection, but in different directions depending on what they've been infected with ... In addition, to make sure that what they saw was really because of reduced caloric intake and... (Science Daily)
Monkeys live longer on low-cal diet; would humans? Jul 12, 2009
The tantalizing possibilities of caloric restriction date back to rodent studies in the 1930s ... All these pieces put together provide rather convincing evidence in our view that caloric restriction can slow the aging process in a primate species, said lead researcher Dr. Richard Weindruch, a University of Wisconsin-Madison professor heading the NIA-funded study. (Chippewa Falls Chippewa Herald, WI)
Newsweek: Eat lesslive longer? Jul 11, 2009
Caloric Restriction May Extend Lives ... For years there has been evidence that a diet extremely low in calories extends the life span of species from mice to monkeys (and a recent study confirms positive results for humans on this type of diet too), and the more we learn about caloric restriction, the more it appears to be something of a medical marvel: this week, a study in the journal Science shows that monkeys on a 20-year calorie-restricted diet not only lived longer, but had younger brains... (MSNBC -- Health)
A fountain of primate youth? Jul 11, 2009
The tantalizing possibilities of caloric restriction date back to rodent studies in the 1930s. But it's a hot topic today among researchers trying to understand the different processes that make our bodies break down with age. (Albany Times Union)
Low-calorie diet slows aging in monkeys: Study Jul 11, 2009
It suggests that caloric restriction could also delay aging in humans ... "We have been able to show that caloric restriction can slow the aging process in a primate species," Richard Weindruch of the University of Wisconsin in Madison, who led the study, said in a statement ... "We observed that caloric restriction reduced the risk of developing an age-related disease by a factor of three and increased survival," Weindruch said. (Xinhuanet, China)
Lighter Meals May Bring Longer Life Jul 11, 2009
"The big question in aging research is, 'Will caloric restriction in species closely related to humans slow aging?'" said Richard Weindruch, senior author of a paper appearing in the July 10 issue of Science. "This is the first clear demonstration that, in a primate species, we're inducing a slowdown of the aging process -- showing increased survival, resistance to disease, less brain atrophy and less muscle loss. "This predicts humans would respond similarly," added Weindruch, professor of... (MEDLINEplus)
Ultra low calorie diet ups life Jul 11, 2009
"It suggests to me that the fundamental biology of caloric restriction being studied in mice, flies, worms, blah, blah, blah seems to apply nicely to primates," team leader Richard Weindruch of University of Wisconsin in Madison said. Text. (India Times, India)
Of mice and monkeys Jul 10, 2009
Caloric restriction, as the dietary method is properly known, was tested by and his team at the University of Wisconsin using rhesus monkeys the workhorses (to mix literal and metaphorical livestock) of laboratory studies on non-human primates. Previously, the nearest species to a human for which caloric restriction had been proved to work was a mouse ... An apparent win, then, for caloric restriction though it will not be possible to say for sure until all members of both groups have died and... (The Economist)
Study of fellow primatesstirs health hope for humans Jul 10, 2009
For years, we ve been asking the question: Will caloric restriction slow the aging process in monkeys. Now we think that we have accumulated solid data to say yes, it will, said Richard Weindruch, a professor of medicine at the University of Wisconsin at Madison and senior author of the paper. (Boston Globe)
Reduced Diet Thwarts Aging, Disease In Monkeys Jul 10, 2009
"We have been able to show that caloric restriction can slow the aging process in a primate species," says Richard Weindruch, a professor of medicine in the UW-Madison School of Medicine and Public Health who leads the National Institute on Aging-funded study. "We observed that caloric restriction reduced the risk of developing an age-related disease by a factor of three and increased survival." ... "There is a major effect of caloric restriction in increasing survival if you look at deaths due... (Science Daily)
Obese or not, you may want to eat less Jul 10, 2009
Evidence has been mounting that caloric restriction - essentially, a permanent diet - greatly reduces the risk of age-related diseases and even postpones death ... Now, in a study funded by the National Institutes of Health and released today, many of the same benefits have been demonstrated in primates, the best evidence yet that caloric restriction could help people ... The study comes as some validation to the cadre of Americans who profess to practice caloric restriction in their daily... (AZCentral -- News)
Key To Evolutionary Fitness: Cut The Calories Jul 3, 2009
ScienceDaily (July 2, 2009) Charles Darwin and his contemporaries postulated that food consumption in birds and mammals was limited by resource levels, that is, animals would eat as much as they could while food was plentiful and produce as many offspring as this would allow them to. However, recent research has shown that, even when food is abundant, energy intake reaches a limit, even in animals with high nutrient demands, such as lactating females. (Science Daily)
Why Low-Calorie Diet Extends Lifespans Jun 28, 2009
"Overexpression of UBC-18 was not enough to extend the lifespan of worms but depleting it negated the effects of caloric restriction," says Carrano, who is busy looking for potential substrates of the UBC-18-WWP-1 ubiquitination complex. "The WWP-1 pathway is highly conserved between worms and mammals and could play a role in the human aging process," says senior author Tony Hunter, Ph. (Science Daily)
Test Detects Molecular Marker Of Aging In Humans Jun 18, 2009
Sharpless said that the researchers were surprised by some of their findings, "We found a very weak correlation between the biomarker and obesity as measured by body mass index (BMI) despite other data suggesting that caloric restriction slows aging. The data suggest the possibility that reduced exercise may actually be worse with regard to molecular age than a higher BMI.". "Although we don't know whether this test is a good reflection of cellular age in all types of human tissues, we believe... (Science Daily)
'Shortcuts' Of The Mind Lead To Miscalculations Of Weight And Caloric Intake, Study Finds Jun 17, 2009
26, 2009) Caloric restriction only benefits obese mice, according to a new study in the Journal of Nutrition. The results suggest that caloric restriction may not be a universally beneficial anti-aging. (Science Daily)
Oxidative stress extends lifespan May 30, 2009
"It may be that adaptation to oxidative stress is the main factor responsible for the lifespan-expanding effects of caloric restriction," said Ideker. "Our next step is to figure out how Mga2 works to create a separate pathway, to discover the up 00004000 stream mechanism that senses low doses of oxidation and triggers a protective mechanism downstream.". (India Times, India -- Health/Science)
How Oxidative Stress May Help Prolong Life May 30, 2009
This is counter to the hypothesis that caloric restriction extends lifespan in some species because it reduces ROS produced as a by-product of the energy regenerated by mitochondria. "It may be that adaption to oxidative stress is the main factor responsible for the lifespan-expanding effects of caloric restriction," said Ideker. (Science Daily)
Red Wine A Weapon In Battle Of The Bulge May 25, 2009
So the next step, they thought, was to see if the substance could mimic the effects of caloric restriction in human fat cells by changing them ... She says that not enough is known about caloric restriction ... Caloric restriction reduces body fat, which has multiple benefits, she says. (CBS News -- 60 minutes)
Glucose-To-Glycerol Conversion In Long-lived Yeast Provides Anti-aging Effects May 14, 2009
ScienceDaily (May 13, 2009) Cell biologists have found a more filling substitute for caloric restriction in extending the life span of simple organisms ... Many studies have shown that caloric restriction can extend the life span of a variety of laboratory animals ... Caloric restriction is also known to cause major improvements in a number of markers for cardiovascular diseases in humans. (Science Daily)
Resveratrol draws interest as a potential anti-aging substance Mar 23, 2009
The caloric restriction appeared to stimulate sirtuin activity. So scientists have focused on finding a substance, such as resveratrol, that could trigger this same effect in humans - without the famine-like diet. (Boston Globe)
Cancer Prevention Through Foods Mar 17, 2009
Additionally, exercise and caloric restriction may reduce cancer risk. Reduction of Chronic Inflammation the Key to Cancer Prevention. (Suite101.com)
Hildreth: Looking at our weight challenge Mar 14, 2009
Caloric restriction diets and low-carbohydrate diets have dominated for years because they induce quick weight loss. Unfortunately, they do not cause significant fat loss. (Green Valley News & Sun, AZ)
Does Eating Fewer Calories Improve the Brain? Mar 4, 2009
Although the links between caloric restriction and longevity are still not fully proven in humans, short-term human trials have clearly shown that CR can improve many vital surrogate health markers, such as body weight, blood pressure, blood sugar and insulin levels, blood and triglyceride levels, and measures of inflammation. High insulin levels and inflammation have both been linked to cognitive problems. (Scientific American)
Anti-aging pathway enhances cell stress response Feb 20, 2009
The researchers discovered a new molecular relationship critical to keeping cells healthy across a long span of time: a protein called SIRT1, important for caloric restriction and lifespan and activated by resveratrol, regulates heat shock factor 1 (HSF1), keeping it active. HSF1 in turn senses the presence of damaged proteins in the cell and elevates the expression of molecular chaperones to keep a cell's proteins in a folded, functional state. (EurekAlert!)
Simplicity and memory Feb 18, 2009
This is the first study that has shown that caloric restriction might be beneficial for memory function in elderly humans, Floel said. An estimated 24 million people worldwide have memory loss, problems with orientation and other symptoms that signal Alzheimers disease and other forms of dementia. (The Star Online, Malaysia)
Losing Weight Can Cure Obstructive Sleep Apnea Feb 8, 2009
This appears to be a fairly straightforward relationship, and while we would not necessarily recommend the severe caloric restriction used in our study to every patient, one of the first treatment for OSA that should be considered in the overweight patient is clearly weight loss, said Dr. Tuomilehto. A more aggressive treatment of obesity in patients with OSA is well-founded. (Newsmax)
Losing weight can cure obstructive sleep apnea in overweight patients Feb 7, 2009
"This appears to be a fairly straightforward relationship, and while we would not necessarily recommend the severe caloric restriction used in our study to every patient, one of the first treatment for OSA that should be considered in the overweight patient is clearly weight loss," said Dr. Tuomilehto. "A more aggressive treatment of obesity in patients with OSA is well-founded. Lifestyle intervention with an early VLCD is a feasible, low-cost, and curative treatment for the vast majority of... (EurekAlert!)
