Myelodysplastic Syndromes Nov 5, 2009
1 The main feature of myeloid neoplasms is stem-cell derived clonal myelopoiesis with altered proliferation and differentiation. The phenotypic diversity of these neoplasms has been ascribed to different patterns of dysregulated signal transduction caused by transforming mutations that affect the hematopoietic stem cell. (New England Journal of Medicine)
Guns dont kill people? Oct 9, 2009
Malignant neoplasms (cancer) 3. Cerebrovascular diseases (stroke) 4. (Atlanta Journal-Constitution -- Opinion)
Cancer incidence in kidney transplant recipients: a study protocol Aug 23, 2009
Different publications show an increased incidence of neoplasms in renal transplant patients ... Patients with neoplasms prior to the transplant will be excluded (n=38). (BioMed Central)
Long-term Health And Social Outcomes For Neuroblastoma Survivors Aug 20, 2009
"Future research should build on these data and investigate risk factors for long-term complications of neuroblastoma treatment and second malignant neoplasms;". In an accompanying editorial, Elizabeth Fox, M.D., of the Pediatric Oncology Branch at the Center for Cancer Research, National Cancer Institute, in Bethesda, Md. (Science Daily)
After Neuroblastoma, Chronic Problems Often Await Aug 4, 2009
"Future researchers should build on these data and investigate risk factors for long-term complications of neuroblastoma treatment and second malignant neoplasms.". The study was published online July 31 in the Journal of the National Cancer Institute. (MEDLINEplus)
Ipsogen Expands its US Market Presence Through Licensing Agreement With ARUP Laboratories for the Commercialization of JAK2 Molecular Diagnostic Assays May 4, 2009
According to the terms of the agreement, Ipsogen grants ARUP, a national clinical and anatomic pathology reference laboratory and a worldwide leader in innovative laboratory research and development, non-exclusive rights, for the US territory, to offer a complete range of assays for the molecular classification and the screening of Myeloproliferative Neoplasms (MPN), a group of leukaemia's caused by JAK2 gene variations that affects more than 100,000 people in the US. Additional terms were not... (PR Newswire)
Obesity Associated With Worse Outcomes After Pancreatic Cancer Surgery Mar 23, 2009
"In many obesity-related diseases and malignant neoplasms [cancerous tumors], an increased prevalence of pancreatic cancer has been reported in numerous epidemiologic and cohort studies focusing on obese patients," the authors write. "Further, obesity has been associated with decreased survival in patients with pancreatic adenocarcinoma, although the mechanism remains unknown.". (Science Daily)
Genetic abnormality may increase risk of blood disorders Mar 16, 2009
The investigators carried out a genome-wide study to identify inherited DNA sequence changes that frequently occur in patients with myeloproliferative neoplasms, in which several types of blood cells are excessively produced in the bone marrow ... More than half of patients afflicted with myeloproliferative neoplasms which affect an estimated 140,000 people in the US carry the JAK2 mutation and suffer from the overproduction of red blood cells, platelets, or fibrous connective tissue. (EurekAlert!)
New NCCN Guidelines for Primary Cutaneous B-Cell Lymphoma and Updates to NCCN Guidelines for Non-Hodgkin's Lymphomas Mar 14, 2009
A new section diagramming the use of immunophenotyping, a technique used to study the protein expressed by cells, in the differential diagnosis of mature B-Cell and T/NK Cell Neoplasms was recently added to the NCCN NHL Guidelines. Dr. Zelenetz noted that this immunophenotyping section will be very helpful to "sorting out difficult diagnosis dilemmas.". (PR Newswire)
Skin Woes Take Toll on U.S. Combat Troops Feb 19, 2009
"This study evaluated a set of patients, all servicemen and women, who were evacuated from the war zones for ill-defined, non-traumatic skin conditions. The main outcome of the study was that dermatitis, benign melanocytic nevus [noncancerous moles], malignant neoplasms [skin cancers], urticaria [hives], and a group of nonspecific diagnoses were the most common post-evacuation diagnoses in our study population," McGraw said. "These diagnoses are similar to the most common dermatologic diagnoses... (MEDLINEplus)
