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    News, Reviews, and Articles on Resistance

    Archives: Resistance

    Gene That Regulates Mold's Resistance To Drugs Identified  Nov 21, 2008
    20, 2008) Montana State University scientists concerned about lethal mold infections have found a gene that regulates the mold's resistance to drugs ... 18, 2005) Those infected with HIV in the UK have one of the highest rates of resistance to anti-HIV drugs of anywhere in the world, prompting fears of a second wave epidemic of resistant virus, a new study ... New flu tests can diagnose the flu in as little as 30 minutes, to cut down on needless antibiotic use, which can build up resistance and... (Science Daily)

    Long-term antibiotics reduce COPD exacerbations, raise questions  Nov 21, 2008
    Furthermore, the threat of growing antibiotic resistance resulting from widespread prophylactic use of erythromycin is not a trivial concern. "In this scenario, substantial, widespread emergence of macrolide bacterial resistance is virtually foreordained, with attendant reduction in the antimicrobial usefulness of this drug class," wrote Ken M. Kunisaki, M.D. and Denise E. Niewoehner, M.D., of the Veterans Affairs Medical Center in Minneapolis, in the accompanying editorial ... "The relative... (EurekAlert!)

    FDA Panel Splits on Pair of Antibiotics  Nov 20, 2008
    While vancomycin is still the standard of care for life-threatening infections, some bacteria have recently developed resistance to it. Acknowledging the need for new bacteria-fighting options, the FDA panel backed Theravance's treatment, despite some evidence of birth defects from animal studies. (ABC News -- Wire)

    Antibiotics Can Cause Pervasive, Persistent Changes To Microbiota In Human Gut  Nov 20, 2008
    Up to 100 trillion microbial cells reside in the gut, and this community plays essential roles in nutrition, development, metabolism, pathogen resistance, and regulation of immune responses ... (June 20, 2007) E. coli bacteria that have developed resistance to antibiotics will probably still be around even if we stop using antibiotics, as these strains have the same good chance as other bacteria of ... New flu tests can diagnose the flu in as little as 30 minutes, to cut down on needless... (Science Daily)

    Battling Bacteria In The Blood: Mathematical Models Help In Tackling Deadly Infections  Nov 20, 2008
    "We're also working on ways to fundamentally change the rules of engagement between the bacteria and the host. There are mechanical features at play in terms of getting these bacteria in flowing blood out. If we can change the mechanics of that interaction, then we can potentially have a therapy that the bacteria don't really have an opportunity to defend against or develop resistance against. And that could be a useful therapy.". The research is funded by the National Institutes of Health and... (Science Daily)

    Superbug found in grocery meats  Nov 19, 2008
    But overuse of antibiotics has allowed the germ to develop resistance in recent years, doctors said, creating the toxic new type that stumps traditional treatment. About 80 percent of C. difficile infections now occur in hospital or health care settings and the number of infections is rising. (MSNBC -- Health)

    Preventing Super Bug Infections  Nov 19, 2008
    (ARA) - Each year more than a million patients in the United States develop infections caused by deadly super bugs that have developed resistance to the antibiotics normally used to treat them. The sources of these life-threatening super bug infections are from both hospitals and outpatient facilities. (Canton Daily Ledger, IL)

    Warning as infections fight back  Nov 18, 2008
    The report was put together by the National Public Health Service for Wales' (NPHS) Antimicrobial Resistance Programme and covers the period 2006-7 ... However, he added that a group set up to look at the issue of antibiotic resistance felt patients needed more information so they could understand when antibiotics were effective or not ... " "The research that's been published does show that there's an increasing amount of resistance to more common antibiotics which is quite worrying. (BBC News -- UK)

    Pupils targeted in superbug fight  Nov 18, 2008
    Dr Cliodna McNulty, the HPA official who led the development of e-Bug, said: "Antibiotic resistance is a problem for all of us and the public has an important role to play in controlling its emergence and spread. "Public campaigns so far have been aimed at adults who are gatekeepers to antibiotic use in our children, but we need to educate our future generation of adults and parents about the benefits of antibiotics and the problems that can arise through their misuse. Antibiotic resistance has... (BBC News -- Health)

    Acinetobacter is emerging hospital superbug: study  Nov 18, 2008
    Nearly a third of cases involving infection by A. baumannii have shown resistance to frontline antibiotics, it said, citing research data ... Long regarded as the "agents of choice," a category of treatment called carbapenems has shown much higher rates of resistance in recent years. (Yahoo News -- Top Stories)

    Theravance antibiotic may get warning  Nov 18, 2008
    The once-a-day injectable antibiotic from the South San Francisco company (NASDAQ: THRX) could prove to be an important weapon in hospitals attempts to fight staph and other skin infections that have been able to build up resistance to traditional antibiotics. A report from an FDA reviewer on Monday also said nine deaths in the company s studies of telavancin were possibly related to the drug. (San Jose Business Journal, CA)

    Biomedical engineers' detective work reveals antibiotic mechanism  Nov 18, 2008
    " said Jeremy M. Berg, director of the National Institutes of General Medical Sciences. Previously, Collins, Boston University doctoral candidate Michael Kohanski, and colleagues found a common mechanism of cell death in bacteria. They reported that several different classes of antibiotics all had this same underlying pathway that caused over-production of hydroxyl radical molecules which contributed to bacterial cell death. The group's new research focused on finding the trigger that set the... (EurekAlert!)

    Wash your hands of the cold and flu this season  Nov 17, 2008
    In fact, the antibacterial soaps may contribute to the growing problem of antibiotic resistance. Balsam also noted that with the increased incidence of diseases such drug-resistant staph infection, simple hand washing is a very effective strategy to avoid the spread of germs. (Brookline TAB, MA)

    Antibiotic Use Increases At Academic Medical Centers  Nov 13, 2008
    "Many professional societies and national agencies have recommended monitoring antibacterial use and linking patterns of use to resistance," the authors write ... (June 8, 2008) Researchers have identified a novel factor that promotes the development of antibiotic resistance in a bacterial pathogen ... New flu tests can diagnose the flu in as little as 30 minutes, to cut down on needless antibiotic use, which can build up resistance and make some. (Science Daily)

    New Path Found To Antibiotics In Dirt  Nov 12, 2008
    Some of the meaner strains of Staphylococcus and other infections, including tuberculosis, have developed resistance to traditional antibiotics after decades of exposure to them ... 24, 2006) Dirt may be a key to how bacteria that infect humans develop a resistance to antibiotic drugs ... Now researchers have a new tool to address the growing problem of antibiotic resistance. (Science Daily)

    Forced Evolution: Can We Mutate Viruses To Death?  Nov 12, 2008
    Forced Evolution: Can We Mutate Viruses To Death. Forced Evolution: Can We Mutate Viruses To Death. (Science Daily)

    5 things you didn’t know about ... MRSA superbug  Nov 12, 2008
    Resistance: When penicillin was discovered in the 1940s, virtually all strains of S. aureus were vulnerable to this new antibiotic. But within a decade, bacterial mutants that could resist penicillin began to emerge. (La Crosse Tribune, WI)

    Hospitals use more antibiotics despite concerns  Nov 11, 2008
    WASHINGTON - Use of antibiotics at U.S. hospitals is rising despite concerns about fueling bacterial resistance, with Wyeth's Zosyn and the older drug vancomycin driving the trend, researchers said ... "We know from past experience that when we start using any antimicrobial drug excessively, that resistance to that drug eventually appears," Polk said in a telephone interview ... Resistance to drugs can render them useless. (MSNBC -- Health)

    Nanoparticles Research Aids Drug Development  Nov 11, 2008
    This increases the possibility of bacteria and other organisms mutating as the high doses make it easier for them to build resistance to the drugs ... Professor Steve Rannard, from the Department of Chemistry who is also co-founder and current Chief Scientific Officer of IOTA NanoSolutions, said: Already our technology has shown the potential to improve a range of current medicines and may lead to treatments that prevent drug resistance. (Science Daily)

    Rice students hope BioBeer can fight disease  Nov 8, 2008
    (Rice's entry, which didn't win, was a bacterial virus that fought antibiotic resistance. . (USA Today -- Tech)

    BETTER LIFE: Smokers more addicted now than in '80s, '90s  Nov 7, 2008
    Addiction - Better Life - USATODAY.com. Study: Smokers more addicted now than in '80s, '90s. (USA Today -- Life)

    Molecule Stops DNA Replication In Its Tracks  Nov 7, 2008
    Polymerase IV, for example, forms additional contacts to the clamp outside of the peptide-binding site, which may account for its resistance to disruption by RU7. The role of polymerase III in replication has been very well studied, but the roles of the other polymerases are not well understood, says O Donnell. (Science Daily)

    Clue Discovered In Spread Of 'Superbugs'  Nov 6, 2008
    D., have obtained the first visual evidence of a key piece in the puzzle of how deadly superbugs spread antibiotic resistance in hospitals and throughout the general population. These superbugs have become increasingly common since the widespread use of antibiotics began and they are now a serious public health menace, said Silverman, who holds the Marjorie Nichlos Chair in Medical Research at OMRF. Now, for the first time, we can begin to see, literally, how they acquire and disseminate... (Science Daily)

    Local Retail Meat Safe From Antibiotic-resistant Organisms, Study Suggests  Nov 1, 2008
    (July 5, 2005) A paper published in the open access journal PLoS Medicine discusses evidence suggesting that antibiotic use in agriculture has contributed to antibiotic resistance in the pathogenic bacteria ... 17, 2006) Antibiotic use as a livestock growth promoter increases the risk of human antibiotic resistance, a Marshfield Clinic researcher and his colleagues have found ... New flu tests can diagnose the flu in as little as 30 minutes, to cut down on needless antibiotic use, which can... (Science Daily)

    Statins Associated With Lower Risk Of Death From Pneumonia  Oct 30, 2008
    "However, because statins target the host, drug resistance, a major problem in treating bacterial infections, is not likely to develop. Thus, it may be useful to consider clinical research testing of combinations of statins with existing antibiotic agents to evaluate whether it is possible to develop optimized combination therapies effective against both acute and persistent infections.". This editorial was supported by a Department of Veterans Affairs Merit Award, Great Lakes Research Center of... (Science Daily)

    Blinking Clock Made In Live Bacteria  Oct 30, 2008
    21, 2005) Bacteria feel pressures to evolve antibiotic resistance and other new abilities in response to a changing environment, and they react by 'stealing' genetic information from other better-adapted types. (Sep. (Science Daily)

    Antibiotic may plug up Montezumas Revenge  Oct 29, 2008
    DuPont noted that several drugs are available to treat traveler's diarrhea, but they either do not affect such a wide range of bacteria, the bacteria has evolved resistance to the drugs, or people do not take the pills properly. Comparable drugs include ciprofloxacin, doxycyclene and ampicillin, but prulifloxacin only needs to be taken once a day for three days. (MSNBC -- Health)

    New Antibiotic Target And Antibiotic Mechanism Identified; Discoveries Hold Promise For Drug-Resistant Tuberculosis  Oct 28, 2008
    The three antibiotics exhibit potent activity against a broad spectrum of bacterial species, including the bacterium that causes TB, and exhibit no cross resistance with current antibacterial agents ... Also, resistance to rifamycins occurs frequently, due to mutations that alter their binding site on RNAP. ... "As a result, these antibiotics can function simultaneously with rifamycins and can be co-administered with rifamycins for more rapid clearance of infection. As a further result, these... (Science Daily)

    Preventing Deaths in Africa by Improving Antibiotic Access and Effectiveness  Oct 27, 2008
    This project was announced in conjunction with a colloquium at the annual ICAAC/IDSA meeting warning of increasing antibiotic resistance ... APUA will work with local field staff in Zambia and Uganda to map antibiotic supply and distribution channels, detect counterfeit drugs and measure laboratory capacity to monitor antibiotic resistance ... It will also document the prevalence and costs of drug resistance. (PR Newswire)

    Paratek Reports Positive Phase 2 Clinical Data on its New Antibiotic PTK 0796 in Late Breaker Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy  Oct 27, 2008
    Dr. Stuart Levy, Co-founder and Chief Scientific Officer of Paratek Pharmaceuticals, stated, "New antibiotics are critically needed as multi-drug resistance grows at alarming rates in both the hospital and community settings. The Phase 2 results for Paratek's PTK 0796 are highly encouraging, particularly in context with previous findings showing activity of PTK 0796 against a broad spectrum of drug resistant bacteria, including MRSA. Overall, the Phase 2 data indicate a convincing safety profile... (PR Newswire)

    Rib-X Pharmaceuticals Reports Positive Phase 2 Study Results for Next Generation Oxazolidinone at 2008 ICAAC/IDSA Joint Meeting  Oct 27, 2008
    "In particular, radezolid offers a broader spectrum that includes atypicals and Haemophilus influenzae and a once-a-day option at a significantly lower dose than linezolid. Additionally, these results further validate Rib-X's proprietary discovery and development approach which led to the identification of this compound as well as multiple other novel compounds in various classes which are able to circumvent bacterial resistance mechanisms." Study Results The poster, entitled "A Phase 2 Study... (PR Newswire)

    Pivotal Phase III Data Confirm the Efficacy and Safety of Arpida's Intravenous Iclaprim in Treating Patients With Complicated Skin and Skin Structure Infections  Oct 27, 2008
    (iii,iv) The most common antibiotic used to treat MRSA infections is vancomycin, but recent evidence suggests resistance to vancomycin is on the rise ... Arpida has a fully integrated platform for the discovery and development of drug candidates to address the increasing prevalence of resistance of bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), to existing antibiotic therapies. (PR Newswire)

    Trial antibiotics help against "superbug"  Oct 27, 2008
    The usual treatment, Pfizer Inc's Zyvox, has side effects and MRSA bacteria are already beginning to elude its effects by developing what is known as resistance ... quickly evolve resistance and adapt most quickly to drugs that are in similar classes to drugs already in use. (Scientific American)

    Placebos and the doctor-patient relationship  Oct 27, 2008
    The harm comes when antibiotics are dispensed needlessly, heightening the risk that bacteria will develop antibiotic resistance, one of the most dangerous medical phenomenon of our time. Or when patients are given sedatives -- drugs that can have serious side-effects -- only because the doctor wants to give something. (Chicago Tribune)

    Study Shows How Antibiotic Sets Up Road Block To Kill Bacteria  Oct 26, 2008
    25, 2008) Scientists have taken a critical step toward the development of new and more effective antibacterial drugs by identifying exactly how a specific antibiotic sets up a road block that halts bacterial growth. The antibiotic, myxopyronin, is a natural substance that is made by bacteria to fend off other bacteria. (Science Daily)

    Acinetobacter Emerging Bacterial ...  Oct 24, 2008
    Some microbiologists have suggested that analyses of resistance patterns in A. baumanni have indicate that antibiotic treatment options are closer to exhaustion than even for MRSA strains of Staphylococcus aureus ... New antibiotics should attack multiple targets on the pathogen to avoid development of resistance ... Strict enforcement of comprehensive and deep cleansing in hospitals and other clinical establishments to prevent infections and the development of resistance. (Suite101.com)

    Unique Properties Of Boron Harnessed To Develop New Drugs And Diagnostics  Oct 24, 2008
    The fact that novel boron compounds will be unfamiliar to life has potential advantages for antibiotic drugs, since pathogens will be less able to develop resistance against them ... "We can thus anticipate that active substances would be less prone to development of resistance," said Lesnikowski ... While eventually pathogens such as bacteria and viruses are capable of evolving resistance against almost any molecule that attacks them, Lesnikowski believed that it would take longer for this to... (Science Daily)

    Novexel Reports Positive Phase II Trial Results With NXL103 in Adult Patients With Community Acquired Pneumonia  Oct 23, 2008
    PARIS, October 23 /PRNewswire/ -- Novexel, a speciality pharmaceutical company focused on the discovery and development of novel antibiotics designed to overcome the significant global problem of microbial resistance, announces positive results from its Phase II clinical trial evaluating NXL103 in the treatment of community acquired pneumonia (CAP) ... Iain Buchanan, Novexel's CEO, commenting on the announcement said, "We are very pleased that the results from our first Phase II clinical trial... (PR Newswire)

    Researchers downplay MRSA screening as effective infection control intervention  Oct 23, 2008
    However, in the last 15 years hospitals are facing multiple bacteria with broad resistance (Vancomycin-resistant enterococci, imipenam-resistant pseudomonas, totally drug resistant Acinetobacter and others), and efforts need to be broad based with a goal of reducing the overall burden of infections. . (EurekAlert!)

    Herbicide-resistant Grape Could Revitalize Midwest Wine Industry  Oct 21, 2008
    21, 2008) An herbicide that is effective at killing broadleaf weeds in corn, but also annihilated most of the grapes in Illinois and other Midwestern states, may finally have a worthy contender. Researchers at the University of Illinois have developed a new grape called Improved Chancellor which is resistant to the popular herbicide 2, 4-D.. (Science Daily)

    New Natural Products Act Against Antibiotic-resistant Bacteria  Oct 21, 2008
    They may be a reservoir for antibiotic resistance genes that can be transferred to more harmful ... New flu tests can diagnose the flu in as little as 30 minutes, to cut down on needless antibiotic use, which can build up resistance and make some. (Science Daily)

    Trashing Joe the Plumber  Oct 21, 2008
    In fact, Tamiflu and the three other antivirals approved by the US over the last 25 years increase resistance to a pandemic H5N1 strain, but Georgia has been increasing resistance as a tradition with rampant inappropriate antibiotic prescribing and inappropriate antiviral prescribing anyway. Welcome to stupidity. (Atlanta Journal-Constitution)

    Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA  Oct 20, 2008
    "We are especially pleased to provide details of our TR-701 Phase 1 clinical trial results that support the once-daily dosing and short course of therapy in our recently initiated Phase 2 study in complicated skin and skin structure infections (cSSSIs). It is also exciting to see that the results of studies by external investigators demonstrate the drug's increased potency and expanded spectrum of activity." The presentations are as follows: Saturday, October 25th (Poster Summary Session,... (PR Newswire)

    Evolution Of Virulence Regulation In Staphylococcus Aureus  Oct 19, 2008
    "It is thought that drugs which interfere with quorum-sensing regulators may prevent production of several virulence factors and be less likely to lead to resistance that drugs which directly kill bacteria." ... (July 7, 2008) By targeting the gene that confers resistance to antibiotics, a new drug may be able to finally outwit drug-resistant staph. (Science Daily)

    Better Beer: College Team Creating Anticancer Brew  Oct 18, 2008
    Their entry last year, a bacterial virus that fought antibiotic resistance, was well-received but finished out of the prize running. "After last year's contest, we were sitting around talking about what we'd do this year," said junior Taylor Stevenson. (Science Daily)

    A New Class of Antibiotics Could Offer Hope Against TB  Oct 18, 2008
    The last two decades of the 20th century saw nearly zero progress, and in those years several disease-causing bacteria evolved resistance to commonly used drugs ... That means the old drugs and the new drugs "should not have cross-resistance," says Ma ... Any new drugs will work against bacteria that have developed resistance to current drugs, but won't interfere with the way the current drugs work. (Time.com)

    I'm sick. How long before I should go back to work?  Oct 15, 2008
    This gives medication the chance to completely kill the infection to prevent future infections and even the same infection from coming back, to reduce antibiotic resistance and to prevent the bug from spreading to others. Regardless of what kind of infection you have, if you don't feel well, stay at home, allow your symptoms to improve, your fever to break and your body to recover before returning to work, school or your daily routine. (Globe and Mail)

    Minimal Composting Of Beef Cattle Manure Greatly Reduces Antibiotic Levels  Oct 14, 2008
    3, 2007) Researchers investigated the effects of manure management on the levels of antibiotics and antibiotic resistance genes in manures and found that certain agricultural practices make a ... New flu tests can diagnose the flu in as little as 30 minutes, to cut down on needless antibiotic use, which can build up resistance and make some. (Science Daily)

    'Nanotech search' for antibiotics  Oct 13, 2008
    UK researchers are using microscopic "nanoprobes" to find new drugs to tackle antibiotic resistance. The tiny ultra-sensitive probes can measure how well a drug binds to bacteria and its ability to weaken and destroy the bug. (BBC News -- Health)

    Nanotechnology boosts war on superbugs  Oct 13, 2008
    " ### The research was funded by the EPSRC (Speculative Engineering Programme), the IRC in Nanotechnology (Cambridge, UCL and Bristol), the Royal Society and the BBSRC. ### Notes for Editors: Contact details: For further information, to speak to Dr Rachel McKendry, or to obtain a copy of the paper ("Nanomechanical Detection of Antibiotic Mucopeptide Binding in a Model for Superbug Drug Resistance"), please contact Dave Weston in the UCL Press Office on +44 (0) 20 7679 7678 or email: . For out of... (EurekAlert!)

    Wielding Microbe Against Microbe, Beetle Defends Its Food Source  Oct 11, 2008
    But in recent years, the number of new compounds successfully isolated from these organisms and indeed from all microbes has dwindled, even as resistance to existing antibiotics has spread ... The researchers instead suspect Entomocorticium has developed some resistance over time, says Scott, allowing it to survive the same low doses of antibiotic that wipe out its competitor. (Science Daily)

    Don't turn to antibiotics to help fight a cold  Oct 10, 2008
    Another negative is the development of antibiotic resistance by germs. But flying largely under the radar is a dangerous type of infection linked to antibiotic use, which has been getting worse and more fatal since 2000. (Honolulu Advertiser)

    Honey Helps To Heal Wounds, Review Suggests  Oct 10, 2008
    19, 2007) Honey is enjoying a resurgence as a wound-healing solution amid rising concerns about antibiotic resistance and a renewed interest in natural healing. Researchers started to document its success in. (Science Daily)

    Researchers Discover How Infectious Bacteria Can Switch Species  Oct 10, 2008
    New flu tests can diagnose the flu in as little as 30 minutes, to cut down on needless antibiotic use, which can build up resistance and make some. . (Science Daily)

    Two Luminaries Join Cequent Scientific Advisory Board: Judy Lieberman, M.D. Ph.D., and Patrice Courvalin, M.D.  Oct 7, 2008
    He is an internationally recognized expert in the genetics and biochemistry of antibiotic resistance and in the transfer and heterologous expression of genetic information. He received master's degrees in sciences and in human biology from the University of Sciences in Paris and his doctorate in medical sciences from the Medical School in Paris. (PR Newswire)

    Innovotech Tests Novel Products on Fire Blight  Oct 7, 2008
    Biofilms are protected communities of microorganisms which are very common and very difficult to treat due to their inherent resistance. They have been implicated in a host of devastating infections in agriculture, human health and industry. (CCNMatthews Press Releases)

    Hospital cleaning chemical fears  Oct 6, 2008
    Hospitals have been warned not to over-dilute cleaning chemicals amid fears that this could boost antibiotic resistance in bacteria ... Biocides can be used in very very high concentrations, and provided this happens, then bacteria will be killed, and therefore not have the opportunity to acquire this resistance ... The NHS has recently met a target for the reduction of MRSA cases, but the rise of antibiotic resistance remains a problem. (BBC News -- Health)

    Free drug samples may not be a great deal  Oct 6, 2008
    Overuse of such drugs could contribute to the growing problem of antibiotic resistance, she says. The prescription drug industry says free samples fill an important role for poor or uninsured patients, but Cutrona's study found few needy kids got them, because they didn't have access to the doctors who gave them out. (USA Today -- News)

    Being smart when using medicines  Oct 4, 2008
    Antibiotic resistance has become one of the most pressing public health issues, Gibson said. It is important to practice the safe use of antibiotics and to understand when they are not appropriate. (Orangeburg Times and Democrat, SC)

    Tuberculosis: An Ancient Disease Continues to Thrive  Oct 4, 2008
    There is also no easy way to detect drug-resistant strains of TB; current sputum-based screens can take anywhere from two weeks to two months, during which time doctors protectively place infected patients on first-line drugs too weak to battle the aggressive strain effectively rather than risk the overuse of last-resort medications that would only feed drug resistance. And in Africa in particular, tuberculosis is nurtured alongside AIDS in a deadly double hit: The weakened immune systems of... (Time.com)

    Public Health: Whats in your groundwater?  Oct 4, 2008
    We are plagued by antibiotic resistance, with higher doses of antibiotics applied when necessary, still leaving the resistant ones. The estrogen in our waters is actually feminizing our fish. (Pembroke Mariner, MA)

    Groundbreaking Discovery May Lead To Stronger Antibiotics  Oct 3, 2008
    27, 2004) Dutch research has shown that the development of permanent resistance by bacteria and fungi against antibiotics cannot be prevented in the longer-term ... New flu tests can diagnose the flu in as little as 30 minutes, to cut down on needless antibiotic use, which can build up resistance and make some. (Science Daily)

    New Way To Make Malaria Medicine Also First Step In Finding New Antibiotics  Oct 3, 2008
    Resistance to classic drugs such as chloroquine and sulphadoxine-pyrimethamine is on the rise, and mosquitoes also are developing resistance to insecticides ... The World Health Organization now advocates treating malaria with multiple antibiotics simultaneously, to combat the parasites' ability to develop resistance ... "Now, if a patient takes a second drug simultaneously, one in 10 million parasites also becomes resistant to that drug. However, the odds that the same parasite will develop a... (Science Daily)

    The New Superbugs  Sep 24, 2008
    A recent editorial in the British Medical Journal warns we could be on the verge of a global pandemic due to resistance being developed by bacteria to antibiotics ... Other medical experts have also been repeatedly cautioning people that antibiotic resistance is growing so enormously that it may become very difficult to carry out major surgeries, organ transplantation and cancer chemotherapy in the near future ... To date, tuberculosis and bacterial pneumonia are prominent examples of... (India Times, India)

    Tomato plant hair throws light on human disease resistance  Sep 23, 2008
    The spiky hairs that grow on tomato plant stems may well give scientists a better understanding of disease resistance in humans, a biotechnology conference in Canberra has heard. Professor Rob Last, a geneticist at , told Australian scientists that tomato hairs, known as glandular trichomes, secrete a chemical compound known to contain an antibiotic quality, Australian Associated Press (AAP) has reported. (The Tech Herald)

    Emergence Of Agriculture Took Much Longer  Sep 20, 2008
    (July 5, 2005) A paper published in the open access journal PLoS Medicine discusses evidence suggesting that antibiotic use in agriculture has contributed to antibiotic resistance in the pathogenic bacteria ... Specific mutations in the HIV genome confer resistance to individual. (Science Daily)

    hefA plays an important role in multidrug resistance of Helicobacter pylori  Sep 20, 2008
    But the contribution of efflux proteins to antibiotic resistance is not well established ... While they could not quantitate the operons expression levels of the efflux systems in multidrug resistance strains of H pylori ... To futher evaluate the contribution of hefA in multidrug resistance of H pylori, the article also constructed an H pylori mutant strain ( H. pylori LZ1026), and detected the susceptibility to 10 antimicrobials of the H pylori LZ1026 with a more sensitive method of twofold... (EurekAlert!)

    Health moves 'halve early deaths'  Sep 18, 2008
    Meanwhile, a study by the British Heart Foundation has found women at high risk of diabetes can reduce their body's insulin resistance - the most important biological risk factor for diabetes - by exercising. After seven weeks of an exercise programme of three 30 minute exercise sessions in the first week, working up to five 60 minute sessions in weeks six and seven, insulin resistance had reduced by 22% in women whose family history put them at a high risk of type 2 diabetes. (BBC News -- Health)

    Sri Lanka war  Sep 18, 2008
    "The battle is now for Kilinochchi but the LTTE will put up a fight before ceding it, if at all. In the past we've seen the Tigers play a defensive role, but lately they have gone on an offensive role. We are seeing very stiff resistance from the LTTE.". Foreign journalists were last allowed by the government a year ago to pass through the crossing point between the two warring parties and travel up to Kilinochchi. (BBC News -- South Asia)

    Is re-emerging superbug the next MRSA?  Sep 16, 2008
    The resistance of the spores to hospital cleaning agents and to alcohol hand disinfectants makes it extremely difficult to eradicate. . (EurekAlert!)

    Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants  Sep 16, 2008
    Predicting antibiotic resistance before it emerges at clinical settings constitutes a novel approach for preventing and fighting resistance of bacterial pathogens. To analyse the possibility that novel plasmid-encoded quinolone resistance determinants (Qnr) can emerge and disseminate among bacterial pathogens, we searched the presence of those elements in nearly 1000 bacterial genomes and metagenomes ... Functional studies of the Stenotrophomonas maltophilia Smqnr gene show that plasmid-encoded... (BioMed Central)

    Discoverers of Small Regulatory RNAs and Cholesterol-Lowering Drugs to Receive Lasker Awards for Medical Research  Sep 14, 2008
    Falkow's discoveries have shed light on how bacteria transmit antibiotic resistance and other traits to one another and revealed the means by which they infect animal hosts and elicit illness ... Early in his career, Falkow discerned that bacteria pass antibiotic resistance among one another on circular pieces of DNA-a finding that paved the way toward recombinant DNA technology. (PR Newswire)

    5 share awards for medical research  Sep 14, 2008
    That talent helped him discover the molecular nature of antibiotic resistance and forge new laboratory tools that revolutionized the way scientists think about how microbes cause disease. The three winners in the basic research category were honored for expanding the versatility of RNA, long regarded as DNA's poor cousin. (Cleveland.com -- News)

    5 Pioneering Scientists Win Lasker Medical Prizes  Sep 14, 2008
    That talent helped him discover the molecular nature of antibiotic resistance; forge new laboratory tools that revolutionized the way scientists think about how microbes cause disease; and train a number of students who have become scientific leaders in infectious diseases. Over his 51-year professional career, Dr. Falkow has also developed techniques to help identify disease-causing bacteria that cannot be grown in the laboratory; show how bacteria pass certain traits to one another; pave the... (Atlanta Journal-Constitution -- Health)

    Switched-on New Nanotechnology Paints For Hospitals Could Kill Superbugs  Sep 12, 2008
    Antibiotic resistance means illnesses last longer, and the risk of complications and death increases. (June 4, 2008) A new study looked into the ability of antimicrobial-surface wipes to remove, kill and prevent the spread of such infections as MRSA. They found that current protocols utilized by hospital staff have. (Science Daily)

    Antibiotic resistance rise fears  Sep 11, 2008
    The rise in antibiotic resistance is reaching worrying levels, experts say ... The fight against drug resistance is an on-going battle because many bacteria constantly mutate, gaining resistance to current antibiotics in the process ... Of these, 12% show signs of resistance - up from about 4% at the turn of the century. (BBC News -- Health)

    Evolving Creationism in the Classroom  Sep 11, 2008
    Sure, is the linchpin of modern biology, explaining everything from antibiotic resistance in to the progression of species found in the fossil record. That didn't stop Republican vice presidential nominee, Alaska Gov. Sarah Palin, from expressing the idea that the biblical notion that God created Earth and its life forms a few thousand years ago should get equal footing with in public school science classes. (Scientific American)

    Doctors running out of antibiotics to fight some infections, say ...  Sep 11, 2008
    "Several major companies have pulled out of antibiotic development. They have not been seen as a particularly profitable area. If you develop a new heart drug, the patient is on it for a matter of years and resistance doesn't develop."With antibiotics on the other hand, the patient is on it for one or two years and resistance may develop. "The cost of developing a new drug is usually said to be somewhere between $500m (285m) and $1bn, depending on whether the many drugs that fail are costed in... (guardian.co.uk)

    New Evidence On The Robustness Of Metabolic Networks  Sep 9, 2008
    21, 2005) Bacteria feel pressures to evolve antibiotic resistance and other new abilities in response to a changing environment, and they react by 'stealing' genetic information from other better-adapted types. (Aug. (Science Daily)

    Marijuana Ingredients Show Promise In Battling Superbugs  Sep 9, 2008
    The scientists also showed that these substances appear to kill bacteria by different mechanisms than conventional antibiotics, making them more likely to avoid bacterial resistance, the scientists note. At least two of the substances have no known mood-altering effects, suggesting that they could be developed into marijuana-based drugs without causing a "high.". (Science Daily)

    Many Young Women Share Their Prescription Meds  Sep 9, 2008
    Risks include allergic reactions to drugs, interactions with other medications, antibiotic resistance, and, for pregnant women, exposing a fetus to a substance that could cause birth defects, the researchers point out in the Journal of Women's Health. Honein and her team looked at data from the 2001-2006 HealthStyles surveys, which are conducted every year by mail to investigate "trends in health behavior." Their analysis included 26,566 people -- 7,456 of whom were women between 18 and 44 years... (MEDLINEplus)

    Medicine wins when doctors say no  Sep 8, 2008
    The path of least resistance was to accept the "unbiased study," along with several free samples for the practice ... Since I had their studies in hand, samples of the "purple medicine" nearby, and easy access to dosage charts, it was the path of least resistance to use the drug, which at the time, was a good medication. (Boston Globe)

    Milk may help bacteria survive against low levels of antibiotics  Sep 8, 2008
    "If we can get the doses right, and the animals are cured quicker, we will have less antibiotic residue in the environment and the risk of bacteria such as Staphylococcus aureus developing and spreading antibiotic resistance is lower.". . (EurekAlert!)

    Promising Method For Reducing MRSA Infections In Hospitals  Sep 6, 2008
    Increasingly problematic in hospitals, these pathogens tend to develop resistance to antibiotics in sterile and contained environments - areas like ICUs - where patients have weakened immune systems due to severe illness, open wounds, surgical incisions, catheters or other implanted medical devices ... "If cycling proves effective at other centers, we might be able to turn the tide on antibiotic resistance, at least for MRSA. In the long run, reducing MRSA should decrease the number of deaths... (Science Daily)

    Safe, Inexpensive Alternative To Antibiotics Developed For Production Of Biofuels And Biopharmaceuticals  Sep 4, 2008
    3, 2008) Researchers at the Royal Veterinary College (RVC) have developed a system that eliminates the need for antibiotics and resistance genes in the engineering of industrial and medical products ... Unfortunately, antibiotic selection methods risk spreading resistance traits, particularly as biotechnology products move into the environment and clinic ... New flu tests can diagnose the flu in as little as 30 minutes, to cut down on needless antibiotic use, which can build up resistance and... (Science Daily)

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