FDA Demands Tougher Warnings on Immunosuppressive Drugs Sep 6, 2008
The drugs, Humira, Cimzia, Enbrel and Remicade, belong to a class of medications known as tumor necrosis factor alpha blockers (TNF-alpha blockers), which suppress the immune system and are approved to treat several conditions including rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, plaque psoriasis, ankylosing spondylitis and Crohn's disease ... The FDA reviewed 240 reports of histoplasmosis in patients taking Enbrel, Humira or Remicade, most of whom reside in the... (MEDLINEplus)
Arthritis drugs must carry stern warnings Sep 5, 2008
Market-leading Enbrel, sold by Amgen and Wyeth, J&J's Remicade, and Humira were among the 25 biggest drugs worldwide last year, with $13. 5 billion in combined sales, according to data compiled by Bloomberg. (Boston Globe)
Stronger warnings issued for 4 arthritis drugs Sep 5, 2008
FDA says Humira, Cimzia, Enbrel and Remicade linked to fatal infections ... The drugs Humira, Cimzia, Enbrel and Remicade work by suppressing the immune system, and the FDA says that can expose some patients to serious, even fatal, fungal infections. (MSNBC -- Health)
4 Arthritis Drugs Get Fungus Warning Sep 5, 2008
FDA Wants Warnings On Embrel, Remicade, Humira, Cimzia ... Three of the drugs, Enbrel, Humira and Remicade, are considered blockbusters, with sales of over $1 billion annually for each. (NBC 11, CA)
Flexible Treatments Sep 5, 2008
said that common treatments include drugs such as , , methotrexate and Remicade. Others try over-the-counter pain relievers such as ibuprofen or naproxen. (NBC 11, CA)
HEALTH BLOG: Opening up the medicine chest Sep 2, 2008
Medicine chest - Better Life - USATODAY.com. Grapefruit juice can reduce drug absorption, too. (USA Today -- Money)
HEALTH BLOG: Digging into the latest cancer studies Aug 28, 2008
FDA reviewing safety of Enbrel, Humira, Remicade and Cimzia. The FDA announced today that it is conducting a review of the safety of the drugs , , and. (USA Today -- Money)
Diabetes therapies take new approach Aug 26, 2008
She said her study suggests that anti-tumor necrosis factor therapies such as etanercept, sold by Wyeth and Amgen under the brand name Enbrel, and Johnson & Johnson's Remicade may cause new autoimmune diseases in some patients with Crohn's and rheumatoid arthritis. A second team, at the University of Texas Southwestern Medical Center in Dallas, took a different tack, using a hormone called leptin. (Boston Globe)
Treating Rheumatoid Arthritis: New Guidelines Developed For Physicians Aug 26, 2008
Newer biologics called anti-TNF agents adalimumab (Humira), etanercept (Enbrel) and infliximab (Remicade) prevent the production of an immunity protein that plays a role in inflammation. Some of the key recommendations include. (Science Daily)
Researchers discover how rheumatoid arthritis causes bone loss Aug 21, 2008
g. Humira, Remicade and Enbrel) reverses the disease process by shutting down TNF alpha activity. While the new drugs are effective for many patients, others experience infections and even lymphoma in a few cases. (EurekAlert!)
HEALTH BLOG: Read the latest child wellness tips Aug 5, 2008
Parenting and kids' health - Better Life - USATODAY.com. Unhappy about Happy Meals and the like. (USA Today -- Money)
'Stuffy Nose' Mouse: A Promise To Help Treat 31 Million With Sinusitis Jul 24, 2008
Another phase of research, he says, involves testing other anti-inflammatory drugs, such as infliximab (Remicade), which is used to treat arthritis, to see if they can spur growth of olfactory neurons during sinusitis. Lane also plans to add more sinusitis features to the animal model, including progressive swelling of sinus tissue and rhinitis. (Science Daily)
Merck, Schering Take A Hit Jul 22, 2008
The company highlighted sales of Remicade, for rheumetoid arthritis, increased 41. 0% to $557. (Forbes)
Making Genentech Disappear Jul 22, 2008
Centocor, one of the pioneers of biotech with drugs like Reopro and Remicade, has continued to churn out important new medicines as part of Johnson on (nyse: - - ). Its golimumab, for rheumatoid arthritis, is one of the best prospects for Jch has U.S. rights, and Schering-Plough (nyse: - - ), which would sell the drug internationally. (Forbes -- Business)
Case Points to Link Between Crohn's Treatment, Cancer Jul 18, 2008
This family of biologic drugs includes adalimumab (Humira), etanercept (Enbrel), and infliximab (Remicade) ... In 2000, she was diagnosed with Crohn's disease, which was then treated with TNF medications -- first Remicade, then Humira. (MEDLINEplus)
Drug Makers: Trial Shows Combination Therapy Helps Arthritis Jul 16, 2008
The FDA said it is reviewing whether a class of drugs called tumor necrosis factor inhibitors, such as Enbrel and Johnson & Johnson's (JNJ) Remicade, heighten the risk of cancer in children and adolescents. The FDA found 30 reports of cancer in children who took the drugs during the past 10 years. (CNNMoney.com)
Abbott shares jump as profit tops forecast Jul 16, 2008
09-billion, despite strong competition from Johnson & Johnson's Remicade and Wyeth's Enbrel. Like its rivals, Humira works by blocking an inflammation-causing protein called tumour necrosis factor. (Globe and Mail -- Business)
Johnson & Johnson posts 8 pct profit jump in Q2 Jul 16, 2008
Sales of Remicade, for rheumatoid arthritis and other immune disorders, edged up 2 percent to $886 million, while another top seller, anemia treatment Procrit, saw sales drop 14 percent to $652 million amid continuing safety concerns. Total pharmaceutical sales increased 3 percent to $6. (The Trentonian, NJ)
J&J Profit Salved by Zyrtec, Sickly Dollar Jul 15, 2008
Jit Salved by Zyrtec, Sickly Dollar (JOHNSON & JOHNSON (JNJ)) at SmartMoney. Tuesday July 15, 2008 9:19 AM ET. (SmartMoney)
32 genes blamed for bowel disorder Jul 1, 2008
Modern biotech drugs like Abbott Laboratories's Humira, UCB's Cimzia and Johnson & Johnson's Remicade can help, but many patients end up needing surgery. By pinpointing genes linked to the condition, researchers hope to find fresh targets for new drugs. (MSNBC -- Health)
A sporting chance Jun 23, 2008
He actually prefers to leave it in all day and deal with curious looks and questions from people rather than take it out and put it in every night," Washington continues. Verma, who has been a pediatric gastroenterologist for 16 years, says the combination of Remicade and tube feeding is imperative to keeping Mark's Crohn's symptoms at bay. "In the spectrum of Crohn's disease, I would put Mark in the moderate area, as opposed to severe or mild," Dr. Verma notes in a recent phone conversation... (NJ.com -- Times)
FDA Panel OKs Enbrel for Psoriasis in Children Jun 20, 2008
the FDA announced that it's investigating whether cancers in about 30 children and young adults are linked to the use of Enbrel, Remicade, Humira, and Cimzia, which make up a class of drugs called tumor necrosis factor (TNF) inhibitors. Enbrel got a "black box warning," the FDA's sternest warning, about the risk of serious infections that may lead to hospitalization or death. (WebMD)
FDA Panel Recommends Enbrel for Pediatric Patients Jun 20, 2008
Four TNF blockers are currently approved in the United States: Enbrel, Humira (adalimumab), Remicade (infliximab) and Cimzia (certolizumab). The FDA review is focusing on the first three. (MEDLINEplus)
FDA sees possible J&J psoriasis drug risks Jun 14, 2008
If approved, ustekinumab would compete with other leading injectable drugs -- Amgen Inc and Wyeth's Enbrel and Abbott Laboratories Inc's Humira -- as well as J&J's Remicade, which is given by intravenous infusion ... Patients taking Remicade, by contrast, need at least six infusions a year. (Scientific American)
FDA May Require Cancer-Risk Labeling on J&J Drug Jun 14, 2008
Johnson on already markets the drug Remicade in the U.S., which is approved to fight psoriasis, rheumatoid arthritis and the intestinal disorder Crohn's Disease ... Remicade requires at least six doses annually. (ABC News -- Wire)
Some Insight Into Incyte's Data Jun 14, 2008
That's stating the obvious, but treatments like Abbott Labs' (NYSE: ABT) Humira, Amgen (Nasdaq: AMGN) and Wyeth's (NYSE: WYE) Enbrel, and J&J and Schering's Remicade all need to be injected or transfused, meaning an oral medication that works just as well could penetrate the market pretty easily. advertisement. (MSNBC -- Business)
Breastfed babies lack vitamin D Jun 7, 2008
The drugs - which include the top-selling brands Remicade (infliximab), Enbrel (etanercept), and Humira (adalimumab) - are designed to reduce inflammation by suppressing the body's disease-fighting immune system. Regulators in both the United States and Canada have issued previous health warnings about these medications. (Globe and Mail)
FDA Starts Safety Review of Autoimmune Disorder Drugs Jun 6, 2008
Four TNF blockers are currently approved in the United States: Enbrel (etanercept), Humira (adalimumab), Remicade (infliximab) and Cimzia (certolizumab). Remicade is approved for use in children with Crohn's disease. (MEDLINEplus)
Drugs' risk of cancer under US scrutiny Jun 5, 2008
The Food and Drug Administration found 30 cases of lymphomas, or immune-cell cancer, in patients age 18 or younger who took anti-inflammatory drugs from a group that includes J&J's Remicade and Amgen's Enbrel, according to an "early communication" posted yesterday on the agency's website ... J&J, of New Brunswick, N.J., had Remicade sales of $5. (Boston Globe)
FDA eyes Abbott arthritis drug for cancer link Jun 5, 2008
The drugs under review include Abbott Labs' Humira, Schering-Plough's Remicade, and Enbrel, which is marketed by Amgen Inc. and Wyeth ... Remicade also topped Schering-Plough's portfolio with sales of $1. (Crain's Chicago Business)
Smucker grows with purchase of Folgers Jun 5, 2008
The drugs under review include Abbott Labs' Humira, Schering-Plough's Remicade, and Enbrel, which is marketed by Amgen and Wyeth. CONFIDENCE IN ALCATEL IS WEAK. (International Herald Tribune -- Business)
Abbott drugs in FDA risk reviews Jun 5, 2008
On Wednesday, the FDA said it will conduct a safety review of Abbott's blockbuster rheumatoid arthritis drug Humira and similar drugs, such as Enbrel and Remicade, following a small number of reports such medicines have been linked to cancer risks in children and young adults ... "The drugs Enbrel, Humira, and Remicade are being reviewed for a possible association between their use and the development of lymphoma and other cancers in children and young adults treated with TNF blockers for... (Chicago Tribune)
Fruit fly protein acts as decoy to capture tumor growth factors, find Penn researchers May 29, 2008
The Avastin antibody works well to block the molecule that activates the vascular endothelial growth factor receptor and several drugs can block tumor necrosis factor- in arthritis, including Remicade, Humira and Enbrel. An Argos-like drug would work the same way in EGFR signaling, suggests Lemmon. (EurekAlert!)
Arthritis Drugs May Impair Response to Flu Vaccine May 23, 2008
Examples of anti-TNF drugs are Enbrel, Remicade and Humira. Gelinck and colleagues compared the immune response after influenza vaccination in 112 patients treated with immunosuppressive therapy, including anti-TNF agents; 48 matched patients not treated with anti-TNF agents, and 18 healthy controls. (MEDLINEplus)
Abbott's Humira tames Crohn's in 29% of cases May 22, 2008
"Remicade's data only goes out to one year in published literature," Kent said in an interview, referring to Johnson on's older blockbuster treatment for the inflammatory bowel disease believed to affect more than 500,000 Americans ... A shorter, previously completed Humira trial called Gain involved 325 patients who were no longer benefiting from Remicade treatment or were intolerant to it ... First-quarter sales of Humira, Abbott's flagship product that also is used to treat rheumatoid... (Crain's Chicago Business)
Daily Briefing May 16, 2008
The truck was reported missing in Tennessee on May 8 while hauling Procrit, an anemia drug; Doxil, for ovarian cancer; and Remicade, an anti-inflammatory medication, J Thursday in a statement. Jlled drugs with the same lot numbers to reduce the chance the stolen drugs could reach patients, the company said. (Atlanta Journal-Constitution -- Business)
Scientists find a quicker way to make antibodies May 2, 2008
And the method could be used to generate fully human monoclonal antibodies for cancer and immune disease treatments such as Genentech Inc's (DNA.N: , , ) breast cancer drug Herceptin and Johnson & Johnson's (JNJ.N: , , ) Remicade for rheumatoid arthritis and other immune diseases. There are more than 20 monoclonal antibody-based therapies approved in the United States, and hundreds more are in development. (Reuters)
New Rheumatoid Arthritis Drugs Equally Effective May 2, 2008
Although the three drugs - Remicade (infliximab), Enbrel (etanercept), and Humira (adalimumab) -- were approved by the US Food and Drug Administration for treatment of rheumatoid arthritis between 1998 and 2003, there are no published "head-to-head" comparative studies, Spanish researchers point out in the journal BMC Musculoskeletal Disorders. Led by Dr. Alberto Alonso-Ruiz at Cruces Hospital in Barakaldo, the research team conducted an analysis of 13 trials lasting at least 6 months involving... (MEDLINEplus)
Takeover costs erode Schering-Plough results Apr 23, 2008
6-billion, led by arthritis and inflammatory disease treatment Remicade, which saw sales jump 36 per cent to $507-million. Animal health products sales totalled $723-million, while sales of consumer products were $377-million. (Globe and Mail -- Business)
University inventions' cash value unrealized Apr 20, 2008
While NYU has several modest winners, the bulk of its $157 million in licensing revenue in 2007 involves patented research that led to the drug Remicade. Used to treat arthritis and other inflammatory diseases, Remicade had annual sales of more than $4 billion last year. (News & Observer)
Abbott profit up on drugs sales Apr 19, 2008
Sales of Abbott's flagship product, arthritis treatment Humira, soared almost 54 percent to 878 million, despite strong competition from Johnson on's (JNJ.N) Remicade and other products. Sales of Depakote, used against epilepsy and bipolar disorder, rose 12 percent to 365 million, while HIV treatment Kaletra rose 18 percent to 353 million. (Yahoo News -- Pharmaceutical Industry News)
New Psoriasis Pill Appears Effective Apr 19, 2008
Other drugs such as infliximab (Remicade) are safe and effective but are expensive and inconvenient to use. In addition, the long-term safety of the drug isn't known. (Health-Finder)
Composer Golijov Defies Borders, Sets His Sights on Brazil's Sultry Beat Apr 4, 2008
Vilcek, a native of the former Czechoslovakia, became wealthy as the co- inventor of the widely used anti-inflammatory drug Remicade. He uses the royalties to fund his foundation and philanthropy. (Bloomberg -- Latin America)
Arthritis pill may cut heart attack risk Mar 7, 2008
This class of drugs includes Johnson & Johnson's Remicade, Amgen Inc.'s Enbrel, and Abbott Laboratories Inc's Humira. The drugs are expensive, which is why people often do not get them right away. (MSNBC -- Health)
Centocor president Fowler leaves for Liquidia Technologies Mar 7, 2008
Members: Not Registered. for free extra services. (Philadelphia Business Journal, PA)
Arthritis Pill Cuts Heart Attack Risk Mar 7, 2008
This class of drugs includes Johnson on's Remicade, Amgen Inc's Enbrel, and Abbott Laboratories Inc's Humira. The drugs are expensive, which is why people often do not get them right away. (Newsmax)
Common Rheumatoid Arthritis Drug Won't Raise Blood Cancer Risk Mar 1, 2008
The study did not present data on any risks associated with new biologic medications, such as Embrel, Humira, and Remicade, which have been available since about 2000, Lindsey and Wilson said. There have been other studies with positive results for one category of these drugs, called TNF-alpha inhibitors, Wilson said. (Health-Finder)
Genentech says key patent rejected, may appeal Feb 26, 2008
Companies that pay royalties to Genentech based on the patent include Abbott Laboratories Inc and Johnson son , for their widely used rheumatoid arthritis medicines, Humira and Remicade, and ImClone Systems Inc for its Erbitux cancer drug. If the patent is ultimately found to be invalid, it could amount to substantial savings for companies now paying royalties. (ABC News -- Wire)
Aggressive Therapy for Crohn's Disease Produces Better Outcomes Feb 23, 2008
Sixty-seven patients assigned to combined immunosuppression received three infusions of Remicade (infliximab) with Imuran (azathioprine) at the start, two weeks later and four weeks after that. The remaining 66 patients received steroids followed by Imuran and Remicade ... " Remicade has its own issues. For instance, it's given intravenously so the individual has to go to the doctor's office," she said. (Health-Finder)
Schering-Plough posts $3.4B loss in 4Q on charges related to Organon Biosciences purchase Feb 13, 2008
Key profit drivers for Schering-Plough include the arthritis treatment Remicade and the allergy treatment Nasonex. Quarterly Remicade sales rose 35 percent to $455 million, while Nasonex sales rose 7 percent to $271 million. (San Diego Union-Tribune -- Business)
Johnson & Johnson Psoriasis Therapy Eases Symptoms With Fewer Injections Feb 3, 2008
It is designed to work differently from Enbrel and Humira and its own drug for psoriasis, Remicade ... Remicade, also approved for rheumatoid arthritis, is taken as an intravenous infusion, making it less convenient for psoriasis patients, doctors say. (Bloomberg -- US)
Newer Rheumatoid Arthritis Drugs Lower Production of B Cells Jan 26, 2008
They found that drugs known as anti-TNF compounds -- including Enbrel, Humira and Remicade -- help reduce the activity of abnormal B cells that play a role in autoimmune diseases such as RA and lupus. TNF is a chemical messenger that fires up the immune system. (Forbes)
J&J profit jumps, boosted by overseas sales Jan 23, 2008
5 per cent to $289-million, while sales of injectable arthritis treatment Remicade jumped 16 per cent to $908-million. Topamax sales grew 23 per cent to $652-million, helped by increasing use of the medicine to also treat migraine headaches. (Globe and Mail -- Business)
A new view of drugs used to treat rheumatoid arthritis Jan 21, 2008
A team of physicians and scientists at the University of Rochester Medical Center reports that drugs known as anti-TNF compounds which include drugs such as Enbrel, Humira and Remicade affect our B cells, which play a role in many autoimmune diseases. In a study published in the cutting-edge section of the Jan. 15 issue of the Journal of Immunology, the team found that anti-TNF compounds help eliminate abnormal B cell activity in patients, raising the possibility that the drugs improve the... (EurekAlert!)
Enbrel Works For Kids With Psoriasis Jan 18, 2008
The chairman of the dermatology department at New York City's Mount Sinai Medical Center, Lebwohl tells WebMD that while many patients show dramatic improvement while taking biologic drugs like Enbrel, Remicade, Humira, and Raptiva, a significant percentage does not. He says more drugs are needed and cites certain investigational drugs as being particularly promising for the treatment of psoriasis. (CBS News)
Adult Drug Effective in Treating Psoriasis in Children Jan 17, 2008
Newer medications, such as etanercept (Enbrel) and infliximab (Remicade), have been approved for treating psoriasis in adults. These medications, called biologics, specifically target the immune response, rather than dampen the entire immune system. (U.S. News & World Report)
FDA approves drug to treat Crohn's disease Jan 16, 2008
The drug is expected to compete with Remicade in the U.S., the leading Crohn's treatment made by Johnson and Johnson. . (Atlanta Journal-Constitution)
More of this story Dec 23, 2007
She began taking the drug Remicade, and for the year and a half that I was on it, I just felt better, she recalled. In 2003, not long after her third child, Caleb, was born, Sara went for a Remicade infusion ... She was in anaphylactic shock from the Remicade. (Patriot Ledger, MA)
Centocor, Schering-Plough revise distribution deal Dec 22, 2007
and revised their 1998 distribution agreement regarding the development, commercialization and distribution of Remicade and new drug golimumab. Remicade is a multibillion-dollar drug approved to treat rheumatoid arthritis, Crohn's disease and other chronic inflammatory disorders ... The revised agreement will extend the duration of Schering-Plough's rights to exclusively market Remicade in its marketing territories outside the United States beyond 2014 to match the current duration of its... (Philadelphia Business Journal, PA)
Severe Psoriasis May Up Risk of Death Dec 18, 2007
These patients generally require treatment with systemic like the drugs and cyclosporine or newer biologics such as Enbrel, Remicade, and Humira. Using a national medical records database from the U.K., Gelfand and colleagues from the University of Pennsylvania School of Medicine identified 133,568 patients with mild psoriasis, defined as having a diagnosis of psoriasis but no history of treatment for the condition. (WebMD)
Severe Psoriasis Associated With Increased Risk Of Death Dec 18, 2007
14, 2005) An international team led by a dermatologist at The University of Manchester has found that treatment with the emerging drug infliximab, marketed as Remicade, can quickly and significantly improve. (Jun. (Science Daily)
$1.5 million judgment entered against former Alva doctor Dec 4, 2007
It was alleged that from 2000 to 2005, Pinegar defrauded Medicare for two prescription medications: Procrit and Remicade ... Remicade is administered by intravenous infusions and is used to treat rheumatoid arthritis, Crohn s disease (chronic inflammation of the gastrointestinal (GI) tract), ulcerative colitis, and other diseases of the GI tract ... From January 2003 to May 2005, Pinegar s practice billed Medicare for 112,110 milligrams of Remicade but ordered no more than 49,600 milligrams from... (Alva Review Courier, OK)
Could Stem Cells Be Used To Cure Crohn's Disease? Dec 4, 2007
(May 4, 2007) A study led by Mayo Clinic found that adalimumab ((HUMIRA) is an effective treatment for adults with Crohn's disease who do not respond to infliximab (REMICADE)). (Nov. (Science Daily)
Multiple Alloantibodies after Transfusion in an Infant Treated with Infliximab Nov 15, 2007
To the Editor: Infliximab (Remicade) is a humanized mouse monoclonal antibody that blocks tumor necrosis factor. 1 It down-regulates type 1 helper T-cell (Th1) immune responses and increases type 2 helper T-cell (Th2) responses, thereby favoring antibody production. (New England Journal of Medicine)
Centocor drug marks milestone Nov 8, 2007
said Tuesday its flagship product Remicade, best known as a treatment for rheumatoid arthritis, has become the first anti-TNF biologic therapy to treat 1 million patients worldwide ... Remicade was originally approved by the Food and Drug Administration in 1998 as a treatment for Crohn's disease ... Remicade is a monoclonal antibody engineered to inhibit TNF-alpha. (Philadelphia Business Journal, PA)
