Well-known Drug (AAT) Could Overcome Obstacles To Islet Transplantation, Study Suggests Oct 31, 2008
Human AAT has been used for more than 20 years in the form of weekly intravenous injections to treat a rare but serious genetic abnormality known as alpha-1 antitrypsin deficiency, the most common cause of hereditary lung emphysema. In these long-lasting treatments, AAT exhibited an impressive safety record. (Science Daily)
Protein Made In Liver Restores Blood Glucose In Type 1 Diabetes Model Oct 16, 2008
The AAT protein is already in widespread use as a replacement therapy in treating Alpha-1 antitrypsin deficiency, an inherited disorder that can cause emphysema-like lung disease in adults and liver disease in children. "In humans, AAT has been used for more than two decades, and has maintained an impressive safety record," says Koulmanda. (Science Daily)
Liver donor's family, recipient unite online Jul 8, 2008
She had been born with a genetic disorder called alpha-1 antitrypsin deficiency, which resulted in her body not producing enough of a key enzyme in the liver. Click for related content. (MSNBC -- Health)
Hepatocellular Carcinoma Jun 1, 2008
An Overview of a Malignant Cancer of the Liver. The diagnosis, treatment, and prognosis of this liver cancer can be burdensome for patients. (Suite101.com)
Mayo Clinic researchers find common gene disorder doubles risk of lung cancer, even among nonsmokers May 27, 2008
Researchers found that the genetic disorder, alpha-1 antitrypsin deficiency (1ATD), could explain up to about 12 percent of lung cancer patients in this study and likely represents the same widespread risk in the general population. "This is a seriously underdiagnosed disorder and suggests that people who have lung cancer and chronic obstructive pulmonary diseases (COPD) in their families should be screened for these gene carriers," says Ping Yang, M.D., Ph. (EurekAlert!)
Melissa Biggs, Fashion Designer and Former Baywatch Actress, Teams with CSL Behring to Raise Awareness of Alpha-1 Antitrypsin Deficiency, a Commonly Misdiagnosed Respiratory Disease May 18, 2008
Biggs Named Spokesperson for Education Campaign on Behalf of CSL Behring, maker of Zemaira(R), Alpha-1 Proteinase Inhibitor (Human) Augmentation Therapy KING OF PRUSSIA, Pa. May 17 /PRNewswire/ -- Melissa Biggs, a fashion designer and actress who appeared on Baywatch was recently named spokesperson for an education campaign on behalf of CSL Behring, and is urging Americans to get tested for alpha-1 antitrypsin (AAT) deficiency after her own diagnosis with the condition in 2005. (PR Newswire)
Kamada and PARI Expand Collaboration Feb 25, 2008
One of these agreements is for the conjoint clinical development of aerosolized AAT for treating the indications of Cystic Fibrosis (CF) and Bronchiectasis, in addition to Alpha-1 Antitrypsin Deficiency (AATD). Under the agreement PARI grants Kamada an exclusive license to use an optimized eFlow Electronic Nebulizer to deliver AAT in its clinical trials also for these indications. (BusinessWire)
Fear of insurance trouble leads many to shun or hide DNA tests Feb 25, 2008
She worried that she might not be able to get health insurance, or even a job, if a genetic predisposition showed up in her medical records, especially since treatment for the condition, alpha-1 antitrypsin deficiency, could cost over $100,000 a year. Instead, Grove sought out a service that sent a test kit to her home and returned the results directly to her. (International Herald Tribune)
Auction to benefit transplant prospect Sep 25, 2007
Crouch suffers from Alpha-1 antitrypsin deficiency, which has caused her lungs to operate on a 13-17 percent capacity. The Alpha-1 deficiency is an inherited disorder which causes a lack of the protein that protects people s lungs from damage caused by common sicknesses and air pollution such as tobacco smoke. (Hartford City News-Times, IN)
Mom who donated daughter's liver meets grateful recipient Sep 23, 2007
Mary Jo - "my friends call me Jo" - was diagnosed with Alpha-1 antitrypsin deficiency before she was 3. Her mother, Joyce Morris, remembers her daughter was given six months to live. (AZCentral -- News)
More of this story Jul 21, 2007
His youngest son Kevin has a condition called Alpha-1 Antitrypsin Deficiency, which may result in serious lung disease in adults. Kevin is healthy, but Kelley saw the Ironman as a way to educate people about the relatively unknown condition. (Brockton Enterprise, MA)
Phoenix to increase fines for illegal handicap parking Apr 13, 2007
My husband has emphysema as a result of an inherited lung disorder (Alpha 1 antitrypsin deficiency). He has difficulty walking short distances but continues to do as much of the grocery shopping & other errands as possible. (AZCentral -- News)
Klebsiella pneumoniae and Alpha 1 antitrypsin deficiency Jan 4, 2007
Dear Dr. Donohue: My 19-year-old grandson has been tentatively diagnosed with alpha 1 antitrypsin deficiency. I understand it is a disease of the liver and lungs. (Herald-Tribune)
