Two-way Communication Between Common Biological Pathways And Body's Daily Clock Sep 22, 2009
The new data, published online in Cell this week, suggest that someday physicians may be able to use small molecules that inhibit or stimulate these biological processes in order to influence a person's clock when it gets out of sync due to jetlag or shift work, and to devise new ways to treat metabolic disorders that are intimately tied to the body's daily cycles. Using a genome-wide screen, the investigators found that reducing expression of any one of hundreds of genes could substantially... (Science Daily)
Why we eat too much, and how to get control Sep 19, 2009
And spending 20 minutes doing progressive muscle relaxation--alternately tensing and relaxing muscle groups--significantly lessens stress, anxiety, and cortisol, according to a study published in the International Journal of Obesity and Related Metabolic Disorders. Exercise will also do the trick. (CNN)
Scientists Pinpoint Protein Link To Fat Storage Sep 18, 2009
Understanding lipid storage and use is important in tackling obesity and other metabolic disorders. (Sep. (Science Daily)
GENova Biotherapeutics signs collaboration agreement with Prime BioResearch Sep 16, 2009
GENova's focus is oncology, while Prime BioResearch specializes in Obesity, Type 2 Diabetes and other metabolic disorders. They are confident that through scientific collaboration in the field of personalized medicines, they will expedite their drug development activities and subsequently add hundreds of millions of dollars to the bottom line by licensing the technology to companies like Pfizer, Merck, Eli Lilly, Sanofi, Roche, and GSK.. (PR Newswire)
Inner Workings Of Molecular Thermostat Point To Pathways To Fight Diabetes, Obesity Sep 14, 2009
Researchers at the University of Pennsylvania School of Medicine have discovered a molecular circuit involving heme that helps maintain proper metabolism in the body, providing new insights into metabolic disorders such as obesity and diabetes ... " When heme levels are high, Rev-erb is activated, reducing heme, which leads the cell back towards a normal state. On the other hand, when heme levels are low, Rev-erb activity is low, and this permits the cell to make more heme, again leading back... (Science Daily)
Loyola's Health Center prepares campus to weather H1N1 influenza Sep 10, 2009
This group of people includes, but is not limited to, persons with the following conditions: pulmonary disease (such as asthma), renal, hepatic, neurologic, diabetes and other metabolic disorders. Pregnant woman, younger people and health care personnel will be given priority as well. (The Loyola Greyhound, MD)
Do High-fat Diets Make Us Stupid And Lazy? Sep 5, 2009
The research, funded by the British Heart Foundation and published in the FASEB Journal, may have implications not only for those eating lots of high-fat foods, but also athletes looking for the optimal diet for training and patients with metabolic disorders ... The results will be important not only in informing athletes of the best diets to help their training routine, but also in developing ideal diets for patients with metabolic disorders such as diabetes, insulin resistance or obesity. (Science Daily)
High-fat diets can make us stupid Sep 5, 2009
The research, funded by the British Heart Foundation, may have implications not only for high-fat addicts, but also athletes looking for the optimal diet for training and patients with metabolic disorders. "We found that rats, when switched to a high-fat diet from their standard low-fat feed, showed a surprisingly quick reduction in their physical performance," says Andrew Murray, who led the study at Oxford University and is now with the University of Cambridge. (India Times, India)
Honolulu City Council moves to kill conduct bill Sep 5, 2009
Dan Gluck, senior staff attorney for the American Civil Liberties Union, said his office has already been contacted by people with metabolic disorders which cause them to have a body odor. "It's not hygienic, it can be from a disease," Gluck said. (Honolulu Advertiser)
Weight-loss surgery can break "obesity cycle": study Sep 3, 2009
"Any medical or surgical treatment to reduce obesity and existing metabolic disorders before pregnancy can be an investment in the life of future offspring," Kral added. Editor: Mu Xuequan. (Xinhuanet, China)
Cell Metabolism Publishes Novel TGR5-Mediated Mechanism for the Treatment of Diabetes and Obesity Sep 2, 2009
The paper reports on the mechanism of action of the selective TGR5 agonist INT-777, providing a clear rationale for its potential as a novel treatment in diabetes, obesity and associated metabolic disorders ... Dr. Mark Pruzanski, founder, President and CEO of Intercept and a co-author on the paper, commented further, "Diabetes, obesity and other associated metabolic disorders are reaching epidemic proportions. At Intercept we are uniquely positioned to exploit the therapeutic potential of... (PR Newswire)
Weight-loss Surgery Can Break A Family's Cycle Of Obesity Sep 2, 2009
"Any medical or surgical treatment to reduce obesity and existing metabolic disorders before pregnancy can be an investment in the life of future offspring.". Weight-loss surgery limits the amount of food a person can consume. (Science Daily)
Hygiene key in battling H1N1 Aug 27, 2009
So are the elderly, as are people with cardiovascular conditions, neuromuscular disorders, and metabolic disorders such as diabetes. If the vaccine is in short supply, who will be vaccinated first. (Sioux City Journal, IO)
Fainting Could Signal Serious Heart Problem Aug 12, 2009
Some types of syncope can be triggered by emotional stress, but other types of syncope can be caused by cardiac conditions, metabolic disorders and neurological issues, Krishnan said. Syncope caused by a cardiovascular condition can be especially challenging to diagnose because abnormal heart rhythm activity may be infrequent or not apparent to the patient, Krishnan said. (Newsmax)
PKU patients have more drug, food options Aug 11, 2009
Lisa Kunkel Independent Record - Shodair Children s Hospital nutritionist Joan Reichert talks about metabolic disorders during an interview last week ... Nutritionists and genetic counselors at Shodair Children s Hospital in Helena work with patients who have metabolic disorders like PKU. Shodair, in fact, contracts with the Department of Public Health and Human Services to carry out the genetic testing on newborns. (Helena Independent Record)
Understanding swine flu Aug 7, 2009
Last Upd: 08:39am 07 Aug 2009. R3,000 free @ Prestige Casino. (iAfrica.com)
Newborn screening test saves lives, money Aug 1, 2009
In 1998 NSW led the world in funding high-tech screening in all newborns for 30 rare metabolic disorders on top of the more well-known conditions identified by the heel-prick test, such as cystic fibrosis and phenylketonuria (PKU). While this screening has since been implemented in other developed countries, the research by the Childrens Hospital at Westmead and the University of Technology, Sydney, is the first to measure the effectiveness of screening for babies and cost. (Sydney Morning Herald -- Australia)
Two Studies On Polycystic Ovarian Syndrome Shed Light On Its Causes And Its Effect On Brothers Of Women With The Condition Jul 31, 2009
Until now, it was not clear whether the male relatives of women with PCOS were at increased risk for the metabolic disorders associated with PCOS, said Dr Mattle, who is chief resident at the University Clinic of Gynecological Endocrinology and Reproduction Medicine in Innsbruck (Austria). Dr Mattle and her colleagues conducted oral glucose tolerance tests on 15 brothers of sisters with PCOS and insulin resistance (group 1). (Science Daily)
70m diabetics in India by 2015: Study Jul 30, 2009
Changing lifestyles and gentic factors lead to metabolic disorders, he says. Dr V Mohan, who heads the Madras Diabetes Research Foundation, says the country is now at a crossroads and the gap between urban-rural incidence of the disorder is decreasing. (India Times, India)
Discovery May Open Door To Drug That Cuts Appetite And Boosts Energy Jul 23, 2009
"Our findings provide a possible new target for the development of drugs to control metabolic disorders such as obesity and type 2 diabetes.". Diano and her team conducted the study in congenic mice that were naturally lean and later in mice that had PRCP removed. (Science Daily)
Shodair Hospital hosting first Montana Metabolic Day Aug. 15 Jul 21, 2009
We want to provide people who have been diagnosed with PKU or another metabolic condition an opportunity to come together from all corners of Montana to discuss the importance of managing metabolic disorders, Shodair Administrator Jack Casey said in a press release. They ll also have a chance to meet other people with special metabolic needs and their families, and ask questions of metabolic healthcare professionals. (Helena Independent Record)
Is Alzheimer's a Form of Diabetes? Jul 12, 2009
The terminology aside, both diseases share many traits and risk factors, including high cholesterol, high blood pressure, and metabolic disorders. So, de la Monte sees the semantic "splitting of hairs" as a good thing. (Time.com)
Froedtert, medical college open clinic Jul 7, 2009
Endocrine and metabolic disorders are usually complex, chronic conditions that should be carefully managed, said Dr. James Findling, a Medical College endocrinologist and professor who heads the college s community division of endocrinology. Our new clinic gives residents of Milwaukee s southern communities easy access to this specialized expertise. (Milwaukee Business Journal, WI)
Sundia MediTech Appoints Dr. Chen Chen as Senior VP of Chemistry Jul 4, 2009
His knowledge also includes neuropathic pain and metabolic disorders. His research interests extend to clinic and preclinic pharmacokinetics of small molecules and the relationship with their chemical properties. (PR Newswire)
Turning research into a tool for economic growth in Kannapolis Jul 2, 2009
Luther joined the institute from , where he oversaw the development of therapeutics for respiratory, endocrine and metabolic disorders at the company s Centre for Therapeutic Research in Montreal. He recently discussed his new job and his plans for the institute with the Charlotte Business Journal. (Charlotte Business Journal, NC)
Healthy Living Made Easy Jun 25, 2009
For more information call (402) 494-8800 or email. This class will help people overcome their addiction to diet soda, reduce their consumption of fast food, and help participants begin to live an active and healthy life. (Sioux City Journal)
Antipsychotic drugs for kids raise hope, worry Jun 22, 2009
While better drugs and increased diagnoses have been a blessing for many families, at FDA hearings in Washington, doctors and parents voiced concerns that the medication can cause long-term health problems - specifically, extreme weight gain that can lead to metabolic disorders like diabetes. Not a trivial decision. (San Francisco Chronicle -- Science)
Staying fit, eating right key to health Jun 19, 2009
Childhood obesity often leads to many different health problems such as heart disease, metabolic disorders, pulmonary problems, gastrointestinal disorders, orthopedic problems, and social and emotional health issues. Poor snack choices, large snacks or too many snacks can lead to to overweight children and adults. (Leavenworth Lamp, KS)
Regular flu lingers, but its not too late for shots May 21, 2009
People recommended to have flu vaccinations include children aged 6 months to 18 years, people older than 50, pregnant women, health care workers and people with underlying health conditions such as asthma, heart disease, kidney disease and blood or metabolic disorders, including diabetes. It is a serious illness, Marfin said. (MSNBC -- Health)
3-D kidney atlas created for researchers and physicians May 15, 2009
According to the project coordinator, Professor Thomas Willnow (MDC), the Kidney Atlas will also be of great significance for the research of metabolic disorders which lead to kidney damage such as diabetes. EUNEFRON follow-up project renal diseases in children. (EurekAlert!)
Why Does a Senior Cat Cry at Night? Apr 15, 2009
Why Does a Senior Cat Cry at Night. Reasons an Older Cat Might Vocalize in the Night. (Suite101.com)
'Good' Energy Burning Fat In Lean Adults Apr 11, 2009
According to the paper, the researchers are hopeful that an increased ability to measure brown fat mass and activity in vivo in humans will lead to a better understanding of its role in physiology and its potential as a target for therapy of obesity and other metabolic disorders. This study answered those questions thanks to the use of modern imaging technology. (Science Daily)
Health in brief Apr 11, 2009
Children eligible for the program may be diagnosed with a variety of illnesses that could limit normal life expectancy such as cancer, major organ failures, HIV, cystic fibrosis, progressive genetic, neurological or metabolic disorders, renal failure or severe cerebral palsy. For information on Pediatric Palliative Care of the North Shore, a program of Hospice of the North Shore, call 978-223-9777 or visit www. (Georgetown Record, MA)
Good 'Brown Fat' Burns Calories Apr 10, 2009
Obesity and other metabolic disorders could be treated by stimulating brown fat growth to control weight and improve glucose metabolism, the researchers said. Brown fat may have a role in regulating body weight metabolism, with higher levels of brown fat helping protect against obesity linked with aging, according to the study. (Newsmax)
Health Canada Approves AVASTIN in Combination with Carboplatin/Paclitaxel for Treatment of Patients with Non-small Cell Lung Cancer Apr 9, 2009
Avastin is the first agent when added to chemotherapy that prolongs survival enabling patients to live longer with a better quality of life (Canada Newswire)
Study points to calorie-burning fat Apr 9, 2009
The researchers said that obesity and other metabolic disorders could be treated by stimulating brown fat growth to control weight and improve glucose metabolism. Brown fat may have a role in regulating body weight metabolism, with higher levels of brown fat helping protect against obesity linked with aging, according to the study. (Yahoo News -- Top Stories)
UW-Madison study reveals new options for people with PKU Apr 1, 2009
The first GMP human feeding trial was published in February in the Journal of Inherited Metabolic Disorders. In it, Ney and her team describe the experience of an individual with PKU who volunteered to consume an all-GMP diet for 10 weeks. (EurekAlert!)
Ticking Of Body's 24-hour Clock Turns Gears Of Metabolism And Aging Mar 22, 2009
"This opens the door to new avenues for treating age-related disorders and ways to restore a healthy daily circadian rhythm. It could also yield new interventions to alleviate metabolic disorders such as obesity and diabetes." ... This new information points potentially to innovative ways to correct metabolic disorders and improve health as people age. (Science Daily)
Internal Clock and Metabolism May Be Linked Mar 21, 2009
The team also said the compound they identified might offer a new drug target to treat metabolic disorders related to circadian disruption caused by shift work, obesity or diabetes. The study of laboratory mice showed that circadian clock genes strongly regulate the production of nicotinamide adenine dinucleotide (NAD), which regulates the activity of an enzyme called SIRT1, an important regulator of aging, metabolism and longevity. (MEDLINEplus)
Doctors Manage Mysterious Fibromyalgia Mar 20, 2009
"There are a lot of things it can be confused with such as thyroid disorders, other metabolic disorders, certain rheumatologic inflammatory conditions," he said. And while experts don't know what causes fibromyalgia, some theorize it could be an injury or traumatic event. (Click2Houston, TX)
N.C. Research Campus names exec Mar 18, 2009
He last worked for Merck Frosst, where he oversaw the development of therapeutics for respiratory, endocrine and metabolic disorders at the company s Centre for Therapeutic Research in Montreal. Luther also spent 15 years at in Research Triangle Park and the United Kingdom. (Raleigh Triangle Business Journal, NC)
Metabolic And Neurological Disorders May Share Common Risk Factors Mar 16, 2009
15, 2009) Metabolic disorders such as obesity and diabetes appear to share risk factors with and may influence the development of Alzheimer's disease and other forms of dementia, according to several reports published in the March issue of Archives of Neurology ... Insulin resistance, when tissues in the body lose sensitivity to the hormone that regulates glucose, may underlie both dementia and metabolic disorders such as obesity and diabetes ... D., of Veterans Administration Puget Sound Health... (Science Daily)
Why get vaccinated? Mar 12, 2009
Adults and children with the following conditions: chronic pulmonary disorders; renal, hepatic, hematological and metabolic disorders and cardiovascular disorders (excluding hypertension though). Adults and children who have immunosuppression. (iAfrica.com)
Epilepsy - Stopping Anti-Seizure Me... Mar 9, 2009
These may include cognitive impairment, metabolic disorders, liver problems, and bone disorders. Many Could Stop Medication. (Suite101.com)
Night Shift Work Hard on the Heart Mar 4, 2009
"Our internal biological clocks represent a whole area of biology that is as critical as blood pressure or breathing. And this work does provide us with a plausible biological mechanism that may underlie and cumulatively contribute to the occurrence of metabolic disorders in certain individuals, because of their work patterns, or because of traveling, or simply because they ignore the normal light cycle.". HealthDay. (MEDLINEplus)
Want to live longer? Eat omega-3 fats Feb 25, 2009
The spread of the seed-oil-rich Western diet around the world has been tracked by a statistical rise in the so-called diseases of civilization: asthma and arthritis, depression and Alzheimer's, heart disease and cancer, as well as metabolic disorders such as diabetes and obesity. Living longer on a 'poor man's diet'Okinawans, of Japan, once had the longest life expectancy in the world. (MSNBC -- Health)
Unrelated And Mismatched Cord Blood Transplantation Can Still Help Children With Deadly Conditions Feb 24, 2009
Bone marrow transplantation has proven to be an effective treatment for thousands of children in the United States each year diagnosed with diseases such as leukemia and sickle cell disease, and inherited metabolic disorders such as Hurler's syndrome ... 11, 2007) Children born with inherited metabolic disorders that cause organ failure and early death can be treated successfully with umbilical cord blood transplants from unrelated donors and, in some cases go. (Science Daily)
Newborn Screenings Now Required Across U.S. Feb 20, 2009
The March of Dimes estimates that about 4,000 babies with metabolic disorders were discovered via newborn screening in 2004, and another 12,000 were found to have a hearing impairment. "Hearing problems are a more frequent occurrence, and it's important to catch when children are newborns," Howse said. (MEDLINEplus)
Pathologically Elevated Blood Fat Levels In Obesity: Molecular Causes Discovered Feb 19, 2009
18, 2009) Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have discovered a mechanism in liver metabolism that is responsible for pathologically elevated blood fat levels found in severe metabolic disorders. Mice suffering from metabolic syndrome or type 2 diabetes produce only small amounts of a molecule called LSR in the liver, as reported by researchers headed by Dr. Stephan Herzig of DKFZ in the specialist journal Diabetes. (Science Daily)
Singapore research organisations team up to advance drug discovery using brain tumor stem cells Feb 18, 2009
In the area of drug discovery LSCDD focuses on the areas of cancer and metabolic disorders some of the world's most challenging disease conditions. The role of epigenetics in these diseases and the application of adult stem cells for drug discovery are particular focus areas. (EurekAlert! -- Business News)
Fat-free Diet Reduces Liver Fat In Fat-free Mice, Researchers Report Feb 14, 2009
Lipodystrophies are metabolic disorders characterized by the selective loss of fat tissues and complications of insulin resistance. Scientists speculate that the condition could be caused by the failure of stem cells to become fat cells. (Science Daily)
Fructose-sweetened drinks increase nonfasting triglycerides in obese adults Feb 13, 2009
"Our findings show that fructose-sweetened beverages raise triglyceride levels in obese people, who already are at risk for metabolic disorders such as cardiovascular disease and diabetes.". Triglycerides are manufactured by the body from dietary fat and are the most common form of fat transported in blood. (EurekAlert!)
