Cross-donor system planned for region's kidney patients Nov 14, 2009
I don't think that there are any ethical issues" to expanding the number of trades, said Dr. Paul Morrissey of Rhode Island Hospital, chairman of the Renal Transplant Oversight Committee. ''It's just setting up the mechanism to carry it out.". Even tough critics such as Dr. Lainie Friedman Ross, medical ethicist at the University of Chicago, agree that the paired-exchange system can be fair. (Yahoo News -- Organ Donation & Transplants)
Brain injured athletes may benefit from hypothermia research Nov 14, 2009
The filter-cooling unit technology works similar to renal dialysis, removing a volume of blood and replacing it with a cooled crystalloid solution through a catheter in the carotid artery. The rest of the brain and body maintain a normal temperature. (EurekAlert!)
Surgery Not Always Best for Narrowed Kidney Arteries Nov 13, 2009
WEDNESDAY, Nov. 11 (HealthDay News) -- People suffering from blocked renal arteries fare just as well when treated with medication as they do by having the narrowed artery opened and a stent implanted, British researchers report ... "There was no difference in renal function in the two arms of the study," Kalra said ... Dr. Ajay Singh, clinical director of the renal division and director of dialysis at Brigham and Women's Hospital in Boston and an associate professor of medicine at Harvard... (MEDLINEplus)
Case Tests Level of Proof for Excluding Coverage for Drug-Related Injuries Nov 13, 2009
One of Matthew Cardiello's guests at the 2003 party, 21-year-old Wendy Flomerfelt, passed out and was taken to a hospital, where she was diagnosed with acute respiratory failure, renal failure, a shocked liver and hearing loss. A toxicology report was positive for alcohol, cocaine, marijuana and various opiates. (Law.com)
Geriatric patients' expectations of their physicians: findings from a tertiary care hospital in Pakistan Nov 13, 2009
5%) and renal disease (32. 1%) were common ailments. (BioMed Central)
Revascularization versus Medical Therapy for Renal-Artery Stenosis Nov 12, 2009
Background Percutaneous revascularization of the renal arteries improves patency in atherosclerotic renovascular disease, yet evidence of a clinical benefit is limited ... The primary outcome was renal function, as measured by the reciprocal of the serum creatinine level (a measure that has a linear relationship with creatinine clearance) ... Secondary outcomes were blood pressure, the time to renal and major cardiovascular events, and mortality. (New England Journal of Medicine)
Outcry over TV kidney competition Nov 12, 2009
"The scenario portrayed in this programme is ethically totally unacceptable," said Professor John Feehally, who has just ended his term as president of the UK's Renal Association. "The show will not further understanding of transplants," he added. (Yahoo News -- Reality TV)
Emory, Georgia Tech, Children's Healthcare of Atlanta team up on kidney replacement devices for kids Nov 12, 2009
"We have invented a new continuous renal replacement therapy device that is designed specifically with kids in mind. It can be used accurately on a six-pound child, all the way up to a football linebacker.". In the United States, it is estimated that at least 5,000 children per year, or 1 percent of the 500,000 children admitted to intensive care units, require some form of renal replacement therapy. (EurekAlert! -- Business News)
Local news briefs Nov 12, 2009
Participants whose screenings that show type 2 diabetes, prediabetes and renal insufficiency will be invited back for a free education class Nov. 20. Article Rating. (Paragould Daily Press, AR)
A Male Renal-Transplant Recipient with Renal Insufficiency, Diabetic Ketoacidosis, and Mental-Status Changes Nov 12, 2009
NEJM -- Case 35-2009 -- A 60-Year-Old Male Renal-Transplant Recipient with Renal Insufficiency, Diabetic Ketoacidosis, and Mental-Status Changes ... Case 35-2009 A 60-Year-Old Male Renal-Transplant Recipient with Renal Insufficiency, Diabetic Ketoacidosis, and Mental-Status Changes ... Dr. Peter P. Moschovis (Medicine and Pediatrics): A 60-year-old man with diabetes mellitus and a history of renal transplantation was admitted to this hospital because of mental-status changes, diarrhea, renal... (New England Journal of Medicine)
Pocket Phones With Bluetooth May Cause Decreased Fertility In Men Nov 11, 2009
-- Men who carry a cellphone in their pants pocket in the talk mode while using a Bluetooth device may experience decreased fertility, according to a study reported today by Renal and Urology News ... "We found increased oxidative stress and a decrease in sperm motility," said investigator Ashok Agarwal, director of Reproductive Research at Cleveland Clinic, according to Renal and Urology News. (W-USA News, DC)
Q&A: What is ricin? Nov 11, 2009
It can damage the organs, and a combination of pulmonary, liver, renal and immunological failure can lead to death, although people can recover from exposure. How is it made. (BBC News -- Science)
Ricin 'antidote' to be produced Nov 11, 2009
" Ricin is extracted from castor beans, which are processed throughout the world to make castor oil. The toxin is part of the waste "mash" produced when castor oil is made. It can cause harm if injected, swallowed or inhaled. But the amount needed to kill depends on the route of administration. A combination of pulmonary, liver, renal and immunological failure can lead to death, though people can recover from exposure. The ricin-filled pellet that killed Georgi Markov was injected using an... (BBC News -- UK)
Ricin vaccine 'shown to be safe' Nov 11, 2009
Ricin acts by damaging the organs, and a combination of pulmonary, liver, renal and immunological failure can lead to death. It can be administered in food and water, or sprayed as an aerosol. (BBC News -- Science)
Low Vitamin D Levels Explains Most End-stage Renal Disease Risk In African-Americans Nov 10, 2009
9, 2009) Low levels of vitamin D may account for nearly 60 percent of the elevated risk of end-stage renal disease (ESRD) in African Americans, according to a report in the December Journal of the American Society of Nephrology (JASN) ... 20, 2007) Approximately ten percent of U.S. adults have a family history of end-stage renal disease (ESRD), and these individuals appear to be at increased risk of developing kidney disease themselves, reports ... 6, 2008) For most patients with chronic kidney... (Science Daily)
Feline Kidney Transplantation Nov 10, 2009
The only curative treatment for chronic renal failure in cats. Chronic renal failure is an irreversible and progressive disease in cats ... When the pet's kidney(s) are unable to filter and cleanse the blood, this is the standard definition of renal failure. (Suite101.com)
New rules change who gets donated kidneys Nov 8, 2009
"End-stage renal failure. Stage 5. I have no kidney function.". Ramirez has hemolytic-uremic syndrome, which can severely damage the kidneys, shutting them down quickly. (AZCentral -- News)
India lets Kashmir leader travel Nov 7, 2009
Mr Geelani, who is in his seventies, is suffering from renal cancer. An official in Indian-administered Kashmir said Mr Geelani, whose Indian passport was impounded in 1981, would be given a new one. (Yahoo News -- Kashmir Dispute)
Exercise Extends Life of Kidney Patients Nov 7, 2009
"These data suggest that increased physical activity might have a survival benefit in the CKD population. This is particularly important as most patients with stage III CKD die before they develop end stage renal disease," wrote Dr. Srinivasan Beddhu, of Salt Lake City Veterans Administration Healthcare System and University of Utah, and colleagues. The study appeared online Oct. 8 in the Clinical Journal of the American Society of Nephrology. (MEDLINEplus)
Travel May Be Hazardous To Dialysis Patients Nov 7, 2009
In a study conceived and led by nurses, Claire Edwards, RGN; Kathleen Lynch, RGN; Neill Duncan, MRCP (West London Renal and Transplant Centre, Imperial College Kidney and Transplant Institute, United Kingdom); and their colleagues collected health information on patients who traveled on vacation at some point between April 2008 to March 2009 ... Study co-authors include Kathleen Lynch, RGN, Seema Singh, MSc, Damien Ashby, MRCP, David Taube, FRCP, Thomas Cairns, FRCP, Adam McLean, FRCP, DPhil,... (Science Daily)
New Class Of Molecules May Help Prevent Fatal Complication In Patients With Kidney Disease Nov 6, 2009
A kidney gene called ROMK (Renal Outer Medullary K+ Channel) controls the levels of potassium excretion in the kidney. In people with kidney disease, the protein made by this gene no longer signals properly to ensure adequate excretion through the urine, so the potassium can build up in the blood. (Science Daily)
Key Player Identified In Cascade That Leads To Hypertension-related Kidney Damage Nov 6, 2009
"We think that endothelin somehow causes an increase in T cells which results in renal injury which makes the hypertension worse and harder to control," says Dr. Karthik Krishnan, an MCG allergy/immunology fellow who presents the findings during the 2009 American College of Allergy, Asthma & Immunology Annual Meeting Nov. 5-9 in Miami ... Standard urinalysis can detect protein in the urine, one of the first signs sign that "the kidneys are falling down on the job," says Dr. David Pollock, renal... (Science Daily)
Nien Cheng; wrote of prison in China’s Cultural Revolution Nov 6, 2009
WASHINGTON -Nien Cheng, whose memoir Life and Death in Shanghai was widely praised as one of the most riveting accounts of the Cultural Revolution, died Monday of cardiovascular and renal disease at her home in Washington. She was 94. (Boston Globe)
On-Pump versus Off-Pump CABG Nov 5, 2009
The primary short-term end point was a composite of death or complications (reoperation, new mechanical support, cardiac arrest, coma, stroke, or renal failure) before discharge or within 30 days after surgery. The primary long-term end point was a composite of death from any cause, a repeat revascularization procedure, or a nonfatal myocardial infarction within 1 year after surgery. (New England Journal of Medicine)
A Peptide-Based Erythropoietin-Receptor Agonist for Pure Red-Cell Aplasia Nov 5, 2009
From the Department of Renal Medicine, King's College Hospital, London (I.C.M.); the Departments of Nephrology (J.R.) and Physiology (M.F.), Georges Pompidou European Hospital, Assistance Publique H pitaux de Paris; Paris-Descartes University (J.R., M.F.); and the Department of Hematology, H pital Saint Antoine, Assistance Publique H pitaux de Paris and Pierre et Marie Curie University (N.C.) all in Paris; INSERM Unit; 790, Villejuif, France (N.C.); BioPharma Consulting Services, Bellevue, WA... (New England Journal of Medicine)
Ankle–Brachial Index for Assessment of Peripheral Arterial Disease Nov 5, 2009
Hirsch AT, Haskal ZJ, Hertzer NR, et al. ACC/AHA Guidelines for the Management of Patients with Peripheral Arterial Disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Associations for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (writing committee to... (New England Journal of Medicine)
FDA Issues Warning for Diabetes Drug Nov 5, 2009
TUESDAY, Nov. 3 (HealthDay News) -- Reports about possible kidney problems, including renal failure, in people taking the diabetes drug exenatide (Byetta) have prompted changes to the drug's prescribing information, the U.S. Food and Drug Administration said Monday. From April 2005 to October 2008, the FDA received 78 reports of kidney function problems in patients taking Byetta. (MEDLINEplus)
Novartis to buy majority in China's Tianyuan US$125mil Nov 4, 2009
Privately-held Tianyuan sells vaccines against diseases such as hemorrhagic fever with renal syndrome, or HFRS, caused by hantaviruses, and conducts research into "various preventable viral and bacterial diseases," Novartis said. The Chinese company had net sales of $25 million in 2008. (The Star Online, Malaysia -- Business)
Renal Cancer: Protein Triggers A Snowball Effect Nov 3, 2009
2, 2009) If a certain protein is missing in kidney cells, fatal cell division errors arise, which can finally lead to genetically unstable cells and to renal cancer ... A lower mtDNA copy number was associated with an increased risk of renal cell cancer in a ... (June 9, 2008) Diabetes is the leading cause of renal failure that requires dialysis. (Science Daily)
Anemia Drug May Raise Stroke Risk in Kidney Patients Nov 3, 2009
Dr. Ajay Singh, clinical chief of the renal division and director of dialysis at Brigham and Women's Hospital, said this "landmark study" raises the fundamental question of whether epoetin or darbepoetin should routinely be used in treating anemia of chronic kidney disease ... D., professor of medicine, cardiovascular division, Brigham and Women's Hospital, Boston; Phillip Marsden, M.D., professor of medicine, University of Toronto, Canada; Ajay Singh, M.D., clinical chief, renal division,... (MEDLINEplus)
Gene Therapy Repairs Injured Human Donor Lungs Nov 2, 2009
2, 2009) Kidneys recovered from deceased donors with acute renal failure -- once deemed unusable for transplant -- appear to work just as well as kidneys transplanted from deceased donors who do not develop. (Jan. (Science Daily)
Plano resident to receive Gift of Life award Nov 2, 2009
Brauss' journey with organ donation began when she was diagnosed with renal failure at age 6. "Back then, when a kidney was failing, doctors just took it out," she said. (McKinney Courier-Gazette, TX)
Border politics keeps artist from clinic he helped fund Nov 1, 2009
As a resident of Kiwirrkurra a small town about 200 kilometres west of the Western Australian and Northern Territory border the celebrated artist had witnessed the rising toll of renal failure on his people and the distressing dislocation of them to Alice Springs, 700 kilometres away, for dialysis ... Sarah Brown, manager of the Western Desert Nganampa Walytja Palyantjaku Tjutaku Project, which set up the Kintore service, said soaring demand for dialysis prompted the NT Government to... (Sydney Morning Herald -- Australia)
'Everyone has the potential of giving the gift of life' Nov 1, 2009
He still requires regular checks of his renal system, but when I said I've always thought of Don as a rock, well this man is granite. The next thing I truly required was a pancreas, not only to rid me of the diabetes and to aid me in securing my overall health, but also to prevent the diabetes from further damaging my new kidney. (Brainerd Daily Dispatch)
Can charcoal fight heart disease in kidney patients? Nov 1, 2009
"This is especially important because there is no effective treatment to reduce the high rate of cardiovascular mortality in patients with end-stage renal disease." ... In mice with profoundly reduced renal mass, treatment with AST-120 led to a dramatic decrease in atherosclerosis ... ASN Renal Week 2009, the largest nephrology meeting of its kind, will provide a forum for 13,000 professionals to discuss the latest findings in renal research and engage in educational sessions related to advances... (EurekAlert!)
Charcoal may help fight heart disease Nov 1, 2009
It was noted that in mice with profoundly reduced renal mass, treatment with AST-120 led to a dramatic decrease in atherosclerosis, even when charcoal treatment was delayed ... Valentina Kon, MD (Vanderbilt University) said: "We found that oral activated charcoal lessens atherosclerotic lesions in experimental mice with kidney damage. This is especially important because there is no effective treatment to reduce the high rate of cardiovascular mortality in patients with end-stage renal... (India Times, India)
Donor Race May Impact Kidney Transplant Survival Nov 1, 2009
Dr. Patel presented a similar study earlier this year which looked at race and the effect on renal allograft survival in different donor/recipients pairs. In that study, Dr. Patel found an increased risk in graft failure in non-black recipients of non-heart beating black donor kidneys. (Science Daily)
H1N1 categories expanded Nov 1, 2009
Custodial parents of infants less than 6 months of age Persons 19-64 years with chronic medical conditions such as chronic pulmonary disease, renal dysfunction, diabetes mellitus, cardiovascular disease, and immunosuppressive illnesses. COMMENTS. (Alva Review Courier, OK)
Switching immunosuppressants reduces cancer risk in kidney Nov 1, 2009
Russ added, "This is the first randomized controlled trial to address whether patients treated with mTOR inhibitors after renal transplantation have less skin cancer." ... ASN Renal Week 2009, the largest nephrology meeting of its kind, will provide a forum for 13,000 professionals to discuss the latest findings in renal research and engage in educational sessions related to advances in the care of patients with kidney and related disorders ... Renal Week 2009 will take place October 27 ... (EurekAlert!)
Amgen Is Sued by New York, 14 States After Investigation of Drug Kickbacks Oct 31, 2009
It was approved by the U.S. Food and Drug Administration in 2001 to treat anemia associated with renal failure and in 2002 to treat chemotherapy-induced anemia. The drug was developed and manufactured by Amgen to stimulate and boost the production of red blood cells in the body, Cuomo said. (Bloomberg -- US)
Preventive Antibiotics Help Some Kids Fend Off Urinary Infections Oct 30, 2009
"Some children have a condition known as vesicoureteral reflux, which with a urinary tract infection can lead to renal scarring, which can eventually lead to high blood pressure, the pregnancy complication preeclampsia and even kidney problems," Hoberman explained. Craig's study included children with varying degrees of vesicoureteral reflux, which means urine backs up from the bladder into the kidney, as well as children without this condition. (MEDLINEplus)
Antimicrobial Prophylaxis for Urinary Tract Infection in Children Oct 29, 2009
Data from observational studies and animal models support the hypothesis that children with vesicoureteral reflux who have urinary tract infection are at increased risk for renal scarring. Vesicoureteral reflux is graded from I (lowest grade, with reflux into the ureter only) to V (highest grade, with marked ureteral tortuosity, calyceal blunting, and severely dilated renal pelvis). (New England Journal of Medicine)
Shire Secures European Wide Label Extension for FOSRENOL(R) in Chronic Kidney Disease Oct 28, 2009
" "This is an important development in helping CKD patients better manage their elevated phosphate and we are pleased that FOSRENOL is now approved as a treatment option for these patients in the EU," said Gian Piero Reverberi, Senior Vice President, International Specialty Pharmaceuticals, Shire. "We are firmly committed to serving the needs of renal patients and ensuring that FOSRENOL is available to the prescribers and patients who can benefit from it. " In relation to the US, Shire continues... (Canada Newswire)
Latest Diabetes Figures Paint Grim Global Picture Oct 27, 2009
(May 24, 2009) Renal diseases shall be diagnosed earlier and treated more successfully in the future. Towards this aim, researchers have been working for years to create a three-dimensional virtual "Kidney ... > (June 22, 2009) A major study of three to 19 year-olds has provided vital data on the weight problems faced by the growing number of children and young people with type 1 diabetes, which is more prevalent in younger ... > (July 18, 2008) Using community-based health advocates, delivering... (Science Daily)
Akram's wife shifted against docs' advice Oct 27, 2009
It was then diagnosed that Huma had developed acute renal failure and her white cell count was increasing. The other complications developed by Huma, a psychologist by profession, reportedly included severe infection of the kidneys with acute tubular necrosis, vasculitis (inflammation of blood vessels), and pulmonary hypertension (high pressure of blood vessels in lungs). (India Times, India)
Girl Born With Rare 'Mermaid' Condition DiesBorn with her legs fused together, Shiloh Pepin defied the odds until the end. Oct 27, 2009
"She had no vaginal vault or rectum, and no way for urine to get out of her body. Most of these babies die because of poor renal tissue makeup in their body.". The cause of the disease is a still a mystery. (ABC News)
Cross-donor system planned for region's kidney patients Oct 27, 2009
I don't think that there are any ethical issues" to expanding the number of trades, said Dr. Paul Morrissey of Rhode Island Hospital, chairman of the Renal Transplant Oversight Committee. ''It's just setting up the mechanism to carry it out.". Even tough critics such as Dr. Lainie Friedman Ross, medical ethicist at the University of Chicago, agree that the paired-exchange system can be fair. (Yahoo News -- Organ Donation & Transplants)
Longtime Arizona newspaper publisher dies at 84 Oct 27, 2009
Kramer died on Sunday at Casa Grande Regional Medical Center of complications from pulmonary and renal failure. Services are pending. (AZCentral -- News)
One in seven Australians to battle diabetes by 2050 Oct 27, 2009
NATSEM projects by 2050 the prevalence of complications experienced by Australians living with Type 2 diabetes will include over 270,000 coronary bypass grafting procedures, over 250,000 heart attacks and more than 750,000 renal complications. Editor: Li Xianzhi. (Xinhuanet, China)
Inventive Approach May Improve Enzyme Replacement Therapy For Fabry Disease Oct 25, 2009
24, 2009) A new study uses a creative structure-based remodeling strategy to design a therapeutic protein that exhibits significant advantages over currently available treatments for a rare disease that often leads to cardiac and renal failure. The research, published by Cell Press on October 22nd in the American Journal of Human Genetics, describes a new and highly promising candidate for enzyme replacement therapy (ERT) for Fabry disease. (Science Daily)
A deputys plight Oct 24, 2009
He had recently been diagnosed with acute renal failure, or damage to the kidneys. Symptoms first showed up just days before he found himself in an intensive care unit at the University of California, Davis. (Hanford Sentinal, CA)
Stem Cells Offer New Hope For Kidney Disease Patients Oct 24, 2009
29, 2006) The discovery that bone-marrow derived stem cells can regenerate damaged renal cells in an animal model of Alport syndrome provides a potential new strategy for managing this inherited kidney disease. (Feb. (Science Daily)
Outcry over TV kidney competition Oct 24, 2009
"The scenario portrayed in this programme is ethically totally unacceptable," said Professor John Feehally, who has just ended his term as president of the UK's Renal Association. "The show will not further understanding of transplants," he added. (Yahoo News -- Reality TV)
A step too far? Oct 23, 2009
Diabetes and osteoporosis are among the consequences of this form of medication which can also lead to renal failure, cardiac arrest, and increasingly, it is believed, cancer. For this reason the womb would be removed after the desired pregnancies were achieved and the babies delivered by caesarean, as the womb would be unlikely to tolerate labour. (BBC News -- Health)
Understanding Arterial Blood Gas Re... Oct 23, 2009
The renal system and the respiratory system are responsible for maintaining the proper balance of Ph. The respiratory system does this by regulating CO2 and the renal system does this by regulating HCO3 ... Compensation is the body s attempt to restore the correct ph balance by using the opposing system (renal system to respiratory system) to return the ph to normal. (Suite101.com)
What is the NCLEX? Oct 23, 2009
The nursing student who momentarily forgets or confuses the specific arterial blood gas (ABG) values but understands the principles of ABG will surmise that the client probably has a ph imbalance that is too alkaline (due to the loss of stomach acid from vomiting the ph is more alkaline) and metabolic because the stomach is directly involved in food consumption (the renal system and respiratory system are ultimately responsible for maintaining ph balance). Although the student must evaluate all... (Suite101.com)
Link Found Between Depression, Early Stages Of Chronic Kidney Disease Oct 23, 2009
22, 2009) One in five patients with chronic kidney disease is depressed, even before beginning long-term dialysis therapy or developing end-stage renal disease, UT Southwestern Medical Center researchers have found ... If treatment does not begin early, the condition progresses to end-stage renal disease ... According to the U.S. Renal Data System Annual Report, expenditures for end-stage renal disease patients totaled 15. (Science Daily)
Intensive Dialysis Doesn't Save Lives of the Sickest Oct 23, 2009
"Findings from previous, smaller studies had suggested that intensive dialysis treatment for people with severe acute kidney injury saved lives," said Cass, director of the renal and metabolic division at the George Institute for International Health in Sydney, Australia ... For this study, 1,508 acutely ill patients were randomized to receive either a high-intensity or low-intensity version of continuous renal-replacement therapy ... Even though the decrease in blood pressure was considered... (MEDLINEplus)
Atypical Hemolytic–Uremic Syndrome Oct 22, 2009
NEJM -- Atypical Hemolytic-Uremic Syndrome. Volume 361:1676-1687. (New England Journal of Medicine)
Ocoee man who donated kidney now needs a transplant himself Oct 22, 2009
He is now, at 61, in stage four of renal failure, and there are only five stages in all, so he is hoping to be cleared for a transplant before Christmas. He is currently undergoing a whole battery of tests to make sure he is a candidate for a transplant, and he and his wife, Yvette, have been overcome with the support they have received from the community. (Winter Garden West Orange Times, FL)
Heart Failure Treatment Underused Oct 22, 2009
"Aldosterone antagonist use in eligible patients was associated with younger age, African-American race/ethnicity, lower systolic blood pressure, history of implantable cardioverter-defibrillator use, depression, alcohol use and pacemaker implantation, and with having no history of renal insufficiency," wrote Nancy M. Albert of the Cleveland Clinic and colleagues. "These data confirm that in the context of a hospital-based performance improvement program, aldosterone antagonist therapy can be... (MEDLINEplus)
India lets Kashmir leader travel Oct 22, 2009
Mr Geelani, who is in his seventies, is suffering from renal cancer. An official in Indian-administered Kashmir said Mr Geelani, whose Indian passport was impounded in 1981, would be given a new one. (Yahoo News -- Kashmir Dispute)
Blood-Pressure Control and Delay in Progression of Kidney Disease in Children Oct 22, 2009
Many children with chronic kidney disease, even those in whom the disease is discovered very early, ultimately lose renal function; some ultimately progress to stage 5 chronic kidney disease (end-stage renal disease). Causes of chronic kidney disease in children differ substantially from those in adults; the largest diagnostic categories in children are congenital renal and genitourinary abnormalities; obstructive uropathy or renal hypoplasia dysplasia are most common, followed by reflux... (New England Journal of Medicine)
Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients Oct 22, 2009
The RENAL Replacement Therapy Study Investigators ... Background The optimal intensity of continuous renal-replacement therapy remains unclear ... Methods We randomly assigned critically ill adults with acute kidney injury to continuous renal-replacement therapy in the form of postdilution continuous venovenous hemodiafiltration with an effluent flow of either 40 ml per kilogram of body weight per hour (higher intensity) or 25 ml per kilogram per hour (lower intensity). (New England Journal of Medicine)
Strict Blood-Pressure Control and Progression of Renal Failure in Children Oct 22, 2009
Background Although inhibition of the renin angiotensin system delays the progression of renal failure in adults with chronic kidney disease, the blood-pressure target for optimal renal protection is controversial ... The primary end point was the time to a decline of 50% in the glomerular filtration rate or progression to end-stage renal disease ... Achievement of blood-pressure targets and a decrease in proteinuria were significant independent predictors of delayed progression of renal... (New England Journal of Medicine)
