Osteoporosis Drugs Linked to Jaw Infection, Study Shows May 2, 2008
Sedghizadeh said there have been increasing reports of osteonecrosis (bone death) of the jaw in patients who have been taking the drugs for osteoporosis or for treatment from the bone-wasting effects of cancer ... "This is the first study that identifies microbial biofilms in the bone of bisphosphonate patients who have osteonecrosis of the jaw," Sedghizadeh said ... Jaw osteonecrosis occurs when bacteria-laden biofilms infect the jaw after the bone is exposed, typically because of a tooth... (Science Daily)
Osteoporosis meds and bone collapse: weighing the risks Apr 9, 2008
Osteonecrosis of the jaw, a disease in which a patient's jawbone rots and dies, has been associated with the use of bisphosphonates, a popular class of medication for the treatment of osteoporosis. In most cases, osteonecrosis of the jaw occurs in cancer patients who receive high-dose intravenous bisphosphonates to control high calcium levels or to treat cancer that has spread to the bones ... Often, these patients have had chemotherapy or radiation therapy, which increase the likelihood of... (Globe and Mail)
Young Patients With Knee Disorder Get Active After New Surgical Procedure Apr 6, 2008
He underwent long-term steroid treatment to prevent transplant rejection, which left him with an excruciating knee disorder called osteonecrosis ... The procedure was done for the first time on three young patients with steroid-induced osteonecrosis of the knee by orthopedic surgeon Stuart Goodman, MD, PhD, and is described in a preliminary report to be published in the April issue of the Journal of Arthroplasty ... Osteonecrosis of the knee is a rare disorder. (Science Daily)
Hip replacement technique helping at St. Francis Mar 21, 2008
Hip replacement surgery may also be recommended in the case of hip fracture or osteonecrosis to relieve chronic pain and enable patients to return to daily activities that were previously too painful. BFH Technology features a significantly larger ball and thinner socket than conventional hip replacement devices and is designed to be a more durable and stable implant alternative. (Maryville Daily Forum, MO)
Musher in wheelchair realizes dream trip Mar 3, 2008
During physical therapy they found I had osteonecrosis, which is bone death, in my hip. My hip was disintegrating. (Anchorage Daily News)
Roles of TNF-|alpha| gene polymorphisms in the occurrence and progress of SARS-Cov infection:a case-control study Mar 1, 2008
This study was to investigate the relationship between tumor necrosis factor (TNF)-alpha gene polymorphisms with the occurrence of SARS-Cov infection and its role in prognosis of patients with lung interstitial fibrosis and femoral head osteonecrosis ... Relationships of TNF-alpha gene polymorphisms with interstitial lung fibrosis and femoral head osteonecrosis were carried out in two case-case studies in discharged SARS patients. (BioMed Central)
Link between treating osteoporosis with bisphosphonates and incidence of bone necrosis examined Feb 17, 2008
In 2003, the first reports emerged of a new disease, called osteonecrosis of the jaw (ONJ), found in patients who were using BFs ... Dr. Grbic and his team have found in a study of more than 7,000 patients, that the use of BFs to treat osteoporosis has little or no effect on the incidence of osteonecrosis. (EurekAlert!)
Aastrom Biosciences Announces Transition of Duties Feb 16, 2008
Currently, the Company has a vascular regeneration product in clinical development for the treatment of critical limb ischemia (called the RESTORE-CLI trial), a bone regeneration product in Phase III development for the treatment of osteonecrosis of the femoral head (called the ON-CORE trial), a cardiac regeneration product in clinical development for dilated cardiomyopathy and a preclinical research program targeting unmet needs in neural health. Aastrom product candidates to treat... (Primezone Releases)
Popular Osteoporosis Drugs Triple Risk Of Painful Bone Necrosis, Study Finds Jan 16, 2008
"Although the osteonecrosis side-effect is rare, the use of the bisphosphonates is very common," Esdaile adds. "People taking bisphosphonates are now hearing about the potential side-effects, and this study result will permit physicians to better inform them what the order of magnitude of the risk may be.". (Science Daily)
Oral Osteoporosis Meds Appear To Reduce The Risk Of Jaw Degradation Jan 7, 2008
30, 2004) Doctors at Long Island Jewish (LIJ) Medical Center recently discovered a link between a common chemotherapy drug and a serious bone disease called osteonecrosis of the jaw (ONJ). The discovery. (Science Daily)
Judge denies class in Fosamax cases against Merck Jan 5, 2008
They allege that Fosamax caused the plaintiffs to either develop the ailment, known as osteonecrosis of the jaw, or to suffer an increased risk of developing the condition in the future, Keenan wrote. Plaintiffs' lawyer Timothy O'Brien said funding the program in the three states would have cost Merck hundreds of millions of dollars. (ABC News -- Wire)
Oral Bisphosphonates May Lower Jaw Necrosis Risk Jan 5, 2008
NEW YORK (Reuters Health) - A report in the Journal of the American Dental Association clarifies the risk of jaw osteonecrosis associated with bisphosphonates, which are used to prevent or slow the progression of osteoporosis ... In 2003, reports first surfaced linking intravenous bisphosphonate treatment with osteonecrosis of the jaw ... To investigate further, the researchers analyzed medical claims from 714,217 patients with osteoporosis or cancer to determine the effect that bisphosphonate... (MEDLINEplus)
Doctors angered by ABC report on bone drugs Dec 19, 2007
The contentious story - presented by Nick Grimm - stated that so-called bisphosphonate drugs can cause the jaw bone to dissolve, a disfiguring condition called osteonecrosis of the jaw, or ONJ.. But the society said the claims were misleading, and warned that if cancer patients stayed off bisphosophonate medications such as Zometa and Aredia for prolonged periods, their disease could more easily spread. (The Australian)
ASK DR. WEIL Beware of drugs for bone boosting Dec 18, 2007
Dentists have observed that some patients on these drugs are at risk of developing an untreatable condition called osteonecrosis of the jaw (ONJ), which can cause chronic pain and disfigurement. Symptoms include toothache, jaw pain, loosening of teeth, recurrent infection of the soft tissue of the jaw and exposed bone. (Houston Chronicle)
Watchdog under fire over 'dead jaw' drug fears Dec 14, 2007
30 Report revealed that increasing numbers of Australians are falling victim to a side effect known as osteonecrosis of the jaw ... The company's Australian subsidiary is now being put on notice to expect a similar class action from those Australians who have developed osteonecrosis of the jaw as a result of using Fosamax. (ABC Online)
Worrying drug side effects: death of the jawbone Dec 13, 2007
It's called osteonecrosis of the jaw ... The bone cancer patient is here because he also has osteonecrosis of the jaw or ONJ, a horrible side-effect of a drug prescribed as part of his cancer treatment. (ABC Online)
Cancer drugs spark 'dead jaw' concerns Dec 11, 2007
An estimated 500 Australians have developed the condition named osteonecrosis of the jaw (ONJ) over the past four years, linked to their prescribed use of bisphosphonate drugs which help to treat osteoporosis. A class action has been launched by ONJ sufferers in the United States, ABC Television reported, where there are questions over whether drug makers have published adequate warnings over side-effect risks. (Sydney Morning Herald -- Australia)
Aastrom Biosciences to Present At RBC Capital Markets Healthcare Conference Dec 8, 2007
Currently, the Company has a vascular regeneration product in clinical development for the treatment of critical limb ischemia (called the RESTORE-CLI trial), a bone regeneration product in Phase III development for the treatment of osteonecrosis of the femoral head (called the ON-CORE trial), and preclinical research programs targeting unmet needs in cardiac and neural health. Aastrom product-candidates to treat osteonecrosis of the femoral head and dilated cardiomyopathy have been designated... (Primezone Releases)
Ugandan Children Are Among the First to Receive Abbott's Lower-Strength Aluvia (lopinavir/ritonavir) Tablet Dec 2, 2007
Some patients taking combination antiretroviral therapy may develop a bone disease called osteonecrosis. Signs and symptoms are joint stiffness, aches and pains (especially in the hip, knee and shoulder) and difficulty in movement. (PR Newswire)
Aastrom Biosciences, Inc. Reports First Quarter Fiscal Year 2008 Financial Results Nov 9, 2007
75) one year post-BRC treatment - 100% of the patients who have healed are fully weight-bearing, have regained range of motion and are no longer impaired by their injuries - Severe bone fracture results supported bone regeneration proof of principle and the initiation of Aastrom's U.S. Phase III osteonecrosis of the femoral head clinical trial -- Encouraging interim results from two German research groups utilizing Aastrom's proprietary Tissue Repair Cell (TRC) Technology platform to manufacture... (Primezone Releases)
Zoledronic Acid in Reducing Mortality after Hip Fracture Nov 1, 2007
No cases of osteonecrosis of the jaw were reported, and no adverse effects on the healing of fractures were noted. The rates of renal and cardiovascular adverse events, including atrial fibrillation and stroke, were similar in the two groups. (New England Journal of Medicine)
Aastrom Announces Positive Interim Results From Phase I/II Study Involving Use of Vascular Repair Cells in Patients With Critical Limb Ischemia Oct 4, 2007
Results Presented Today At the Congress of the German Society for Stem Cell Research in Wurzburg, Germany Early Clinical Data Supporting Use of Aastrom Bone Repair Cells (Brcs) in Treatment of Osteonecrosis of the Femoral Head Also Presented ... In another presentation, positive results from the use of Aastrom Bone Repair Cells (BRCs) in the treatment of osteonecrosis of the femoral head were presented ... In a second oral presentation at the same meeting, clinical results were presented by... (Primezone Releases)
New Study Shows Once-Monthly Boniva(R) is as Clinically Effective as Once-Weekly Fosamax(R) at Increasing Bone Mineral Density in Postmenopausal Women With Osteoporosis Sep 20, 2007
Additionally, osteonecrosis of the jaw has been reported in patients treated with bisphosphonates; most cases have been in cancer patients undergoing dental procedures. The most commonly reported adverse events with once-monthly Boniva regardless of causality were abdominal pain (Boniva 150 mg 7. (PR Newswire)
Once-a-Year Bone Drug Lowers Fracture Risk Sep 19, 2007
They also found no reports of osteonecrosis of the jaw, a painful jaw condition, which had previously been associated with this class of drugs. More information. (Health-Finder)
Novartis Bone Drug Prevents Fractures, Lengthens Life in Study Sep 19, 2007
In 2005, Novartis warned doctors that some patients on Zometa experienced a condition called osteonecrosis of the jaw, which destroys the jawbone. There were no cases in the study. (Bloomberg)
Reclast Improves Survival Following Hip Repair, New Study Sep 19, 2007
There were no reported cases of osteonecrosis (loss of blood supply to the bone). No adverse effects on the healing of fractures were observed. (Medical News Today)
First Osteoporosis Study in Hip Fracture Patients Finds Once-Yearly Reclast(R) Prevents Additional Fractures and Improves Survival Sep 18, 2007
No cases of osteonecrosis of the jaw (ONJ) were seen in the study. The most common adverse events with Reclast were transient post-dose symptoms (such as fever, muscular pain, etc). (PR Newswire)
Study: Drug reduces death after hip breaks Sep 18, 2007
Past side effects of zoledronic acid have included abnormal heart rhythms and a rare jaw condition called osteonecrosis, but neither emerged as a risk in the recent trials, Lyles said. newsobserver. (News & Observer)
Once A Year Osteoporosis Drug Reclast Gets FDA Approval Aug 21, 2007
There were no spontaneous reports of osteonecrosis of the jaw (ONJ) in the Pivotal Fracture Trial. ONJ has occurred, albeit rarely, in other trials involving bisphosphonates. (Medical News Today)
Bone Drugs Linked to Jaw Disease in Cancer Patients Jun 28, 2007
NEW YORK (Reuters Health) - Corroborating previous evidence, the results of a large study strongly suggest that cancer patients treated with "bisphosphonates" are at increased risk for the destruction or "osteonecrosis" of the jawbone, according to a study in the Journal of the National Cancer Institute ... But since 2003, physicians have reported more than 600 cases of jaw osteonecrosis that may have been caused by bisphosphonate use ... Evidence is growing that bisphosphonate treatment causes... (MEDLINEplus)
First Patient Treated in Aastrom Adult Stem Cell Trial for Critical Limb Ischemia Jun 28, 2007
TRC-based products have been used in over 250 patients, and are currently in clinical trials for bone regeneration (osteonecrosis of the femoral head and long bone fractures) and vascular regeneration (critical limb ischemia applications) ... TRC-based products have received Orphan Drug Designation from the FDA for use in the treatment of osteonecrosis of the femoral head and the treatment of dilated cardiomyopathy, a severe chronic disease of the heart. (Primezone Releases)
Down in the mouth? Jun 26, 2007
Bisphosphonates may place patients at risk for developing osteonecrosis of the jaws, which is irreversible damage in which the jaw bone rots away ... According to Dr. Svirsky, adverse affects from oral bisphosphonates will not show up until three years after the treatment starts, and after that time, the chance of developing osteonecrosis is still low ... In addition, there is a new screening tool now available that can help patients who have been taking an oral bisphosphonate for more than... (EurekAlert!)
Merck Sued in Ontario Court Over Fosamax Drug, Canadian Law Firm Says May 29, 2007
Use of the drug has been linked to an increased risk of developing osteonecrosis, also known as ``jaw death,'' according to the Canadian law firm ... Fiona Peters, 45, the lead plaintiff, took the drug between October 2001 and August 2004 and was diagnosed with osteonecrosis of the jaw last year, according to the complaint. (Bloomberg -- Canada)
Fosamax class action commenced in Canada May 28, 2007
Use of Fosamax has been linked to an increased risk of developing Osteonecrosis of the jaw ("ONJ"), also known as "jaw death". ONJ can be extremely painful and can cause jaw bones to rot and die. (Canada Newswire)
Experts Outline Use of Bisphosphonates Against Myeloma May 25, 2007
Risks associated with bisphosphonates include reduced kidney function, acute kidney failure and osteonecrosis (bone loss or deterioration) of the jaw. Among the recommendations included in the new guidelines. (MEDLINEplus)
Hannan’s Miller battles back from rare disease May 14, 2007
It s a disease that affects 1 in 1200 children, and of those afflicted, about three of four are boys, according to the National Osteonecrosis Foundation Web site (www. nonf. (Scranton Times, PA)
Tuesday's Stocks to Watch May 8, 2007
Aastrom Biosciences Inc. () said the Food and Drug Administration has approved its investigational new drug application to initiate a 120-patient Phase III clinical trial for the treatment of osteonecrosis, also known as avascular necrosis, of the femoral head. Osteonecrosis is a progressive disease, with no established effective treatments, that often leads to a total hip replacement. (Fox News)
New hope, concern on osteoporosis May 4, 2007
Another side effect, jaw osteonecrosis - jawbone death - has recently been recognized as a rare problem of certain bisphosphonates ... Last year, Merck estimated the risk of osteonecrosis to be less than one out of 100,000 patients per year. (Philadelphia Inquirer)
New method predicts hip joint decay from chemotherapy Apr 20, 2007
St. Jude study shows that the extent of hip decay is key to predicting which survivors of leukemia/lymphoma who develop osteonecrosis of the femoral head will suffer hip joint collapse requiring surgical repair ... The study is significant because the intensive use of corticosteroid drugs that have been implicated in development of osteonecrosis, or bone deterioration, is a major component of chemotherapy for pediatric leukemia and lymphoma ... Degeneration of this area, called osteonecrosis of... (EurekAlert!)
Side effect of jaw osteonecrosis Apr 16, 2007
Dear Dr. Donohue: After a bone density test, my physician prescribed Fosamax. I have heard that it has a serious side effect -- jaw decay. (Herald-Tribune)
Abbott Agrees With World Health Organization (WHO) Director-General to Expand Access to Kaletra/Aluvia (lopinavir/ritonavir) Apr 10, 2007
Although the etiology is considered multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy. At this stage of development, little information is available on the cross-resistance of viruses selected during therapy with Kaletra. (PR Newswire)
Overgrowth of gums, unexepected side effect of blood pressure med Mar 29, 2007
31) in which you spoke of a dentist recommending that the patient stop taking her blood pressure medication Norvasc due to the risk of bone loss to the jaw, the dental recommendation probably had more to do with the risk of gingival hyperplasia than osteonecrosis of the jaw ... While CCBs do not cause osteonecrosis of the jaw, nor do they directly cause bone loss, they can indirectly cause it if they're causing significant gingival hyperplasia. (Atlanta Journal-Constitution)
Body Parts: Femur is bone with the most ---- in a lot of categories Feb 25, 2007
The tissue then dies, causing osteonecrosis. Because bone is living tissue, osteonecrosis weakens it ... Osteonecrosis is most likely to occur in the femoral head. (North County Times)
BioMimetic drug on fast track for approval Feb 22, 2007
The product, called recombinant human platelet derived growth factor, attracts cells necessary for tissue healing in patients with Osteonecrosis of the jaw, which is characterized by pain, swelling and infection, loosening of teeth and exposed bone. The condition affects fewer than 20,000 people in the country. (Nashville Business Journal, TN)
Maple Hill students unite for classmate Jan 31, 2007
According to the National Osteonecrosis Foundation, Legg-Calve Perthes is a rare disease of the hip found only in children that afflicts approximately one in 1,200 children. Of those, only about one in four are girls. (Hillsdale Independent, NY)
Adult Stem Cells Spur Rush to Market as Remedies Avoid Bush's Embryo Ban Jan 11, 2007
Aastrom is also conducting trials that use stem cells in spinal fusion, jawbone reconstruction and a rare disease, osteonecrosis, which damages the hip and often leads to repeated hip replacements. The company plans to begin final-stage trials for osteonecrosis in the first half of this year. (Bloomberg)
