Pipex Pharmaceuticals, Inc. Completes Corporate Name Change to Adeona Pharmaceuticals and Receives New Ticker Symbol Oct 16, 2008
Adeona is focused on developing products to treat, rheumatoid arthritis, multiple sclerosis, dry age-related macular degeneration (AMD), and fibromyalgia. This press release contains forward-looking statements, within the meaning of Section 21E of the Securities Exchange Act of 1934, that reflect Adeona Pharmaceuticals, Inc.'s current expectations about its future results, performance, prospects and opportunities, including statements regarding our late stage pipeline of products and its focus... (Primezone Releases)
Too Much Sun, Too Few Antioxidants Spell Eye Trouble Oct 16, 2008
The combination contributes to age-related macular degeneration, study finds ... That's the message from a new study that found that older people with low levels of certain antioxidants present in many fruits and vegetables, and who are exposed to short-wavelength blue light from the sun, are more likely to develop certain types of age-related macular degeneration (AMD). (MEDLINEplus)
Sunlight, lack of antioxidants tied to eye disease Oct 15, 2008
NEW YORK (Reuters Health) - A combination of sunlight exposure and low blood levels of antioxidants may make older adults more vulnerable to a common vision-robbing disease called age-related macular degeneration, or AMD, researchers have found. In a study of older adults from seven European countries, investigators found that among those with relatively low antioxidant levels, sun exposure was linked to an increased risk of advanced AMD. There was no such link seen in people with high... (Reuters India)
UMKC doctor brings future of eye treatment into focus Oct 14, 2008
Needle injections, which were once the only option in treating advanced back-of-the-eye problems like age-related macular degeneration, may also become obsolete in the future because of his work. The injections are often painful and can cause hemorrhaging and retinal damage, but Mitra's new application method is non-invasive and harmless. (University News, MO)
Age-related Macular Degeneration: New Genetic Association Identified Oct 14, 2008
13, 2008) A team of clinicians and scientists at the University of Southampton has identified a major new genetic association with age-related macular degeneration, the most common cause of blindness in developed countries ... Their research adds to the growing understanding of the genetics of age-related macular degeneration and they believe it will better help predict those at risk and ultimately lead to better treatments. (Science Daily)
Sunlight exposure plus low antioxidant levels may place older adults at risk for eye disease Oct 14, 2008
A European study suggests that the combination of low plasma levels of antioxidants and blue light exposure from the sun is associated with certain forms of the eye disease age-related macular degeneration (AMD), according to a report in the October issue of Archives of Ophthalmology, one of the JAMA/Archives journals. "The retina is vulnerable to the damaging effects of light," the authors write as background information in the article. (EurekAlert!)
Taking vitamins and avoiding the sun 'could help prevent blindness' Oct 14, 2008
This can lead to age-related macular degeneration (AMD), which affects 250,000 people in Britain, the research found. The disease, in which the central part of the retina of the eye gradually thins, leaves one in 10 sufferers blind. (Telegraph.co.uk)
Genetic Finding Implicates Innate Immune System In Major Cause Of Blindness Oct 11, 2008
10, 2008) The research, published recently in the Lancet, adds to the growing understanding of the genetics of age-related macular degeneration (AMD), which the researchers believe should ultimately lead to novel treatments for the disease ... Ennis et al. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case & control study ... 4, 2008) Scientists have identified a new genetic risk factor for age-related macular degeneration (AMD), a major cause of... (Science Daily)
Case Western Reserve University research finds drug candidate slows age-related macular degeneration Oct 10, 2008
CLEVELAND Research results from the Case Western Reserve University School of Medicine show that the progression of age-related macular degeneration (AMD) is markedly slowed in new laboratory-engineered mice when they received treatments of retinylamine, a trial drug that has been tested in a medical school lab. AMD is a leading cause of vision loss in Americans 60 years of age and older. (EurekAlert!)
Receptor Could Halt Blinding Diseases, Stop Tumor Growth, Preserve Neurons After Trauma Oct 8, 2008
While investigating the molecular mechanisms that lead to vision loss, the research team uncovered that the GPR91 receptor can mediate irregular vascular growth that is responsible for some of the main causes of blindness in the industrial world: retinopathy of prematurity in infants, diabetic retinopathy in adults (vision loss or blindness that affects up to 90 percent of diabetics) or age-related macular degeneration in seniors (central vision loss). "We found that GPR91 is a master regulator... (Science Daily)
Genes Give Clues to Age-Linked Eye Trouble Oct 8, 2008
MONDAY, Oct. 6 (HealthDay News) -- Variants in the gene that helps produce vital proteins in the eye have been linked to age-related macular degeneration (AMD), a major source of blindness, a new report says ... "Our findings add to the growing understanding of the genetics of age-related macular degeneration, which should ultimately lead to novel treatments for this common and devastating disease.". (MEDLINEplus)
Seniors threatened by blindness Oct 7, 2008
Major threats are age-related macular degeneration, cataract, refractive error and glaucoma. Eye care organizations operating in Canada (see list below) are also focused on this issue, knowing that most vision problems can be prevented or treated. (Canada Newswire)
Gene discovery may help hunt for blindness cure Oct 7, 2008
British scientists said on Tuesday they had found six variants within the gene called Serping1 that were associated with age-related macular degeneration (AMD). "Our findings add to the growing understanding of the genetics of age-related macular degeneration, which should ultimately lead to novel treatments for this common and devastating disease," Sarah Ennis and Andrew Lotery of the University of Southampton reported in the Lancet journal ... A simulation of age-related macular degeneration... (Yahoo News -- Top Stories)
Pipex Pharmaceuticals' Oral Flupirtine Receives IRB Approval to Initiate Phase II Clinical Trial for Fibromyalgia Oct 7, 2008
Pipex is focused on developing products to treat rheumatoid arthritis, dry age-related macular degeneration (AMD), multiple sclerosis, and fibromyalgia. For further information, please visit. (Primezone Releases)
Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration Oct 3, 2008
Background Age-related macular degeneration is the most common cause of irreversible visual impairment in the developed world. Advanced age-related macular degeneration consists of geographic atrophy and choroidal neovascularization ... Methods We tested for an association between the functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving the substitution of phenylalanine for leucine at amino acid 412) and age-related macular degeneration in Americans of European descent. (New England Journal of Medicine)
Gene Therapy Promises Cure For Leber's Congenital Amaurosis Sep 25, 2008
Robin Ali and his team at University College of London Institute of Ophthalmology and Moorfields Eye Hospital, who performed the worlds first gene transplant for blindness, firmly believe that in two years gene therapy will be ready for treating inherited diseases of the retina, including age related macular degeneration (AMD), a common condition affecting many. or to post comments. (TopNews)
'Dramatic results' in eye gene op Sep 23, 2008
Within three years, they believe it could be ready for testing on people who suffer age related macular degeneration, a condition that affects 500,000 Britons. The paper adds to the body of evidence supporting the value of gene therapy for people with inherited disease. (BBC News)
Simple eye test you can do at home could save your vision - Canadians urged to set their sights on the Amsler Grid Sep 22, 2008
The Amsler Grid is a simple test for an eye disease called wet age-related macular degeneration (AMD), the leading cause of significant vision loss in Canadians over 50. The devastating disease develops quickly, often in a matter of days or weeks, robbing people of their central vision. (Canada Newswire)
Receptor Activation Protects Retina From Diabetes Destruction Sep 22, 2008
(July 11, 2008) Preliminary research shows encouraging results with transplantation of retinal cells in patients with blindness caused by retinitis pigmentosa and age-related macular degeneration, according to a new. . (Science Daily)
XOMA to Webcast Analyst and Investor Event 'Interleukin-1 Blockers: Unlocking Their Potential in Diabetes and Beyond' On September 25 Sep 22, 2008
XOMA's technologies and experienced team have contributed to the success of marketed antibody products, including RAPTIVA(r) (efalizumab) for chronic moderate to severe plaque psoriasis, LUCENTIS(r) (ranibizumab injection) for wet age-related macular degeneration and CIMZIA(r) (certolizumab pegol) for Crohn's disease. The Company has a premier antibody discovery and development platform that incorporates leading antibody phage display libraries and XOMA's proprietary Human Engineering(tm) and... (Primezone Releases)
My DNA Test: Too Much Information? Sep 10, 2008
I clicked on the very next category, "Age Related Macular Degeneration" and saw that my risk level was 20%, more than TWICE the normal rate. It couldn't have been a more chilling result for me. (WNBC.com, NY)
AMD and Vision Loss: Low-Luminance Study Yields a New Predictive Tool Sep 8, 2008
30, 2007) A computer-based method for evaluating the eye's ability to distinguish object details and shape in patients with age-related macular degeneration could provide a more accurate way to assess the ... 21, 2008) Scientists have won a major battle in the fight against age-related macular degeneration, or AMD, a blinding eye disease that affects millions of people ... (July 30, 2006) Vanderbilt University Medical Center recently began offering a new treatment for wet age-related macular... (Science Daily)
Antioxidant-Rich Diet May Protect against Eye Disease Sep 3, 2008
Compounds likely extend life of retinal cells that fight age-related macular degeneration ... "This new knowledge," added Bernstein, who wasn't involved in the study, "suggests the possibility of interventions which could prove to be powerful ways to prevent or delay age-related macular degeneration.". (MEDLINEplus)
September Ophthalmology research highlights Sep 2, 2008
Also highlighted this month are two research studies that will help doctors identify patients who are most vulnerable to advanced age-related macular degeneration (AMD), the leading cause of severe vision loss in the United States and most Western countries ... The Complications of Age-Related Macular Degeneration Prevention Trial (CAPT) was a multicenter randomized clinical trial (conducted from 1999 to 2005) that investigated whether low-intensity laser treatment could prevent vision loss in... (EurekAlert!)
Gene Thwarts Dry Macular Degeneration Aug 29, 2008
Study Shows Gene Variant May Protect Against Dry Form of Age-Related Macular Degeneration By WebMD Health News Reviewed by ... Age-related macular degeneration (AMD), the leading cause of loss in the U.S., typically strikes after age 55 ... Certain vitamin supplements may slow age-related macular degeneration down and save your sight. (WebMD)
First Gene Associated With Dry Macular Degeneration Found Aug 29, 2008
28, 2008) In a study that underscores the important role that individual genetic profiles will play in the development of new therapies for disease, a multi-institutional research team led by Kang Zhang, MD, PhD professor of ophthalmology and human genetics at Shiley Eye Center at the University of California, San Diego, School of Medicine has made two important discoveries related to age-related macular degeneration (AMD), the leading cause of blindness in adults over the age of 60 ... 2, 2008)... (Science Daily)
Gene linked to eye disease Aug 29, 2008
LA JOLLA An international team led by a UCSD eye researcher has found the first genetic link to dry age-related macular degeneration, the most common form of progressive blindness ... In a separate finding, Zhang's study sounds a warning for makers of some drugs being used in clinical trials for treatment of other diseases, including wet age-related macular degeneration, the same type of blindness caused by a different process ... Ironically in some individuals, using RNAi to cure wet... (San Diego Union-Tribune)
Study of 2 drugs places spotlight on Genentech Aug 28, 2008
The company declined to seek federal approval for the cheaper drug, Avastin, to treat the wet form of age-related macular degeneration. Nor would it help finance a National Eye Institute study comparing the effectiveness and safety of Avastin, a cancer drug, and the more expensive eye drug, Lucentis. (Boston Globe)
An NHS dilemma Aug 28, 2008
But that is just what a two-year course of the drug does for people suffering from wet age-related macular degeneration, the leading cause of blindness in the UK.. However, the treatment comes at a price - 10,000 for each eye to be precise. (BBC News -- UK)
How Diet, Antioxidants Prevent Blindness In Aging Population Aug 28, 2008
Age-related macular degeneration affects more than 1 ... This new knowledge suggests the possibility of interventions which could prove to be powerful ways to prevent or delay age-related macular degeneration. (Science Daily)
Postcode lottery ends for eye drug Aug 28, 2008
The National Institute for Health and Clinical Excellence recommended that the drug Lucentis should be made available for people with wet age-related macular degeneration (AMD) across the UK.. The technology appraisal guidance , published by Nice means Local Health Boards in Wales will have to fund Lucentis for patients who have wet AMD in either eye. (Daily Post)
Patients to get sight-saving drug Aug 27, 2008
Lucentis treats age-related macular degeneration, the leading cause of sight loss in the country ... Age-related macular degeneration (AMD) comes in two forms - wet and dry - with the dry form being much more common. (BBC News)
Pensioners win sight drug battle Aug 27, 2008
The RNIB said there was now no excuse for the NHS in England to restrict access to the drug, which treats age-related macular degeneration. For other PCTs currently denying sight-saving treatment to patients in their care, our message is clear - change your policy now. (BBC News -- UK)
Woman 'denied sight drugs' Aug 27, 2008
Margaret Coates, 79, from Bromley, south-east London, has wet age-related macular degeneration (AMD), which can lead to blindness in both eyes. Her local Primary Care Trust (PCT) will not pay for a drug called Lucentis, Mrs Coates said. (BBC News -- UK)
Lifeline: Joan Armstrong, 82, has been refused funding for the ... Aug 27, 2008
Wet age-related macular degeneration is the leading cause of blindness. But previously, the National Institute for Health and Clinical Excellence suggested that the drug Lucentis should only be given to those already blind in one eye. (Daily Mail)
Block that blue light Aug 20, 2008
Luteins role in protecting the eyes from age-related macular degeneration begins at birth ... This is known as age-related macular degeneration (AMD) and affects those aged 60 and above. (The Star Online, Malaysia)
Senior notes Aug 15, 2008
Adaptive Technology/Perkins Products hosts a free hands-on seminar, Living Well with Age-related Macular Degeneration, at Perkins School for the Blind, 175 North Beacon St., Watertown, on Saturday, Sept. 20, 8:30 a.m.-12:30 p.m.. Dr. Mary Lou Jackson, director of Massachusetts Eye & Ear Infirmary, will speak along with staff from Perkins Strategies for Life/Outreach 55+ and The Braille & Talking Books Library. (Watertown TAB & Press, MA)
Some Obese Individuals Appear 'Metabolically Healthy,' Without Increased Cardiovascular Risk Aug 13, 2008
9, 2007) The interplay between genetic predisposition and exposure to modifiable risk factors can multiply the risk for age-related macular degeneration, according to a report in the January issue of Archives. (Oct. (Science Daily)
Levels Of C-reactive Protein In The Blood Do Not Cause Diabetes Aug 13, 2008
10, 2007) High blood levels of C-reactive protein, a substance linked to inflammation, appear to be associated with an increased risk for age-related macular degeneration, according to a new. (Aug. (Science Daily)
Eye health is important! Aug 12, 2008
As adults age the eyes are more susceptible to Age-Related Macular Degeneration (AMD); a progressive eye disease which attacks the macula of the eye where sharpest vision occurs. A healthy lifestyle, no smoking, a healthy diet and protecting the eyes from harmful UV rays are recommended preventative methods to minimise the risk of AMD.. (iAfrica.com)
Consuming Oily Fish May Protect Eyesight in the Elderly Aug 11, 2008
According to the National Eye Institute, age-related macular degeneration is of two types, wet AMD and dry AMD. The dry form is more common and can progress to wet AMD later on ... Age-Related Macular Degeneration or AMD is the leading cause of blindness in people aged over 55 in the United States ... Age-related macular degeneration usually affects elderly people. (News Locale)
Eat oily fish weekly to protect eyesight Aug 9, 2008
WASHINGTON: Eating oily fish once a week may reduce age-related macular degeneration which is the major cause of blindness and poor vision in adults in western countries and the third highest cause of global blindness, according to a study. There are two types of age-related macular dengeneration (AMD), wet and dry. (Economic Times)
MHS alum sets his sites on sight: Drug helps people losing their eyesight (2) Aug 4, 2008
Dr. Robert L. Steinmetz, a 1974 Muscatine High School graduate, was one of the national researchers who tested the effectiveness of a promising new drug for the treatment of age-related macular degeneration (AMD) earlier this year. The eye surgeon has done extensive international research and teaching, and now lives in Tallahassee, Fla. (Muscatine Journal, IO)
Modified Salmonella Slows Tumor Growth Jul 31, 2008
3, 1999) Investigators at Washington University School of Medicine in St. Louis have found that a mechanism key to immune-privilege in the eye also plays a role in age-related macular degeneration, the. . (Science Daily)
DeKalb team tops in Chicago Vision Walk Jul 30, 2008
The goal of the event is to raise funds and awareness for the foundation, the leading non-government organization in the world providing money for research to find preventions, treatments and cures for all forms of retinal degenerative diseases, including age-related macular degeneration the leading cause of blindness in people over age 55. The event raised just under 240,000. (DeKalb Daily Chronicle, IL)
QLT announces second quarter results for 2008 Jul 29, 2008
The drop in Visudyne sales was primarily due to the approval and reimbursement in Europe of alternative therapeutics for age-related macular degeneration. However, Visudyne's sales for the second quarter increased 11. (Canada Newswire)
Japanese Diet Rich In Fish May Hold Secret To Healthy Heart: Omega-3 Fatty Acids From Fish Appear To Prevent Clogged Arteries Jul 29, 2008
ScienceDaily (July 29, 2008) If you're fishing for ways to reduce the risk of heart disease, you might start with the seafood-rich diet typically served up in Japan. According to new research, a lifetime of eating tuna, sardines, salmon and other fish appears to protect Japanese men against clogged arteries, despite other cardiovascular risk factors. (Science Daily)
What is an Amsler Grid? Jul 28, 2008
Macular Degeneration is a normal part of the aging process, but can be caused by things other than aging and in young people, as well as those who have added more birthdays The doctor may refer to ARMD, or AMD, which stands for Age Related Macular Degeneration. If your doctor determines that you have macular degeneration, he will probably send you home with your own Amsler Grid and have you monitor your vision. (Suite101.com)
What is Cystoid Macular Edema? Jul 27, 2008
Age-related Macular Degeneration (): ARMD occurs in two forms: exudative (wet) or atrophic (dry). The exudative form, if untreated, can cause detachment of the retina overlying the macula and resultant CME.. (Suite101.com)
Scientists offer new hope for blind Jul 27, 2008
It identifies people who are genetically at risk of age-related macular degeneration (AMD). The disease damages the retina and can be arrested but not reversed. (Mirror.co.uk)
Boost To Halt Blind Disease Jul 26, 2008
Age-related macular degeneration - or AMD - affects 250,000 people in the UK. It damages the central part of the retina and leaves one in 10 sufferers blind. The test identifies those who are genetically predisposed to the condition, allowing early treatment that can prevent blindness. (Glasgow Daily Record)
Blindness In Old Age May Be Triggered By Hyperactive Immune Resistance Jul 25, 2008
ScienceDaily (July 25, 2008) Age-dependent macular degeneration (AMD) is the commonest cause of blindness in the western industrialised nations. Hereditary changes in the regulation of the immune system influence the risk of contracting AMD.. (Science Daily)
Telescope embedded in glasses lens promises to make driving easier for visually impaired Jul 25, 2008
Says Peli, "The short height of the actual magnifier, its position, and inclusion of a small tilt of the last flat mirror (the one closest to the user's eye), enables the wearer to simultaneously view the magnified field above the unmagnified view of the uninterrupted horizontal field. Not only will the new glasses improve the cosmetics and usefulness of this type of device, the in-the-lens design will make it possible to mass-produce the telescopic magnifier as a standard spectacle lens blank... (EurekAlert!)
Pensioners win treatment after court battle for sight-saving drug Jul 23, 2008
Jean Middleton, 78, from Kingsbury, Raymond Liggins, 76, from Nuneaton, and Patricia Meadows, 65, from Stratford-on-Avon went to the high court because Warwickshire PCT said it could not afford the cost of a new drug, Lucentis, which can prevent blindness from age-related macular degeneration. A course of treatment over two years costs about 10,700 per eye per patient. (guardian.co.uk)
Trials for 'bionic' eye implants Jul 20, 2008
5 million people worldwide have retinitis pigmentosa, and one in 10 people over the age of 55 have age-related macular degeneration. Both diseases cause the retinal cells which process light at the back of the eye to gradually die. (Yahoo News -- Disabilities and the Disabled)
Protein Transports Nutrients Believed To Protect Against Eye Disease Jul 19, 2008
ScienceDaily (July 18, 2008) Scientists have identified the protein responsible for transporting nutrients to the eye that are believed to protect against the development of age-related macular degeneration, a leading cause of vision loss in elderly Americans ... An estimated 10 million Americans have age-related macular degeneration, which gradually destroys sharp, central vision ... 14, 2007) Consuming higher levels of the yellow plant pigments lutein and zeaxanthin may be associated with a... (Science Daily)
Eye Test Could Spot Diabetes Vision Trouble Early Jul 17, 2008
"Diabetes is the best example of that because of the prevalence of the disease in our population. But the technique is also capable of screening other diseases such as glaucoma or age-related macular degeneration," he added. Elner has a financial interest in this technology, and started a company to make it commercially available. (MEDLINEplus)
Visual Impairment May Be Associated With Higher Suicide Risk Jul 16, 2008
(July 12, 2007) Individuals age 49 and older with cataract and those age 49 to 74 years with age-related macular degeneration appear to have higher mortality rates over an 11-year period than those without such. (Oct. (Science Daily)
Retinal transplant boosts vision Jul 14, 2008
The retinal cells, taken from aborted foetuses, were implanted into 10 people with retinitis pigmentosa and age-related macular degeneration ... Retinitis pigmentosa and age-related macular degeneration (AMD) are the most common causes of blindness in old age, and involve the gradual and normally irreversible destruction of the cells on the eye's retina which receive light. (BBC News -- Health)
Sight-drug battle in High Court Jul 13, 2008
The judicial review follows a decision by Warwickshire Primary Care Trust not to fund the drug for people with age-related macular degeneration (AMD). Success for the trio could mean more patients in England being able to have the drug, Lucentis, said the RNIB.. (BBC News -- UK)
Regeneron paying $12.45M settlement Jul 4, 2008
Regeneron is developing protein-based pharmaceuticals for treatment of diseases ranging from age-related macular degeneration to cancer and inflammatory diseases. OTHER STORIES. (Albany Times Union)
New Oral Angiogenesis Inhibitor Offers Potential Nontoxic Therapy For A Wide Range Of Cancers Jul 1, 2008
Lodamin may also be useful in other diseases that involve aberrant blood-vessel growth, such as age-related macular degeneration and arthritis. Developed by Ofra Benny, PhD, in the Children s laboratory of the late Judah Folkman, MD, Lodamin is a novel slow-release reformulation of TNP-470, a drug developed nearly two decades ago by Donald Ingber, MD, PhD, then a fellow in Folkman s lab, and one of the first angiogenesis inhibitors to undergo clinical testing. (Science Daily)
Food pairings: Working for or against you? Jul 1, 2008
So add a little extra-virgin olive oil to your zucchini, spinach, and other dark green vegetables to unleash the carotenoid lutein, an antioxidant that may help protect against age-related macular degeneration. And instead of using fat-free dressing on your salad, drizzle on an olive oil--based one. (CNN -- Health)
Next-generation artificial retina focuses on clinical trials Jul 1, 2008
(It only works for patients whose retina has degenerated, but still have intact nerves connecting to the brain--a condition brought on the disease retinitis pigmentosa and by age-related macular degeneration. The artificial retina has an array of electrodes that stimulates optic nerve cells, sending an image to the brain's vision centers. (EETimes)
Accidental fungus leads to promising cancer drug Jun 30, 2008
The researchers believe lodamin may also be useful in other diseases marked by abnormal blood vessel growth, such as age-related macular degeneration. (Editing by Todd Eastham). (Scientific American)
