School of hard knocks Nov 8, 2009
Kept alive by kidney dialysis, Yoichi Imai, a young local civil servant in Tokyo, has been afflicted with chronic nephritis since he was 8 years old. However, it is the love and care from his family and his environs that has encouraged him to live with his excruciating illness. (Xinhuanet, China)
Kidney transplants generally safe for lupus patients Nov 1, 2009
Contrary to previous studies, lupus patients who receive kidney transplants rarely develop lupus nephritis. Individuals with a history of lupus who receive a kidney transplant rarely develop the serious inflammatory condition lupus nephritis in their new organ, according to a paper being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA. The findings indicate that having lupus should not keep individuals from seeking a kidney... (EurekAlert!)
Guns dont kill people? Oct 9, 2009
Nephritis, nephrotic syndrome and nephrosis (kidney disease) 10. Septicemia 11. (Atlanta Journal-Constitution -- Opinion)
Lupus Worse in Blacks, Hispanics Than in Whites, Study Finds Sep 15, 2009
These women, for example, had a 61 percent greater chance of having kidney inflammation -- or nephritis -- in addition to lupus, and a 55 percent greater likelihood of also having diabetes, the study found. In all, Hispanic and black patients with SLE were twice as likely as whites to also have nephritis, kidney failure and inflammation of the heart lining, all of which complicate the treatment and severity of the disease, according to the researchers. (MEDLINEplus)
A Boy with Headache, Nausea, Seizures, and Hypertension Jul 23, 2009
Rapidly Progressive Glomerulonephritis. The Hemolytic Uremic Syndrome. (New England Journal of Medicine)
Anti-CTLA4 Antibody–Induced Lupus Nephritis Jul 9, 2009
NEJM -- Anti-CTLA4 Antibody-Induced Lupus Nephritis ... Anti-CTLA4 Antibody Induced Lupus Nephritis. (New England Journal of Medicine)
A Woman with Abdominal Pain, Weight Loss, and Renal Failure Jul 9, 2009
Tubulointerstitial Nephritis with Uveitis (TINU). -->Clinical Diagnosis. (New England Journal of Medicine)
Novel DNA Vaccine Leads To Kidney Damage Prevention In Systemic Lupus Erythematosus Models Jun 18, 2009
ScienceDaily (June 18, 2009) DNA vaccination using lupus autoantigens and interleukin-10 (IL-10, a cytokine that plays an important role in regulating the immune system) has potential as a novel therapy to induce antigen specific tolerance and may help to prevent kidney damage in patients with systemic lupus erythematosus (SLE), according to a new study presented June 11 at EULAR 2009, the Annual Congress of the European League Against Rheumatism in Copenhagen, Denmark. SLE is a complex, chronic... (Science Daily)
* Cancer still top killer in Taiwan: DOH Jun 18, 2009
9 percent), and nephritis, nephritic syndrome and nephrosis (2. 8 percent). (Taipei Times, Taiwan -- Business)
Human Genome Sciences shares jump on test results Jun 16, 2009
In March, California-based and Massachusetts-based racked up one of the most recent failures in third-stage clinical trials for a drug to treat lupus nephritis, a kidney inflammation that s a complication of systemic lupus erythematosus. Human Genome Sciences initial Phase II trial for belimumab was conducted with 449 patients in 2005 in a trial that hadn t achieved everything it had set out to do, though patients were measured after less than a year in some cases at that time. (Baltimore Business Journal, MD)
Popular Cancer Drug Linked To Often Fatal Brain Virus May 20, 2009
4, 2009) Treatment with the targeted drug rituximab can significantly benefit some patients with severe lupus nephritis who do not respond to conventional therapy, according to a new study. The findings. (Science Daily)
Lupus Kidney Damage Linked To Malfunction Of Immune Cells Apr 28, 2009
Liu et al. Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans ... (May 14, 2007) Good patient information is essential for choosing the best treatment for the kidney disease lupus nephritis ... 4, 2009) Treatment with the targeted drug rituximab can significantly benefit some patients with severe lupus nephritis who do not respond to conventional therapy, according to a new study. (Science Daily)
Protective Role For Kallikrein Proteins In Kidney Disease Apr 3, 2009
3, 2009) A team of researchers, at the University of Texas Southwestern Medical Center, Dallas, and Uppsala University, Sweden, has shed new light on several forms of the kidney disease known as nephritis ... Specifically, the data indicate a protective role for kallikrein proteins in anti-GBM antibody induced nephritis (a mouse model of Goodpasture syndrome) and spontaneous lupus nephritis in mice and humans ... In the study, which was led by Chandra Mohan, Edward Wakeland, and Marta... (Science Daily)
BioMarin returns rights to lupus drug Apr 3, 2009
But an independent data monitoring committee said Feb. 12 that continuation of a Phase III study of Riquent for lupus nephritis kidney disease characterized by extreme, acute inflammation was futile. The trial and further development of Riquent was discontinued. (San Francisco Business Times, CA)
Biogen Idec lupus trial fails Mar 13, 2009
Massachusetts' Biogen Idec (Nasdaq: BIIB) and California-based (NYSE: DNA) announced after the close of the stock market Wednesday that their phase III clinical trial using the drug Rituxan in combination with other drugs to treat lupus nephritis failed to meet its primary endpoint ... Lupus nephritis is an inflammation of the kidney and a complication of lupus, an autoimmune disease that causes inflammation in different organs. (Raleigh Triangle Business Journal, NC)
Roche Completes $46.8 Billion Deal for Genentech Mar 13, 2009
Although analysts welcomed the deal, which is ending months of uncertainty, Roche shares traded lower because Rituxan, its best-selling drugs, had failed to meet the primary goal in a study that investigated its potential in treating lupus nephritis. At 1015 GMT, Roche shares were down CHF4, or 2. (SmartMoney)
Genentech says lupus tests fell short Mar 12, 2009
Lupus nephritis is an inflammation of the kidney and a complication of systemic lupus erythematosus, an autoimmune disease. We are disappointed that Rituxan did not show a significant benefit in patients with lupus nephritis, a complex and serious disease. (San Jose Business Journal, CA)
Rituxan fails in lupus test Mar 12, 2009
Rituxan is approved for use in rheumatoid arthritis and non-Hodgkin lymphoma, and the companies hoped to get it approved as a treatment for lupus nephritis. The companies said they will still look for new ways to treat lupus. (Boston Globe)
Canine Lyme Disease Nephritis Mar 7, 2009
Though the most common symptom of in dogs is lameness caused by joint pain and swelling, veterinarians are also recognizing a form of the disease referred to as Lyme nephritis ... Lyme disease nephritis symptoms are those of renal failure and may consist of ... Diagnosing nephritis caused by Lyme disease is based on identifying a positive Lyme disease antibody test using either a Idexx SNAP 3DX or 4DX or a quantitative C6 antibody level along with evidence of renal involvement. (Suite101.com)
