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    News, Reviews, and Articles on Carcinoma

    Archives: Carcinoma

    Mechanisms of cardiovascular disease and cancer give clues to new therapies  Nov 22, 2008
    Some tumour cells, for example in ovarian carcinoma, exploit endothelins to suppress their death while migrating to other parts of the body in the metastasis process, enabling the tumour to spread, usually with fatal results. Understanding the endothelin axis and its role in both cancer and cardiovascular disease is now increasing as a result of collaboration between these two medical research fields spawned by the ESF workshop and similar events elsewhere in the world. (EurekAlert!)

    Broccoli May Lower Lung Cancer Risk In Smokers  Nov 20, 2008
    Researchers further divided their findings by four subtypes of lung cancer and found the strongest risk reduction among patients with squamous or small-cell carcinoma. These two subtypes are more strongly associated with heavy smoking. (Science Daily)

    Survival of head and neck cancer patients is greatly affected by coexisting ailments  Nov 20, 2008
    The researchers reviewed the medical records of 183 patients with squamous cell carcinoma of the oral cavity, throat and larynx who were treated in 1997 and 1998 at Barnes-Jewish Hospital in St. Louis, which has carefully tracked comorbidities since 1995. Comorbid ailments in these patients included heart attack, coronary artery disease, tumors other than the primary tumor, psychiatric disease, lung disease, stroke, diabetes and alcohol abuse. (EurekAlert!)

    Study Helps Identify Beachgoers At Increased Risk Of Skin Cancer  Nov 19, 2008
    29, 2000) Smoking more than triples the risk of developing squamous cell carcinoma, one of the most common forms of skin cancer, researchers from the Netherlands have shown. (Aug. (Science Daily)

    Vaccine for skin cancer 'within five years'...  Nov 18, 2008
    The jab would protect against squamous cell carcinoma, the second most common skin cancer, but not the more deadly melanomas. It works by targeting papillomavirus, a common infection which can turn abnormal cells into cancerous cells and is believed to cause at least five per cent of all cancers. (The Drudge Report)

    Cancer patients unfamiliar with hospice care  Nov 18, 2008
    The 67-year-old Tanti said she had to figure out her own way of taking care of her brother, who was dying of carcinoma nasopharyngeal cancer, in 1989. "Everything was so confusing. I wanted to help him ease his pain, but I did not know how.". (Jakarta Post, Indonesia -- City)

    Elevation of circulating big endothelin-1: an independent prognostic factor for tumor recurrence and survival in patients with esophageal squamous cell carcinoma  Nov 16, 2008
    Circulating plasma big ET-1 levels were measured in patients with esophageal squamous cell carcinoma(ESCC) to evaluate the value of ET-1 as a biomarker for predicting tumor recurrence and patients survival. Methods. (BioMed Central)

    Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery  Nov 15, 2008
    COMMON AND CANCER TYPE-SPECIFIC LOSS-OF-HETEROZYGOSITY (LOH) IN THE TUMOR STROMA AND EPITHELIUM OF 3 CARCINOMA TYPES ASSOCIATED WITH CLINICAL OUTCOME ... D., Chair and Director of Cleveland Clinic's Genomic Medicine Institute, has found that in-common genetic alterations in both cancerous cells and the surrounding normal-looking cells (called tumor microenvironment or stroma) play an important role in predicting and dictating the outcome of three cancer types: breast cancer (BC), prostate cancer... (EurekAlert!)

    Epstein-Barr Virus Associated With Inflammatory Diseases Of The Mouth  Nov 14, 2008
    It is associated with many diseases, including infectious mononucleosis, malignant lymphomas, and naspharyngeal carcinoma. See also. (Science Daily)

    HPV: an unwanted gift at Christmas  Nov 11, 2008
    The last category, CIN3, is officially recorded as carcinoma in situ - pre-cancerous changes confined to the cell. Each year about 3,000 cases of cancer of the cervix that has become embedded and is beginning to spread are diagnosed; of these patients, about 1,000 die as a result of the condition. (Times Online)

    OHSU finds association between Epstein-Barr virus, inflammatory diseases of the mouth  Nov 11, 2008
    It is associated with many diseases, including infectious mononucleosis, malignant lymphomas, and naspharyngeal carcinoma. The findings are published online () in the Journal of Endodontics, one of the leading peer-reviewed endodontology journals. (EurekAlert!)

    Migraine Might Slow Down Breast Cancer, Study Shows  Nov 10, 2008
    "The researchers saw a very important connection between hormones, migraines and breast cancer. The November issue of Cancer Epidemiology, Biomarkers & Prevention published the study which shows that women who suffer from migraines have 30% less chances of developing breast cancer. The lead author, Li, said that the mechanism behind this connection is not entirely known, but it has to do with fluctuations in the levels of circulating hormones. He added that migraines have a hormonal component... (Enews 2.0)

    Migraines May Cut Breast Cancer Risk  Nov 7, 2008
    "Women who reported a clinical diagnosis of migraine had a 33 percent reduced risk of IDC [invasive ductal carcinoma] and a 32 percent reduced risk of ILC [invasive lobular carcinoma] compared with women with no history of migraine," the authors write. "These reductions in risk did not vary substantially by age at migraine diagnosis or by history of ever using prescription migraine medications.". (CBS News)

    Breast cancer migraine link  Nov 7, 2008
    In total, this gave the researchers 1,199 cases of ductal carcinoma, 739 cases of lobular carcinoma, and 1,474 controls ... As the purpose of this study was to evaluate the cause of lobular carcinomas (one type of breast cancer), sampling of cancer cases differed by histologic type ... The researchers say that women who reported a clinical diagnosis of migraine had reduced risks of ductal carcinoma and lobular carcinoma. (NHS Choices)

    Recurrence of Hepatocellular Carcinoma  Nov 6, 2008
    Although the treatment of hepatocellular carcinoma is evolving, hepatic resection remains the treatment of choice for many patients. Resection is associated with a 5-year survival rate of 50% but also a 70% recurrence rate. (New England Journal of Medicine)

    Gene Signatures for Liver-Cancer Recurrence  Nov 6, 2008
    NEJM -- Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma ... Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma ... Background It is a challenge to identify patients who, after undergoing potentially curative treatment for hepatocellular carcinoma, are at greatest risk for recurrence. (New England Journal of Medicine)

    Breast cancer was an 'adventure', says eight-year survivor  Nov 4, 2008
    In situ ductal carcinoma, that was the diagnosis. I heard what he said, and I didn t even cry, which is unusual for me. (Atlanta Journal-Constitution -- Health)

    Aggressive, Personalized Treatment Increases Kidney Cancer Patient Survival, Study Shows  Nov 3, 2008
    (May 31, 2007) The U.S. Food and Drug Administration (FDA) today approved Torisel (temsirolimus) for the treatment of a certain type of advanced kidney cancer known as renal cell carcinoma ... (June 1, 2007) The results of a phase III, randomized clinical study involving patients with advanced renal cell carcinoma and poor prognostic features show temsirolimus improved overall survival when compared to. (Science Daily)

    Breast cancer inquiry ends on alarming testimony  Nov 1, 2008
    Problems with the testing were detected in the spring of 2005, when doctors began questioning the hormone receptor test results of a patient with invasive lobular carcinoma, a form of breast cancer. After retesting, it was discovered that the initial test result was wrong, as were those for a small sample of other patients. (Toronto Star)

    Research Reveals Why Tamoxifen Doesn't Always Work  Oct 31, 2008
    The findings could also help explain why invasive lobular carcinoma -- the subtype of breast cancer examined in this study -- may not respond as well to tamoxifen as other breast cancer subtypes. "It is unclear whether tamoxifen is very effective in this cancer, and has been a point of debate among clinicians. This study is a good first step toward clarifying the role that tamoxifen resistance apparently plays in treatment of invasive lobular cancer," Riggins said. (U.S. News & World Report)

    Cancer Drug Resistance: 'New' Estrogen Receptor Found To Be Key Player In Tamoxifen Resistance  Oct 31, 2008
    A second important insight is that the discovery could help explain why invasive lobular carcinoma the sub-type of breast cancer in which these findings were made may not respond as well to tamoxifen as perhaps other subtypes do, she says ... Invasive lobular carcinoma, which accounts for 15 percent of newly diagnosed invasive breast cancers diagnosed each year, appear under the microscope as long, very thin tumors actually a single stream of cancer cells that line up in a row ... That makes... (Science Daily)

    Melbourne scientists hit on cancer treatment  Oct 31, 2008
    Cancerous melanoma and colon carcinoma cells survive because the body's internal mechanism for killing cancer cells known as apoptosis can no longer counteract dangerous mutations. Dr Clare Scott, who along with Professor Andreas Strasser and Dr Mark Cragg led the research team, said scientists hoped the entire treatment might be orally delivered sparing some patients the pain of chemotherapy. (The Age)

    NCI Funded Clinical Trial to Study Treatment of Breast Cancer Using Cryoablation  Oct 29, 2008
    Oct. 28 /PRNewswire/ -- The American College of Surgeons Oncology Group (ACOSOG) which just initiated a National Cancer Institute (NCI) funded clinical trial entitled, "A Phase II Trial Exploring the Success of Cryoablation Therapy in the Treatment of Invasive Breast Carcinoma," has selected the Visica 2(TM) Treatment System from Sanarus Medical as the exclusive technology to be utilized in the cryoablation portion of this study. The ACOSOG study protocol (designated as Z1072) will evaluate not... (PR Newswire)

    Early Trial Of New Multi-kinase Inhibitor Shows Impressive Activity In Thyroid Cancer  Oct 28, 2008
    4, 2000) New research published recently in the journal Thyroid shows that paclitaxel (Taxol) has significant clinical activity against anaplastic thyroid carcinoma (ATC). (June 6, 2006) Research has found a promising, novel biomarker that may be used to predict the survival of patients with advanced lung cancer and their response to treatment. (Science Daily)

    "Breast Cancer: The Journey" Discussion | WUS...  Oct 26, 2008
    My 51 year old sister was diagnosed last week with ductal carcinoma which has spread to her pelvis and thigh ... My 51 year old sister was diagnosed last week with ductal carcinoma which has spread to her pelvis and thigh ... DCIS is Ductal Carcinoma In Situ, or cancer that is in the ducts only. (W-USA News, DC)

    The Helicobacter pylori duodenal ulcer promoting gene, dupA in China  Oct 25, 2008
    H. pylori were isolated from gastric biopsies of patients with chronic gastritis, duodenal ulcer (DU), gastric ulcer (GU), or non-cardia gastric carcinoma ... Isolates from 360 patients including 133 with chronic gastritis, 101 with DU, 47 with GU, and 79 with non-cardia gastric carcinoma were examined. (BioMed Central)

    Thallion's TLN-4601 Inhibits Mutated K-Ras Signaling in Cancer Cells  Oct 24, 2008
    The results also demonstrate that TLN-4601 inhibits the growth of wild-type and KRAS-mutated pancreatic carcinoma cell lines and modulates downstream signaling events subsequent to Ras activation in a dose-dependent manner. Mutated K-Ras is associated with 90 percent of pancreatic cancers, as well as being highly expressed in other cancers such as non-small cell lung cancer and colorectal cancer. (CCNMatthews Press Releases)

    Chest Scans May Help Monitor Spread Of Head And Neck Cancer In High-risk Patients  Oct 23, 2008
    Developing a second, distant cancer (a metastasis or a new primary cancer) is an important factor affecting survival of patients with head and neck squamous cell carcinoma, which accounts for most head and neck cancers, according to background information in the article ... Yen-Bin Hsu, M.D., of Taipei Veterans General Hospital, Taiwan, and colleagues evaluated 270 screening chest CT scans performed over 42 months in 192 patients with head and neck squamous cell carcinoma ... "For patients with... (Science Daily)

    Chest CT Scans Detect Spread of Head, Neck Cancers  Oct 23, 2008
    They evaluated 270 screening chest CT scans conducted over 42 months in 192 patients with head and neck squamous cell carcinoma, which accounts for most head and neck cancers ... "For patients with head and neck squamous cell carcinoma, chest diagnosis is crucial and may influence their treatment plan," they noted ... "In conclusion, chest CT is recommended for high-risk patients, especially every six months for the first two years during the follow-up period, although its role is controversial... (MEDLINEplus)

    A family nurse practitioner's experience  Oct 18, 2008
    Nonetheless, she was diagnosed with infiltrating ductal carcinoma in March 2006 ... Nonetheless, she was diagnosed with infiltrating ductal carcinoma in March 2006 ... Nonetheless, she was diagnosed with infiltrating ductal carcinoma in March 2006. (Juneau Empire)

    THINK PINK: 'Early detection saves lives and I am proud to help raise money ...'  Oct 18, 2008
    My diagnosis was a Stage 2 tumor with bilateral lobular carcinoma in situ. That means I had a pre-existing condition on both sides with cells that favored the growth of this cancer. (Florida Times-Union)

    Genetic 'Fingerprint' Shown To Predict Liver Cancer's Return  Oct 17, 2008
    Unlike many cancers, hepatocellular carcinoma, a form of liver cancer, is often detected early ... However, a major obstacle to applying such methods to hepatocellular carcinoma, as well as other cancers, has been the technical requirements samples must be frozen, not preserved, or "fixed," in the chemical formalin ... Hoshida Y. et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. (Science Daily)

    Life with breast cancer: Head-to-toe truths  Oct 17, 2008
    "I have no plans for reconstruction," says Debbie Arkin, 49, of Tampa, Florida who had a double mastectomy to remove stage IIA invasive ductal carcinoma in 2006 and is featured on Health ... Dawn Reinhart, who learned she had stage IIB invasive ductal carcinoma at age 34, had a more difficult time. (CNN -- Health)

    Not an advocate - MacAulay encourages women to have mammograms  Oct 16, 2008
    Eight years ago, Marcy was diagnosed with a ductal carcinoma, a type of breast cancer that develops in the breast's milk ducts. In Marcy's case, the cancer was in situ meaning it was a non-invasive cancer which had not spread to surrounding breast tissue. (Sleepy Eye Herald Dispatch, MN)

    Kevin Foster, 39; was pitcher for Cubs  Oct 15, 2008
    He died in an Oklahoma City hospital Saturday of renal cell carcinoma, his brother, Mark, said. Mr. Foster spent seven years in the majors, pitching mostly with the Chicago Cubs. (Boston Globe)

    Obituaries in the news  Oct 15, 2008
    He died Saturday in an Oklahoma City hospital after a six-month bout with renal cell carcinoma, his brother Mark Foster said. Foster was drafted by the Montreal Expos in the 29th round in 1987 as an infielder. (International Herald Tribune -- Technology)

    Rangers prospect had heart condition  Oct 15, 2008
    He died in an Oklahoma City hospital Saturday after a six-month bout with renal cell carcinoma, brother Mark Foster said. FROM NEWS SERVICES. (San Diego Union-Tribune -- Sports)

    Common Variant Increase Risk Of Most Common Form Of Skin Cancer By 170%  Oct 15, 2008
    14, 2008) Scientists at deCODE genetics have report the discovery of common versions of two single-letter variations in the human genome (SNPs) that confer risk of basal cell carcinoma (BCC), the most common cancer among people of European ancestry ... The paper, entitled Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigrmentation traits, appears in the online edition of Nature Genetics ... 29, 2000) Smoking more than triples the... (Science Daily)

    Two More Genes Linked to Common Skin Cancer  Oct 15, 2008
    The variations play no role in skin colour but people with both of them are nearly three times more likely to develop basal cell carcinoma compared with people without the changes, researchers from Iceland's Decode Genetics said on Sunday ... "Here we have two variants that have no impact on pigmentation and only affect the risk of basal cell carcinoma," Kari Stefansson, Decode's chief executive, who led the study, said in a telephone interview ... Basal cell carcinoma is the most common form of... (MEDLINEplus)

    Ex-Wyeth researcher to lead Temple drug discovery team  Oct 14, 2008
    The five major Wyeth drugs for which he led the development are: Effexor and Pristiq, both antidepressants; Mylotarg, a Leukemia drug; Tygacil, a broad-spectrum antibiotic; and Torisel, a treatment for renal cell carcinoma. He led his team in identifying drug compounds with great potential, moving them through years of development and testing; and giving the compounds the quality and stamina necessary to survive through the challenging clinical trials and regulatory process, said Dr. Jerry... (Philadelphia Business Journal, PA)

    New Properties Of Skin Stem Cells  Oct 14, 2008
    We re now investigating the part played by the stem cells in the wound-healing process and the development of basal cell carcinoma, the most common form of skin cancer. The stem cells examined by the present study are found in the skin s hair follicles, around which the cells are able to move depending on their stage of growth. (Science Daily)

    Endoscopic Therapy May Offer An Alternative To Surgery In Patients With Esophageal Cancer  Oct 14, 2008
    In a retrospective study of a prospectively collected database conducted at the University of Chicago, Dr. Jennifer Chennat and her colleagues, under the direction of Dr. Irving Waxman, examined medical records of 48 patients who underwent CBE-EMR for the treatment of Barrett's esophagus with high-grade dysplasia or intramucosal carcinoma from August 2003 to May 2008 ... (May 31, 2006) Two new Mayo Clinic studies draw attention to the risk factors and possible genetic basis for Barrett's... (Science Daily)

    Liver transplant patients highly vulnerable to cancer  Oct 14, 2008
    Last Updated: Tuesday 14 October 2008 07:45 GMT. by Published on October 12, 2008 - 0 comments. (TheMedGuru)

    Aesthetic Results of Breast Surgery Can Be Improved  Oct 14, 2008
    Postoperatively, 21 of the tumors were confirmed to be ductal or lobular carcinoma in situ and 12 were invasive malignancies. Eight of the invasive cancers had a widespread intraductal component. (MEDLINEplus)

    Prognostic parameters for recurrence of papillary thyroid microcarcinoma  Oct 14, 2008
    Papillary thyroid microcarcinoma (PTMC) is defined as a papillary thyroid carcinoma less than or equal to 1. 0 cm in size. (BioMed Central)

    New devices push college students' buttons  Oct 11, 2008
    The question on the board was: basal cell carcinoma is common on the floor of the mouth, under the tongue and on the side of the tongue ... basal cell carcinoma most commonly appears on the lip), a small percentage of students answered true. (Lompoc Record, CA)

    Drug Sorafenib Improves Kidney Cancer Outcomes  Oct 11, 2008
    "Sorafenib treatment appeared to improve outcomes among patients with advanced renal cell carcinoma, regardless of age," the authors wrote. "Additionally, side effects were expected, mild, and medically manageable. There was no notable difference in the frequency or severity of sorafenib-related toxicity between younger and older patients.". (MEDLINEplus)

    Etheridge: Knowledge Gave Her Courage  Oct 10, 2008
    Kaufman was diagnosed in February 2001 and said she knows what it's like to get that phone call and hear the word "carcinoma" on the other end. "They say the scientific word, you're like -- that's cancer. Right?" Etheridge said. (CBS News -- Early Show)

    Breast Reconstruction after Mastectomy  Oct 10, 2008
    A 45-year-old woman undergoes core needle biopsy of a breast mass 4 cm in diameter and fine-needle aspiration of a palpable axillary lymph node, the results of both of which are found to be consistent with invasive ductal carcinoma. . (New England Journal of Medicine)

    Merkel-Cell Carcinoma  Oct 10, 2008
    Volume 359:1629-1631. Since this article has no abstract, we have provided an extract of the first 100 words of the and any section headings. (New England Journal of Medicine)

    Faces of Survival: Jan Redd  Oct 8, 2008
    PERSONAL: After a mammogram in August 2001, I was diagnosed with invasive lobular carcinoma on Sept. 28, 2001. I had a lumpectomy followed by chemotherapy and radiation through June 2002. (The Augusta Chronicle)

    Women Require Less Tobacco Exposure Than Men To Increase Colon Cancer Risk  Oct 7, 2008
    According to lead investigator Dr. Ludwig, "Because more of the relatives with positive findings smoked than did relatives without positive findings, our study suggests that smoking may have been responsible for the development of the precursor lesions, especially in light of the fact that smoking is a known risk factor for pancreatic carcinoma.". Adapted from materials provided by , via , a service of AAAS.. (Science Daily)

    Urine Samples Could Reveal Breast Cancer Risk  Oct 7, 2008
    To explore the potential of urine screening for breast cancer, the authors obtained samples from 148 women, 44 of whom had a precancerous condition known as "atypical hyperplasia." Another 24 women had a cancer-risk elevating condition known as lobular carcinoma in situ (LCIS), while the rest of the patients were healthy. The research team concluded that elevated MMP-9 levels were associated with a fivefold increase in the risk for atypical hyperplasia and more than a 13-fold increased risk for... (MEDLINEplus)

    Renewed call for tanning regulations  Oct 7, 2008
    This translated to an estimated 51 cases of melanoma, 294 cases of squamous cell carcinoma and seven deaths. The figures were higher in NSW and Queensland, where there were an estimated 12 and 14 deaths a year. (The Age)

    H. Pylori bacteria may help prevent some esophageal cancers  Oct 6, 2008
    PHILADELPHIA Some bacteria may help protect against the development of a type of esophageal cancer, known as adenocarcinoma, according to a new review of the medical literature ... The review, published in the October issue of Cancer Prevention Research, a journal of the American Association for Cancer Research, found that people who had H. pylori strains carrying a gene called CagA were almost half as likely to get adenocarcinoma of the esophagus, a cancer that develops in the tube that... (EurekAlert!)

    Hospital fined for needless tests  Oct 6, 2008
    In one of the cases, Dr Gopi Chand Ram, deputy director (health) in Bihar government was admitted to the hospital with tests suggestive of lymphoma and anaplastic carcinoma (both cancers) on June 11, 1999. On July 2 1999, he was referred to the Rajiv Gandhi Cancer Institute for treatment as Apollo didn't have adequate arrangements for treating cancer. (India Times, India)

    Saliva Could Be Used To Detect Oral Cancer: Study  Oct 5, 2008
    squamous cell carcinoma, a form of oral cancer have a low five-year survival rate and a high rate of recurrence especially when the cancer has metastasized in lymph nodes located in the neck ... In the recent research, researchers have found a simple way to detect oral squamous cell carcinoma ... Researchers collected saliva samples from 64 patients with oral squamous cell carcinoma and 64 healthy patients. (TopNews)

    Epstein-Barr Virus Protein Contributes To Cancer  Oct 4, 2008
    3, 2008) Researchers at the University of Toronto have shown that the EBNA1 protein of Epstein-Barr virus (EBV) disrupts structures in the nucleus of nasopharyngeal carcinoma (NPC) cells, thereby interfering with cellular processes that normally prevent cancer development ... The researchers conclude that there is "an important role for EBNA1 in the development of NPC, in which EBNA1-mediated disruption of PML nuclear bodies promotes the survival of cells with DNA damage." Since EBNA1 is... (Science Daily)

    Breakthrough Optical Technology To Assess Colon Cancer Risk, Accuracy  Oct 4, 2008
    "Our premise is that since the lining of the large intestine -- rectum and colon -- is contiguous, if you see an abnormality in one part of the colon, then somewhere else in the colon you have a higher likelihood of harboring an adenoma [benign tumor] or carcinoma [malignant tumor]," said Hemant K. Roy, M.D., director of gastroenterology research at NorthShore University HealthSystem and the study's principal clinical researcher. "EIBS strengthens our premise thanks largely to the unique and... (Science Daily)

    MRI Spots Early Breast Cancer In Mice  Oct 3, 2008
    2, 2008) A new magnetic resonance imaging procedure can detect very early breast cancer in mice, including ductal carcinoma in situ (DCIS), a precursor to invasive cancer ... They found that, when optimal methods were used, both DCIS and early invasive tumors "appeared clearly against a darker background." In those 12 mice, MRI was able to detect the sole relatively large tumor, 17 out of 18 small tumors that were less than 1 millimeter in size, and 13 out of 16 milk ducts that were distended... (Science Daily)

    Saliva Proteins Could Help Detection Of Oral Cancer  Oct 3, 2008
    2, 2008) Clinicians could detect oral squamous cell carcinoma, a form of oral cancer, using a simple test that detects proteins in saliva, according to a report in the October 1, 2008, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research ... Researchers collected saliva samples from 64 patients with oral squamous cell carcinoma and 64 healthy patients. (Science Daily)

    ImClone: USD 70 per share proposal submitted by US-based large pharma; Takeda not mystery bidder  Oct 3, 2008
    One market investor said Erbitux has shown a benefit in NSCLC patients with squamous cell carcinoma, one indication which Lillys Alimta is currently not approved for. The source close to Takeda speculated that Celgene and Amgen could emerge as bidders for ImClone, however, said it was unclear whether it would make such synergistic sense from a product perspective. (FT.com -- Markets)

    Spit Proteins Could Lead to Oral Cancer Test  Oct 3, 2008
    The latest findings focus on oral squamous cell carcinoma, which affects more than 300,000 people worldwide ... Researchers at UCLA's School of Dentistry collected saliva samples from 64 patients with oral squamous cell carcinoma and compared them with samples from 64 healthy patients. (MEDLINEplus)

    Second lumpectomy for breast cancer reduces survival rates  Oct 3, 2008
    In the United States in 2008, an estimated 182,460 new cases of invasive breast cancer will be diagnosed, an additional 67,770 new cases of carcinoma in situ or "pre-cancer" will be discovered and 40,480 women will die from breast cancer. Designated by the National Cancer Institute, UC Davis Cancer Center cares for 9,000 adults and children each year from throughout the Central Valley and inland Northern California. (EurekAlert!)

    Pitt research indicates new virus is culprit, not bystander, in deadly skin cancer  Sep 23, 2008
    PITTSBURGH, Sept. 22 University of Pittsburgh scientists are uncovering more evidence that a virus they recently discovered is the cause of Merkel cell carcinoma, an aggressive and deadly form of skin cancer ... "You can see the specific molecular steps." The team's current work could account for known risk factors for Merkel cell carcinoma such as UV exposure and ionizing radiation, which damage DNA and can lead to the viral mutations. (EurekAlert!)

    No Tan is a Safe Tan  Sep 20, 2008
    "There is no controversy whatsoever about the presence of UV signature mutations in squamous cell carcinoma. You can see that the genes have been mutated in a way that UV directly caused it," he explained. "The melanoma connection to UV is probably indirect, so you wouldn't see the mutation directly in the melanoma cell even though the UV caused it.". (MEDLINEplus)

    A new option to ameliorate quality of life of advanced gallbladder carcinoma?  Sep 20, 2008
    A new option to ameliorate quality of life of advanced gallbladder carcinoma ... A new option to ameliorate quality of life of advanced gallbladder carcinoma ... Reference: Qin TJ, Zhao XH, Yun J, Zhang LX, Ruan ZP, Pan BR. Efficacy and safety of gemcitabine-oxaliplatin combined with huachansu in patients with advanced gallbladder carcinoma. (EurekAlert!)

    How to treat gastroesophageal adenocarcinom patients?  Sep 18, 2008
    Gastroesophageal adenocarcinomas have a poor prognosis ... A study of esophageal adenocarcinoma and squamous cell carcinoma patients diagnosed between 1996 and 1999 found that chemoradiation without surgery was most frequent therapy, although patients given chemoradiation followed by surgery had better survival compared to chemoradiation alone ... A research study to be published on 28 May 2008, in the World Journal of Gastroenterology investigates treatments received and factors that influence... (EurekAlert!)

    Gastric cancer with 3 pathological features  Sep 18, 2008
    Primary carcinoma of the stomach is almost always adenocarcinoma or signet ring cell carcinoma and there are few reports of choriocarcinoma or neuroendocrine cell carcinoma. We report a patient with adenocarcinoma of the stomach combined with choriocarcinoma and neuroendocrine cell carcinoma ... Yasumitsu Hirano from Kanazawa University Graduate school of Medical Science described a patient with adenocarcinoma of the stomach combined with choriocarcinoma and neuroendocrine cell carcinoma. (EurekAlert!)

    New 3-D X-ray Detects Breast Cancer Early  Sep 18, 2008
    For the experiment, researchers chose a particularly challenging specimen: a breast invaded by a lobular carcinoma (a diffusely growing cancer), the second most common form of breast cancer, which is also very difficult to visualize in clinical mammography. In this kind of sample, the determination of the extension of the cancer frequently fails in X-ray mammograms and ultrasonographs of the breast. (Newsmax)

    New Tool To Speed Cancer Therapy Approval Available  Sep 16, 2008
    (May 31, 2007) The U.S. Food and Drug Administration (FDA) today approved Torisel (temsirolimus) for the treatment of a certain type of advanced kidney cancer known as renal cell carcinoma. Torisel was approved. (Science Daily)

    Investigational Drug Shows Promise In Ovarian Cancer  Sep 16, 2008
    Michael Friedlander from Australia presented the results of an international collaborative trial which administered the drug to 35 patients with recurrent ovarian, fallopian tube or peritoneal carcinoma. At the ESMO Congress, he presented final results of the trial on behalf of his co-investigators. (Science Daily)

    Registration statement including financial report  Sep 16, 2008
    AK lesions may progress to a form of skin cancer called squamous cell carcinoma, or SCC. We believe that our lead product candidate, PEP005 Gel for AK, once developed and, if approved for commercialization by the appropriate regulatory authorities, could offer patients an effective and well-tolerated treatment alternative for AK with a short, two-to-three day application regimen that could be performed by the patient at home. We are also developing a product candidate containing PEP005 for the... (Sydney Morning Herald)

    RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors  Sep 14, 2008
    In addition to pancreatic NET, RAD001 is being evaluated as a single agent or in combination with existing therapies in renal cell carcinoma, lymphoma, breast, gastric, lung and other cancers, as well as tuberous sclerosis. About Sandostatin LAR Depot Sandostatin LAR(R) Depot (octreotide acetate for injectable suspension) is a long-acting, injectable depot formulation of octreotide acetate, a somatostatin analogue that exerts similar pharmacologic effects on the human body as the natural hormone... (PR Newswire)

    Illness forces band director to retire  Sep 14, 2008
    Reid was diagnosed with renal cell carcinoma (RCC) and was given approximately one year to live last month after he collapsed at band practice 10 days earlier ... Renal cell carcinoma (RCC) is the most common form of kidney cancer arising from the renal tubule. (Atmore Advance, AL)

    Despite breast cancer diagnosis, women care for loved ones first  Sep 14, 2008
    By any measure, Camacho's diagnosis was devastating: infiltrating multicentric ductal carcinoma, a stage 2 B cancer that demanded aggressive chemotherapy, surgery and radiation, "the full nine yards.". CONTINUED 1. (OregonLive, OR -- News)

    Platinum-Based Chemotherapy plus Cetuximab in Head and Neck Cancer  Sep 11, 2008
    Background Cetuximab is effective in platinum-resistant recurrent or metastatic squamous-cell carcinoma of the head and neck. We investigated the efficacy of cetuximab plus platinum-based chemotherapy as first-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck ... Methods We randomly assigned 220 of 442 eligible patients with untreated recurrent or metastatic squamous-cell carcinoma of the head and neck to receive cisplatin (at a dose of 100 mg... (New England Journal of Medicine)

    Gaining A Better Understanding Of Kidney Diseases  Sep 9, 2008
    Cystic kidney disease, renal fibrosis, or renal cell carcinoma: Many diseases of the excretory organs are characterized by overproduction or on the contrary absence of characteristic proteins in the renal cells ... Pathologists also discovered renal cell carcinomas in some of the mice. (Science Daily)

    Adult Cancer Therapies May Benefit Kids  Sep 6, 2008
    "The same gene that's mutated in 30 percent of medulloblastoma is mutated in 90 percent of basil cell carcinoma," Curran said. Curran is working on a drug that specifically targets the defective gene - and turns it off. (CBS News)

    Now what? Dealing with a Breast Can...  Sep 6, 2008
    The most common kind is invasive ductal carcinoma, which accounts for 70 percent or more of all breast cancers, according to the Mayo Clinic (http://www. mayoclinic. (Suite101.com)

    Grand Adventures Ranch Launches Holistic Equine Cancer Recovery Program  Sep 6, 2008
    Successful recoveries with the ranch's protocol have included horses with squamous cell carcinoma, sarcoids and melanomas ... squamous cell carcinoma. (Yahoo News -- Press Releases)

    Down-staged liver cancer associated with good post-transplant outcomes  Sep 5, 2008
    For patients with liver cancer (also known as hepatocellular carcinoma), transplantation has been restricted to those who fit the Milan criteria ... Rather than expand the Milan criteria, researchers have suggested down-staging hepatocellular carcinoma to select for tumors with more favorable biology that will respond to treatment and do well following liver transplantation ... Article: "Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: An... (EurekAlert!)

    Cellular profile of the peritumoral inflammatory infiltrate in squamous cells carcinoma of oral mucosa :correlation with the expression of Ki67 and histologic grading.  Sep 3, 2008
    Cellular profile of the peritumoral inflammatory infiltrate in squamous cells carcinoma of oral mucosa :correlation with the expression of Ki67 and histologic grading ... Squamous cells carcinoma is the most important malignant tumor with primary site in the oral cavity and, given the great exposure of mucosa and lips to the etiologic factors of this neoplasm, its incidence is high ... Methods: In this study, oral mucosa samples of squamous cells carcinoma were analyzed, separated according to... (BioMed Central)

    How much is one mans life worth?  Sep 2, 2008
    Neil Haines, aged 46, suffers from Metastatic Renal Cell Carcinoma, he was chosen to take a new drug called Sutent that reduced the size of his kidney tumour after only one full cycle of treatment. Mr Haines, who was born and lived in Ebbw Vale before moving to Epsom to work as a graphic designer, has since been told that NICE have made a decision to withdraw the drug because it costs too much. (WalesOnline)

    Muscle invasive bladder cancer in Upper Egypt: the shift in risk factors and tumor characteristics  Aug 30, 2008
    In Egypt, where bilharziasis is endemic, bladder cancer is the commonest cancer in males and the 2nd in females; squamous cell carcinoma (SCC) is the commonest type found, with a peculiar mode of presentation. The aim of this study is to identify and rank the risk factors of muscle invasive bladder cancer (MIBC) in Upper Egypt and describe its specific criteria of presentation and histopathology. (BioMed Central)

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