Breast cancer statistics Oct 25, 2009
- An estimated 62,280 new cases of carcinoma in situ (CIS) will be diagnosed (CIS is non-invasive and is the earliest form of breast cancer). - About 40,170 women will die from breast cancer. (Ellensburg Daily Record, WA)
Drinking Coffee Slows Progression Of Liver Disease In Chronic Hepatitis C Sufferers, Study Suggests Oct 25, 2009
8-year study period to assess clinical outcomes which included: ascites (abnormal accumulation of fluid in the abdomen), prognosis of chronic liver disease, death related to liver disease, hepatic encephalopathy (brain and nervous system damage), hepatocellular carcinoma (liver cancer), spontaneous bacterial peritonitis, variceal hemorrhage, or increase in fibrosis ... 2, 2007) A new study on the relationship between coffee drinking and the risk of liver cancer (hepatocellular carcinoma)... (Science Daily)
Scientists Identify Specific Markers That Trigger Aggressiveness Of Liver Cancer Oct 24, 2009
23, 2009) Hepatocellular carcinoma (HCC) or primary liver cancer forms in the epithelial tissue of the liver and is most commonly caused by the hepatitis B virus (HBV) or hepatitis C virus (HCV) ... Yang et al. Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. (Science Daily)
Trust yourself Oct 23, 2009
Seavey was diagnosed with stage one invasive, non-invasive ductal carcinoma. It is a kind of cancer that feeds on estrogen. (Burlington Union, MA)
HEALTH SEC SICK? Oct 22, 2009
Sebelius had a basal cell carcinoma removed from her forehead on Tuesday during a successful standard outpatient procedure, according to HHS spokeswoman Jenny Backus ... Basal cell carcinoma is a slow-growing form of skin cancer that can appear as a bump or growth ... The fact that Kathleen Sebelius had a basal cell carcinoma removed from her forehead is sad and we pray she will have a total recovery. (The Drudge Report)
Survivor stresses early detection in success of breast cancer recovery Oct 19, 2009
Strawn was diagnosed with invasive ductal carcinoma in February 2008. Once diagnosed, she and her oncologist, Dr. Timothy Pluard, decided on a treatment strategy using Taxotere, Carboplatin and Herceptin. (Mattoon Journal-Gazette, IL)
Better tests sharpen treatment options Oct 16, 2009
The doctor told her they had a lot of work ahead and said it was a ductile carcinoma of the highest grade, a very aggressive form of cancer. DeSisto returned to her apartment and her parents came over. (Ipswich Chronicle, MA)
Skin cells may provide early warning for cancer risk elsewhere in body Oct 16, 2009
"Even though they look normal, they multiply in places where they shouldn't and eventually accumulate enough mutations to form a carcinoma. They are the first stage in cancer, but not cancer.". The inappropriate growth - called cancerization - is a sign that the normal processes that stop growth when cells contact one another have been disrupted, though not fully, because otherwise the cells would invade the underlying connective tissue and become cancerous. (EurekAlert!)
How organs are selected for transplant Oct 16, 2009
One incident reported to the NRLS read: "Kidney arrived completely surrounded by fat and muscle -- nothing was recognizable. After dissection, a fatty tumor appeared on the upper pole, decision was taken to transplant anyway. "After unclamping, there was a massive bleed from the tumor leading to urgent transplantectomy -- kidney sent to the path lab -- renal cell carcinoma. not fit for purpose. (CNN -- Health)
Using RNAi-based Technique, Scientists Find New Tumor Suppressor Genes In Lymphoma Oct 15, 2009
Furthermore, the study showed that genes that act as tumor suppressors in lymphoma do not act as tumor suppressors in certain other cancer types, such as liver carcinoma. These findings imply that genes can act as pro- or anti-cancer genes depending on genetic or cellular context, said Lowe. (Science Daily)
FTC Clears $68 Billion Pfizer-Wyeth Merger Oct 15, 2009
The commission found that both companies market treatments for a few common diseases, such as MRSA infections and renal cell carcinoma, but that their products are not close substitutes or even competitors. The FTC also looked into the drug development pipeline and found both companies are working on osteoporosis products. (Law.com)
Male Patients Fight Against Breast Cancer Oct 14, 2009
The diagnosis revealed infiltrating ductal carcinoma, the most common type of breast cancer. When the doctor told Wilson he may need a mastectomy, he remembers just "fogging up.". (Click2Houston, TX)
DNA damage induced by cis- and carboplatin as indicator for in vitro sensitivity of ovarian carcinoma cells Oct 11, 2009
DNA damage induced by cis- and carboplatin in primary cells of ovarian carcinomas was determined by the alkaline comet assay. In parallel the reduction of cell viability was measured by the fluorescein diacetate (FdA) hydrolysis assay. (BioMed Central)
11-Year-Old One of Youngest Breast Cancer Survivors Oct 10, 2009
The form of breast cancer that Hannah had, secretory carcinoma, has been found in only a few hundred cases of young girls, representing less than. 1 percent of all breast cancers, according to the National Institutes of Health. (ABC News)
Terms Breast Cancer Patients Need To Know Oct 9, 2009
Ductal carcinoma According to MayoClinic ... WebMD.com notes two particular types of ductal carcinoma: invasive ductal carcinoma, which begins in the ducts and spreads to the fatty tissue around the duct, and ductal carcinoma in situ, where the cancer is still contained in the duct ... Lobular carcinoma This type of breast cancer begins in the lobules of the breast, where breast milk is made, according to WebMD.com. (Click2Houston, TX)
What Are Different Kinds Of Breast Cancer? Oct 8, 2009
In-situ ductal carcinoma is often thought of as noninvasive breast cancer because cancer cells have not migrated to other parts of the body ... According to , in-situ ductal carcinoma occurs when cancer cells originate and grow in the milk ducts of the breast ... Infiltrating ductal carcinoma starts just like ISDC, in the milk ducts of the breast. (Click2Houston, TX)
DNA Test Could Be Key To Targeting Treatments For Head And Neck Cancer Oct 8, 2009
16, 2007) A simple oral rinse could detect the early development of head and neck squamous cell carcinoma, according to researchers. Currently, only 50 percent of head and neck cancer patients are cured of the. (Science Daily)
MicroRNA Expression, Survival, and Response to Interferon in Liver Cancer Oct 8, 2009
Background Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly in men ... Methods We analyzed three independent cohorts that included a total of 455 patients with hepatocellular carcinoma who had undergone radical tumor resection between 1999 and 2003 ... MicroRNA-expression profiling was performed in a cohort of 241 patients with hepatocellular carcinoma to identify tumor-related microRNAs and determine their association with survival in men and women. (New England Journal of Medicine)
Many Childhood Cancer Survivors Have Uncomplicated Pregnancies, Healthy Babies Oct 6, 2009
"The increased occurrence of low birth weight and preterm delivery among childhood cancer survivors and of preterm delivery among young genital tract carcinoma survivors that we and others have observed may indicate relatively less severe potential problems among offspring. However, these outcomes can still greatly affect families, are associated with significantly increased costs and indicate a need for close monitoring of pregnancies among childhood and adolescent cancer survivors.". In... (Science Daily)
Breast cancer made her tougher: One woman's tale Oct 6, 2009
The doctors assessment was confirmed by a biopsy several days later: infiltrating (or invasive) ductal carcinoma, a cancer that forms in the ducts that carry milk to the nipple. Ductal carcinoma is the most common form of breast cancer, making up about 70 percent to 80 percent of all breast cancers. (MSNBC -- Health)
Curcumin may inhibit nicotine-induced activation of head and neck cancers Oct 5, 2009
In a paper presented at the 2009 American Academy of Otolaryngology Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting XPO in San Diego, researchers examined the effects of curcumin on head and neck squamous cell carcinoma (HNSCC) growths. The study used an in vitro model of a variety of head and neck cancer cell lines. (EurekAlert!)
It can happen to men, too: North Andovers Peter Devereaux fighting breast cancer Oct 3, 2009
The doctor called and told me I had invasive ductal carcinoma. At Dana Farber Cancer Center in Boston, Devereaux went through a mastectomy and had 22 lymph nodes removed in 2008, followed by treatment with Herceptin, chemotherapy and radiation. (North Andover Citizen, MA)
Case Western Reserve University discovers Merkel cell originates from skin, not the neural crest Oct 3, 2009
"It is thought that Merkel cells give rise to Merkel cell carcinoma, a rare but aggressive form of skin cancer that responds poorly to current treatments," said Dr. Maricich. "In addition to solving a 130 year-old mystery, our data may be relevant to the understanding of Merkel cell carcinoma, and may provide important clues in the search for novel therapeutic targets.". (EurekAlert!)
Weathering the storms Oct 2, 2009
Fortunately, her first cancer was an early-stage melanoma and the second was a low-grade non-invasive intraductal carcinoma. But her illness took its toll, and business dipped 10-15. (Dallas Business Journal, TX)
Soccer mom chronicles: Its not too late Oct 2, 2009
This past February, my mother was diagnosed with a fairly rare and incurable form of cancer called Primary Peritoneal Carcinoma, which stemmed from undetected ovarian cancer. The reason the ovarian cancer went undetected, was because my mother refused to see a doctor after months of complaining of pain in her stomach. (Kingston Mariner, MA)
Molecular Imaging Holds Promise For Early Intervention In Common Uterine Cancer Oct 2, 2009
1, 2009) A promising new molecular imaging technique may provide physicians and patients with a noninvasive way to learn more information about a type of cancer of the uterus lining called "endometrial carcinoma" one of the most common malignant female tumors ... "Endometrial carcinoma is one of the most common female malignant tumors," says Hidehiko Okazawa, M.D., Ph ... "The method of positron emission tomography (PET) imaging we used in the study is noninvasive, and it has tremendous... (Science Daily)
Non-AIDS-Related Cancers Growing Among HIV Patients Oct 2, 2009
Because of their weakened immune system, AIDS patients are at increased risk for so-called AIDS-defining malignancies, which include cancers such as cervical carcinoma, non-Hodgkin's lymphoma and Kaposi's sarcoma. There has been speculation that non-AIDS-defining malignancies are becoming more common among HIV patients because antiretroviral drugs help them live longer. (MEDLINEplus)
KIRO 7's Michelle Millman: 'Overwhelmed' By Cancer Diagnosis Sep 30, 2009
That's when I was diagnosed with invasive lobular carcinoma in my right breast. When you're told you have cancer the world seems to stop, like it's really not happening to you but to someone sitting just behind you in the room. (KIRO TV, WA)
Research needed to learn which DCIS patients may be candidates for less invasive therapy Sep 26, 2009
Ductal carcinoma in situ (DCIS), the most common non-invasive lesion of the breast, presents unique challenges for patients and providers largely because the natural course of the untreated disease is not well understood ... Despite the connotations associated with the term carcinoma, DCIS is associated with ten-year survival rates close to 100% when treated with currently available therapies. (EurekAlert!)
Certain cancers more common among HIV patients than non-HIV patients Sep 26, 2009
AIDS patients with suppressed immune systems are at higher risk for so-called AIDS-defining malignancies cancers such as non-Hodgkin's lymphoma, Kaposi's sarcoma and cervical carcinoma ... The non-AIDS-defining malignancies included all forms of cancer except skin, lymphoma, cervical carcinoma, Kaposi's sarcoma and ill-defined cancers. (EurekAlert!)
Seasonal flu shot may increase H1N1 risk... Sep 26, 2009
Remove the word "carcinoma" from the diagnosis of a common growth in milk ducts, a new U.S. report says. Health Canada said Friday it is aware of a warning sounded over potentially confusing dosage directions on the liquid form of the antiviral drug Tamiflu. (The Drudge Report)
Early Form of Breast Cancer May Need New Name Sep 26, 2009
CHICAGO (Reuters) - A common, nonmalignant tumor of the breast called ductal carcinoma in-situ or DCIS may need a name change because the word "carcinoma" scares so many women, a U.S. panel of experts said on Thursday. They said the term carcinoma creates a lot of worry in women who fear they will develop cancer, even though long-term survival rates for DCIS are excellent, approaching 100 percent ... "If you use a word that evokes fear, as the word carcinoma may, I think we need to consider is... (MEDLINEplus)
Merkel Cell Polyomavirus Associated With Rare Skin Cancer, Merkel Cell Carcinoma Sep 26, 2009
25, 2009) The Merkel cell polyomavirus (MCPyV) is the only human polyomavirus known to be associated with a rare skin cancer, known as Merkel cell carcinoma, according to a new study published online September 23 in the Journal of the National Cancer Institute ... The majority of patients with Merkel cell carcinoma carry MCPyV, but little is known about the polyomavirus' prevalence in the general population and the association between circulating antibodies against MCPyV and the rare skin cancer... (Science Daily)
Specialists want carcinoma out of diagnosis Sep 25, 2009
Specialists want carcinoma out of diagnosis - Cancer- msnbc ... Specialists want carcinoma out of diagnosis ... A less scary formal name could help, says a new report that urges removing the word "carcinoma" from the diagnosis of a common growth in milk ducts. (MSNBC -- Health)
Goemans sponsor Survivor Madison team in Race for the Cure event Sep 25, 2009
Goeman feels fortunate because her cancer was caught early, and it was a type that was more easily treatable -- ductal carcinoma. At the same time, she feels guilty "because people have it worse than I do," she said. (Madison Daily Leader, SD)
Acid Reflux Doesn't Just Cause Heartburn Sep 25, 2009
About ten percent of patients with long-standing acid reflux develop changes in the swallowing tube that increase the risk of developing adenocarcinoma, a deadly cancer with a 5-year survival rate of less than fifteen percent ... As smoking has declined, the incidence of squamous cell carcinoma has dropped ... But for reasons that are not clear, esophageal adenocarcinoma - the kind linked to acid reflux (and smoking) - has dramatically increased over the past forty years and now accounts for... (CBS News -- Health)
The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma Sep 25, 2009
Three human oral squamous cell carcinoma cell lines, Tca8113, TSCC and NT, were treated with GA alone, celastrol alone or GA plus celastrol ... The level of constitutive NF-kappa B activity in oral squamous cell carcinoma cell lines was determined by immunofluorescence assays and nuclear extracts and electrophoretic mobility shift assays (EMSAs) in vitro ... To further investigate the role of NF-kappa B activity in GA and celastrol treatment in oral squamous cell carcinoma, we used the dominant... (BioMed Central)
Carcinoma of the Gastroesophageal Junction Sep 24, 2009
Volume 361:1315-1316. Since this article has no abstract, we have provided an extract of the first 100 words of the and any section headings. (New England Journal of Medicine)
A Man with Recurrent Transitional-Cell Carcinoma of the Ureter Sep 24, 2009
NEJM -- Case 30-2009 -- A 77-Year-Old Man with Recurrent Transitional-Cell Carcinoma of the Ureter ... Case 30-2009 A 77-Year-Old Man with Recurrent Transitional-Cell Carcinoma of the Ureter ... Dr. Donald S. Kaufman: A 77-year-old man with a history of transitional-cell carcinoma of the right ureter was seen in the multidisciplinary urologic oncology clinic of this hospital because of a mass in the left ureter and cytologic evaluations of urine specimens that were positive for transitional-cell... (New England Journal of Medicine)
Short-term Stress Fights Tumors In Mice Sep 22, 2009
The researchers studied a particular type of skin cancer called squamous cell carcinoma that is known to be vulnerable to attack by the immune system. Understanding how the intricate two-step between stress and the immune system plays out in the dance hall of diseases like cancer is important for future therapies. (Science Daily)
Bayer's Novel Anti-Cancer Compound Regorafenib (BAY 73-4506) Showed Stabilization or Regression in 81 Percent of Kidney Cancer Patients Sep 22, 2009
- Results of a Phase II Study in Renal Cell Carcinoma (RCC) ... BERLIN, Sept. 22 /PRNewswire/ -- Bayer today announced results from a Phase II trial of regorafenib (BAY 73-4506), a potent oral multi-kinase inhibitor, which demonstrated that treatment with regorafenib resulted in a 31 percent partial response rate and 50 percent stabilization rate in patients with metastatic renal cell carcinoma (RCC). (PR Newswire)
Regulating The Regulators: New Therapeutic Approach Against Cancer Sep 22, 2009
For example, a Toll-like receptor (TLR) agonist, called imiquimod, which activates dendritic cells, is in clinical use as a topical application for basal cell carcinoma. In addition, a number of TLR agonists have been evaluated in clinical trials as an adjuvant for cancer vaccines. (Science Daily)
Dogs Get Skin Cancer Too Sep 19, 2009
Squamous cell carcinoma: This form of dog skin cancer, which occurs in the epidermis, is often caused by exposure to the sun ... Squamous cell carcinomas tend to appear in dogs that are between six and 10-years-old ... In general, dogs with short coats (especially those with light skin) are more prone to squamous cell carcinomas. (CBS News)
Cancer sufferer spurned Sep 19, 2009
The toothache turned out to be a squamous carcinoma in his jaw. Mr Oram had surgery to remove the affected part of his jaw and then a section of his leg was used to rebuild his jaw. (Sydney Morning Herald -- Australia)
Cases Of Liver Cancer Reduced In Younger Population Vaccinated For Hepatitis B Sep 18, 2009
In July 1984, a universal vaccination program was initiated among newborn children in Taiwan to prevent the hepatitis B virus infection, which can predispose to the development of hepatocellular carcinoma, a primary malignancy of the liver. For this study, Mei-Hwei Chang, M.D., of the Department of Pediatrics, National Taiwan University Hospital in Taipei, and colleagues collected data from almost 2,000 patients with hepatocellular carcinoma who were aged 6-29 years at diagnosis in Taiwan... (Science Daily)
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma Sep 17, 2009
Background Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue (SMO), occur in basal-cell carcinoma. In a phase 1 clinical trial, we assessed the safety and pharmacokinetics of GDC-0449, a small-molecule inhibitor of SMO, and responses of metastatic or locally advanced basal-cell carcinoma to the drug ... Methods We selected 33 patients with metastatic or locally advanced basal-cell carcinoma to receive oral GDC-0449 at one of three... (New England Journal of Medicine)
Bayer Announces New Data on Oncology Portfolio To Be Presented at the ECCO-ESMO Congress 2009 Sep 17, 2009
Nexavar is currently approved in more than 80 countries for the treatment of patients with hepatocellular carcinoma (HCC), or liver cancer, and in more than 90 countries for the treatment of patients with advanced renal cell carcinoma (RCC), or kidney cancer ... Based on the currently approved U.S. package insert for the treatment of patients with unresectable hepatocellular carcinoma and advanced kidney cancer, hypertension may occur early in the course of therapy and blood pressure should be... (PR Newswire)
Annual Courage Ride set for September 26 Sep 17, 2009
Oswald is currently on her second round of chemotherapy following radiation treatment for squamous cell carcinoma, a cancer that can occur in many different organs. A teacher associate at Washington Township Elementary School for 21 years, Oswald said the cancer began in her shoulder and was diagnosed in December of 2008. (Kalona News, IA)
Yes-associated Protein: Early Diagnosis Of Gastric Carcinoma Sep 17, 2009
A research team led by Professor Yan Xin, from The Fourth Laboratory of Cancer Institute in China measured the expression of YAP and survivin in normal gastric mucosa, precancerous lesions and gastric carcinoma using an immunohistochemical method to analyze the significance and correlations of the 2 factors with gastric carcinogenesis ... The investigation found that the expression of YAP and survivin in gastric carcinoma were positively correlated, and according to the data, they speculated... (Science Daily)
Critical Illness Plans Help Pay for What Health Insurance Won't Sep 15, 2009
Text hiding to spacing. New Colonial Life voluntary critical illness plan covers more illnesses, helps fill health insurance gaps. (PR Newswire)
What does 46.3 million uninsured mean? Sep 11, 2009
What does it mean when a woman gets an infiltrating duct carcinoma with axillary nodes positive and the insurance company she and her employer paid for years drops her on the spot and she goes bankrupt. Finn McCool. (Atlanta Journal-Constitution -- Opinion)
Survey Shows At-Risk Men Lacking In Prostate Cancer Knowledge Sep 11, 2009
Menon M, Tewari A, Peabody JO, Shrivastava A, Kaul S, Bhandari A, Hemal AK. Vattikuti Institute prostatectomy, a technique of robotic radical prostatectomy for management of localized carcinoma of the prostate: experience of over 1100 cases. Urol Clin North Am. (PR Newswire)
Overexpressed Protein Converts Noninvasive Breast Cancer Into Invasive Disease Sep 10, 2009
ErbB2, an oncoprotein that promotes metastasis, is overexpressed in 50 to 60 percent of the noninvasive breast cancer known as ductal carcinoma in situ (DCIS) ... An estimated 80 percent of all solid tumors are carcinomas, cancers of the epithelial tissue ... (May 27, 2009) Women with ductal carcinoma in situ (DCIS) who exhibit an overexpression of the protein HER2/neu have a six-fold increase in risk of invasive breast cancer, according to a new study. (Science Daily)
Gum Disease May Increase Head and Neck Cancer Risk Sep 10, 2009
Having chronic periodontitis, a gum disease involving the progressive loss of the bone and soft tissue attached to the teeth, appeared to increase one's odds of developing head and neck squamous cell carcinoma, especially in the mouth and throat. The findings was published online Sept. 8 in the journal Cancer Epidemiology, Biomarkers ntion. (MEDLINEplus)
Can Stopping Gum Disease Stop Cancer? Sep 9, 2009
Chronic periodontitis, a form of gum disease, is an independent risk factor for head and neck squamous cell carcinoma ... The researchers assessed the role of chronic periodontitis on head and neck squamous cell carcinoma, as well as the individual roles on three subsites: oral cavity, oropharyngeal and laryngeal ... Findings showed that chronic periodontitis might represent a clinical high-risk profile for head and neck squamous cell carcinoma. (Newsmax)
Prevent periodontitis to reduce the risk of head and neck cancer Sep 8, 2009
PHILADELPHIA Chronic periodontitis, a form of gum disease, is an independent risk factor for head and neck squamous cell carcinoma ... The researchers assessed the role of chronic periodontitis on head and neck squamous cell carcinoma, as well as the individual roles on three subsites: oral cavity, oropharyngeal and laryngeal ... Findings showed that chronic periodontitis might represent a clinical high-risk profile for head and neck squamous cell carcinoma. (EurekAlert!)
Beware of heartburn or Acid Reflux! Sep 8, 2009
It has now become apparent, through studies and research in the US and India, that people who suffer from acid reflux are likely to be predisposed to carcinoma of the esophagus ... However, the good news is that due to advances in technology and surgical techniques, Acid Reflux can be treated laparoscopically in cases where the problem cant be treated non-surgically in order to prevent further damage and other serious ailments like carcinoma of esophagus. (India Times, India)
Johnson & Johnson Honors 2009 Recipient of The Dr. Paul Janssen Award for Biomedical Research Sep 8, 2009
Years later, a small molecule inhibitor of the VEGFR2 kinase function was developed, from which a derivative was approved in 2006 for the treatment of kidney carcinoma and gastro-intestinal stromal tumors. "It is an honor to be recognized with an award of this stature," said Ullrich. (PR Newswire)
HPV Vaccine Could Prevent Some Forms Of Breast Cancer, Australian Research Suggests Sep 5, 2009
The team confirmed the presence of high-risk HPV in the nuclei of breast cancer epithelial cells in five (39 per cent) of 13 ductal carcinoma in situ and three (21 per cent) of 14 invasive ductal carcinoma (IDC) breast cancer specimens. Non-invasive or in situ cancers are those confined to the milk-making glands and do not spread to other parts of the breast or body. (Science Daily)
Fundraiser invites supporters to Be Bold, Be Bald! Sep 4, 2009
But in 2005, cancer struck again as he was diagnosed with late stage squamous cell carcinoma. Once again, Mike stayed active and positive through years of surgeries and radiation, which caused him to lose all his hair, but it was clear that this time, Mike was losing his battle. (Lincoln Journal, MA)
Novel Anti-cancer Drug Yields Positive Response In People With Advanced Skin And Brain Cancer Sep 4, 2009
15, 2008) A novel molecule, GDC-0449, shrinks tumors for patients with advanced basal cell carcinoma with limited side effects, suggesting a viable new treatment option for patients with the advanced form of. (Jan. (Science Daily)
New Compound Shrinks Skin Cancers Sep 4, 2009
Study found more than half of advanced basal cell carcinomas responded to treatment ... WEDNESDAY, Sept. 2 (HealthDay News) -- An experimental cancer drug that switches off the so-called "Hedgehog" pathway beat back tumors in more than half of patients with advanced basal cell carcinoma, a type of skin cancer ... Some 1 million Americans get basal cell carcinoma each year. (MEDLINEplus)
Pill shows promise in hard-to-treat cancers Sep 3, 2009
Dr. Charles Rudin of the Johns Hopkins Kimmel Cancer Center, who worked on the studies, said the Hedgehog signaling pathway appears to play a role in lots of cancers, but it seems to be particularly important in medulloblastoma and basal cell carcinoma, the most common type of skin cancer. "We know that both of these cancer types have mutations in Hedgehog pathway genes, and our results with Hedgehog inhibitors could be the starting point for developing a new type of therapy for these... (MSNBC -- Health)
Potential Skin Cancer Breakthrough Tested at Scottsdale Healthcare Published Today in New England Journal of Medicine Sep 3, 2009
"Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma" is authored by lead investigator Daniel D. Von Hoff, MD, a world-renowned expert in developing new drugs for patients with cancer ... These findings are significant because there is no proven therapy for advanced basal cell carcinoma (BCC) ... In a Phase I clinical trial conducted in Arizona at the Virginia G. Piper Cancer Center at Scottsdale Healthcare, Dr. Von Hoff and colleagues at Johns Hopkins University and Karmanos... (PR Newswire)
Experimental cancer drug shows promise Sep 3, 2009
It was used to test patients with advanced basal cell carcinoma, a rare type of skin cancer. Basal cell skin cancer is the most common type of cancer and is easily treated if detected in time. (AZCentral -- Business)
