The girl doesnt know how to stop Oct 13, 2009
According to the National Osteonecrosis Foundation, the rare disease of the hip afflicts approximately one in 1,200 children. Of those children, only about one in four are female but the disease is usually more severe in girls. (Gillette News-Record, WY)
Phase 3 Trial Shows Denosumab Delayed Skeletal Related Events in Advanced Cancer Patients With Bone Metastases Sep 21, 2009
THOUSAND OAKS, Calif. There is no need for renal monitoring or dose adjustments due to renal impairment," said David Henry, M.D., clinical professor of Medicine, Pennsylvania Hospital, Philadelphia, PA, United States of America. "Furthermore, the positive results of this study, combined with the convenience of a monthly subcutaneous injection and without the flu-like symptoms associated with Zometa administration, make this an exciting potential treatment option for advanced cancer patients. (Canada Newswire)
Citing deadlock, judge declares mistrial in first Fosamax case Sep 12, 2009
Merck faces lawsuits by roughly 1,500 plaintiffs who allege Fosamax caused the same painful jaw condition that Boles now has - osteonecrosis of the jaw, in which bone tissue dies and detaches from the gum. Copyright 2009 Globe Newspaper Company. (Boston Globe)
Yeast Unravels Effects Of Chemotherapy Drugs Sep 12, 2009
(May 12, 2009) Bisphosphonates have been found to place people at risk for developing osteonecrosis of the jaws (a rotting of the jaw bones). Dentists, as well as oncologists, are now using X-rays to detect "ghost ... > Number of stories in archives: 44,032 Find with keyword(s): Enter a keyword or phrase to search ScienceDaily's archives for related news topics, the latest news stories, reference articles, science videos, images, and books. Just In: Biomedicine scientists identified and... (Science Daily)
Fosamax jury gets cooling-off period Sep 10, 2009
Boles used Fosamax from 1997 to 2006 and by September 2003 had developed osteonecrosis of the jaw, according to her lawyers. Her doctor prescribed Fosamax because of a stress fracture in her foot, she testified. (Boston Globe)
New osteoporosis diagnostic tool 'FRAX' draws criticism Sep 9, 2009
Mercks popular drug Fosamax is the subject of hundreds of lawsuits by patients who assert that it caused osteonecrosis of the jaw, a rare disease that breaks down the jawbone. The FRAX guidelines in the United States call for medication when the calculated risk for hip fracture in the next 10 years is 3 percent or the combined risk of a broken hip, vertebra, shoulder or wrist is 20 percent. (India Times, India -- Health/Science)
Denosumab Increases Bone Density, Cuts Fracture Risk In Prostate Cancer Survivors Sep 8, 2009
Few adverse events were associated with treatment, and there were no reports of osteonecrosis of the jaw, a problem reported in some patients taking bisphosphonates. "Denosumab is an important new therapy to prevent painful fractures in prostate cancer survivors," Smith says. (Science Daily)
Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis Aug 20, 2009
There was no increase in the risk of cancer, infection, cardiovascular disease, delayed fracture healing, or hypocalcemia, and there were no cases of osteonecrosis of the jaw and no adverse reactions to the injection of denosumab. Conclusions Denosumab given subcutaneously twice yearly for 36 months was associated with a reduction in the risk of vertebral, nonvertebral, and hip fractures in women with osteoporosis. (New England Journal of Medicine)
Merck Faces First Trial of 900 Claims Its Drug Fosamax Attacks Jawbones Aug 10, 2009
Jawbone tissue death is called osteonecrosis of the jaw, or ONJ. ... Boles, of Walton Beach, Florida, says she used Fosamax from 1997 to 2006 and eventually developed osteonecrosis. (Bloomberg -- US)
Amgen's Uphill Marketing Battle Jul 9, 2009
And unlike some of the older drugs, denosumab does not seem to touch off a frightening side effect called osteonecrosis of the jaw (ONJ), which can cause pain and bone protrusions in the mouth. (In the most recent trial, ONJ was rare in the Zometa group, too. (BusinessWeek)
Analyst Picks and Pans: Amgen, RF Micro, Chattem Jul 9, 2009
A concern for osteoporosis drugs is a side effect called osteonecrosis of the jaw, where the blood supply is cut off to an area of bone, therefore weakening the bone ... "Though a significant difference in osteonecrosis of the jaw would have been a home run, we believe that superior efficacy will be enough to drive additional (denosumab) front-line use," Somaiya said, in a note to investors ... Also on July 8, William Blair nalyst John Sonnier reaffirmed a outperform rating, but raised some... (BusinessWeek)
Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases Jul 8, 2009
Of note, osteonecrosis of the jaw (ONJ), which had not been observed in previously reported Phase 3 studies with denosumab, was seen infrequently in both treatment groups. There was no statistically significant difference in the rate of ONJ between the two treatment arms. (PR Newswire)
Treating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation Jun 25, 2009
Common adverse effects included allergic reactions to asparaginase, osteonecrosis, thrombosis, and disseminated fungal infection. Conclusions With effective risk-adjusted chemotherapy, prophylactic cranial irradiation can be safely omitted from the treatment of childhood ALL. (ClinicalTrials. (New England Journal of Medicine)
Health Canada approves Canada's first and only once-a-month treatment for postmenopausal osteoporosis Jun 1, 2009
In postmarketing reporting, osteonecrosis of the jaw has been reported in patients treated with bisphosphonates. Clinical judgement based on individual risk assessment should guide the management of patients undergoing dental procedures. (Canada Newswire)
X-rays help predict permanent bone damage from bisphosphonates May 8, 2009
These drugs have been found to place people at risk for developing osteonecrosis of the jaws (a rotting of the jaw bones). Dentists, as well as oncologists, are now using X-rays to detect "ghost sockets" in patients that take these drugs and when these sockets are found, it signals that the jawbone is not healing the right way. (EurekAlert!)
Renowned Stem Cell Researcher Files Study Results With Stemedica Mar 18, 2009
Wed Mar 18, 3:01 am ET. Stemedica Cell Technologies, Inc. received the results today from a Stemedica-sponsored clinical study conducted by renowned stem cell researcher and clinician Professor Philippe Hernigou, MD, Ph. (Yahoo News -- Press Releases)
Childhood Chicken Pox Can Lead To Shingles Later In Life Feb 25, 2009
Herpes zoster manifests as painful blisters that erupt along the sensory nerves usually on one side of the body or face, according to co-author of the study, M.A. Pogrel, DDS, MD. It can be a debilitating disease that can lead to osteonecrosis of the jaw and vision loss in addition to a prolonged painful syndrome. Osteonecrosis is a condition in which bone in the lower or upper jaw becomes exposed ... However, AGD spokesperson, Laura Murcko, DMD, notes that, Your dentist can help detect early... (Science Daily)
Most people could use calcium supplements Feb 20, 2009
Don't be scared about osteonecrosis, or death of the jaw bone, as this is a rare complication mostly seen in folks with cancer who receive such drugs via IV through the veins. Evista, another drug, may not reduce hip fractures. (Honolulu Advertiser)
Study Links Osteoporosis Drugs to Jaw Trouble Feb 7, 2009
Previous reports had indicated that the risk of developing osteonecrosis of the jaw (ONJ) from bisphosphonates in pill form were "negligible," although there was a noted risk in people taking the higher-dose intravenous form of the drug. But Dr. Parish Sedghizadeh, an assistant professor of clinical dentistry at the University of Southern California School of Dentistry in Los Angeles, said his clinic is seeing one to four new cases a week, compared to one a year in the past. (MEDLINEplus)
