HIV Vaccine Failure Probably Caused by Virus Used, Says New Research Nov 20, 2009
Dr Steven Patterson, who is the corresponding author of the study from the Division of Investigative Science at Imperial College London, said: "HIV is a huge threat to global health, with 2.7 million people becoming infected every year. We were all hopeful that the STEP trial would be a success, so when the researchers published their results and the trial was halted, we were all very surprised and disappointed. Scientists use adenoviruses in all sorts of vaccines and we did not expect this... (Science Daily)
Renewed Hope for an AIDS Vaccine Nov 17, 2009
And a new analysis of the stopped STEP trial, published online Monday in , provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development) used to distribute the inactive HIV strains can actually prime the immune system to be infected by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity. Finding a vaccine has become an increasingly urgent undertaking. (Scientific American)
PATH Malaria Vaccine Initiative and Crucell to test new malaria vaccine approach Jul 29, 2009
This approach uses Crucell's proprietary recombinant adenoviruses (a type of virus associated with the common cold and other mild respiratory infections) to deliver a malaria antigen to the immune system ... "Adenoviruses are one of the most potent vaccine delivery systems tested to date in humans. We are excited about the potential of Crucell's adenovirus-based program and the novel Ad35/Ad26 approach. The prime-boost regimen may be a critical next step in malaria vaccine development and, if... (EurekAlert! -- Business News)
Alcon Commences Phase 2 Clinical Trial of NovaBay's NVC-422 for Viral Conjunctivitis Jul 6, 2009
The viral disease is principally caused by adenoviruses, but also can be caused by other viruses, such as enterovirus. There is no specific treatment for adenoviral conjunctivitis, which can take up to three weeks or longer to clear on its own. (PR Newswire)
Therapeutic Delivery Of A Gene To Dysfunctional Nerves Jun 27, 2009
The authors developed a system to generate helper-dependent adenoviruses that targeted only DRG nerves. These were used to deliver genes to DRG nerves in mice and found to be dramatically more efficient at gene delivery than nontargeted helper-dependent adenoviruses ... In mice lacking the Hexb gene, which are consider a mouse model of Sandhoff disease, administration of DRG-targeted helper-dependent adenoviruses carrying the Hexb gene restored Hexb expression in DRG nerves and eliminated... (Science Daily)
Chile confirms 37 new cases of A/H1N1 flu Jun 2, 2009
"We have seen cases of respiratory syncytial, adenoviruses, parainfluenza and now only 65 percent is of H1N1 flu," Salgado said. Chile is the country with the largest number of confirmed A/H1N1 flu cases across South America. (Xinhuanet, China)
What Blocks Effects Of Newly Developed Anticancer Therapy? May 9, 2009
In the study, they found that human pancreatic cancer cell lines expressing the protein CEACAM6 were not sensitive to being killed by adenoviruses ... The authors therefore suggest that identifying whether or not a tumor expresses CEACAM6 and the downstream proteins required to block tumor cell killing by adenoviruses might provide a way to predict the response of patients to adenovirus-based therapies, and that these proteins might provide targets for the development of more effective... (Science Daily)
Milestone tumor virus publication by Elsevier journal Virology Apr 10, 2009
In the field of viral oncology, particularly the studies of the small DNA tumor viruses (the polyomaviruses, the adenoviruses and the papillomaviruses) have led to fundamental discoveries that have advanced our understanding of basic biology. They have helped unravel some of the most complex aspects of the host cells they infect, from signal transduction cascades, to DNA replication, to transcription. (EurekAlert!)
NovaBay Pharmaceuticals Announces Lead Anti-infective Product Candidate, NVC-422, Shown to be Effective in Treating Topical Fungal Infection Mar 8, 2009
In-vitro studies to date have shown that NVC-422 has a potentially expansive therapeutic utility against bacteria of all types, including multidrug resistant species; shedding viruses including adenoviruses; and herpes viruses, yeasts and fungi. In addition, in Phase I human studies, NVC-422 has been shown to be safe and well-tolerated in the nose and bladder. (PR Newswire)
Dynamic distribution and expression in vivo of human interferon gamma gene delivered by adenoviral vector Feb 16, 2009
Considering about the fact that the clinical application of recombinant IFNgamma was limited by its short half-life and systemic side effects, we developed a recombinant adenoviruses Ad-IFNgamma. Methods. (BioMed Central)
