New Mouse Model Of Severe Kidney Disease Leads To Potential New Therapy Sep 4, 2009
3, 2009) X-linked nephrogenic diabetes insipidus (XNDI) is a severe congenital kidney disease caused by mutations in the V2R gene ... Jian Hua Li et al. A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. (Science Daily)
Receptor Also Active Inside The Cell Aug 4, 2009
One of these disorders is nephrogenic diabetes insipidus ... The most common cause of the inheritable form of nephrogenic diabetes insipidus (NDI) are errors in the gene that encodes the vasopressin receptor, leading to absence of this receptor at the cell surface and making it unable to bind its hormone vasopressin ... Intracellular Activation of Vasopressin V2 Receptor Mutants in Nephrogenic Diabetes Insipidus by Non-peptide Agonists. (Science Daily)
Diabetes in Dogs Jul 19, 2009
Diabetes insipidus is caused by lack of vasopressin, an anti-diuretic hormone that controls water resorption by the kidneys. Diabetes mellitus is the most common type in dogs. (Suite101.com)
Structural Biology Scores With Protein Snapshot Jul 13, 2009
Sanders and his team, who got interested in protein folding because of their work with DAGK, are now pursuing structural studies of misfolded membrane proteins that cause diseases including peripheral neuropathy (Charcot-Marie-Tooth Disease), diabetes insipidus and Alzheimer's disease. "For proteins that misfold because of mutations, we're using NMR tools to understand exactly what the mutations do to the proteins in terms of structure and stability," Sanders said. (Science Daily)
Hospital to award Lindheimer for research that aids mothers, infants Mar 6, 2009
Understanding this process led them to predict the existence of an as-yet-unrecognized disease, now known as transient diabetes insipidus during pregnancy. After finding such patients, they were able to treat them. (Univeristy of Chicago Chronicle, IL)
