Prospective study of daily low-dose nedaplatin and continuous 5-fluorouracil infusion combined with radiation for the treatment of esophageal squamous cell carcinoma Nov 22, 2009
8% of the cases, thrombocytopenia in 24. 2%, anemia in 9. (BioMed Central)
Prednisone and Prednisolone in Dogs... Nov 21, 2009
The immunosuppressive nature of these drugs is used to treat conditions such as pemphigus, systemic lupus, autoimmune hemolytic anemia, thrombocytopenia, certain forms of cancer and several other diseases. Glucocorticoid or Steroid Usages for Prednisone and Prednisolone. (Suite101.com)
Atypical Hemolytic–Uremic Syndrome Oct 22, 2009
NEJM -- Atypical Hemolytic-Uremic Syndrome. Volume 361:1676-1687. (New England Journal of Medicine)
Askwig Sidelined by Heart Condition Oct 9, 2009
The Bengals are no stranger to life-threatening conditions as the team was affected in head coach Gibson's first season with Idaho State in 2006 when was diagnosed with Thrombocytopenia, a rare occurrence of relatively few platelets in the blood. It is a serious condition as platelets lead to the formation of blood clots. (Isubengals.com)
NIH ups ClevelandBioLabs research Sep 23, 2009
Currently, there is no approved therapeutic drug in the national stockpile for such radiation-induced complications as thrombocytopenia, a disorder resulting in not enough platelets, which help blood clot. The company has received patent protection on a method of using the compound to treat radiation exposure in animals. (Buffalo Business First, NY)
18 month Follow-up Data on Phase III Study of Pixantrone in Late Stage Relapsed or Refractory, Aggressive Non-Hodgkin's Lymphoma Continues to Demonstrate Significant Improvement in Complete Remission and Progression Free Survival Over Standard Chemotherapy Sep 16, 2009
The most common (incidence greater than or equal to 20%) adverse reactions reported for pixantrone-treated subjects were neutropenia, infection, anemia, leucopenia, thrombocytopenia, asthenia, pyrexia, and cough. Pixantrone has been accepted for standard review by the Food & Drug Administration (FDA), with fast track status with a Prescription Drug User Fee Act (PDUFA) date of April 23, 2010. (PR Newswire)
Fewer injection site reactions in patients using Avonex Sep 12, 2009
Decreased peripheral blood counts in all cell lines, including rare pancytopenia and thrombocytopenia, have been reported from post-marketing experience. Severe hepatic injury, including cases of hepatic failure, has been reported rarely in patients taking AVONEX. Patients should be monitored for signs of hepatic injury and caution exercised when AVONEX is used concomitantly with other drugs associated with hepatic injury. (EurekAlert!)
Shire Completes Submission of NDA for Velaglucerase Alfa for Type 1 Gaucher Disease and Reports Positive Results for Remaining Two Phase III Trials Sep 1, 2009
Patients were eligible to participate in the study if they presented with disease-related anemia and had at least one of the following clinical manifestations of Gaucher disease: thrombocytopenia, moderate splenomegaly or a readily palpable enlarged liver ... Deposits in the bone marrow and splenic sequestration lead to clinically significant anemia and thrombocytopenia. (PR Newswire)
Shire Reports Positive Results From First of Three Phase III Trials of velaglucerase alfa for Type 1 Gaucher Disease and Provides Important Updates on Interactions With FDA Aug 3, 2009
Patients aged two years and older who were treatment naive were eligible to participate in the study if they presented with disease-related anemia and had at least one of the following clinical manifestations of Gaucher disease: thrombocytopenia, moderate splenomegaly or a readily palpable enlarged liver. Patients were randomized to receive velaglucerase alfa at either 45 U/ kg or 60 U/ kg for a duration of 12 months. (PR Newswire)
Dr. Kim-Chi Vu in Portland Selects Artefill to Meet Growing Patient Demand for a Longer Lasting Dermal Filler Jul 25, 2009
During her residency, Dr. Vu was involved in several research projects, including the heparin effect on thrombocytopenia, bioresorbable ribs stabilization in rib fractures, and a clinical study on composite grafting for correction of bilateral cleft nasal deformity. For more information visit. (PR Newswire)
R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent Jul 24, 2009
Rigel has product development programs in inflammatory/autoimmune diseases such as rheumatoid arthritis, thrombocytopenia and asthma, as well as in cancer. This press release contains "forward-looking" statements, including statements related to the potential efficacy and commercial potential of R788 and Rigel's plans to pursue further clinical development thereof and a corporate partnership. (PR Newswire)
Thrombomodulin Mutations in Atypical Hemolytic–Uremic Syndrome Jul 23, 2009
Background The hemolytic uremic syndrome consists of the triad of microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. The common form of the syndrome is triggered by infection with Shiga toxin producing bacteria and has a favorable outcome. (New England Journal of Medicine)
Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer Jul 16, 2009
In patients with multiple myeloma, the most common all-grade ARs greater than 20 percent (VELCADE plus DOXIL vs VELCADE, respectively) included: neutropenia (36 percent vs 22 percent), thrombocytopenia (33 percent vs 28 percent), anemia (25 percent vs 21 percent), fatigue (36 percent vs 28 percent), pyrexia (31 percent vs 22 percent), asthenia (22 percent vs 18 percent), nausea (48 percent vs 40 percent), diarrhea (46 percent vs 39 percent), vomiting (32 percent vs 22 percent), constipation (31... (PR Newswire)
Poly(ADP-Ribose) Polymerase Inhibitor in BRCA-Related Cancer Jul 9, 2009
Reversible dose-limiting toxicity was seen in one of eight patients receiving 400 mg twice daily (grade 3 mood alteration and fatigue) and two of five patients receiving 600 mg twice daily (grade 4 thrombocytopenia and grade 3 somnolence). This led us to enroll another cohort, consisting only of carriers of a BRCA1 or BRCA2 mutation, to receive olaparib at a dose of 200 mg twice daily. (New England Journal of Medicine)
Rigel to Host Conference Call to Discuss Results of Its Phase 2b TASKi2 Clinical Trial of R788 in Rheumatoid Arthritis Jul 9, 2009
Rigel has product development programs in inflammatory/autoimmune diseases such as rheumatoid arthritis, thrombocytopenia and asthma, as well as in cancer. Contact: Raul Rodriguez Phone: 650. (PR Newswire)
Four Miami-Area Residents Sentenced In $10 Million Medicare Fraud Scheme Jun 6, 2009
All four defendants had admitted to working at Midway Medical Center Inc. (Midway), a Miami clinic that purported to specialize in the treatment of patients with HIV. According to plea documents, most of the services allegedly provided to patients at Midway were billed to the Medicare program as treatments for a diagnosis of thrombocytopenia, a disorder involving a low count of platelets in the blood. None of Midway's patients actually had low blood platelet counts. (PR Newswire)
Study Showed Lilly's GEMZAR(R) (gemcitabine HCl for injection) Improved Progression-Free Survival in Cervical Cancer Patients Jun 1, 2009
Most side effects were hematologic, including anemia (low red blood cell count), neutropenia (low white blood cell count) and thrombocytopenia (low blood platelet count). "While there have been tremendous advances in cervical cancer prevention in the form of early screening and vaccination, oncologists have essentially been using the same treatment standard for the last decade," said study lead author Alfonso Duenas-Gonzalez, M.D., Ph. (PR Newswire)
Investigational Cancer Drug BSI-201 Showed Clinical Benefit in 62% of Patients With Triple-Negative Metastatic Breast Cancer and Significantly Prolonged Survival Jun 1, 2009
The most common severe (grades 3 and 4) side effects included neutropenia [25/57 in patients treated with GC and BSI-201; 31/59 patients treated with GC alone], thrombocytopenia and anemia. No febrile neutropenia was observed in patients receiving BSI-201 combined with chemotherapy. (Primezone Releases)
Threshold Pharmaceuticals Presents Encouraging Data From Clinical Trials of TH-302 for Solid Tumors May 31, 2009
Hematologic toxicity has been minimal with grade 2 neutropenia reported in two patients, grade 2 thrombocytopenia reported in one patient, and worsening anemia and lymphopenia in 14 (45%) and 20 (65%) patients, respectively. In the expansion phase of the trial, which includes weekly doses of TH-302 at the MTD of 575 mg/m2 the drug continues to be tolerated. (Primezone Releases)
Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting May 29, 2009
In patients with AIDS related Kaposi's sarcoma, ARs reported in greater than or equal to 5% of DOXIL-treated patients were: neutropenia (ANC <1000/mm3, 46%; <500/mm3, 11%), anemia (Hb <10 g/dL, 58%; <8 g/dL, 16%), thrombocytopenia (<150,000 platelets/mm3, 61%), nausea (18%), asthenia (7%), fever (8%), alopecia (9%), vomiting (8%), diarrhea (5%), and stomatitis (5%). Please see accompanying full Prescribing Information, including Boxed WARNINGS.. (PR Newswire)
Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types May 28, 2009
6%-48%), anemia (1%-42%), thrombocytopenia (<1%-33%), and hepatotoxicity (approx 5%)--and severe adverse experiences (NCI Grades 3/4), including severe fluid retention (e ... For DFSP, severe (NCI Grades 3/4) lab abnormalities included anemia (17%), thrombocytopenia (17%), neutropenia (8%), and increased creatinine (8%) ... In GIST, severe (NCI Grades 3/4) lab abnormalities (400 mg/day; 600 mg/day)--including neutropenia (10%; 11%), anemia (3%; 9%), thrombocytopenia (0%; 1%), and hepatotoxicity... (PR Newswire)
UCB's CIMZIA(R) (certolizumab pegol) Approved by the U.S. FDA for Adult Patients Suffering From Moderate to Severe Rheumatoid Arthritis May 14, 2009
g., leukopenia, pancytopenia, thrombocytopenia) has been infrequently reported with CIMZIA. The causal relationship of these events to CIMZIA remains unclear. Advise all patients to seek immediate medical attention if they develop signs and symptoms suggestive of blood dyscrasias or infection (e. (PR Newswire)
STIM1 Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity May 7, 2009
We report on three siblings from one kindred with a clinical syndrome of immunodeficiency, hepatosplenomegaly, autoimmune hemolytic anemia, thrombocytopenia, muscular hypotonia, and defective enamel dentition. Two of these patients have a homozygous nonsense mutation in STIM1 that abrogates expression of STIM1 and Ca2+ influx. (New England Journal of Medicine)
New, Highly Effective Treatment For Blood Disorder Mar 27, 2009
Promacta (eltrombopag) was granted accelerated approval by the U.S. Food and Drug Administration in November 2008 for the treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura who have had an insufficient response to corticosteroids, immunoglobulins or splenectomy ... Ongoing and future studies will evaluate the safety and efficacy of eltrombopag as a long-term treatment for ITP, and its efficacy and safety in populations like the 4 million... (Science Daily)
Miami Doctor and Chemist Plead Guilty in HIV Infusion Fraud Scheme Mar 27, 2009
Most of the services allegedly provided to patients at Midway were billed to the Medicare program as treatments for a diagnosis of thrombocytopenia, a disorder involving a low count of platelets in the blood ... In her plea, Del Cueto admitted to ordering that patients at Midway receive medications to treat thrombocytopenia despite knowing that the laboratory results had been falsified and the patients did not actually have any such condition. (PR Newswire)
3SBio Inc. Announces Unaudited Fourth Quarter and Fiscal Year 2008 Results Mar 12, 2009
-- TPIAO, the Company's protein-based therapeutic recombinant human thrombopoietin ("TPO") products, continued their rapid uptake trend and are increasingly adopted as the standard of care for Chemo Induced Thrombocytopenia. TPIAO net revenue increased 39. (PR Newswire)
IMPACT Study Demonstrates That Longer Prophylactic Therapy With Valcyte(R) (Valganciclovir Hydrochloride Tablets) Increases Protection Against CMV - the Most Serious Viral Infection Affecting Transplant Patients Feb 14, 2009
The clinical toxicity of Valcyte, which is metabolized to ganciclovir, includes granulocytopenia, anemia, and thrombocytopenia ... Valcyte tablets should not be administered if the absolute neutrophil count is less than 500 cells/micro liter, the platelet count is less than 25,000/micro liter, or the hemoglobin is less than 8 g/dL. Severe leucopenia, neutropenia, anemia, thrombocytopenia, pancytopenia, bone morrow depression, and aplastic anemia have been observed in patients treated with... (PR Newswire)
$15M Lawsuit claims Baseball pro had sex -- knowing he had AIDS... Feb 12, 2009
" Alomar's father, Mets bench coach , said the claims were news to him. "That's the first time we ever heard of that," he said from . He didn't think his son could keep a serious illness secret. "I imagine I would know," he said. Dall, a mother of two who has run a massage spa in , would not discuss the suit. "I have no comment," she said outside her lavish home in , after getting out of a black . She referred inquiries to her lawyer, , who declined to comment. The suit was filed Jan. 30 in .... (The Drudge Report)
Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Feb 7, 2009
Chronic ITP is a serious autoimmune disorder characterised by low platelet counts in the blood (thrombocytopenia), which can lead to serious bleeding events ... Nplate is the first treatment specifically developed for ITP. It is also being investigated for potential use in paediatric ITP, myelodysplastic syndromes (MDS) and chemotherapy-induced thrombocytopenia (CIT) ... Reoccurrence of thrombocytopenia and bleeding after cessation of treatment and increased bone marrow reticulin have been... (PR Newswire)
