Researchers Have Immune Cells Running In Circles Nov 14, 2009
The work was funded by grants from the National Institutes of Health and the Department of Defense Neurofibromatosis Research Program Career Development Award. Adapted from materials provided by , via , a service of AAAS. Email or share this story. (Science Daily)
Researchers Reconstitute Enzyme That Synthesizes Cholesterol Drug Lovastatin Nov 10, 2009
(July 31, 2008) Lovastatin, a drug used to lower cholesterol and help prevent cardiovascular disease, has been shown to improve bone healing in an animal model of neurofibromatosis type 1. The research, reported. (Science Daily)
Hearing Improvement after Bevacizumab for Neurofibromatosis Type 2 Oct 29, 2009
To the Editor: Plotkin et al. (July 23 issue)1 report a sustained tumor-volume reduction in 4 of 10 patients and a hearing response in 4 of 10 patients with neurofibromatosis type 2 after bevacizumab treatment ... Shrinkage of a vestibular schwannoma, especially in cystic tumors in patients with neurofibromatosis type 2, can also occur during an observation period without any treatment. (New England Journal of Medicine)
Acreage residents seek cancer answers from health officials Oct 21, 2009
Here is a clip from the report I found:"Risk Factors--Like most pediatric cancers, no specific risk factor explains more than a small proportion of childhood brain tumors. The known risk factors for childhood brain tumors include ionizing radiation and certain genetic conditions. Therapeutic doses of ionizing radiation to the head increase the risk of brain tumors in children (Bunin, 2000). Some hereditary conditions clearly predispose to CNS cancer in children. These include neurofibromatosis... (The Palm Beach Post)
7 Points: A Little Face Time For Brady Oct 18, 2009
" This season, Folk's kicks mean more than ever. He's become a spokesperson for the Children's Tumor Foundation, a cause that's very personal to him and his family since he has a 14-year-old cousin with neurofibromatosis, a disease that causes tumors to grow along nerves throughout the body. Folk is donating money to the foundation for every extra point and field goal that he makes. You can learn more about his "Kick for a Cure" campaign and join him in supporting research for a cure . Point 5:... (eDuck.com)
10 Minutes With Nick Folk Oct 17, 2009
Folk: I was just announced the head spokesperson for the Childrens Tumor Foundation, which is a foundation that helps kids with neurofibromatosis. Its a disease that causes kids to get tumors in their nerves. (CatTracks.net)
Loss Of Tumor Supressor Gene Essential To Transforming Benign Nerve Tumors Into Cancers Oct 14, 2009
The work, a collaboration between the Institute for Molecular Medicine, the Department of Molecular and Medical Pharmacology and the cancer center's Sarcoma Program, could lead to the development of new therapies that target the cell signaling pathway regulated by PTEN. A novel mouse model of neurofibromatosis type 1 (NF1) developed at UCLA first illustrated the importance of PTEN tumor suppressor in malignant transformation and this finding was validated in human malignant peripheral nerve... (Science Daily)
Column: Assault on bus shows flaws in the system Oct 4, 2009
He s entitled to that seat because he has neurofibromatosis, a disease that causes tumors to attack his nervous system. His spinal cord is deteriorating. (Longview Daily News, WA)
Travolta Defendants Caught in the Act? Sep 30, 2009
My grandson has neurofibromatosis and also has had (possibly in utero) a stroke. He was having multiple focal seizures every day, and eventually had a full tonic-clonic seizure. (CBS News -- Early Show)
Burlington charity featured on NECN Sep 30, 2009
From left to right is: Dylan Flynn, Patty Flynn, and Joe Joyce from New England Cable News, Karen Peluso, executive director of Neurofibromatosis, Inc., Northeast and Lori Ryan, chairperson of Steps2Cure NF ... Representatives from Neurofibromatosis, Inc., Northeast, a nonprofit organization based in Burlington, were recent guests of Joe Joyce on (NECN), where they spoke about neurofibromatosis and the organization s upcoming run/walk to benefit the charity ... Neurofibromatosis is not rare,... (Burlington Union, MA)
Learning curve Sep 26, 2009
Within months however they had the shocking diagnosis that not only had Emma got a potentially serious illness of the nervous system, but that at least four other members of her close family also had the same condition, neurofibromatosis. Neurofibromatosis 1 (NF1) occurs in one in 2,500 births and mainly affects the nervous system and the skin ... NEUROFIBROMATOSIS NF1 occurs in 1 in 2,500 births The complications of NFI include benign and malignant tumours The Elephant Man was wrongly thought... (BBC News -- UK)
Cancer Drug Shrinks Benign Tumors That Steal Hearing Sep 15, 2009
Four years earlier, Garrett learned she had neurofibromatosis type 2 (NF2), a condition characterized by tumors in the nervous system ... "This treatment is indeed a novel approach," said Dr. Bruce Korf, chair of the department of genetics at the University of Alabama in Birmingham and an expert on neurofibromatosis ... SOURCES: Scott Plotkin, M.D., clinical director, Neurofibromatosis Clinic, Massachusetts General Hospital, Boston; Bruce Korf, M.D., professor and chair, department of genetics,... (MEDLINEplus)
Researchers Restore Missing Protein In Rare Genetic Brain Disorder Sep 11, 2009
The new discovery provides new insights into an old mystery, revealing why patients with neurofibromatosis. (May 3, 2006) At the Institut Curie, CNRS and Inserm researchers have shown that cysteamine, which is already used to treat a rare disease called cystinosis, prevents the death of neurons in Huntington's disease. (Science Daily)
NexGenix Pharmaceuticals to Present at Two Industry Conferences: Rodman & Renshaw 11th Annual Healthcare Conference and Life Sciences Summit 2009 Sep 11, 2009
In addition, the Company has a clinical stage intralesional treatment for dermal neurofibromas, the most common lesion in Neurofibromatosis Type 1, and a research stage program in inhibitors of p21-activated kinase for indications including Neurofibromatosis Type 2, and Autism Spectrum Disorders. SOURCE NexGenix Pharmaceuticals. (PR Newswire)
New Research Strategy For Understanding Drug Resistance In Leukemia Sep 9, 2009
The research was supported by grants from the National Institutes of Health, the Leukemia and Lymphoma Society, the US Army Neurofibromatosis Research Program, the Ronald McDonald House Charities of Southern California/Couples Against Leukemia, the Jeffrey and Karen Peterson Family Foundation, and the Frank A. Campini Foundation. One of the nation s top children s hospitals, UCSF Children s Hospital creates an environment where children and their families find compassionate care at the healing... (Science Daily)
Enzyme inhibitor takes an unexpected approach toward blocking cancer-promoting protein Sep 8, 2009
The study was funded by grants from the National Institutes of Health, the Department of Defense Neurofibromatosis Research Program, an AACR-Fox Chase Cancer Center Career Development Award, the Fondation pour la Rescherche Mdicale, the National Cancer Institute, and the Commonwealth of Pennsylvania Department of Health. The initial screening that resulted in the identification of IPA-3 was made possible through a generous donation by the Gralla Family to Fox Chase Professor Jonathan Chernoff,... (EurekAlert!)
Bunger students, staff play ball to raise money for classmate with cancer (1) Aug 20, 2009
He suffers from a genetic disorder of the nervous system called neurofibromatosis, severe scoliosis and a collapsed lung. On Thursday, the Galles were not focused on those difficulties. (Waterloo Courier, IO)
Hearing Improvement after Bevacizumab in Patients with Neurofibromatosis Type 2 Jul 23, 2009
Background Profound hearing loss is a serious complication of neurofibromatosis type 2, a genetic condition associated with bilateral vestibular schwannomas, benign tumors that arise from the eighth cranial nerve ... Methods We determined the expression pattern of vascular endothelial growth factor (VEGF) and three of its receptors, VEGFR-2, neuropilin-1, and neuropilin-2, in paraffin-embedded samples from 21 vestibular schwannomas associated with neurofibromatosis type 2 and from 22 sporadic... (New England Journal of Medicine)
Obama, Science and God Jul 15, 2009
As a pioneering "gene hunter," he helped identify the genetic markers for cystic fibrosis, neurofibromatosis, Huntington's disease and adult onset diabetes. He was in charge of the program at NIH that mapped the human genome, the biological equivalent of the Apollo space program. (Townhall.com)
Hearing Improved: First Successful Medical Treatment For Tumor-inducing Genetic Disorder Jul 10, 2009
ScienceDaily (July 9, 2009) Treatment with the angiogenesis inhibitor bevacizumab improved hearing and alleviated other symptoms in patients with neurofibromatosis type 2 (NF2) ... The study was supported by the HMS Center for Neurofibromatosis and Allied Disorders, Neurofibromatosis Inc. New England, Children's Tumor Foundation, the Department of Defense, the National Institutes of Health, and the MGH Executive Committee on Research. (Science Daily)
Drug Shows Promise in Nervous-System Tumor Treatment Jul 10, 2009
WEDNESDAY, July 8 (HealthDay News) -- U.S. researchers report the first successful drug treatment of tumors in patients with neurofibromatosis type 2 (NF2). In people with NF2, benign tumors develop throughout the nervous system. (MEDLINEplus)
Obama nominates geneticist to head health agency Jul 9, 2009
Using that technique, he and his group subsequently identified the genes for Huntington's disease, neurofibromatosis, multiple endocrine neoplasia type 1 (a tumor of the parathyroid and pituitary glands) and the M4 type of adult acute leukemia. Collins replaced James Watson as head of the National Human Genome Research Institute (NHGRI) at the National Institutes of Health in 1993. (Xinhuanet, China)
A drug’s unintended userestores the gift of hearing Jul 9, 2009
As a 19-year-old college student, she was diagnosed with neurofibromatosis type 2, which causes tumors to sprout inside the brain ... General s Neurofibromatosis Clinic and lead author of the study ... Neurofibromatosis type 2 - known in medical shorthand as NF-2 - typically arrives with quiet stealth. (Boston Globe)
Secrets Revealed About How Disease-causing DNA Mutations Occur Jul 6, 2009
ScienceDaily (July 5, 2009) A team of Penn State scientists has shed light on the processes that lead to certain human DNA mutations that are implicated in hundreds of inherited diseases such as tuberous sclerosis and neurofibromatosis type 1. The results one day could influence the way couples who seek to have children receive genetic counseling. (Science Daily)
Chromosomal Problems Affect Nearly All Human Embryos: Discovery May Explain Low Fertility Rates In Humans Jul 2, 2009
PGD is carried out where one or both parents have a known genetic abnormality, in this case an X-linked disorder or the microdeletions (loss of a tiny piece of a chromosome) that can cause such disorders as the cancer predisposition syndrome neurofibromatosis type 1. The embryos are screened to avoid the implantation of one carrying that abnormality. (Science Daily)
Fifteen-year-old Galle loses battle with cancer (3892) Jul 2, 2009
He suffered from neurofibromatosis, a genetic disorder in which soft tissue tumors entwine with blood vessels and veins. Galle was first diagnosed at 10 months old with the disorder. (Waterloo-Cedar Falls Courier)
Ross TuckerINSIDE COLLEGE FOOTBALL Jun 16, 2009
Doctors diagnosed the daughter of Lafayette defensive coordinator John Loose and his wife Marianne with Neurofibromatosis, Moyamoya disease and Evan's Syndrome at nine months old. As Lauren battled brain and spinal cord tumors, John and Marianne would agonize over what they could do to help their daughter's cause. (SportsIllustrated.CNN -- NCAA Football)
Weekend benefit brings in $20,000 for Hanover family May 22, 2009
In 1997, Kathy Cadogan lost her husband, Mark, to neurofibromatosis, a genetic disorder that causes tumors to form along the central nervous system ... Kathy said Patrick, who is 19, is being very courageous in living with neurofibromatosis, but stressed the effects of the disease are getting worse for him every day ... A week after he died, Kathy found out both her children had inherited the neurofibromatosis. (Hanover Mariner, MA)
Oakland still ponders outdoor displays May 21, 2009
proclaimed May 2009 as Neurofibromatosis Awareness Month and May 17-23 as National Public Works Week. approved a shared-parking agreement between Anointed Ground Church/Pastor Joseph Reeves and Oakland Avenue Charter School/the town of Oakland. (Winter Garden West Orange Times, FL)
Rockland run will benefit Hanover family May 14, 2009
In 1997, Kathy lost her husband, Mark, to neurofibromatosis, a genetic disorder that causes tumors to form along the central nervous system ... Kathy said Patrick, who is 19, is being very courageous in living with neurofibromatosis, but stressed that the effects of the disease are getting worse for him every day ... A week after he died, Kathy found out that both her children had inherited the neurofibromatosis. (Hanover Mariner, MA)
Area runners headed for Boston Apr 19, 2009
"This year I'll be on the course to encourage the people I coach," said the 49-year-old NASA engineer who, since 2006, has provided on-line marathon training to those who run to fight neurofibromatosis (NF) through the Children's Tumor Foundation. Since 1994, the Boston Athletic Association has helped an assortment of charities raise more than$85 million by providing them with Boston bib numbers. (Florida Today)
World's first hands, face transplant Apr 7, 2009
In a 2007 operation in France, the recipient was a 29-year-old man who suffered from a rare genetic disorder called neurofibromatosis- commonly known as "elephant man" syndrome- that had covered much of his face in a disfiguring tumour. Face and limb transplants must be undertaken on very short notice, as soon as medical teams are alerted to the availability of donor who is brain dead. (India Times, India)
Tumornators to host fundraising show tonight Apr 3, 2009
Schwannomatosis is a form of neurofibromatosis, a series of hereditary disorders that cause noncancerous tumors to grow along the outside of nerves; neurofibromatosis affects some 100,000 Americans. Other than procedures to reduce or remove tumors and medication, there is no other way for Drew (who has more than 6 feet of scars on his body) to find relief from the pain. (Athens Banner-Herald)
UPDATE: New face transplant in France... Mar 28, 2009
The 29-year-old recipient of the 2007 transplant, known as Pascal, suffered from a rare genetic disorder called neurofibromatosis that had covered much of his face in a disfiguring tumour. The first successful face transplant was performed in France in 2005 on Isabelle Dinoire, a 38-year-old woman who had been mauled by her dog. (The Drudge Report)
Fishing For Microdeletions That Predispose An Embryo To Develop Cancer Syndromes In Later Life Mar 19, 2009
Professor Joris Vermeesch, coordinator of the Genomics Core and head of Constitutional Cytogenetics, and Evelyne Vanneste, a PhD student, both at the Center for Human Genetics, University Hospital Leuven (Belgium), and their colleagues used FISH to carry out PGD in embryos from three couples where the women carried microdeletions for either neurofibromatosis type 1 (NF1) or Von Hippel-Lindau disease (VHL) ... Neurofibromatosis type 1 (also known as Von Recklinghausen disease) is a common... (Science Daily)
Brain Cells' Hidden Differences Linked To Potential Cancer Risk Feb 25, 2009
To gain insights into the significance of potential genetic differences between astrocytes from different brain regions, Gutmann and his colleagues used a mouse model of a common inherited cancer syndrome, neurofibromatosis type 1 (NF1) ... The condition is caused by a mutation in a gene known as the neurofibromatosis 1 gene ... For example, astrocytes from the cortex have low levels of neurofibromatosis-1 gene expression compared to astrocytes from the optic nerve or brainstem. (Science Daily)
One very brave Idaho cowboy poet Feb 24, 2009
He's undergone years of operations, radiation and other treatment for neurofibromatosis. That's a genetic disease that causes nerve tissue to grow tumors and can cause serious damage by compressing nerves or other tissues; in McCall's case, it's resulted in hearing and balance problems. (Burley South Idaho Press, ID)
