Most Newer Antipsychotics No Better Than Older Ones, Just Different Feb 7, 2009
But, other second generation drugs, such as aripiprazole (Abilify), quetiapine (Seroquel), sertindole (Serdolect), ziprasidone (Geodon) and zotepine (Nipolept), were no more effective than first-generation drugs, the researchers reported. And, only aripiprazole and ziprasidone among the second-generation drugs did not induce more weight gain than the first-generation drug haloperidol (Haldol), the study found. (MEDLINEplus)
New Drugs No Better Than Older Ones for Schizophrenia Apr 1, 2008
Kahn's team randomly assigned 498 patients to haloperidol, or higher-dose second-generation drugs that included amisulpride, olanzapine, quetiapine and ziprasidone. Over the following year, 63 patients discontinued haloperidol, compared with 32 who stopped using amisulpride, 30 who stopped using olanzapine, 51 who quit quetiapine and 31 who stopped taking ziprasidone, the researchers found. (MEDLINEplus)
Bipolar Disorder Medications Feb 16, 2008
Newer atypical antipsychotic drugs including risperidone (Risperdal), quetiapine (Seroquel), ziprasidone (Geodon), aripriprazole (Abilify) and olanzapine (Zyprexa) are often used as mood stabilizers and have been found to be particularly helpful for acutely manic patients. Mood Stabilizers and Antidepressants. (Suite101.com)
Ethnicity Predicts How Gene Variations Affect Response to Schizophrenia Medications Jan 10, 2008
Patients of African ancestry with a certain variation responded better to the medication perphenazine than to the newer medications quetiapine and ziprasidone ... Differences in response to ziprasidone were striking ... During treatment with ziprasidone, schizophrenia symptoms actually worsened in patients of African descent with certain variations of the gene. (Science Daily)
Vanda Presents Phase III Iloperidone Efficacy Data Dec 13, 2007
Following fixed-dose titration, inpatients were randomized to receive iloperidone at 24 mg/day, ziprasidone at 160 mg/day, or placebo. Patients treated with iloperidone had significantly greater improvements in Positive and Negative Syndrome Scale-Total (PANSS-T) scores than those on placebo and had PANSS-T improvement comparable to ziprasidone ... "Iloperidone's combination of comparable efficacy and favorable tolerability profile is good news for physicians and patients as a potential new... (PR Newswire)
Ziprasidone May Control Unresponsive Schizophrenia Nov 1, 2007
NEW YORK (Reuters Health) - Ziprasidone, sold under the trade name Geodon, is well tolerated by patients and shows long-term efficacy as maintenance therapy for patients with schizophrenia who have not responded to other drugs, according to the results of a clinical trial published in the Journal of Clinical Psychiatry. Dr. Antony D. Loebel, of Pfizer Inc. in New York, and colleagues studied patients with a diagnosis of treatment-resistant schizophrenia based on DMS-III-R criteria who were... (MEDLINEplus)
New Medications More Effective for Treating Bipolar Oct 10, 2007
The latest generation of bipolar drugs includes aripiprazole, clozapine, olanzapine, quetiapine, ziprasidone, and risperidone. These drugs are considered a class of atypical antipsychotics that are FDA approved for the treatment of acute manic and mixed episodes associated with bipolar disorder. (Fox News)
our opinion: Recent events spotlight previously discussed concerns Aug 1, 2007
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Bank, FMCG, oil & gas keep market aloft May 21, 2007
44% to Rs 724 on it receiving tentative approval from the US Food & Drug Administration for its abbreviated new drug application for Ziprasidone capsules. Ranbaxy Laboratories was up 1. (India Times)
New details in schizophrenia treatment trial emerge Mar 1, 2007
In the first phase of the CATIE study, patients were randomly assigned to take either perphenazinean older, first-generation antipsychotic medicationor one of several newer, second-generation medications (olanzapine, quetiapine, risperidone, or ziprasidone). The researchers found that those patients who stuck with their initial treatment showed some improvement in their psychosocial functioning, and there were no differences among the medications in making these gains. (EurekAlert!)
Study Questions 'Off-Label' Use of Antipsychotics Jan 20, 2007
Atypical antipsychotics such as aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (Risperdal) and ziprasidone (Geodon) are designed to cause fewer neurological complications than older antipsychotics. They are approved to treat schizophrenia and bipolar disorder but are increasingly used to treat dementia, geriatric aggression, depression, obsessive-compulsive disorder, post-traumatic stress disorder and personality disorders. (Health-Finder)
