Cell Metabolism Publishes Novel TGR5-Mediated Mechanism for the Treatment of Diabetes and Obesity Sep 2, 2009
INT-747 is completing two additional Phase II trials in patients with primary biliary cirrhosis, an autoimmune cholestatic liver disease and orphan indication. Results from the first of the two studies are expected in the fourth quarter of 2009. (PR Newswire)
Genetic Links to Rare Liver Disease Found Jun 16, 2009
Understanding primary biliary cirrhosis may lead to new treatments, researchers say ... WEDNESDAY, June 10 (HealthDay News) -- Scientists have found genetic variations that appear to increase the risk of developing primary biliary cirrhosis, a baffling disease that can destroy the liver ... Primary biliary cirrhosis is an autoimmune disorder that blocks the bile ducts in the liver. (MEDLINEplus)
Primary Biliary Cirrhosis Associated with HLA, IL12A, and IL12RB2 Variants Jun 16, 2009
Background Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with antimitochondrial antibodies. Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown ... Methods To identify genetic loci conferring a risk for primary biliary cirrhosis, we carried out a genomewide association analysis in which DNA samples from 2072 Canadian and U.S. subjects... (New England Journal of Medicine)
Mayo Researchers Help Discover Genetic Cause for Primary Biliary Cirrhosis May 28, 2009
Primary biliary cirrhosis has no known cause ... "Now that we better understand the molecular basis of primary biliary cirrhosis, we can look for ways to specifically fix those elements," says , a Mayo Clinic hepatologist and a senior researcher in the study ... Currently, treatments for primary biliary cirrhosis can slow progression of the disease, which affects 1 in 2,500 Americans, 90 percent of them women. (PR Newswire)
Genetic Cause For Primary Biliary Cirrhosis Identified May 28, 2009
ScienceDaily (May 28, 2009) Researchers have discovered a novel molecular path that predisposes patients to develop primary biliary cirrhosis, a disease that mainly affects women and slowly destroys their livers. Primary biliary cirrhosis has no known cause ... "Now that we better understand the molecular basis of primary biliary cirrhosis, we can look for ways to specifically fix those elements," says Konstantinos Lazaridis, M.D., a Mayo Clinic hepatologist and a senior researcher in the study.... (Science Daily)
What causes my biliary cirrhosis? Mar 10, 2009
com: What causes my biliary cirrhosis ... What causes my biliary cirrhosis ... Now I have been told I have biliary cirrhosis. (Erie Times-News, PA)
• Did statins cause liver disease? Mar 10, 2009
Now I have been told I have biliary cirrhosis ... However, I can find nothing indicating that statins lead to biliary cirrhosis ... This is not to say it is not caused by the medication, but there is a chance your biliary cirrhosis is completely unrelated. (Burley South Idaho Press, ID)
Celiac disease: Years of pain end with correct Feb 17, 2009
"I recently diagnosed a 55-year-old lady who came to me with bad breath and progressive tooth decay with celiac disease."Patients with celiac disease also appear to have increased risks for a broad spectrum of liver diseases, including acute hepatitis, primary biliary cirrhosis and chronic hepatitis including autoimmune hepatitis. Several reports have suggested increased risk for some malignancies, particularly non-Hodgkin's lymphoma and gastrointestinal cancers in adults with celiac disease,... (Orangeburg Times and Democrat, SC)
