Drug Failed To Reduce Heart Attack Risk After Bypass Apr 3, 2008
"Coronary artery bypass graft (CABG) surgery is one of the most important therapeutic options for relieving angina and improving survival and quality of life in patients with multi-vessel coronary artery disease," the Duke University scientists wrote. "It is the most commonly performed cardiac surgical procedure in the world, and, in 2005, more than 250,000 CABG procedures were performed in the United States." ... But CABG surgery can lead to serious complications such as heart attack, recurrent... (MEDLINEplus)
Angioplasty Proves Reasonable Alternative to Bypass Surgery Apr 2, 2008
Current guidelines recommend coronary artery bypass grafting (CABG) over percutaneous coronary intervention unless a previous graft has been performed. And until more studies are conducted, CABG should remain the treatment of choice in these patients, the study authors stressed ... Currently, there is limited long-term data comparing CABG and percutaneous coronary intervention with stents in patients with left main coronary artery disease. (MEDLINEplus)
Allon Reports 2007 Audited Operating Results and Updates 2008 Plans Mar 19, 2008
- Commencement of the randomized stage of the Phase II clinical trial evaluating AL-208 (intravenous) as a treatment for the mild cognitive impairment (MCI) that commonly results from coronary artery bypass graft (CABG) surgery ... - Complete enrolment and dosing, analyze data and release results of a Phase II clinical trial evaluating the safety, tolerability and effect of AL-208 as treatment for MCI resulting from ischemic damage during CABG surgery. (CCNMatthews Press Releases)
New 300mg Loading Dose Tablet for Plavix(R) Receives Positive Opinion From the European Committee for Medicinal Products (CHMP) Mar 5, 2008
About Plavix(R) Plavix(R) is an antiplatelet agent which prevents platelets from sticking together and forming clots in the arteries and is the only widely available prescription antiplatelet approved to reduce the risk of heart attack and stroke across the entire spectrum of ACS. Plavix(R) is indicated for the reduction of atherothrombotic events in patients with a history of recent MI, recent stroke or established peripheral arterial disease (P.A.D.) Plavix(R) is also indicated for patients... (PR Newswire)
'Cardiac surgery drug ups death rate' Feb 22, 2008
All patients underwent coronary-artery bypass surgery (CABG), and 1181 of them also underwent valve surgery. Patients who received either aminocaproic acid or no therapy did not have high rates of death or poor kidney function seen in the aprotinin group. (India Times, India -- Health/Science)
Anapol Schwartz Attorney Representing Trasylol(R) Victims Says Medical Study - Confirming Heart Bypass Drug Mortality Risk - to Open Floodgates for More Litigation Feb 21, 2008
PHILADELPHIA, Feb. 20 /PRNewswire/ -- According to Anapol Schwartz () attorney James Ronca (), a New England Journal of Medicine study () (to be released in the February 21, 2008, print edition) confirms that Bayer AG's blood-clotting drug Trasylol(R), used in coronary artery bypass graft (CABG) procedures, causes kidney/renal failure and increases mortality risk ... Pulled by Bayer from the market in November 2007 in response to FDA concerns, Trasylol(R) is administered by an anesthesiologist... (PR Newswire)
Aprotinin during Coronary-Artery Bypass Grafting and Risk of Death Feb 21, 2008
Background Aprotinin (Trasylol) is used to mitigate bleeding during coronary-artery bypass grafting (CABG) ... Methods Using electronic administrative records of the Premier Perspective Comparative Database, we studied hospitalized patients with operating-room charges for the use of aprotinin (33,517 patients) or aminocaproic acid (44,682 patients) on the day CABG was performed ... We tabulated the numbers of patients with a hospital-discharge status of death and performed three types of... (New England Journal of Medicine)
Learning from Aprotinin — Mandatory Trials of Comparative Efficacyand Safety Needed Feb 21, 2008
Aprotinin, a hemostatic agent that inhibits the fibrinolytic enzyme plasmin,1 was approved by the Food and Drug Administration (FDA) in 1993 for reducing blood loss during coronary-artery bypass grafting (CABG). By 2006, aprotinin was prescribed for approximately 200,000 patients undergoing cardiac surgery worldwide. (New England Journal of Medicine)
60 Minutes to Report on Dangers of Trasylol: Cory Watson Crowder & DeGaris Involved in Litigation Against Pharmaceutical Giant Bayer AG Feb 16, 2008
Feb. 15 /PRNewswire/ -- Cory Watson Crowder is, P.C. ), has filed lawsuits against Bayer AG on behalf of plaintiffs throughout the United States, who allegedly suffered permanent kidney damage after being given Trasylol(R) -- a Bayer-manufactured drug used to prevent excessive bleeding during coronary artery bypass graft surgery (also called CABG or more commonly bypass). According to CBS News, 60 Minutes will report Sunday night that 22,000 additional lives could have been saved had the FDA... (PR Newswire)
Coronary Artery Bypass Graft Surgery Promising In 90-Year-Olds Feb 8, 2008
7, 2008) Coronary artery bypass graft (CABG) surgery is becoming increasingly common, and appears to be a viable treatment, among individuals in their 90s, according to a study published in the American Journal of Cardiology ... CABG surgery creates new pathways around narrowed and blocked arteries, allowing sufficient delivery of blood, oxygen, and nutrients to the heart ... Our results indicate that nonagenarians who are currently selected for CABG procedures can achieve years of life... (Science Daily)
Downsized Heart Aids Bypass Surgery Jan 30, 2008
the Hopkins team found that by combining so-called coronary artery bypass grafting, known as CABG, with surgical ventricular restoration, or SVR, in patients with advanced heart failure, the likelihood of subsequent heart problems was 24 percent, compared to 55 percent in those undergoing CABG alone ... Conte, an associate professor of surgery at the Johns Hopkins University School of Medicine and its Heart Institute, cautions that not all CABG patients can benefit from SVR and that the... (Science Daily)
Biopure Announces 2007 Fourth Quarter and Year-End Financial Results Jan 29, 2008
This trial, begun in 2006, is a Phase 2 clinical trial in patients undergoing multi-vessel coronary artery bypass graft (CABG) surgery. The objective of this trial is to assess the safety and feasibility of Hemopure in reducing heart damage, as measured by cardiac enzyme elevation, and enhancing tissue preservation during CABG surgery. (PR Newswire)
Newsweek: The debate isn't over yet Jan 24, 2008
One of the studies, the first of its kind, pits drug-eluting stents against coronary artery bypass graft (CABG) operations and finds that the devices are not as effective as the surgery ... "Drug-eluting stents are much less invasive than CABG, so people who didn't want to be cut open and laid up for a long time favored them," says , a health policy analyst at SUNY Albany and the lead researcher on the other new study. (MSNBC -- Health)
Drug-Eluting Stents vs. CABG Jan 24, 2008
Background Numerous studies have compared the outcomes of two competing interventions for multivessel coronary artery disease: coronary-artery bypass grafting (CABG) and coronary stenting ... Methods We identified patients with multivessel disease who received drug-eluting stents or underwent CABG in New York State between October 1, 2003, and December 31, 2004, and we compared adverse outcomes (death, death or myocardial infarction, or repeat revascularization) through December 31, 2005, after... (New England Journal of Medicine)
Allon Trial Studies Pharmacokinetics of AL-108 & AL-208 Jan 10, 2008
AL-208 is being evaluated in a Phase II trial as a prevention for the mild cognitive impairment (MCI) resulting from ischemic damage during coronary bypass graft surgery (CABG). Trial results will also indicate AL-208's potential as a treatment for the ischemic damage resulting from stroke. (CCNMatthews Press Releases)
Statins After Bypass Lower Stroke Risk Nov 8, 2007
TUESDAY, Nov. 6 (HealthDay News) -- Treatment with cholesterol-lowering statin drugs after coronary artery bypass graft (CABG) surgery reduces a patient's risk of stroke, U.S. researchers report. The study, from the Cleveland Clinic, included more than 5,200 patients who underwent bypass between early 1993 and late 2005. (MEDLINEplus)
A Phase II, Randomized, Double Blind, Placebo-Controlled Dose-Escalating Study, Meets the Clinical Endpoints of MTR106 Tablets During the Treatment of Acute Migraine Attacks Without Aura in Females Nov 7, 2007
v. formulation) for the treatment of hypotension associated with cardiac (CABG) surgery. Meditor's patent portfolio provides the company with a strong proprietary position in the U.S. and worldwide. (PR Newswire)
Regado Biosciences Presents Positive Data From REG1 Anticoagulation System Phase Ic Study at American Heart Association 2007 Scientific Sessions Nov 5, 2007
These procedures, which include coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI), put patients at a high-risk for therapy-related bleeding complications. REG1 is being developed initially to increase therapeutic flexibility and improve patient outcomes in coronary revascularization procedures. (PR Newswire)
Canadian Trial Of Heart Surgery Drug Trasylol Halted Oct 27, 2007
The trial is called BART, Blood Conservation using Antifibrinolytics: A Randomized Trial in High-Risk Cardiac Surgery Patients, and involves 3000 high risk cardiac patients having either a repeat operation for coronary heart bypass graft (CABG) or an operation to replace an aortic valve, or combined valves or valve/CABG procedures. The drug company said it had issued new guidance to physicians and healthcare providers using Trasylol (aprotinin injection) to treat patients having coronary artery... (Medical News Today)
Voltaren Gel receives FDA approval as first topical prescription treatment for osteoarthritis pain Oct 23, 2007
Voltaren Gel is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery. Voltaren Gel should not be used in combination with other oral NSAIDs or aspirin because of the potential for increased adverse effects. (EurekAlert! -- Business News)
What we doMario Petrou is a cardiac and transplant surgeon Oct 21, 2007
This is a coronary artery bypass grafting, also known as CABG (pronounced cabbage) ... Its use for CABG has been shown over the years to provide the best survival benefit ... This can include patients referred for CABG or valve replacement as well as transplant patients. (BBC News -- UK)
Coronary Artery Revascularization Sep 24, 2007
Whether a patient receives percutaneous transluminal coronary angioplasty (PTCA) or coronary artery bypass grafting (CABG) depends on many factors ... With involvement of two or more vessels, CABG is preferred because it already takes enough time to thread just one balloon catheter for PTCA. ... Tortuosity of Vessels: If the artery is straight enough, the cardiologist should be able to maneuver a balloon cathether into it and perform PTCA. Otherwise, CABG is the better option. (Suite101.com)
Prevention and Treatment of Major Blood Loss Sep 21, 2007
We would add that in patients with an acute coronary syndrome who require urgent coronary-artery bypass grafting (CABG), antiplatelet therapy with aspirin, clopidogrel, and a glycoprotein IIb/IIIa antagonist (e. g., tirofiban) should be discontinued before surgery. (New England Journal of Medicine)
FDA Advisory Committees Recommend Continued U.S. Marketing Authorization for Trasylol(R) Sep 13, 2007
Sept. 12 /PRNewswire/ -- Today, the Cardiovascular and Renal Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee to the U.S. Food and Drug Administration (FDA) held a meeting to discuss the risk /benefit profile of Trasylol(R) (aprotinin injection), a Bayer drug used in coronary artery bypass graft (CABG) surgery ... The benefit of Trasylol(R) to patients undergoing primary CABG surgery should be weighed against the risk of anaphylaxis associated with any... (PR Newswire)
'Broader' Look At Cardiac CTA Images Often Finds Disorders Beyond The Heart Aug 20, 2007
Performing cardiac CTA after coronary artery bypass surgery (CABG) can reveal unsuspected and potentially significant findings beyond the heart, according to a recent study conducted by researchers at the University of Maryland School of Medicine, located in Baltimore, MD.. Our interest in this topic developed because we were performing many cardiac CTA examinations, including those for bypass grafting, and we wondered how often we would find unrelated but clinically significant findings in the... (Science Daily)
Arm Squeezing Before CABG May Help Protect Heart Aug 19, 2007
Explain to interested patients that this proof-of-concept study found that restricting blood flow to the arm before CABG surgery may stave off injury to the heart ... In the study of 57 CABG patients, the 27 who received ischemic preconditioning showed significant reductions in levels of troponin T, starting six hours after CABG compared with the 30 controls, reported Derek J. Hausenloy, Ph ... The ischemic preconditioning was applied following anesthesia and before CABG.. (MedPage Today)
Pay for Performance, Version 2.0? Aug 9, 2007
"Old wine in a new bottle." "A financial gamble." "An early glimpse of the next generation of pay for performance." All these appraisals have been applied to Geisinger Health System's new approach to elective coronary-artery bypass grafting (CABG), which has been described with words rarely invoked in health care, such as "promise" and "guarantee." Geisinger, an integrated health care delivery system in northeastern Pennsylvania, promises that 40 key processes will be completed for every patient... (New England Journal of Medicine)
Researchers To Develop Method For Treating Heart Failure And Depression Simultaneously Jul 31, 2007
Since 2004, he and his co-principal study investigator, Charles F. Reynolds III, M.D., UPMC Professor of Geriatric Psychiatry, University of Pittsburgh School of Medicine, and their research team have been recruiting patients from several Pittsburgh-area hospitals, including UPMC Presbyterian and UPMC Passavant, into the first NIH-funded clinical trial titled, "Bypassing the Blues," designed to examine the impact of treating depressive symptoms following coronary artery bypass graft (CABG)... (Science Daily)
* Taiwan Quick Take Jul 17, 2007
At the invitation of the Japanese Association of Cardiovascular Surgery, Far Eastern Memorial Hospital took part in the 9th annual symposium of the Japanese off-pump coronary artery bypass graft (CABG) association in Tokyo via satellite hookup. More than 300 heart doctors took part in the symposium, during which they watched surgeries conducted live in Taiwan and Japan. (Taipei Times, Taiwan -- World)
Blood Pressure Drop During Bypass Might Impair Thinking Jun 16, 2007
Researchers at the Johns Hopkins University School of Medicine in Baltimore studied 15 patients, aged 57 to 81, who were given cognitive tests before and then three to five days after they had coronary artery bypass graft (CABG) surgery. All the patients had a decrease in mean arterial pressure (MAP) during surgery compared with their MAP before surgery. (MEDLINEplus)
Race-based Differences in Revascularization after MI Jun 14, 2007
3% of blacks had either PCI or CABG, but 50 ... 3% of black patients eventually had PCI or CABG compared with 25. (MedPage Today)
Blacks Less Likely to Get Angioplasty After Heart Attack Jun 13, 2007
The most common type of revascularization is coronary artery bypass graft (CABG) ... Less than one-fifth of U.S. acute-care hospitals provide coronary revascularization, and many Medicare beneficiaries are initially admitted to hospitals that don't provide CABG or percutaneous coronary intervention (PCI, formerly known as angioplasty). (Forbes)
Health Canada's approval of an expanded indication for PLAVIX(R) (clopidogrel bisulfate) now offers protection from all types of heart attacks Jun 5, 2007
In secondary prevention with early and long-term use, PLAVIX has been shown to decrease the rate of atherothrombotic events (cardiovascular death, MI, ischemic stroke, refractory ischemia) when taken in combination with ASA in patients with ACS without ST segment elevation (unstable angina or non-Q-wave myocardial infarction) including patients who are to be managed medically and those who are to be managed with percutaneous coronary intervention (with or without stent) or coronary artery bypass... (Canada Newswire)
Cardiome And Astellas Announce Positive Results From ACT 2 Trial Jun 4, 2007
The trial evaluated the efficacy and safety of the intravenous formulation of vernakalant hydrochloride ("vernakalant (iv)") for the treatment of patients who developed atrial fibrillation or atrial flutter between 24 hours and 7 days following coronary artery bypass graft (CABG) or valve replacement surgery ... The study was focused on the treatment of patients with atrial fibrillation or atrial flutter occurring after CABG or valve replacement surgery. (Canada Newswire)
Rheumatoid Illness, Smoking Can Harm Heart's Aorta May 31, 2007
"Our method of tissue examination allows the condition to be diagnosed in patients undergoing CABG surgery without increasing the preoperative risk.". The findings indicate the need for further research into an inflammatory process that may increase the risk of dying from a heart attack or aneurysm, the researchers said. (MEDLINEplus)
New insights into chronic inflammation and atherosclerosis May 25, 2007
To shed light on the link between chronic inflammation and atherosclerosis, a team of researchers in Norway and the United States, affiliated with the Cleveland Clinic Foundation and Brigham and Women's Hospital in Boston, focused on the aortas of recent recipients of coronary artery bypass graft (CABG) surgery, comparing biopsy specimens from patients with inflammatory rheumatic disease to those from patients without it ... Aortic samples were obtained during CABG surgery, performed at two... (EurekAlert!)
Experts debate role of stenting, bypass surgery in left main coronary artery disease May 12, 2007
At the 30th Annual Scientific Sessions of the Society for Cardiovascular Angiography and Interventions (SCAI), May 912, 2007, in Orlando, FL, two renowned experts will debate the role of PCI and coronary artery bypass grafting (CABG) for the treatment of patients with left main coronary artery disease ... "It is time to start making comparisons of CABG and DES for disease involving the left main coronary artery.". (EurekAlert!)
'Tables link' to heart death cut Apr 24, 2007
The death rate for coronary artery bypass graft (CABG) patients after public disclosure was significantly lower than it had been before, falling from 2. 4% to 1. (BBC News -- UK)
Dyax Jumps on Positive Drug News Apr 14, 2007
Dyax is also developing an alternative treatment for people undergoing coronary artery bypass graft (CABG) surgery, which is typically used for people who have blocked arteries ... If the company can commercialize DX-88 by 2008 and CABG by 2009, S&P expects Dyax to hit operating profitability by 2010. (BusinessWeek)
Atrial Fibrillation Risk Reduced After Cardiac Surgery Through Use of Hydrocortisone Apr 12, 2007
The incidence of AF has been reported to range between 20 percent and 40 percent after coronary artery bypass graft (CABG) surgery and is even higher after heart valve surgery and combined valve and bypass surgery, according to background information in the article ... The study, conducted at three university hospitals in Finland, included 241 patients without prior AF who were scheduled to undergo CABG surgery, aortic valve replacement, or combined CABG surgery and aortic valve replacement. (Science Daily)
More Women Surviving Heart Surgery Apr 12, 2007
NEW YORK (Reuters Health) - There has been a marked decline in early death after coronary artery bypass surgery (CABG), particularly in women, study results indicate. Nevertheless, women remain at higher risk of early death after CABG than men, owing in part to the smaller size of their coronary arteries ... Researchers evaluated gender differences and trends in 30-day mortality after CABG in all adults who had the procedure between 1991 and 2004 in the province of British Columbia, Canada. (MEDLINEplus)
Novel Platelet Therapy May Reduce PCI Complications Apr 5, 2007
Of the total patient population, 573 underwent PCI (primary cohort) while 75 underwent CABG and 382 received medical management. Patients undergoing PCI (primary cohort) were further randomized to a 0. (Science Daily)
Critics blast PM's health targets as 'soft' Apr 5, 2007
Coronary artery bypass graft (CABG) surgery. Common waiting-times benchmarks, meaning the typical time recommended by medical specialists. (Globe and Mail -- National)
Trust 'must improve heart surgery' Mar 28, 2007
The Healthcare Commission started investigating in November 2005 after it emerged that the number of trust patients who died between April 2002 and March 2005 after their first coronary artery bypass graft (CABG) was more than double the national average - 4 ... The report said: "The cardiothoracic unit had rates of mortality for CABG that were higher than other comparable units and that should have prompted an open and questioning response to make certain that everything was being done to... (Channel 4 News)
Bone Mineral Loss Seen in Men After Heart Surgery Mar 22, 2007
NEW YORK (Reuters Health) - In the year following coronary artery bypass grafting (CABG), bone mineral content declines significantly in men, according to findings published in the American Journal of Cardiology ... Dr. Larry E. Miller, of Virginia Polytechnic Institute and State University, and colleagues evaluated changes in bone mineral and body composition in 26 men, between the ages of 50 and 79 years, who underwent CABG. In each patient, blockages were removed in more than one coronary... (MEDLINEplus)
Regis Philbin To Undergo Heart Bypass Mar 14, 2007
Heart bypass surgery is also called coronary artery bypass graft surgery, or CABG (pronounced "cabbage"). When Philbin announced his upcoming bypass surgery on TV, he said he had hoped to get angioplasty instead of bypass surgery, but he said doctors recommended bypass surgery. (CBS News)
Heart of Darkness Mar 14, 2007
Also of interest to the vice president's people may be the ticklish question of whether heart surgery itself, most notably coronary artery bypass grafting (typically referred to as cabg, or "cabbage," surgery), has a long-term impact on cognitive function ... Such personality changes are extremely common in the short term and may persist indefinitely for some, as the Cleveland Clinic notes in its literature on the subject: "Long-term deficits in mental functioning--such as an inability to... (Ocnus.net)
Symptoms Of Depression Linked To Early Stages Of Artery Disease Feb 21, 2007
(January 25, 2005) -- People with symptoms of clinical depression who undergo coronary artery bypass surgery (CABG) have long been known to be at a higher risk of death, hospital readmissions and cardiac events. But does. (Science Daily)
West Virginia Ranks Last in Heart Disease Feb 19, 2007
He has experienced numerous MI's, chronic CHF, angioplasty (1994), CABG (1998), occluded graft (2001), pacemaker insertion (2004), and cardiac ablation (2005) ... We were told there simply was not enough "healthy" heart tissue left undamaged by the MI's to perform another CABG. His cardiologists suggested he be placed on the heart transplant list in order to give researchers time for new meds, technology, and other treatments to be developed in the future that would assist my husband in living a... (MedPage Today)
Drug Used In Coronary Artery Bypass Graft Surgery May Increase Risk Of Death Feb 9, 2007
and colleagues assessed survival rates at six weeks, six months and annually for five years for 3,876 patients undergoing coronary artery bypass graft (CABG) surgery at 62 medical centers around the world ... "These findings indicate that in addition to the previously reported acute renal and vascular safety concerns, aprotinin use is associated with an increased risk of long-term mortality following CABG surgery. Use of aprotinin among patients undergoing CABG surgery does not appear prudent... (Science Daily)
Blacks Likely to Get Less Experienced Surgeons Jan 24, 2007
Until recently, coronary artery bypass grafting (CABG) was usually performed with a heart-lung machine, which allows the heart to be stopped while the bypass grafts are sewn in place ... Performing CABG "off-pump," while the heart is beating normally, is technically demanding and many surgeons are still gaining experience with the technique ... The new findings are based on a study of 15,313 CABG patients who were entered in the New York State Cardiac Surgery Reporting System, which covers all... (MEDLINEplus)
Heart surgeon faces criminal charges Jan 9, 2007
Q: ``When you say you are doing about 10 CABG procedures a year, are you the attending physician, the guy in the chest doing the sewing and cutting. . (The Miami Herald)
Lawsuits may get settled Jan 5, 2007
An unnecessary CABG should be considered assault with a deadly weapon. I was told I needed a quintuple bypass or I could die in three months. (Fredericksburg Free Lance-Star, VA)
Transfusions Blamed for Deaths After Bypass Jan 4, 2007
Moreover, this may explain in part why women are more likely than men to die after coronary artery bypass grafting (CABG), since women more commonly need transfusions than men do ... "To the best of our knowledge, this is the first study to state that ... transfusions may be the reason why women have a greater post-CABG mortality than men," Dr. Mary A. M. Rogers, from the University of Michigan in Ann Arbor, said in a statement ... In a study of Michigan Medicare beneficiaries, 88 percent of... (MEDLINEplus)
